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positive regulation of receptor-mediated endocytosis - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of receptor-mediated endocytosis
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Accession:GO:0048260 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
Synonyms:exact_synonym: up regulation of receptor mediated endocytosis;   upregulation of receptor mediated endocytosis
 narrow_synonym: activation of receptor mediated endocytosis;   stimulation of receptor mediated endocytosis

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positive regulation of receptor-mediated endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 IMP RGD PMID:11717353 RGD:13452389 NCBI chr 1:104,520,789...104,550,655
Ensembl chr 1:95,384,309...95,414,147 		JBrowse link
G B2m beta-2 microglobulin involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:P02787|UniProtKB:Q07891|UniProtKB:Q30201|UniProtKB:Q9UP52 (PMID:18353247) 		Ensembl
RGD		 PMID:18353247 GO_REF:0000107 NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Bicd1 BICD cargo adaptor 1 involved_in ISO
IBA 		(PMID:20164183)
GO_REF:0000033 		RGD
GO_Central		 PMID:20164183 GO_REF:0000033 NCBI chr 4:184,208,891...184,362,840
Ensembl chr 4:182,479,071...182,627,434 		JBrowse link
G C3 complement C3 involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:P05555 (PMID:20199584), (PMID:22438044) 		Ensembl
RGD		 PMID:20199584 PMID:22438044 GO_REF:0000107 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cbl Cbl proto-oncogene involved_in ISO
IEA 		(PMID:15465819), (PMID:25178484)
GO_REF:0000107 		RGD
Ensembl		 PMID:15465819 PMID:25178484 GO_REF:0000107 NCBI chr 8:53,384,656...53,468,067
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:12609829) RGD PMID:12609829 NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (PMID:12609829) RGD PMID:12609829 NCBI chr 5:61,776,411...61,777,515
Ensembl chr 5:56,980,558...56,981,686 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Clu clusterin involved_in IEA
ISO
ISS 		GO_REF:0000107
(PMID:11697889)
UniProtKB:C0HL13 (PMID:9228033)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:9228033 PMID:11697889 GO_REF:0000024 GO_REF:0000107 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G H1f1 H1.1 linker histone, cluster member involved_in ISO (PMID:9664069) RGD PMID:9664069 NCBI chr17:41,366,268...41,367,011
Ensembl chr17:41,366,268...41,367,011 		JBrowse link
G Hfe homeostatic iron regulator involved_in ISO UniProtKB:P02787|UniProtKB:P61769|UniProtKB:Q07891|UniProtKB:Q9UP52 (PMID:18353247) RGD PMID:18353247 NCBI chr17:41,841,302...41,849,359
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
G Hip1 huntingtin interacting protein 1 involved_in ISO (PMID:11532990), (PMID:11577110)
(PMID:11577110) 		RGD PMID:11532990 PMID:11577110 NCBI chr12:21,133,364...21,267,796
Ensembl chr12:21,133,406...21,267,725 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K acts_upstream_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr17:6,269,302...6,280,429
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Il4 interleukin 4 involved_in ISO
IDA 		(PMID:18941241) RGD PMID:18941241 PMID:18941241 RGD:13825436 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Kif3a kinesin family member 3a IDA RGD PMID:15181154 RGD:1581596 NCBI chr10:38,226,388...38,263,062
Ensembl chr10:37,725,970...37,759,191 		JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 involved_in ISO (PMID:15166224) RGD PMID:15166224 NCBI chr 5:152,239,296...152,262,290
Ensembl chr 5:146,955,607...146,978,601 		JBrowse link
G LOC100359916 heterogeneous nuclear ribonucleoprotein K-like acts_upstream_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 5:58,668,326...58,670,222
Ensembl chr 5:58,668,327...58,670,220 		JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase IMP RGD PMID:21807099 RGD:152999022 NCBI chr10:89,227,937...89,357,383
Ensembl chr10:88,727,912...88,857,386 		JBrowse link
G Pld2 phospholipase D2 IMP RGD PMID:15470141 RGD:2299909 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 involved_in ISO
ISS
IEA 		(PMID:16542649)
PMID:8895569
GO_REF:0000107 		RGD
Ensembl		 PMID:16542649 PMID:8895569 GO_REF:0000107, RGD:8553248 NCBI chr 5:140,406,318...140,427,201
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Rab21 RAB21, member RAS oncogene family involved_in ISO
IEA 		(PMID:15561770)
GO_REF:0000107 		RGD
Ensembl		 PMID:15561770 GO_REF:0000107 NCBI chr 7:52,790,158...52,814,943
Ensembl chr 7:50,904,057...50,928,839 		JBrowse link
G Serpine1 serpin family E member 1 involved_in IMP
ISO
IEA 		PMID:8626514
(PMID:8626514)
GO_REF:0000107 		RGD
Ensembl		 PMID:8626514 PMID:8626514 GO_REF:0000107, RGD:8554276 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sgip1 SH3GL interacting endocytic adaptor 1 involved_in ISS
ISO 		PMID:17626015
(PMID:17626015) 		RGD PMID:17626015 PMID:17626015 RGD:8554282 NCBI chr 5:117,536,752...117,734,593
Ensembl chr 5:117,537,746...117,734,575 		JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 IMP RGD PMID:15541315 RGD:2314546 NCBI chr 1:43,917,640...44,388,802
Ensembl chr 1:41,512,030...41,983,322 		JBrowse link
G Synj1 synaptojanin 1 IMP RGD PMID:15821731 RGD:2312450 NCBI chr11:43,678,709...43,755,526
Ensembl chr11:30,192,629...30,269,220 		JBrowse link
G Tf transferrin involved_in ISO UniProtKB:Q07891|UniProtKB:Q9UP52 (PMID:12704209), (PMID:18353247) RGD PMID:12704209 PMID:18353247 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Vtn vitronectin involved_in ISO
IEA 		(PMID:8626514)
GO_REF:0000107 		RGD
Ensembl		 PMID:8626514 GO_REF:0000107 NCBI chr10:63,892,782...63,895,862
Ensembl chr10:63,394,719...63,397,810 		JBrowse link
positive regulation of clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dab2 DAB adaptor protein 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:16984970) 		Ensembl
RGD		 PMID:16984970 GO_REF:0000107 NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Dgkd diacylglycerol kinase, delta involved_in ISO (PMID:17880279) RGD PMID:17880279 NCBI chr 9:88,516,686...88,607,349
Ensembl chr 9:88,516,715...88,607,345 		JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:11925437 RGD:728683 NCBI chr 8:28,254,344...28,336,297
Ensembl chr 8:19,978,400...20,060,157 		JBrowse link
G Wasl WASP like actin nucleation promoting factor involved_in IDA PMID:20730103 BHF-UCL PMID:20730103 RGD:8554834 NCBI chr 4:54,049,081...54,097,653
Ensembl chr 4:53,083,536...53,132,022 		JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) RGD PMID:25639753 NCBI chr16:29,460,855...29,469,962
Ensembl chr16:24,694,324...24,703,465 		JBrowse link
G Apln apelin involved_in IDA
IEA
ISO 		PMID:11359874
GO_REF:0000107
(PMID:11359874) 		Ensembl
RGD		 PMID:11359874 PMID:11359874 GO_REF:0000107, RGD:12907555 NCBI chr  X:132,058,739...132,091,518
Ensembl chr  X:127,203,823...127,213,391 		JBrowse link
G Aplnr apelin receptor involved_in ISO
IEA 		(PMID:25639753)
GO_REF:0000107 		RGD
Ensembl		 PMID:25639753 GO_REF:0000107 NCBI chr 3:90,624,055...90,627,700
Ensembl chr 3:70,217,385...70,221,050 		JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:18723082) RGD PMID:18723082 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
positive regulation of receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahi1 Abelson helper integration site 1 involved_in ISO
ISS 		(PMID:20956301)
GO_REF:0000024 		RGD
UniProt		 PMID:20956301 GO_REF:0000024 NCBI chr 1:17,580,859...17,711,775
Ensembl chr 1:15,762,462...15,891,041 		JBrowse link
G Angpt1 angiopoietin 1 involved_in ISO
IEA 		(PMID:19424712)
GO_REF:0000107 		RGD
Ensembl		 PMID:19424712 GO_REF:0000107 NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 IMP RGD PMID:12105201 RGD:13461854 NCBI chr11:93,859,690...93,868,600
Ensembl chr11:80,328,041...80,364,140 		JBrowse link
G Arrb1 arrestin, beta 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:22457824) 		UniProt
RGD		 PMID:22457824 GO_REF:0000024 NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrb2 arrestin, beta 2 involved_in IMP
ISO 		Oprm1
(PMID:22457824) 		RGD PMID:22457824 PMID:16120787 RGD:5510008 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Atad1 ATPase family, AAA domain containing 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:21496646) 		UniProt
RGD		 PMID:21496646 GO_REF:0000024 NCBI chr 1:239,957,329...240,023,792
Ensembl chr 1:230,544,047...230,596,548 		JBrowse link
G Cd63 Cd63 molecule involved_in ISO
IEA
ISS 		(PMID:23632027)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:23632027 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:1,909,538...1,924,937
Ensembl chr 7:1,325,103...1,399,178 		JBrowse link
G Dab2 DAB adaptor protein 2 involved_in ISO (PMID:23354168) RGD PMID:23354168 NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Drd2 dopamine receptor D2 IMP RGD PMID:18809670 RGD:2311559 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Dtnbp1 dystrobrevin binding protein 1 IMP RGD PMID:17989303 RGD:8553895 NCBI chr17:19,891,313...19,982,770
Ensembl chr17:19,685,215...19,776,661 		JBrowse link
G Egf epidermal growth factor involved_in ISO
IEA 		(PMID:22732145)
GO_REF:0000107 		RGD
Ensembl		 PMID:22732145 GO_REF:0000107 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:25561520) 		UniProt
Ensembl
RGD		 PMID:25561520 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:152,284,857...152,322,686
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Gh1 growth hormone 1 NOT|involved_in ISO (PMID:9360546) RGD PMID:9360546 NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:20660291) RGD PMID:20660291 NCBI chr 3:120,966,639...120,978,319
Ensembl chr 3:100,512,313...100,524,082 		JBrowse link
G Hamp hepcidin antimicrobial peptide involved_in ISO (PMID:15514116) RGD PMID:15514116 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Insr insulin receptor involved_in ISO (PMID:25401701) RGD PMID:25401701 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 involved_in IEA
ISO
ISS 		GO_REF:0000107
(PMID:11526121)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:11526121 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:15,278,518...16,762,427
Ensembl chr 4:14,386,399...15,870,240 		JBrowse link
G Ntf3 neurotrophin 3 involved_in IEA
ISO 		GO_REF:0000107
(PMID:23027130) 		Ensembl
RGD		 PMID:23027130 GO_REF:0000107 NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Pard3 par-3 family cell polarity regulator involved_in ISO (PMID:23354168) RGD PMID:23354168 NCBI chr19:71,977,420...72,527,273
Ensembl chr19:55,080,282...55,629,778 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO
IEA 		(PMID:17328821)
GO_REF:0000107 		RGD
Ensembl		 PMID:17328821 GO_REF:0000107 NCBI chr 5:126,440,102...126,462,507
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
G Pick1 protein interacting with PRKCA 1 involved_in IDA
IBA 		PMID:18297063
GO_REF:0000033 		GO_Central PMID:18297063 GO_REF:0000033, RGD:8554748 NCBI chr 7:112,676,890...112,697,275
Ensembl chr 7:110,797,117...110,816,848 		JBrowse link
G Plcg2 phospholipase C, gamma 2 involved_in ISO (PMID:22078883) RGD PMID:22078883 NCBI chr19:62,456,196...62,592,684
Ensembl chr19:45,547,416...45,683,930 		JBrowse link
G Plk2 polo-like kinase 2 IMP RGD PMID:20802490 RGD:152995511 NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:41,969,176...41,974,947 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 IMP RGD PMID:19625523 RGD:9835004 NCBI chr 1:106,756,896...106,817,369
Ensembl chr 1:97,620,642...97,679,882 		JBrowse link
G Sele selectin E involved_in ISO (PMID:9312078) RGD PMID:9312078 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sfrp4 secreted frizzled-related protein 4 involved_in IEA
ISO 		GO_REF:0000107
(PMID:16151791) 		Ensembl
RGD		 PMID:16151791 GO_REF:0000107 NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in IEA
ISO 		GO_REF:0000107
(PMID:22078883), (PMID:23962979) 		Ensembl
RGD		 PMID:22078883 PMID:23962979 GO_REF:0000107 NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Synj2bp synaptojanin 2 binding protein involved_in ISO (PMID:16648306) RGD PMID:16648306 NCBI chr 6:106,920,970...106,958,653
Ensembl chr 6:101,189,714...101,227,406 		JBrowse link
G Tbc1d5 TBC1 domain family, member 5 involved_in ISO (PMID:22354992) RGD PMID:22354992 NCBI chr 9:3,740,032...4,256,971
Ensembl chr 9:3,513,623...4,016,913 		JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO
IEA 		(PMID:20660291)
GO_REF:0000107 		RGD
Ensembl		 PMID:20660291 GO_REF:0000107 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wnt3a Wnt family member 3A involved_in ISO
IEA 		(PMID:16890161)
GO_REF:0000107 		RGD
Ensembl		 PMID:16890161 GO_REF:0000107 NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
positive regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07018244.2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr15:39,788,233...39,788,853 JBrowse link
G Anxa2 annexin A2 involved_in ISO
IBA 		(PMID:22848640)
GO_REF:0000033 		RGD
GO_Central		 PMID:22848640 GO_REF:0000033 NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 involved_in ISO (PMID:12417523), (PMID:12464675), (PMID:15166224) RGD PMID:12417523 PMID:12464675 PMID:15166224 NCBI chr 5:152,239,296...152,262,290
Ensembl chr 5:146,955,607...146,978,601 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20567
    positive regulation of biological process 6770
      positive regulation of transport 1085
        positive regulation of endocytosis 202
          positive regulation of receptor-mediated endocytosis 67
            positive regulation of clathrin-dependent endocytosis 4
            positive regulation of receptor internalization + 35
            positive regulation of receptor-mediated endocytosis involved in cholesterol transport 3
Path 2
Term Annotations click to browse term
  biological_process 20567
    localization 5739
      establishment of localization 5084
        transport 4772
          vesicle-mediated transport 1654
            regulation of vesicle-mediated transport 646
              regulation of endocytosis 365
                regulation of receptor-mediated endocytosis 153
                  positive regulation of receptor-mediated endocytosis 67
                    positive regulation of clathrin-dependent endocytosis 4
                    positive regulation of receptor internalization + 35
                    positive regulation of receptor-mediated endocytosis involved in cholesterol transport 3
paths to the root