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PPARbeta/delta agonist - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:PPARbeta/delta agonist
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Accession:CHEBI:73730 term browser browse the term
Definition:A PPAR modulator which activates the peroxisome proliferator-activated receptor-beta/delta.
Synonyms:related_synonym: NR1C2 agonist;   NR1C2 agonists;   PPAR-beta agonist;   PPAR-beta agonists;   PPAR-beta/delta agonist;   PPAR-beta/delta agonists;   PPAR-delta agonist;   PPAR-delta agonists;   PPARD agonist;   PPARD agonists;   PPARD receptor agonist;   PPARD receptor agonists;   PPARbeta agonist;   PPARbeta agonists;   PPARbeta/delta agonists;   PPARdelta agonist;   PPARdelta agonists;   nuclear receptor subfamily 1, group C, member 2 agonist;   nuclear receptor subfamily 1, group C, member 2 agonists;   peroxisome proliferator-activated receptor-beta agonist;   peroxisome proliferator-activated receptor-beta agonists;   peroxisome proliferator-activated receptor-delta agonist;   peroxisome proliferator-activated receptor-delta agonists
 alt_id: CHEBI:73729
 xref: Wikipedia:Peroxisome_proliferator-activated_receptor_delta

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GW 501516 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO GW 501516 results in increased expression of ABCA1 mRNA; GW 501516 results in increased expression of ABCA1 protein CTD PMID:19201410 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abhd3 abhydrolase domain containing 3, phospholipase multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of ABHD3 mRNA CTD PMID:16197558 NCBI chr18:1,723,203...1,778,488
Ensembl chr18:1,720,718...1,803,428 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of ACADM mRNA CTD PMID:16197558 NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of ACADVL mRNA CTD PMID:16197558 NCBI chr10:55,231,558...55,236,786
Ensembl chr10:54,732,469...54,738,075 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO GW 501516 results in increased expression of ACOX1 mRNA CTD PMID:16574099 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions
increases expression		 ISO [GW 501516 binds to PPARD protein] which results in increased expression of ANGPTL4 mRNA
GW 501516 results in increased expression of ANGPTL4 mRNA		 CTD PMID:16197558 PMID:34627044 NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO GW 501516 promotes the reaction [APOA1 protein results in increased secretion of Lipids] CTD PMID:19201410 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of GCH1 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD1 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD3 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased phosphorylation of NOS3 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased susceptibility to Acetylcholine]; GW 501516 inhibits the reaction [APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin]; GW 501516 inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; GW 501516 inhibits the reaction [APP gene mutant form results in increased expression of CYBB protein]; GW 501516 inhibits the reaction [APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin] CTD PMID:22886847 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bcl6 BCL6, transcription repressor multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:23737761 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
GW 501516 inhibits the reaction [Palmitates results in increased expression of CCL2 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
GW 501516 results in decreased expression of CCL2 mRNA		 CTD PMID:16574099 PMID:21966476 PMID:23737761 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of CEBPA mRNA CTD PMID:16197558 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression		 ISO [GW 501516 binds to PPARD protein] which results in increased expression of CPT1A mRNA
GW 501516 results in increased expression of CPT1A mRNA		 CTD PMID:16197558 PMID:16574099 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions
increases expression		 EXP RELA protein inhibits the reaction [GW 501516 results in increased expression of CPT1B mRNA] CTD PMID:18701451 NCBI chr 7:122,370,974...122,380,473
Ensembl chr 7:120,491,354...120,500,404 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 decreases expression ISO GW 501516 results in decreased expression of CX3CR1 mRNA CTD PMID:19850645 NCBI chr 8:128,661,294...128,679,048
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in increased expression of CYBB protein] CTD PMID:22886847 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions ISO GW 501516 inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] CTD PMID:19667161 NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of DDIT4 mRNA CTD PMID:16197558 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of ECH1 mRNA CTD PMID:16197558 NCBI chr 1:93,241,076...93,248,314
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
multiple interactions		 ISO GW 501516 results in increased expression of FABP1 mRNA
[GW 501516 binds to PPARD protein] which results in increased expression of FABP1 mRNA		 CTD PMID:16197558 PMID:16574099 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Gch1 GTP cyclohydrolase 1 multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of GCH1 protein] CTD PMID:22886847 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of HADHA mRNA CTD PMID:16197558 NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of HMGCS2 mRNA CTD PMID:16197558 NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of HSDL2 mRNA CTD PMID:16197558 NCBI chr 5:79,238,881...79,274,051
Ensembl chr 5:74,443,872...74,479,839 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] CTD PMID:23737761 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]
GW 501516 results in decreased expression of IL1B mRNA		 CTD PMID:16574099 PMID:23737761 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression ISO GW 501516 results in decreased expression of IL6 mRNA CTD PMID:16574099 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kiz kizuna centrosomal protein multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of KIZ mRNA CTD PMID:16197558 NCBI chr 3:154,730,873...154,838,410
Ensembl chr 3:134,277,687...134,385,190 		JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of LIPC mRNA CTD PMID:16197558 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions EXP MDM2 protein inhibits the reaction [GW 501516 results in increased activity of PPARB protein] CTD PMID:19103650 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; PPARD mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]] CTD PMID:23737761 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of NEDD9 mRNA CTD PMID:16197558 NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,282,326...23,468,019 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO GW 501516 results in increased activity of NFE2L2 protein CTD PMID:30114225 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO GW 501516 results in decreased expression of NFKB1 mRNA CTD PMID:16574099 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased phosphorylation of NOS3 protein] CTD PMID:22886847 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:18701451 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA] CTD PMID:18701451 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 increases expression ISO GW 501516 results in increased expression of NR1H2 mRNA CTD PMID:19201410 NCBI chr 1:104,178,483...104,183,863
Ensembl chr 1:95,041,967...95,047,377 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression
multiple interactions
affects response to substance		 ISO GW 501516 results in increased expression of NR1H3 mRNA
NR1H3 protein affects the reaction [GW 501516 results in increased expression of PPARA mRNA]
NR1H3 protein affects the susceptibility to GW 501516		 CTD PMID:19201410 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO GW 501516 promotes the reaction [Indomethacin results in increased cleavage of PARP1 protein] CTD PMID:21400612 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of PCK1 mRNA CTD PMID:16197558 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO GW 501516 results in increased expression of PDK4 mRNA CTD PMID:34627044 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pdzk1 PDZ domain containing 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of PDZK1 mRNA CTD PMID:16197558 NCBI chr 2:187,064,995...187,096,348
Ensembl chr 2:184,376,161...184,407,514 		JBrowse link
G Plin2 perilipin 2 multiple interactions
increases expression		 ISO [GW 501516 binds to PPARD protein] which results in increased expression of PLIN2 mRNA; PPARD mutant form inhibits the reaction [GW 501516 results in increased expression of PLIN2 mRNA] CTD PMID:16197558 PMID:23737761 NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Pltp phospholipid transfer protein multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of PLTP mRNA CTD PMID:16197558 NCBI chr 3:173,994,162...174,011,982
Ensembl chr 3:153,574,825...153,592,647 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
affects binding
increases expression
affects response to substance		 ISO [Calcitriol co-treated with GW 501516] results in increased expression of PPARA mRNA; NR1H3 protein affects the reaction [GW 501516 results in increased expression of PPARA mRNA]
GW 501516 binds to PPARA protein
PPARA protein affects the susceptibility to GW 501516		 CTD PMID:19201410 PMID:19667161 PMID:23843199 PMID:25689681 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding
increases activity
multiple interactions
increases expression		 ISO
EXP		 GW 501516 binds to PPARB protein; GW 501516 binds to PPARD protein
GW 501516 results in increased activity of PPARB protein
[Calcitriol co-treated with GW 501516] results in increased expression of PPARD mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ABHD3 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ACADM mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ACADVL mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ANGPTL4 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of CEBPA mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of CPT1A mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of DDIT4 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ECH1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of FABP1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of HADHA mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of HMGCS2 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of HSDL2 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of KIZ mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of LIPC mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of NEDD9 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PCK1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PDZK1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PLIN2 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PLTP mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of RNU7-65P mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SERPINE1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SLC22A7 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SLC30A10 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SULT2A1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of TRIB2 mRNA; GW 501516 binds to and results in increased activity of PPARD protein; GW 501516 promotes the reaction [PPARD protein results in increased expression of SIRT1 mRNA]; PPARD mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; PPARD mutant form inhibits the reaction [GW 501516 results in increased expression of PLIN2 mRNA]
[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MDM2 protein inhibits the reaction [GW 501516 results in increased activity of PPARB protein]
GW 501516 results in increased activity of PPARD protein
GW 501516 results in increased expression of PPARD mRNA
4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW 501516 results in increased expression of PPARD mRNA]; [GW 501516 co-treated with PPARD protein] results in increased expression of PPARGC1A mRNA; GW 501516 binds to and results in increased activity of PPARD protein		 CTD PMID:16197558 PMID:17275789 PMID:18292206 PMID:18701451 PMID:19103650 More... NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
increases activity		 ISO GW 501516 results in increased expression of PPARG mRNA
GW 501516 results in increased activity of PPARG protein		 CTD PMID:16386710 PMID:19201410 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression		 ISO [GW 501516 co-treated with PPARD protein] results in increased expression of PPARGC1A mRNA
GW 501516 results in increased expression of PPARGC1A mRNA		 CTD PMID:17275789 PMID:23056435 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO cannabidiolic acid inhibits the reaction [GW 501516 results in increased expression of PTGS2 mRNA] CTD PMID:32238697 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; RELA protein inhibits the reaction [GW 501516 results in increased expression of CPT1B mRNA] CTD PMID:18701451 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sele selectin E multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:23737761 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of SERPINE1 mRNA CTD PMID:16197558 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO GW 501516 promotes the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of SLC22A7 mRNA CTD PMID:16197558 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc30a10 solute carrier family 30, member 10 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of SLC30A10 mRNA CTD PMID:16197558 NCBI chr13:99,529,664...99,584,442
Ensembl chr13:96,998,143...97,009,103 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD1 protein] CTD PMID:22886847 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD3 protein] CTD PMID:22886847 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO GW 501516 results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of SULT2A1 mRNA CTD PMID:16197558 NCBI chr 1:84,582,011...84,639,001
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO GW 501516 results in decreased expression of TGFB1 mRNA CTD PMID:16574099 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; PPARD mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]
GW 501516 results in decreased expression of TNF mRNA		 CTD PMID:16574099 PMID:21966476 PMID:23737761 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trib2 tribbles pseudokinase 2 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of TRIB2 mRNA CTD PMID:16197558 NCBI chr 6:44,274,762...44,299,139
Ensembl chr 6:38,545,975...38,569,370 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP GW 501516 results in increased expression of UCP2 mRNA CTD PMID:16239165 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:23737761 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdr vitamin D receptor increases expression
multiple interactions		 ISO GW 501516 results in increased expression of VDR mRNA
[Calcitriol co-treated with GW 501516] results in increased expression of VDR mRNA		 CTD PMID:19667161 NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        pharmacological role 19088
          PPAR modulator 4189
            PPARbeta/delta agonist 65
              (2E,6E)-farnesyl monophosphate 0
              GW 501516 + 65
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