Kif3a (kinesin family member 3a) - Rat Genome Database

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Gene: Kif3a (kinesin family member 3a) Rattus norvegicus
Analyze
Symbol: Kif3a
Name: kinesin family member 3a
RGD ID: 621536
Description: Enables kinesin binding activity. Involved in positive regulation of establishment or maintenance of cell polarity regulating cell shape; positive regulation of transport; and response to silicon dioxide. Located in axon cytoplasm; axoneme; and neuronal cell body. Colocalizes with ribbon synapse. Biomarker of silicosis. Orthologous to human KIF3A (kinesin family member 3A); PARTICIPATES IN Hedgehog signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kinesin-like protein KIF3A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,226,388 - 38,263,062 (+)NCBIGRCr8
mRatBN7.21037,725,930 - 37,761,183 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,725,970 - 37,759,191 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,418,009 - 42,451,222 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,908,061 - 41,941,287 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,411,789 - 37,445,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,918,705 - 38,953,958 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,918,748 - 38,952,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,700,206 - 38,734,498 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,029,351 - 39,062,570 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,057,446 - 39,068,547 (+)NCBI
Celera1037,070,450 - 37,103,611 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
anterograde axonal transport  (IBA)
anterograde dendritic transport  (ISO)
anterograde dendritic transport of neurotransmitter receptor complex  (ISO)
centriole-centriole cohesion  (ISO)
cilium assembly  (IBA,ISO)
cilium movement  (ISO)
dentate gyrus development  (ISO)
determination of left/right symmetry  (ISO)
dorsal/ventral neural tube patterning  (ISO)
dorsal/ventral pattern formation  (ISO)
epidermal stem cell homeostasis  (ISO)
epidermis development  (ISO)
forebrain development  (ISO)
heart development  (ISO)
heart looping  (ISO)
in utero embryonic development  (ISO)
inner ear receptor cell stereocilium organization  (ISO)
keratinocyte proliferation  (ISO)
kidney development  (ISO)
microtubule anchoring at centrosome  (ISO)
mitotic spindle organization  (IEA)
motile cilium assembly  (ISO)
neural precursor cell proliferation  (ISO)
neural tube development  (ISO)
non-motile cilium assembly  (ISO)
positive regulation of axo-dendritic protein transport  (IMP)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of establishment or maintenance of cell polarity regulating cell shape  (IMP)
positive regulation of intracellular protein transport  (IMP)
positive regulation of keratinocyte proliferation  (ISO)
positive regulation of receptor-mediated endocytosis  (IDA)
protein localization to cell junction  (ISO)
protein transport  (ISO)
response to silicon dioxide  (IEP)
smoothened signaling pathway  (ISO)
spindle elongation  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Microtubule-dependent movement of late endocytic vesicles in vitro: requirements for Dynein and Kinesin. Bananis E, etal., Mol Biol Cell. 2004 Aug;15(8):3688-97. Epub 2004 Jun 4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Dynamics of Kv1 channel transport in axons. Gu Y and Gu C, PLoS One. 2010 Aug 4;5(8):e11931. doi: 10.1371/journal.pone.0011931.
4. Silica Perturbs Primary Cilia and Causes Myofibroblast Differentiation during Silicosis by Reduction of the KIF3A-Repressor GLI3 Complex. Li S, etal., Theranostics. 2020 Jan 1;10(4):1719-1732. doi: 10.7150/thno.37049. eCollection 2020.
5. Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Lin F, etal., Proc Natl Acad Sci U S A 2003 Apr 29;100(9):5286-91.
6. Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. Massinen S, etal., PLoS One. 2011;6(6):e20580. doi: 10.1371/journal.pone.0020580. Epub 2011 Jun 16.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. The kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptors. Muresan V, etal., J Neurosci. 1999 Feb 1;19(3):1027-37.
9. KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles. Muresan V, etal., Mol Biol Cell 1998 Mar;9(3):637-52.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nishimura T, etal., Nat Cell Biol. 2004 Apr;6(4):328-34. Epub 2004 Mar 28.
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
17. APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity. Shi SH, etal., Curr Biol. 2004 Nov 23;14(22):2025-32.
18. Myosin Va and kinesin II motor proteins are concentrated in ribosomal domains (periaxoplasmic ribosomal plaques) of myelinated axons. Sotelo-Silveira JR, etal., J Neurobiol. 2004 Aug;60(2):187-96.
19. Active zone proteins are dynamically associated with synaptic ribbons in rat pinealocytes. Spiwoks-Becker I, etal., Cell Tissue Res. 2008 Aug;333(2):185-95. doi: 10.1007/s00441-008-0627-3. Epub 2008 Jun 4.
Additional References at PubMed
PMID:8889548   PMID:10220415   PMID:10330409   PMID:12821668   PMID:15067314   PMID:15755804   PMID:16298999   PMID:17360631   PMID:17825299   PMID:18066062   PMID:18297065   PMID:18590716  
PMID:18729223   PMID:19056867   PMID:19208653   PMID:19286674   PMID:19384852   PMID:19684112   PMID:21209331   PMID:21429982   PMID:21670265   PMID:21703454   PMID:23376485   PMID:23386061  
PMID:23704327   PMID:24338362   PMID:26021297   PMID:28291836   PMID:29891944  


Genomics

Comparative Map Data
Kif3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,226,388 - 38,263,062 (+)NCBIGRCr8
mRatBN7.21037,725,930 - 37,761,183 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,725,970 - 37,759,191 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,418,009 - 42,451,222 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,908,061 - 41,941,287 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,411,789 - 37,445,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,918,705 - 38,953,958 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,918,748 - 38,952,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,700,206 - 38,734,498 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,029,351 - 39,062,570 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,057,446 - 39,068,547 (+)NCBI
Celera1037,070,450 - 37,103,611 (+)NCBICelera
Cytogenetic Map10q22NCBI
KIF3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,688,812 - 132,737,546 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,692,628 - 132,737,638 (-)EnsemblGRCh38hg38GRCh38
GRCh375132,028,323 - 132,073,238 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,056,222 - 132,101,164 (-)NCBINCBI36Build 36hg18NCBI36
Build 345132,059,220 - 132,101,163NCBI
Celera5128,158,460 - 128,203,363 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,220,971 - 127,265,873 (-)NCBIHuRef
CHM1_15131,461,606 - 131,506,536 (-)NCBICHM1_1
T2T-CHM13v2.05133,208,481 - 133,257,281 (-)NCBIT2T-CHM13v2.0
Kif3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,456,531 - 53,495,075 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,458,206 - 53,492,794 (+)EnsemblGRCm39 Ensembl
GRCm381153,565,701 - 53,604,248 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,567,379 - 53,601,967 (+)EnsemblGRCm38mm10GRCm38
MGSCv371153,380,881 - 53,417,746 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,410,826 - 53,445,377 (+)NCBIMGSCv36mm8
Celera1158,146,946 - 58,183,772 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.97NCBI
Kif3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554084,069,639 - 4,115,998 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554084,072,823 - 4,115,975 (-)NCBIChiLan1.0ChiLan1.0
KIF3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24128,004,995 - 128,049,749 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,144,560 - 126,189,314 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,112,636 - 128,154,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,268,505 - 134,315,431 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,274,352 - 134,315,431 (-)Ensemblpanpan1.1panPan2
KIF3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,988,516 - 21,044,151 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,928,655 - 21,044,090 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,790,183 - 19,845,775 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,774,466 - 21,830,159 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,774,475 - 21,830,123 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,492,965 - 20,548,637 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,340,508 - 20,396,333 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,983,018 - 21,038,700 (-)NCBIUU_Cfam_GSD_1.0
Kif3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,458,121 - 115,499,788 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,461,138 - 2,501,871 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,461,017 - 2,502,550 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,932,615 - 135,069,377 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,932,339 - 135,069,408 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,400,867 - 140,537,919 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KIF3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,496,770 - 35,554,536 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,514,130 - 35,551,472 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,387,830 - 42,436,606 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,354,232 - 39,407,121 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,354,360 - 39,406,574 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kif3a
143 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:7
Count of miRNA genes:5
Interacting mature miRNAs:7
Transcripts:ENSRNOT00000009999
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat

Markers in Region
D10Rat168  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,729,374 - 37,729,617 (+)MAPPERmRatBN7.2
Rnor_6.01038,922,153 - 38,922,395NCBIRnor6.0
Rnor_5.01038,703,881 - 38,704,123UniSTSRnor5.0
RGSC_v3.41039,032,755 - 39,032,998RGDRGSC3.4
RGSC_v3.41039,032,756 - 39,032,998UniSTSRGSC3.4
RGSC_v3.11039,041,271 - 39,041,661RGD
Celera1037,073,855 - 37,074,097UniSTS
SHRSP x BN Map1036.2799RGD
SHRSP x BN Map1036.2799UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 20 4 4 4 74 20 40 10
Low 3 23 53 37 19 37 8 11 15 1 1 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF155825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM180763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW530197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB616593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR474808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV116151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000009999   ⟹   ENSRNOP00000009999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,725,970 - 37,759,191 (+)Ensembl
Rnor_6.0 Ensembl1038,918,748 - 38,951,967 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077569   ⟹   ENSRNOP00000069057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,726,277 - 37,759,191 (+)Ensembl
Rnor_6.0 Ensembl1038,919,167 - 38,952,785 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096824   ⟹   ENSRNOP00000085263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,729,166 - 37,757,761 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110159   ⟹   ENSRNOP00000096291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,728,722 - 37,757,761 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111035   ⟹   ENSRNOP00000096108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,725,970 - 37,759,188 (+)Ensembl
RefSeq Acc Id: NM_053377   ⟹   NP_445829
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,226,770 - 38,259,989 (+)NCBI
mRatBN7.21037,725,970 - 37,759,191 (+)NCBI
Rnor_6.01038,918,748 - 38,951,967 (+)NCBI
Rnor_5.01038,700,206 - 38,734,498 (+)NCBI
RGSC_v3.41039,029,351 - 39,062,570 (+)RGD
Celera1037,070,450 - 37,103,611 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246347   ⟹   XP_006246409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,226,388 - 38,263,062 (+)NCBI
mRatBN7.21037,725,937 - 37,761,180 (+)NCBI
Rnor_6.01038,918,705 - 38,953,958 (+)NCBI
Rnor_5.01038,700,206 - 38,734,498 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246351   ⟹   XP_006246413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,226,388 - 38,263,062 (+)NCBI
mRatBN7.21037,725,937 - 37,759,191 (+)NCBI
Rnor_6.01038,918,706 - 38,953,958 (+)NCBI
Rnor_5.01038,700,206 - 38,734,498 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597556   ⟹   XP_017453045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,226,388 - 38,263,062 (+)NCBI
mRatBN7.21037,726,318 - 37,759,141 (+)NCBI
Rnor_6.01038,919,098 - 38,953,958 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597557   ⟹   XP_017453046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,226,388 - 38,263,062 (+)NCBI
mRatBN7.21037,725,936 - 37,759,141 (+)NCBI
Rnor_6.01038,918,705 - 38,953,958 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086966   ⟹   XP_038942894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,226,388 - 38,249,719 (+)NCBI
mRatBN7.21037,725,930 - 37,748,899 (+)NCBI
RefSeq Acc Id: XM_039086967   ⟹   XP_038942895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,226,388 - 38,249,719 (+)NCBI
mRatBN7.21037,725,932 - 37,748,899 (+)NCBI
RefSeq Acc Id: XM_063269987   ⟹   XP_063126057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,226,388 - 38,263,062 (+)NCBI
RefSeq Acc Id: XM_063269988   ⟹   XP_063126058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,226,388 - 38,263,062 (+)NCBI
RefSeq Acc Id: XM_063269989   ⟹   XP_063126059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,226,388 - 38,263,062 (+)NCBI
RefSeq Acc Id: XM_063269990   ⟹   XP_063126060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,226,388 - 38,249,719 (+)NCBI
RefSeq Acc Id: NP_445829   ⟸   NM_053377
- UniProtKB: A0A0G2JUD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246409   ⟸   XM_006246347
- Peptide Label: isoform X1
- UniProtKB: F1LQZ3 (UniProtKB/TrEMBL),   A0A0G2JUD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246413   ⟸   XM_006246351
- Peptide Label: isoform X5
- UniProtKB: A6HED3 (UniProtKB/TrEMBL),   A0A0G2JUD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453046   ⟸   XM_017597557
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JUD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453045   ⟸   XM_017597556
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JUD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069057   ⟸   ENSRNOT00000077569
RefSeq Acc Id: ENSRNOP00000009999   ⟸   ENSRNOT00000009999
RefSeq Acc Id: XP_038942894   ⟸   XM_039086966
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038942895   ⟸   XM_039086967
- Peptide Label: isoform X9
RefSeq Acc Id: ENSRNOP00000096291   ⟸   ENSRNOT00000110159
RefSeq Acc Id: ENSRNOP00000096108   ⟸   ENSRNOT00000111035
RefSeq Acc Id: ENSRNOP00000085263   ⟸   ENSRNOT00000096824
RefSeq Acc Id: XP_063126058   ⟸   XM_063269988
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063126057   ⟸   XM_063269987
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063126059   ⟸   XM_063269989
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063126060   ⟸   XM_063269990
- Peptide Label: isoform X10
Protein Domains
Kinesin motor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQZ3-F1-model_v2 AlphaFold F1LQZ3 1-702 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697181
Promoter ID:EPDNEW_R7704
Type:initiation region
Name:Kif3a_1
Description:kinesin family member 3a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7705  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01038,918,751 - 38,918,811EPDNEW
RGD ID:13697185
Promoter ID:EPDNEW_R7705
Type:multiple initiation site
Name:Kif3a_2
Description:kinesin family member 3a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7704  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01038,919,203 - 38,919,263EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621536 AgrOrtholog
BioCyc Gene G2FUF-25137 BioCyc
Ensembl Genes ENSRNOG00000007515 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009999.8 UniProtKB/TrEMBL
  ENSRNOT00000077569.2 UniProtKB/TrEMBL
  ENSRNOT00000096824.1 UniProtKB/TrEMBL
  ENSRNOT00000110159.1 UniProtKB/TrEMBL
  ENSRNOT00000111035.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.850.10 UniProtKB/TrEMBL
InterPro Kinesin-like_fam UniProtKB/TrEMBL
  Kinesin_motor_CS UniProtKB/TrEMBL
  Kinesin_motor_dom UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:84392 UniProtKB/TrEMBL
NCBI Gene 84392 ENTREZGENE
PANTHER CENTROMERE PROTEIN E UniProtKB/TrEMBL
  CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED UniProtKB/TrEMBL
  KINESIN-LIKE PROTEIN UniProtKB/TrEMBL
  KINESIN-LIKE PROTEIN UniProtKB/TrEMBL
Pfam Kinesin UniProtKB/TrEMBL
PharmGKB KIF3A RGD
PhenoGen Kif3a PhenoGen
PRINTS KINESINHEAVY UniProtKB/TrEMBL
PROSITE KINESIN_MOTOR_DOMAIN1 UniProtKB/TrEMBL
  KINESIN_MOTOR_DOMAIN2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007515 RatGTEx
SMART KISc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2JUD6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AL48_RAT UniProtKB/TrEMBL
  A0A8I6AP89_RAT UniProtKB/TrEMBL
  A0A8I6GCQ1_RAT UniProtKB/TrEMBL
  A6HED3 ENTREZGENE, UniProtKB/TrEMBL
  F1LQZ3 ENTREZGENE, UniProtKB/TrEMBL
  Q2P9S3_RAT UniProtKB/TrEMBL
  Q9WV62_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Kif3a  kinesin family member 3a      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kif3a  kinesin family member 3a      Symbol and Name status set to provisional 70820 PROVISIONAL