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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:3682
Term: chrysazin
Definition: A dihydroxyanthraquinone that is anthracene-9,10-dione substituted by hydroxy groups at positions 1 and 8.
Chemical ID: MESH:C004315
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDdanthron results in increased expression of CASP3 mRNAPMID:21126053
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDbenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP3 protein]; danthron results in increased activity of and results in increased expression of CASP3 proteinPMID:21126053
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