Pard3 (par-3 family cell polarity regulator) - Rat Genome Database

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Gene: Pard3 (par-3 family cell polarity regulator) Rattus norvegicus
Analyze
Symbol: Pard3
Name: par-3 family cell polarity regulator
RGD ID: 620374
Description: Enables identical protein binding activity; phosphatidylinositol phosphate binding activity; and protein phosphatase binding activity. Involved in several processes, including bicellular tight junction assembly; establishment of epithelial cell polarity; and protein targeting to membrane. Located in axonal growth cone; cell-cell junction; and neuronal cell body. Part of protein-containing complex. Orthologous to human PARD3 (par-3 family cell polarity regulator); PARTICIPATES IN protein kinase C (PKC) signaling pathway; chemokine mediated signaling pathway; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ASBP; ASIP; atypical PKC isotype-specific-interacting protein; atypical PKC-specific binding protein; atypical PKC-specific-binding protein; par-3 (partitioning defective 3) homolog; par-3 (partitioning defective 3) homolog (C. elegans); Par3; PARD-3; partitioning defective 3 homolog; partitioning-defective 3 homolog; partitioning-defective 3 homolog (C. elegans); three-PDZ containing protein similar to C. elegans PAR3 (partitioning defect)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21955,080,282 - 55,630,111 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1955,080,282 - 55,629,778 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1961,870,365 - 62,419,736 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01962,730,267 - 63,279,652 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01964,812,741 - 65,362,286 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01960,017,746 - 60,580,628 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1960,017,746 - 60,580,651 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01970,690,939 - 71,249,213 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41957,015,742 - 57,603,133 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11957,020,801 - 57,608,193 (+)NCBI
Celera1954,418,687 - 54,967,349 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dibromoethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2-nitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
dibenzo[a,l]pyrene  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
glyphosate  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
Monobutylphthalate  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
permethrin  (EXP,ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). Ebnet K, etal., EMBO J. 2001 Jul 16;20(14):3738-48.
2. Par-3-mediated junctional localization of the lipid phosphatase PTEN is required for cell polarity establishment. Feng W, etal., J Biol Chem. 2008 Aug 22;283(34):23440-9. doi: 10.1074/jbc.M802482200. Epub 2008 Jun 10.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. Izumi Y, etal., J Cell Biol 1998 Oct 5;143(1):95-106.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cultured neurons. Rosso S, etal., Mol Biol Cell. 2004 Jul;15(7):3433-49. Epub 2004 Apr 16.
12. The PAR-aPKC system: lessons in polarity. Suzuki A and Ohno S, J Cell Sci. 2006 Mar 15;119(Pt 6):979-87.
13. Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis. Wong EW, etal., Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9657-62. Epub 2008 Jul 10.
14. PDZ domains of Par-3 as potential phosphoinositide signaling integrators. Wu H, etal., Mol Cell. 2007 Dec 14;28(5):886-98.
15. The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis. Zhang H and Macara IG, Nat Cell Biol. 2006 Mar;8(3):227-37. Epub 2006 Feb 12.
16. Structural insights into the intrinsic self-assembly of Par-3 N-terminal domain. Zhang Y, etal., Structure. 2013 Jun 4;21(6):997-1006. doi: 10.1016/j.str.2013.04.004. Epub 2013 May 2.
Additional References at PubMed
PMID:10954424   PMID:12045219   PMID:12203721   PMID:12515806   PMID:12756256   PMID:14676191   PMID:14760703   PMID:15556865   PMID:15723051   PMID:15766746   PMID:15775979   PMID:16510873  
PMID:17082460   PMID:17476308   PMID:18070611   PMID:19383721   PMID:19540120   PMID:19620967   PMID:19812038   PMID:20080746   PMID:20152177   PMID:20237282   PMID:20332120   PMID:20619750  
PMID:20966078   PMID:21467691   PMID:21685893   PMID:21949390   PMID:22006950   PMID:22128191   PMID:22512338   PMID:22975380   PMID:23354168   PMID:25631815   PMID:25931508   PMID:25948265  
PMID:25977476   PMID:31868265   PMID:32811537  


Genomics

Comparative Map Data
Pard3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21955,080,282 - 55,630,111 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1955,080,282 - 55,629,778 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1961,870,365 - 62,419,736 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01962,730,267 - 63,279,652 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01964,812,741 - 65,362,286 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01960,017,746 - 60,580,628 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1960,017,746 - 60,580,651 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01970,690,939 - 71,249,213 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41957,015,742 - 57,603,133 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11957,020,801 - 57,608,193 (+)NCBI
Celera1954,418,687 - 54,967,349 (+)NCBICelera
Cytogenetic Map19q12NCBI
PARD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381034,109,561 - 34,815,296 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1034,109,560 - 34,815,325 (-)EnsemblGRCh38hg38GRCh38
GRCh371034,398,489 - 35,104,224 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361034,440,103 - 35,143,929 (-)NCBINCBI36Build 36hg18NCBI36
Build 341034,440,102 - 35,143,929NCBI
Celera1034,163,865 - 34,869,585 (-)NCBICelera
Cytogenetic Map10p11.22-p11.21NCBI
HuRef1034,117,758 - 34,726,488 (-)NCBIHuRef
CHM1_11034,399,927 - 35,105,524 (-)NCBICHM1_1
T2T-CHM13v2.01034,138,078 - 34,843,839 (-)NCBIT2T-CHM13v2.0
Pard3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398127,790,131 - 128,338,767 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8127,790,643 - 128,338,767 (+)EnsemblGRCm39 Ensembl
GRCm388127,063,381 - 127,612,286 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8127,063,893 - 127,612,286 (+)EnsemblGRCm38mm10GRCm38
MGSCv378129,587,956 - 130,136,186 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368129,950,335 - 130,496,920 (+)NCBIMGSCv36mm8
Celera8131,381,912 - 131,927,387 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map874.66NCBI
Pard3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554622,849,181 - 3,457,478 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554622,930,171 - 3,457,358 (+)NCBIChiLan1.0ChiLan1.0
PARD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11046,752,167 - 47,459,972 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01034,225,791 - 34,933,907 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11034,807,707 - 35,393,308 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1034,808,380 - 35,393,287 (-)Ensemblpanpan1.1panPan2
PARD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.122,252,262 - 2,791,459 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl22,076,502 - 2,789,886 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha22,230,563 - 2,886,867 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.022,424,015 - 3,081,365 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl22,423,645 - 3,081,059 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.122,196,687 - 2,846,282 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.022,239,554 - 2,889,603 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.022,363,846 - 3,014,354 (+)NCBIUU_Cfam_GSD_1.0
Pard3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934412,972,567 - 13,521,798 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365742,473,675 - 3,013,582 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365742,472,064 - 3,013,590 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1056,967,434 - 57,600,456 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11056,968,100 - 57,600,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21062,681,290 - 63,023,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1933,396,738 - 34,104,479 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl933,396,246 - 33,803,997 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605642,479,238 - 43,193,119 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pard3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248057,205,092 - 7,808,542 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248057,204,915 - 7,810,050 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pard3
3409 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:295
Count of miRNA genes:179
Interacting mature miRNAs:223
Transcripts:ENSRNOT00000042623
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat

Markers in Region
D19Rat100  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21955,167,319 - 55,167,549 (+)MAPPERmRatBN7.2
Rnor_6.01960,104,248 - 60,104,475NCBIRnor6.0
Rnor_5.01970,777,124 - 70,777,351UniSTSRnor5.0
RGSC_v3.41957,111,023 - 57,111,251RGDRGSC3.4
RGSC_v3.41957,111,024 - 57,111,251UniSTSRGSC3.4
RGSC_v3.11957,116,083 - 57,116,311RGD
Celera1954,507,099 - 54,507,326UniSTS
Cytogenetic Map19q12UniSTS
D19Rat99  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21955,610,506 - 55,610,666 (+)MAPPERmRatBN7.2
Rnor_6.01960,561,023 - 60,561,182NCBIRnor6.0
Rnor_5.01971,229,608 - 71,229,767UniSTSRnor5.0
RGSC_v3.41957,583,860 - 57,584,020RGDRGSC3.4
RGSC_v3.41957,583,861 - 57,584,020UniSTSRGSC3.4
RGSC_v3.11957,588,920 - 57,589,080RGD
Celera1954,948,077 - 54,948,236UniSTS
Cytogenetic Map19q12UniSTS
D19Rat57  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21955,283,146 - 55,283,277 (+)MAPPERmRatBN7.2
Rnor_6.01960,220,451 - 60,220,581NCBIRnor6.0
Rnor_5.01970,892,012 - 70,892,142UniSTSRnor5.0
RGSC_v3.41957,234,802 - 57,235,101RGDRGSC3.4
RGSC_v3.41957,234,859 - 57,234,989UniSTSRGSC3.4
RGSC_v3.11957,239,862 - 57,240,161RGD
Celera1954,621,043 - 54,621,173UniSTS
SHRSP x BN Map1942.5498RGD
SHRSP x BN Map1942.5498UniSTS
Cytogenetic Map19q12UniSTS
RH128030  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21955,629,880 - 55,630,081 (+)MAPPERmRatBN7.2
Rnor_6.01960,580,398 - 60,580,598NCBIRnor6.0
Rnor_5.01971,248,983 - 71,249,183UniSTSRnor5.0
RGSC_v3.41957,603,236 - 57,603,436UniSTSRGSC3.4
Celera1954,967,452 - 54,967,652UniSTS
Cytogenetic Map19q12UniSTS
RH133010  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21955,380,950 - 55,381,150 (+)MAPPERmRatBN7.2
Rnor_6.01960,318,402 - 60,318,601NCBIRnor6.0
Rnor_5.01970,989,929 - 70,990,128UniSTSRnor5.0
RGSC_v3.41957,332,950 - 57,333,149UniSTSRGSC3.4
Celera1954,718,765 - 54,718,964UniSTS
Cytogenetic Map19q12UniSTS
RH143682  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21955,428,195 - 55,428,300 (+)MAPPERmRatBN7.2
Rnor_6.01960,365,404 - 60,365,508NCBIRnor6.0
Rnor_5.01971,036,455 - 71,036,559UniSTSRnor5.0
RGSC_v3.41957,389,281 - 57,389,385UniSTSRGSC3.4
Celera1954,766,217 - 54,766,321UniSTS
Cytogenetic Map19q12UniSTS
BE121212  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21955,416,080 - 55,416,269 (+)MAPPERmRatBN7.2
Rnor_6.01960,353,290 - 60,353,478NCBIRnor6.0
Rnor_5.01971,024,341 - 71,024,529UniSTSRnor5.0
RGSC_v3.41957,377,166 - 57,377,354UniSTSRGSC3.4
Celera1954,754,102 - 54,754,290UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 28 24 24 1 1 47 28 31 11 1
Low 1 17 29 17 19 17 7 10 27 7 10 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB005549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000042623   ⟹   ENSRNOP00000048964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1955,080,282 - 55,629,778 (+)Ensembl
Rnor_6.0 Ensembl1960,017,746 - 60,580,295 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078559   ⟹   ENSRNOP00000075058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1955,168,279 - 55,629,778 (+)Ensembl
Rnor_6.0 Ensembl1960,104,804 - 60,580,651 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095548   ⟹   ENSRNOP00000079662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1955,080,282 - 55,629,778 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104177   ⟹   ENSRNOP00000089028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1955,080,282 - 55,629,778 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105322   ⟹   ENSRNOP00000097873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1955,080,282 - 55,418,657 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109223   ⟹   ENSRNOP00000079670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1955,080,282 - 55,452,129 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110687   ⟹   ENSRNOP00000095679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1955,080,282 - 55,629,778 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111522   ⟹   ENSRNOP00000092087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1955,080,282 - 55,629,778 (+)Ensembl
RefSeq Acc Id: NM_031235   ⟹   NP_112514
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,282 - 55,629,778 (+)NCBI
Rnor_6.01960,017,746 - 60,580,295 (+)NCBI
Rnor_5.01970,690,939 - 71,249,213 (+)NCBI
RGSC_v3.41957,015,742 - 57,603,133 (+)RGD
Celera1954,418,687 - 54,967,349 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255828   ⟹   XP_006255890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,630,111 (+)NCBI
Rnor_6.01960,017,761 - 60,580,628 (+)NCBI
Rnor_5.01970,690,939 - 71,249,213 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255830   ⟹   XP_006255892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,630,111 (+)NCBI
Rnor_6.01960,017,761 - 60,580,628 (+)NCBI
Rnor_5.01970,690,939 - 71,249,213 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255833   ⟹   XP_006255895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,630,111 (+)NCBI
Rnor_6.01960,017,761 - 60,580,628 (+)NCBI
Rnor_5.01970,690,939 - 71,249,213 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255836   ⟹   XP_006255898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,452,311 (+)NCBI
Rnor_6.01960,017,761 - 60,389,518 (+)NCBI
Rnor_5.01970,690,939 - 71,249,213 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255837   ⟹   XP_006255899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,452,311 (+)NCBI
Rnor_6.01960,017,761 - 60,389,518 (+)NCBI
Rnor_5.01970,690,939 - 71,249,213 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601367   ⟹   XP_017456856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,630,111 (+)NCBI
Rnor_6.01960,118,630 - 60,580,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601368   ⟹   XP_017456857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,363,867 - 55,630,111 (+)NCBI
Rnor_6.01960,300,704 - 60,580,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601369   ⟹   XP_017456858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,452,311 (+)NCBI
Rnor_6.01960,118,630 - 60,389,518 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601370   ⟹   XP_017456859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,418,657 (+)NCBI
Rnor_6.01960,118,630 - 60,355,866 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601371   ⟹   XP_017456860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,418,657 (+)NCBI
Rnor_6.01960,118,630 - 60,355,866 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098022   ⟹   XP_038953950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,630,111 (+)NCBI
RefSeq Acc Id: XM_039098023   ⟹   XP_038953951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,630,111 (+)NCBI
RefSeq Acc Id: XM_039098024   ⟹   XP_038953952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,630,111 (+)NCBI
RefSeq Acc Id: XM_039098025   ⟹   XP_038953953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,630,111 (+)NCBI
RefSeq Acc Id: XM_039098026   ⟹   XP_038953954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,080,297 - 55,630,111 (+)NCBI
RefSeq Acc Id: XM_039098027   ⟹   XP_038953955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21955,363,871 - 55,630,111 (+)NCBI
Protein Sequences
Protein RefSeqs NP_112514 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255890 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255892 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255895 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255898 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255899 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456856 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456857 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456858 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456859 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456860 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953950 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953951 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953952 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953953 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953954 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953955 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA34216 (Get FASTA)   NCBI Sequence Viewer  
  EDL96780 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048964
  ENSRNOP00000075058.1
  ENSRNOP00000079662
  ENSRNOP00000079662.1
  ENSRNOP00000079670
  ENSRNOP00000079670.1
  ENSRNOP00000089028
  ENSRNOP00000089028.1
  ENSRNOP00000092087
  ENSRNOP00000092087.1
  ENSRNOP00000095679
  ENSRNOP00000095679.1
  ENSRNOP00000097873
  ENSRNOP00000097873.1
GenBank Protein Q9Z340 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_112514   ⟸   NM_031235
- UniProtKB: Q9Z340 (UniProtKB/Swiss-Prot),   A6KJ58 (UniProtKB/TrEMBL),   A0A8I6A9A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255890   ⟸   XM_006255828
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A9A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255892   ⟸   XM_006255830
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AGY4 (UniProtKB/TrEMBL),   A0A8I6A9A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255895   ⟸   XM_006255833
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZNZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255898   ⟸   XM_006255836
- Peptide Label: isoform X13
- UniProtKB: A0A8I5ZN95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255899   ⟸   XM_006255837
- Peptide Label: isoform X14
- UniProtKB: A0A8I5ZN95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456856   ⟸   XM_017601367
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZNZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456858   ⟸   XM_017601369
- Peptide Label: isoform X12
- UniProtKB: A0A8I5ZN95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456859   ⟸   XM_017601370
- Peptide Label: isoform X15
- Sequence:
RefSeq Acc Id: XP_017456860   ⟸   XM_017601371
- Peptide Label: isoform X16
- UniProtKB: A0A8I6GMQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456857   ⟸   XM_017601368
- Peptide Label: isoform X10
- UniProtKB: A0A8I6AK77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075058   ⟸   ENSRNOT00000078559
RefSeq Acc Id: ENSRNOP00000048964   ⟸   ENSRNOT00000042623
RefSeq Acc Id: XP_038953952   ⟸   XM_039098024
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A9A7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953950   ⟸   XM_039098022
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A9A7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953954   ⟸   XM_039098026
- Peptide Label: isoform X9
- UniProtKB: A0A8I6A9A7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953951   ⟸   XM_039098023
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A9A7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953953   ⟸   XM_039098025
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A9A7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953955   ⟸   XM_039098027
- Peptide Label: isoform X11
- UniProtKB: A0A8I6AK77 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079662   ⟸   ENSRNOT00000095548
RefSeq Acc Id: ENSRNOP00000092087   ⟸   ENSRNOT00000111522
RefSeq Acc Id: ENSRNOP00000079670   ⟸   ENSRNOT00000109223
RefSeq Acc Id: ENSRNOP00000095679   ⟸   ENSRNOT00000110687
RefSeq Acc Id: ENSRNOP00000097873   ⟸   ENSRNOT00000105322
RefSeq Acc Id: ENSRNOP00000089028   ⟸   ENSRNOT00000104177
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z340-F1-model_v2 AlphaFold Q9Z340 1-1337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701258
Promoter ID:EPDNEW_R11780
Type:initiation region
Name:Pard3_1
Description:par-3 family cell polarity regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01960,017,749 - 60,017,809EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620374 AgrOrtholog
BioCyc Gene G2FUF-5141 BioCyc
Ensembl Genes ENSRNOG00000032437 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042623 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000078559.2 UniProtKB/TrEMBL
  ENSRNOT00000095548 ENTREZGENE
  ENSRNOT00000095548.1 UniProtKB/TrEMBL
  ENSRNOT00000104177 ENTREZGENE
  ENSRNOT00000104177.1 UniProtKB/TrEMBL
  ENSRNOT00000105322 ENTREZGENE
  ENSRNOT00000105322.1 UniProtKB/TrEMBL
  ENSRNOT00000109223 ENTREZGENE
  ENSRNOT00000109223.1 UniProtKB/TrEMBL
  ENSRNOT00000110687 ENTREZGENE
  ENSRNOT00000110687.1 UniProtKB/TrEMBL
  ENSRNOT00000111522 ENTREZGENE
  ENSRNOT00000111522.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Par3/HAL_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81918 UniProtKB/Swiss-Prot
NCBI Gene 81918 ENTREZGENE
PANTHER PARTITIONING DEFECTIVE 3 HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PARTITIONING DEFECTIVE 3 RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Par3_HAL_N_term UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pard3 PhenoGen
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032437 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9M8_RAT UniProtKB/TrEMBL
  A0A8I5ZN95 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNZ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9A7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGY4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AK77 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GMQ2 ENTREZGENE, UniProtKB/TrEMBL
  A6KJ58 ENTREZGENE, UniProtKB/TrEMBL
  PARD3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-19 Pard3  par-3 family cell polarity regulator  Pard3  par-3 (partitioning defective 3) homolog (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pard3  par-3 (partitioning defective 3) homolog (C. elegans)  Par3  three-PDZ containing protein similar to C. elegans PAR3 (partitioning defect)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Par3  three-PDZ containing protein similar to C. elegans PAR3 (partitioning defect)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an NH2-terminal conserved region (CR1), the three PDZ domains (CR2), and a conserved sequence (CR3) 633671
gene_physical_interaction binds to PKC-delta 633671
gene_protein 1337 amino acids 633671