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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ruxolitinib
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Accession:CHEBI:66919 term browser browse the term
Definition:A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis.
Synonyms:exact_synonym: (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
 related_synonym: Formula=C17H18N6;   INCB018424;   InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1;   InChIKey=HFNKQEVNSGCOJV-OAHLLOKOSA-N;   SMILES=N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
 xref: CAS:941678-49-5;   Drug_Central:4190;   KEGG:D09959;   LINCS:LSM-1139
 xref_mesh: MESH:C540383
 xref: PMID:21602517;   PMID:21919691;   PMID:21926964;   PMID:22034658;   PMID:22227528;   PMID:22279053;   PMID:22281165;   PMID:22375970;   PMID:22375971;   PMID:22399854;   PMID:22422826;   PMID:22474318;   PMID:22544377;   PMID:22718840;   PMID:22830345;   Patent:US2008312258;   Patent:US2010190981;   Reaxys:18703668;   Wikipedia:Ruxolitinib


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ruxolitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of APAF1 mRNA CTD PMID:30012499 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased phosphorylation of ATM protein CTD PMID:30012499 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]
[ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of BAX mRNA		 CTD PMID:24973641 PMID:30012499 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of BBC3 mRNA CTD PMID:30012499 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA CTD PMID:30012499 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of BIRC5 mRNA CTD PMID:30012499 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Cat catalase multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of CAT mRNA CTD PMID:30012499 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of CCND1 mRNA CTD PMID:30012499 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ruxolitinib inhibits the reaction [DDT results in decreased expression of CDH1 mRNA] CTD PMID:24820114 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO ruxolitinib inhibits the reaction [DDT results in increased expression of CDH2 mRNA] CTD PMID:24820114 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of CDK2 mRNA CTD PMID:30012499 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased phosphorylation of CHEK2 protein CTD PMID:30012499 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
decreases expression		 ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of CXCL10 mRNA]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]
ruxolitinib results in decreased expression of CXCL10 mRNA		 CTD PMID:22941906 PMID:28365849 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions
decreases expression		 ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of CXCL11 mRNA]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of CXCL11 mRNA]
ruxolitinib results in decreased expression of CXCL11 mRNA		 CTD PMID:22941906 PMID:28365849 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Edn1 endothelin 1 decreases phosphorylation EXP ruxolitinib results in decreased phosphorylation of EDN1 protein CTD PMID:30670587 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:24973641 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of GSR mRNA CTD PMID:30012499 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Arsenic Trioxide co-treated with ruxolitinib] results in increased phosphorylation of H2AX protein CTD PMID:30012499 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Ifna1 interferon, alpha 1 multiple interactions ISO ruxolitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT2 protein] CTD PMID:22941906 NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of CXCL10 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of CXCL11 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of IRF1 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of IRF9 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of SP100 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of STAT1 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of STAT2 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of TLR3 mRNA] CTD PMID:28365849 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ifng interferon gamma multiple interactions ISO ruxolitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT2 protein] CTD PMID:22941906 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL10 protein] CTD PMID:24973641 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO ruxolitinib inhibits the reaction [Particulate Matter results in increased secretion of IL13 protein] CTD PMID:32725971 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased secretion of and results in decreased expression of IL17A protein] CTD PMID:24973641 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL1B protein]
ruxolitinib inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]		 CTD PMID:24973641 PMID:32725971 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO ruxolitinib inhibits the reaction [Particulate Matter results in increased secretion of IL5 protein] CTD PMID:32725971 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of IRF1 mRNA] CTD PMID:28365849 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO ruxolitinib results in decreased expression of IRF7 mRNA CTD PMID:22941906 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Irf9 interferon regulatory factor 9 multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of IRF9 mRNA] CTD PMID:28365849 NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO ruxolitinib inhibits the reaction [DDT results in increased expression of ITGB1 mRNA] CTD PMID:24820114 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Jak1 Janus kinase 1 multiple interactions
decreases activity		 ISO ruxolitinib inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]
ruxolitinib results in decreased activity of JAK1 protein		 CTD PMID:24820114 PMID:24883332 PMID:26300391 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Jak2 Janus kinase 2 affects response to substance
decreases activity
multiple interactions		 ISO JAK2 gene mutant form affects the susceptibility to ruxolitinib
ruxolitinib results in decreased activity of JAK2 protein
[ruxolitinib co-treated with Arsenic Trioxide] results in decreased phosphorylation of JAK2 protein		 CTD PMID:24883332 PMID:26300391 PMID:30012499 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO ruxolitinib promotes the reaction [TNF protein affects the localization of JUN protein] CTD PMID:22941906 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein] CTD PMID:24973641 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of MYC mRNA CTD PMID:30012499 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO ruxolitinib promotes the reaction [TNF protein affects the localization of NFATC1 protein] CTD PMID:22941906 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO ruxolitinib inhibits the reaction [TNF protein affects the localization of NFKB2 protein] CTD PMID:22941906 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of NOX1 mRNA CTD PMID:30012499 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of RAC1 mRNA CTD PMID:30012499 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased expression of and affects the localization of RELA protein] CTD PMID:24973641 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit multiple interactions ISO ruxolitinib inhibits the reaction [TNF protein affects the localization of RELB protein] CTD PMID:22941906 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of SOD1 mRNA CTD PMID:30012499 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sp100 SP100 nuclear antigen multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of SP100 mRNA] CTD PMID:28365849 NCBI chr 9:86,310,990...86,377,036
Ensembl chr 9:86,311,032...86,377,034 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression
multiple interactions
decreases phosphorylation		 ISO ruxolitinib results in decreased expression of STAT1 mRNA
ruxolitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of STAT1 mRNA]; ruxolitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of STAT1 protein]
ruxolitinib results in decreased phosphorylation of STAT1 protein		 CTD PMID:22941906 PMID:28365849 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions ISO ruxolitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT2 protein]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of STAT2 mRNA]; ruxolitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT2 protein] CTD PMID:22941906 PMID:28365849 NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased phosphorylation of STAT3 protein; ruxolitinib inhibits the reaction [DDT results in increased phosphorylation of STAT3 protein] CTD PMID:24820114 PMID:30012499 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases phosphorylation ISO ruxolitinib results in decreased phosphorylation of STAT5B protein
ruxolitinib results in decreased phosphorylation of STAT5B protein; ruxolitinib results in decreased phosphorylation of STAT5B protein mutant form		 CTD PMID:29200404 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of TLR3 mRNA] CTD PMID:28365849 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ruxolitinib inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [TNF protein affects the localization of NFKB2 protein]; ruxolitinib inhibits the reaction [TNF protein affects the localization of RELB protein]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of CXCL11 mRNA]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of IFIT1 mRNA]; ruxolitinib promotes the reaction [TNF protein affects the localization of JUN protein]; ruxolitinib promotes the reaction [TNF protein affects the localization of NFATC1 protein]
ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased secretion of TNF protein]		 CTD PMID:22941906 PMID:24973641 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of TP53 mRNA; [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of TP53 protein CTD PMID:30012499 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of TXNRD1 mRNA CTD PMID:30012499 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ucp1 uncoupling protein 1 increases expression ISO ruxolitinib results in increased expression of UCP1 mRNA CTD PMID:25487280 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO ruxolitinib results in increased expression of VEGFA mRNA CTD PMID:26300391 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      group 19850
        pseudohalo group 4587
          cyano group 4587
            nitrile 4587
              ruxolitinib 53
                ruxolitinib phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19724
                              organic cyclic compound 19514
                                organic heterocyclic compound 18893
                                  heteroarene 17176
                                    monocyclic heteroarene 15001
                                      azole 14525
                                        diazole 10786
                                          pyrazoles 2333
                                            ruxolitinib 53
                                              ruxolitinib phosphate 0
paths to the root