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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:PPARbeta/delta agonist
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Accession:CHEBI:73730 term browser browse the term
Definition:A PPAR modulator which activates the peroxisome proliferator-activated receptor-beta/delta.
Synonyms:related_synonym: NR1C2 agonist;   NR1C2 agonists;   PPAR-beta agonist;   PPAR-beta agonists;   PPAR-beta/delta agonist;   PPAR-beta/delta agonists;   PPAR-delta agonist;   PPAR-delta agonists;   PPARD agonist;   PPARD agonists;   PPARD receptor agonist;   PPARD receptor agonists;   PPARbeta agonist;   PPARbeta agonists;   PPARbeta/delta agonists;   PPARdelta agonist;   PPARdelta agonists;   nuclear receptor subfamily 1, group C, member 2 agonist;   nuclear receptor subfamily 1, group C, member 2 agonists;   peroxisome proliferator-activated receptor-beta agonist;   peroxisome proliferator-activated receptor-beta agonists;   peroxisome proliferator-activated receptor-delta agonist;   peroxisome proliferator-activated receptor-delta agonists
 alt_id: CHEBI:73729
 xref: Wikipedia:Peroxisome_proliferator-activated_receptor_delta


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GW 501516 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO GW 501516 results in increased expression of ABCA1 mRNA; GW 501516 results in increased expression of ABCA1 protein CTD PMID:19201410 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abhd3 abhydrolase domain containing 3, phospholipase multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of ABHD3 mRNA CTD PMID:16197558 NCBI chr18:1,892,413...1,946,840
Ensembl chr18:1,892,413...1,946,840
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of ACADM mRNA CTD PMID:16197558 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of ACADVL mRNA CTD PMID:16197558 NCBI chr10:56,619,321...56,624,468
Ensembl chr10:56,619,303...56,624,526
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO GW 501516 results in increased expression of ACOX1 mRNA CTD PMID:16574099 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of ANGPTL4 mRNA CTD PMID:16197558 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO GW 501516 promotes the reaction [APOA1 protein results in increased secretion of Lipids] CTD PMID:19201410 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of GCH1 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD1 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD3 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased phosphorylation of NOS3 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased susceptibility to Acetylcholine]; GW 501516 inhibits the reaction [APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin]; GW 501516 inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; GW 501516 inhibits the reaction [APP gene mutant form results in increased expression of CYBB protein]; GW 501516 inhibits the reaction [APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin] CTD PMID:22886847 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bcl6 BCL6, transcription repressor multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:23737761 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
GW 501516 results in decreased expression of CCL2 mRNA
GW 501516 inhibits the reaction [Palmitates results in increased expression of CCL2 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
CTD PMID:16574099, PMID:21966476, PMID:23737761 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of CEBPA mRNA CTD PMID:16197558 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression
ISO [GW 501516 binds to PPARD protein] which results in increased expression of CPT1A mRNA
GW 501516 results in increased expression of CPT1A mRNA
CTD PMID:16197558, PMID:16574099 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions
increases expression
EXP RELA protein inhibits the reaction [GW 501516 results in increased expression of CPT1B mRNA] CTD PMID:18701451 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 decreases expression ISO GW 501516 results in decreased expression of CX3CR1 mRNA CTD PMID:19850645 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in increased expression of CYBB protein] CTD PMID:22886847 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions ISO GW 501516 inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] CTD PMID:19667161 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of DDIT4 mRNA CTD PMID:16197558 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ech1 enoyl-CoA hydratase 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of ECH1 mRNA CTD PMID:16197558 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
multiple interactions
ISO GW 501516 results in increased expression of FABP1 mRNA
[GW 501516 binds to PPARD protein] which results in increased expression of FABP1 mRNA
CTD PMID:16197558, PMID:16574099 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Gch1 GTP cyclohydrolase 1 multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of GCH1 protein] CTD PMID:22886847 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of HADHA mRNA CTD PMID:16197558 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of HMGCS2 mRNA CTD PMID:16197558 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of HSDL2 mRNA CTD PMID:16197558 NCBI chr 5:76,812,881...76,848,853
Ensembl chr 5:76,812,931...76,848,101
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] CTD PMID:23737761 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]
GW 501516 results in decreased expression of IL1B mRNA
CTD PMID:16574099, PMID:23737761 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression ISO GW 501516 results in decreased expression of IL6 mRNA CTD PMID:16574099 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kiz kizuna centrosomal protein multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of KIZ mRNA CTD PMID:16197558 NCBI chr 3:141,067,981...141,173,738
Ensembl chr 3:141,068,023...141,173,858
JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of LIPC mRNA CTD PMID:16197558 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions EXP MDM2 protein inhibits the reaction [GW 501516 results in increased activity of PPARB protein] CTD PMID:19103650 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; PPARD mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]] CTD PMID:23737761 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of NEDD9 mRNA CTD PMID:16197558 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO GW 501516 results in increased activity of NFE2L2 protein CTD PMID:30114225 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO GW 501516 results in decreased expression of NFKB1 mRNA CTD PMID:16574099 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased phosphorylation of NOS3 protein] CTD PMID:22886847 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:18701451 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA] CTD PMID:18701451 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 increases expression ISO GW 501516 results in increased expression of NR1H2 mRNA CTD PMID:19201410 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression
affects response to substance
multiple interactions
ISO GW 501516 results in increased expression of NR1H3 mRNA
NR1H3 protein affects the susceptibility to GW 501516
NR1H3 protein affects the reaction [GW 501516 results in increased expression of PPARA mRNA]
CTD PMID:19201410 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO GW 501516 promotes the reaction [Indomethacin results in increased cleavage of PARP1 protein] CTD PMID:21400612 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of PCK1 mRNA CTD PMID:16197558 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pdzk1 PDZ domain containing 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of PDZK1 mRNA CTD PMID:16197558 NCBI chr 2:198,965,685...198,999,323
Ensembl chr 2:198,965,685...198,999,323
JBrowse link
G Plin2 perilipin 2 multiple interactions
increases expression
ISO [GW 501516 binds to PPARD protein] which results in increased expression of PLIN2 mRNA; PPARD mutant form inhibits the reaction [GW 501516 results in increased expression of PLIN2 mRNA] CTD PMID:16197558, PMID:23737761 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Pltp phospholipid transfer protein multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of PLTP mRNA CTD PMID:16197558 NCBI chr 3:161,304,469...161,322,289
Ensembl chr 3:161,304,469...161,322,289
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
affects response to substance
increases expression
affects binding
ISO [Calcitriol co-treated with GW 501516] results in increased expression of PPARA mRNA; NR1H3 protein affects the reaction [GW 501516 results in increased expression of PPARA mRNA]
PPARA protein affects the susceptibility to GW 501516
GW 501516 binds to PPARA protein
CTD PMID:19201410, PMID:19667161, PMID:23843199, PMID:25689681 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding
increases expression
multiple interactions
increases activity
ISO
EXP
GW 501516 binds to PPARB protein; GW 501516 binds to PPARD protein
GW 501516 results in increased expression of PPARD mRNA
4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW 501516 results in increased expression of PPARD mRNA]; [GW 501516 co-treated with PPARD protein] results in increased expression of PPARGC1A mRNA; GW 501516 binds to and results in increased activity of PPARD protein
GW 501516 results in increased activity of PPARD protein
[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MDM2 protein inhibits the reaction [GW 501516 results in increased activity of PPARB protein]
[Calcitriol co-treated with GW 501516] results in increased expression of PPARD mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ABHD3 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ACADM mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ACADVL mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ANGPTL4 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of CEBPA mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of CPT1A mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of DDIT4 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ECH1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of FABP1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of HADHA mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of HMGCS2 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of HSDL2 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of KIZ mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of LIPC mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of NEDD9 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PCK1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PDZK1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PLIN2 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PLTP mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of RNU7-65P mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SERPINE1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SLC22A7 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SLC30A10 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SULT2A1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of TRIB2 mRNA; GW 501516 binds to and results in increased activity of PPARD protein; GW 501516 promotes the reaction [PPARD protein results in increased expression of SIRT1 mRNA]; PPARD mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; PPARD mutant form inhibits the reaction [GW 501516 results in increased expression of PLIN2 mRNA]
CTD PMID:16197558, PMID:17275789, PMID:18292206, PMID:18701451, PMID:19103650, PMID:19201410, PMID:19667161, PMID:20160399, PMID:20516370, PMID:21966476, PMID:23391484, PMID:23737761, PMID:23843199, PMID:27551952, PMID:32407875 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
increases activity
ISO GW 501516 results in increased expression of PPARG mRNA
GW 501516 results in increased activity of PPARG protein
CTD PMID:16386710, PMID:19201410 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
ISO [GW 501516 co-treated with PPARD protein] results in increased expression of PPARGC1A mRNA
GW 501516 results in increased expression of PPARGC1A mRNA
CTD PMID:17275789, PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO cannabidiolic acid inhibits the reaction [GW 501516 results in increased expression of PTGS2 mRNA] CTD PMID:32238697 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; RELA protein inhibits the reaction [GW 501516 results in increased expression of CPT1B mRNA] CTD PMID:18701451 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sele selectin E multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:23737761 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of SERPINE1 mRNA CTD PMID:16197558 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO GW 501516 promotes the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of SLC22A7 mRNA CTD PMID:16197558 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc30a10 solute carrier family 30, member 10 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of SLC30A10 mRNA CTD PMID:16197558 NCBI chr13:103,396,295...103,406,759
Ensembl chr13:103,396,314...103,410,363
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD1 protein] CTD PMID:22886847 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD3 protein] CTD PMID:22886847 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO GW 501516 results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of SULT2A1 mRNA CTD PMID:16197558 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO GW 501516 results in decreased expression of TGFB1 mRNA CTD PMID:16574099 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; PPARD mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]
GW 501516 results in decreased expression of TNF mRNA
CTD PMID:16574099, PMID:21966476, PMID:23737761 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trib2 tribbles pseudokinase 2 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of TRIB2 mRNA CTD PMID:16197558 NCBI chr 6:41,016,722...41,040,972
Ensembl chr 6:41,016,730...41,039,437
JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP GW 501516 results in increased expression of UCP2 mRNA CTD PMID:16239165 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:23737761 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vdr vitamin D receptor increases expression
multiple interactions
ISO GW 501516 results in increased expression of VDR mRNA
[Calcitriol co-treated with GW 501516] results in increased expression of VDR mRNA
CTD PMID:19667161 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link

Term paths to the root
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  CHEBI ontology 19792
    role 19738
      biological role 19737
        pharmacological role 18819
          PPAR modulator 3871
            PPARbeta/delta agonist 64
              (2E,6E)-farnesyl monophosphate 0
              GW 501516 + 64
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.