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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:GW 501516
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Accession:CHEBI:73726 term browser browse the term
Definition:An aromatic ether that is phenoxyacetic acid in which the phenyl group is substituted at position 2 by a methyl group and at position 4 by a (1,3-thiazol-5-ylmethyl)sulfanediyl group, and in which the 1,3-thiazolyl group is substituted at positions 2 and 4 by p-trifluoromethylphenyl and methyl groups, respectively.
Synonyms:exact_synonym: {2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid
 related_synonym: Endurobol;   Formula=C21H18F3NO3S2;   GSK-516;   GW 1516;   GW 501,516;   GW-516;   GW1516;   GW501,516;   GW501516;   InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27);   InChIKey=YDBLKRPLXZNVNB-UHFFFAOYSA-N;   SMILES=Cc1cc(SCc2sc(nc2C)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O;   UNII-7I2HA1NU22
 xref: CAS:317318-70-0;   LINCS:LSM-5330
 xref_mesh: MESH:C425931
 xref: PMID:14604391;   PMID:14758356;   PMID:16242326;   PMID:16625823;   PMID:18047848;   PMID:19946680;   PMID:21511987;   PMID:22466297;   PMID:22814748;   PMID:22982594;   PMID:23046570;   PMID:23100242;   PMID:23607100;   Reaxys:9440826;   Wikipedia:GW_501516


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GW 501516 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO GW 501516 results in increased expression of ABCA1 mRNA; GW 501516 results in increased expression of ABCA1 protein CTD PMID:19201410 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abhd3 abhydrolase domain containing 3, phospholipase multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of ABHD3 mRNA CTD PMID:16197558 NCBI chr18:1,723,203...1,778,488
Ensembl chr18:1,720,718...1,803,428 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of ACADM mRNA CTD PMID:16197558 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of ACADVL mRNA CTD PMID:16197558 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO GW 501516 results in increased expression of ACOX1 mRNA CTD PMID:16574099 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions
increases expression		 ISO [GW 501516 binds to PPARD protein] which results in increased expression of ANGPTL4 mRNA
GW 501516 results in increased expression of ANGPTL4 mRNA		 CTD PMID:16197558 PMID:34627044 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO GW 501516 promotes the reaction [APOA1 protein results in increased secretion of Lipids] CTD PMID:19201410 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of GCH1 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD1 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD3 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased phosphorylation of NOS3 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased susceptibility to Acetylcholine]; GW 501516 inhibits the reaction [APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin]; GW 501516 inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; GW 501516 inhibits the reaction [APP gene mutant form results in increased expression of CYBB protein]; GW 501516 inhibits the reaction [APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin] CTD PMID:22886847 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bcl6 BCL6, transcription repressor multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:23737761 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
GW 501516 inhibits the reaction [Palmitates results in increased expression of CCL2 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
GW 501516 results in decreased expression of CCL2 mRNA		 CTD PMID:16574099 PMID:21966476 PMID:23737761 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of CEBPA mRNA CTD PMID:16197558 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression		 ISO [GW 501516 binds to PPARD protein] which results in increased expression of CPT1A mRNA
GW 501516 results in increased expression of CPT1A mRNA		 CTD PMID:16197558 PMID:16574099 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions
increases expression		 EXP RELA protein inhibits the reaction [GW 501516 results in increased expression of CPT1B mRNA] CTD PMID:18701451 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 decreases expression ISO GW 501516 results in decreased expression of CX3CR1 mRNA CTD PMID:19850645 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in increased expression of CYBB protein] CTD PMID:22886847 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions ISO GW 501516 inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] CTD PMID:19667161 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of DDIT4 mRNA CTD PMID:16197558 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of ECH1 mRNA CTD PMID:16197558 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
multiple interactions		 ISO GW 501516 results in increased expression of FABP1 mRNA
[GW 501516 binds to PPARD protein] which results in increased expression of FABP1 mRNA		 CTD PMID:16197558 PMID:16574099 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Gch1 GTP cyclohydrolase 1 multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of GCH1 protein] CTD PMID:22886847 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of HADHA mRNA CTD PMID:16197558 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of HMGCS2 mRNA CTD PMID:16197558 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of HSDL2 mRNA CTD PMID:16197558 NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] CTD PMID:23737761 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]
GW 501516 results in decreased expression of IL1B mRNA		 CTD PMID:16574099 PMID:23737761 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression ISO GW 501516 results in decreased expression of IL6 mRNA CTD PMID:16574099 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kiz kizuna centrosomal protein multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of KIZ mRNA CTD PMID:16197558 NCBI chr 3:134,277,631...134,385,260
Ensembl chr 3:134,277,687...134,385,190 		JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of LIPC mRNA CTD PMID:16197558 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions EXP MDM2 protein inhibits the reaction [GW 501516 results in increased activity of PPARB protein] CTD PMID:19103650 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; PPARD mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]] CTD PMID:23737761 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of NEDD9 mRNA CTD PMID:16197558 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO GW 501516 results in increased activity of NFE2L2 protein CTD PMID:30114225 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO GW 501516 results in decreased expression of NFKB1 mRNA CTD PMID:16574099 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased phosphorylation of NOS3 protein] CTD PMID:22886847 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:18701451 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA] CTD PMID:18701451 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 increases expression ISO GW 501516 results in increased expression of NR1H2 mRNA CTD PMID:19201410 NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression
multiple interactions
affects response to substance		 ISO GW 501516 results in increased expression of NR1H3 mRNA
NR1H3 protein affects the reaction [GW 501516 results in increased expression of PPARA mRNA]
NR1H3 protein affects the susceptibility to GW 501516		 CTD PMID:19201410 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO GW 501516 promotes the reaction [Indomethacin results in increased cleavage of PARP1 protein] CTD PMID:21400612 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of PCK1 mRNA CTD PMID:16197558 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO GW 501516 results in increased expression of PDK4 mRNA CTD PMID:34627044 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pdzk1 PDZ domain containing 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of PDZK1 mRNA CTD PMID:16197558 NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514 		JBrowse link
G Plin2 perilipin 2 multiple interactions
increases expression		 ISO [GW 501516 binds to PPARD protein] which results in increased expression of PLIN2 mRNA; PPARD mutant form inhibits the reaction [GW 501516 results in increased expression of PLIN2 mRNA] CTD PMID:16197558 PMID:23737761 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Pltp phospholipid transfer protein multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of PLTP mRNA CTD PMID:16197558 NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
affects binding
increases expression
affects response to substance		 ISO [Calcitriol co-treated with GW 501516] results in increased expression of PPARA mRNA; NR1H3 protein affects the reaction [GW 501516 results in increased expression of PPARA mRNA]
GW 501516 binds to PPARA protein
PPARA protein affects the susceptibility to GW 501516		 CTD PMID:19201410 PMID:19667161 PMID:23843199 PMID:25689681 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding
increases activity
multiple interactions
increases expression		 ISO
EXP		 GW 501516 binds to PPARB protein; GW 501516 binds to PPARD protein
GW 501516 results in increased activity of PPARB protein
[Calcitriol co-treated with GW 501516] results in increased expression of PPARD mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ABHD3 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ACADM mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ACADVL mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ANGPTL4 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of CEBPA mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of CPT1A mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of DDIT4 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ECH1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of FABP1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of HADHA mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of HMGCS2 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of HSDL2 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of KIZ mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of LIPC mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of NEDD9 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PCK1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PDZK1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PLIN2 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PLTP mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of RNU7-65P mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SERPINE1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SLC22A7 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SLC30A10 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SULT2A1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of TRIB2 mRNA; GW 501516 binds to and results in increased activity of PPARD protein; GW 501516 promotes the reaction [PPARD protein results in increased expression of SIRT1 mRNA]; PPARD mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; PPARD mutant form inhibits the reaction [GW 501516 results in increased expression of PLIN2 mRNA]
[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MDM2 protein inhibits the reaction [GW 501516 results in increased activity of PPARB protein]
GW 501516 results in increased activity of PPARD protein
GW 501516 results in increased expression of PPARD mRNA
4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW 501516 results in increased expression of PPARD mRNA]; [GW 501516 co-treated with PPARD protein] results in increased expression of PPARGC1A mRNA; GW 501516 binds to and results in increased activity of PPARD protein		 CTD PMID:16197558 PMID:17275789 PMID:18292206 PMID:18701451 PMID:19103650 More... NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
increases activity		 ISO GW 501516 results in increased expression of PPARG mRNA
GW 501516 results in increased activity of PPARG protein		 CTD PMID:16386710 PMID:19201410 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression		 ISO [GW 501516 co-treated with PPARD protein] results in increased expression of PPARGC1A mRNA
GW 501516 results in increased expression of PPARGC1A mRNA		 CTD PMID:17275789 PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO cannabidiolic acid inhibits the reaction [GW 501516 results in increased expression of PTGS2 mRNA] CTD PMID:32238697 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; RELA protein inhibits the reaction [GW 501516 results in increased expression of CPT1B mRNA] CTD PMID:18701451 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sele selectin E multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:23737761 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of SERPINE1 mRNA CTD PMID:16197558 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO GW 501516 promotes the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of SLC22A7 mRNA CTD PMID:16197558 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc30a10 solute carrier family 30, member 10 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of SLC30A10 mRNA CTD PMID:16197558 NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD1 protein] CTD PMID:22886847 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD3 protein] CTD PMID:22886847 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO GW 501516 results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of SULT2A1 mRNA CTD PMID:16197558 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO GW 501516 results in decreased expression of TGFB1 mRNA CTD PMID:16574099 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; PPARD mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]
GW 501516 results in decreased expression of TNF mRNA		 CTD PMID:16574099 PMID:21966476 PMID:23737761 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trib2 tribbles pseudokinase 2 multiple interactions ISO [GW 501516 binds to PPARD protein] which results in increased expression of TRIB2 mRNA CTD PMID:16197558 NCBI chr 6:38,545,971...38,570,349
Ensembl chr 6:38,545,975...38,569,370 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP GW 501516 results in increased expression of UCP2 mRNA CTD PMID:16239165 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:23737761 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdr vitamin D receptor increases expression
multiple interactions		 ISO GW 501516 results in increased expression of VDR mRNA
[Calcitriol co-treated with GW 501516] results in increased expression of VDR mRNA		 CTD PMID:19667161 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19908
    role 19883
      biological role 19881
        aetiopathogenetic role 19215
          carcinogenic agent 18512
            GW 501516 65
              GW 501516 sulfone 0
              GW 501516 sulfoxide + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19908
    subatomic particle 19906
      composite particle 19906
        hadron 19906
          baryon 19906
            nucleon 19906
              atomic nucleus 19906
                atom 19906
                  main group element atom 19853
                    p-block element atom 19853
                      carbon group element atom 19799
                        carbon atom 19794
                          organic molecular entity 19794
                            organic molecule 19751
                              organic cyclic compound 19559
                                organic heterocyclic compound 18896
                                  heteroarene 17157
                                    monocyclic heteroarene 14798
                                      azole 14291
                                        thiazoles 1791
                                          1,3-thiazoles 1215
                                            GW 501516 65
                                              GW 501516 sulfone 0
                                              GW 501516 sulfoxide + 0
paths to the root