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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ruxolitinib
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Accession:CHEBI:66919 term browser browse the term
Definition:A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis.
Synonyms:exact_synonym: (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
 related_synonym: Formula=C17H18N6;   INCB018424;   InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1;   InChIKey=HFNKQEVNSGCOJV-OAHLLOKOSA-N;   SMILES=N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
 xref: CAS:941678-49-5;   Drug_Central:4190;   KEGG:D09959;   LINCS:LSM-1139
 xref_mesh: MESH:C540383
 xref: PMID:21602517;   PMID:21919691;   PMID:21926964;   PMID:22034658;   PMID:22227528;   PMID:22279053;   PMID:22281165;   PMID:22375970;   PMID:22375971;   PMID:22399854;   PMID:22422826;   PMID:22474318;   PMID:22544377;   PMID:22718840;   PMID:22830345;   Patent:US2008312258;   Patent:US2010190981;   Reaxys:18703668;   Wikipedia:Ruxolitinib


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ruxolitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of APAF1 mRNA CTD PMID:30012499 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased phosphorylation of ATM protein CTD PMID:30012499 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]
[ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of BAX mRNA 		CTD PMID:24973641 PMID:30012499 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of BBC3 mRNA CTD PMID:30012499 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA CTD PMID:30012499 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of BIRC5 mRNA CTD PMID:30012499 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Cat catalase multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of CAT mRNA CTD PMID:30012499 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of CCND1 mRNA CTD PMID:30012499 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ruxolitinib inhibits the reaction [DDT results in decreased expression of CDH1 mRNA] CTD PMID:24820114 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO ruxolitinib inhibits the reaction [DDT results in increased expression of CDH2 mRNA] CTD PMID:24820114 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of CDK2 mRNA CTD PMID:30012499 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased phosphorylation of CHEK2 protein CTD PMID:30012499 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
decreases expression 		ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of CXCL10 mRNA]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]
ruxolitinib results in decreased expression of CXCL10 mRNA 		CTD PMID:22941906 PMID:28365849 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions
decreases expression 		ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of CXCL11 mRNA]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of CXCL11 mRNA]
ruxolitinib results in decreased expression of CXCL11 mRNA 		CTD PMID:22941906 PMID:28365849 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,973,720...15,976,567 		JBrowse link
G Edn1 endothelin 1 decreases phosphorylation EXP ruxolitinib results in decreased phosphorylation of EDN1 protein CTD PMID:30670587 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:24973641 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of GSR mRNA CTD PMID:30012499 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Arsenic Trioxide co-treated with ruxolitinib] results in increased phosphorylation of H2AX protein CTD PMID:30012499 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Ifna1 interferon, alpha 1 multiple interactions ISO ruxolitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT2 protein] CTD PMID:22941906 NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of CXCL10 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of CXCL11 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of IRF1 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of IRF9 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of SP100 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of STAT1 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of STAT2 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of TLR3 mRNA] CTD PMID:28365849 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487 		JBrowse link
G Ifng interferon gamma multiple interactions ISO ruxolitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT2 protein] CTD PMID:22941906 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL10 protein] CTD PMID:24973641 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO ruxolitinib inhibits the reaction [Particulate Matter results in increased secretion of IL13 protein] CTD PMID:32725971 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased secretion of and results in decreased expression of IL17A protein] CTD PMID:24973641 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL1B protein]
ruxolitinib inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein] 		CTD PMID:24973641 PMID:32725971 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO ruxolitinib inhibits the reaction [Particulate Matter results in increased secretion of IL5 protein] CTD PMID:32725971 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of IRF1 mRNA] CTD PMID:28365849 NCBI chr10:38,417,935...38,424,946
Ensembl chr10:38,417,148...38,424,947 		JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO ruxolitinib results in decreased expression of IRF7 mRNA CTD PMID:22941906 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023 		JBrowse link
G Irf9 interferon regulatory factor 9 multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of IRF9 mRNA] CTD PMID:28365849 NCBI chr15:33,065,422...33,071,881
Ensembl chr15:33,065,659...33,071,879 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO ruxolitinib inhibits the reaction [DDT results in increased expression of ITGB1 mRNA] CTD PMID:24820114 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269 		JBrowse link
G Jak1 Janus kinase 1 multiple interactions
decreases activity 		ISO ruxolitinib inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]
ruxolitinib results in decreased activity of JAK1 protein 		CTD PMID:24820114 PMID:24883332 PMID:26300391 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758 		JBrowse link
G Jak2 Janus kinase 2 affects response to substance
decreases activity
multiple interactions 		ISO JAK2 gene mutant form affects the susceptibility to ruxolitinib
ruxolitinib results in decreased activity of JAK2 protein
[ruxolitinib co-treated with Arsenic Trioxide] results in decreased phosphorylation of JAK2 protein 		CTD PMID:24883332 PMID:26300391 PMID:30012499 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO ruxolitinib promotes the reaction [TNF protein affects the localization of JUN protein] CTD PMID:22941906 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein] CTD PMID:24973641 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of MYC mRNA CTD PMID:30012499 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO ruxolitinib promotes the reaction [TNF protein affects the localization of NFATC1 protein] CTD PMID:22941906 NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO ruxolitinib inhibits the reaction [TNF protein affects the localization of NFKB2 protein] CTD PMID:22941906 NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of NOX1 mRNA CTD PMID:30012499 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of RAC1 mRNA CTD PMID:30012499 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased expression of and affects the localization of RELA protein] CTD PMID:24973641 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit multiple interactions ISO ruxolitinib inhibits the reaction [TNF protein affects the localization of RELB protein] CTD PMID:22941906 NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:88,385,717...88,413,420 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of SOD1 mRNA CTD PMID:30012499 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sp100 SP100 nuclear antigen multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of SP100 mRNA] CTD PMID:28365849 NCBI chr 9:93,758,975...93,825,068
Ensembl chr 9:93,759,075...93,825,068 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression
multiple interactions
decreases phosphorylation 		ISO ruxolitinib results in decreased expression of STAT1 mRNA
ruxolitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of STAT1 mRNA]; ruxolitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of STAT1 protein]
ruxolitinib results in decreased phosphorylation of STAT1 protein 		CTD PMID:22941906 PMID:28365849 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions ISO ruxolitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT2 protein]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of STAT2 mRNA]; ruxolitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT2 protein] CTD PMID:22941906 PMID:28365849 NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:1,287,024...1,303,459 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased phosphorylation of STAT3 protein; ruxolitinib inhibits the reaction [DDT results in increased phosphorylation of STAT3 protein] CTD PMID:24820114 PMID:30012499 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases phosphorylation ISO ruxolitinib results in decreased phosphorylation of STAT5B protein
ruxolitinib results in decreased phosphorylation of STAT5B protein; ruxolitinib results in decreased phosphorylation of STAT5B protein mutant form 		CTD PMID:29200404 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990 		JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of TLR3 mRNA] CTD PMID:28365849 NCBI chr16:53,554,916...53,572,321
Ensembl chr16:53,555,131...53,568,385 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ruxolitinib inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [TNF protein affects the localization of NFKB2 protein]; ruxolitinib inhibits the reaction [TNF protein affects the localization of RELB protein]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of CXCL11 mRNA]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of IFIT1 mRNA]; ruxolitinib promotes the reaction [TNF protein affects the localization of JUN protein]; ruxolitinib promotes the reaction [TNF protein affects the localization of NFATC1 protein]
ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased secretion of TNF protein] 		CTD PMID:22941906 PMID:24973641 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of TP53 mRNA; [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of TP53 protein CTD PMID:30012499 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of TXNRD1 mRNA CTD PMID:30012499 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
G Ucp1 uncoupling protein 1 increases expression ISO ruxolitinib results in increased expression of UCP1 mRNA CTD PMID:25487280 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO ruxolitinib results in increased expression of VEGFA mRNA CTD PMID:26300391 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      group 20803
        pseudohalo group 4793
          cyano group 4793
            nitrile 4793
              ruxolitinib 53
                ruxolitinib phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  heteroarene 17448
                                    monocyclic heteroarene 15186
                                      azole 14620
                                        diazole 10859
                                          pyrazoles 2365
                                            ruxolitinib 53
                                              ruxolitinib phosphate 0
paths to the root