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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrazoles
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Accession:CHEBI:26410 term browser browse the term
Synonyms:alt_id: MESH:D011720
 xref_mesh: MESH:D011720

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pyrazoles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora3 adenosine A3 receptor multiple interactions ISO Pyrazoles analog binds to and results in decreased activity of ADORA3 protein CTD PMID:16033279 NCBI chr 2:208,336,909...208,379,217
Ensembl chr 2:208,373,154...208,376,803 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions ISO Pyrazoles analog binds to and results in decreased activity of CNR1 protein CTD PMID:16279795 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056 		JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO Pyrazoles analog binds to and results in decreased activity of CNR2 protein CTD PMID:16279795 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126 		JBrowse link
G Csk C-terminal Src kinase decreases activity ISO Pyrazoles analog results in decreased activity of CSK protein CTD PMID:12534346 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303 		JBrowse link
G Csnk1d casein kinase 1, delta decreases activity ISO Pyrazoles analog results in decreased activity of CSNK1D protein CTD PMID:12534346 NCBI chr10:110,147,786...110,182,413
Ensembl chr10:110,148,600...110,182,408 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Pyrazoles analog binds to and results in increased activity of ESR1 protein CTD PMID:19772920 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Pyrazoles analog binds to and results in decreased activity of ESR2 protein CTD PMID:19772920 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Hcar2 hydroxycarboxylic acid receptor 2 multiple interactions ISO
EXP		 Pyrazoles binds to and results in increased activity of HCAR2 protein
[Pyrazoles binds to and results in increased activity of HCAR2 protein] which results in decreased abundance of Fatty Acids, Nonesterified; Pyrazoles binds to and results in increased activity of HCAR2 protein		 CTD PMID:17588745, PMID:17804224 NCBI chr12:38,160,464...38,161,546
Ensembl chr12:38,160,464...38,161,546 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression EXP Pyrazoles affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO Pyrazoles analog inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; Pyrazoles analog inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 mRNA] CTD PMID:11592964 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO Pyrazoles analog results in decreased activity of LCK protein CTD PMID:12534346 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 decreases activity ISO Pyrazoles analog results in decreased activity of MAPK11 protein CTD PMID:12534346 NCBI chr 7:130,121,678...130,129,199
Ensembl chr 7:130,121,687...130,128,604 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases activity ISO Pyrazoles analog results in decreased activity of MAPK14 protein CTD PMID:12534346 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
1H-pyrazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) multiple interactions
decreases activity		 ISO
EXP		 pyrazole inhibits the reaction [ADH1 protein results in increased metabolism of Ethanol]
pyrazole results in decreased activity of ADH1 protein		 CTD PMID:7646056, PMID:15551062, PMID:16289176 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases activity EXP pyrazole results in decreased activity of ADH4 protein CTD PMID:15551062 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899 		JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO pyrazole results in increased expression of AHSA1 mRNA CTD PMID:17945193 NCBI chr 6:111,296,168...111,304,224
Ensembl chr 6:111,296,417...111,304,224 		JBrowse link
G Aifm3 apoptosis inducing factor, mitochondria associated 3 decreases expression ISO pyrazole results in decreased expression of AIFM3 mRNA CTD PMID:17945193 NCBI chr11:87,364,452...87,380,705
Ensembl chr11:87,366,621...87,380,704 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO pyrazole inhibits the reaction [AKR1A1 protein results in increased reduction of muconaldehyde] CTD PMID:16289176 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO pyrazole results in increased expression of ALDOA mRNA CTD PMID:17945193 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO pyrazole results in decreased expression of ALDOC mRNA CTD PMID:17945193 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126 		JBrowse link
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase increases expression ISO pyrazole results in increased expression of ALKBH2 mRNA CTD PMID:17945193 NCBI chr12:48,257,575...48,262,244
Ensembl chr12:48,257,609...48,262,243 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression ISO pyrazole results in increased expression of APEX1 mRNA CTD PMID:17945193 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082 		JBrowse link
G Asf1a anti-silencing function 1A histone chaperone increases expression ISO pyrazole results in increased expression of ASF1A mRNA CTD PMID:17945193 NCBI chr20:34,894,419...34,909,265
Ensembl chr20:34,894,419...34,909,265 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO pyrazole results in increased expression of ATF4 mRNA CTD PMID:17945193 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772 		JBrowse link
G Atf5 activating transcription factor 5 increases expression ISO pyrazole results in increased expression of ATF5 mRNA CTD PMID:17945193 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO pyrazole results in increased expression of ATF6 mRNA CTD PMID:17945193 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443 		JBrowse link
G Atf6b activating transcription factor 6 beta increases expression ISO pyrazole results in increased expression of ATF6B mRNA CTD PMID:17945193 NCBI chr20:4,414,283...4,422,283
Ensembl chr20:4,414,276...4,422,283 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP [Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BAD mRNA CTD PMID:16610055 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bag3 BAG cochaperone 3 increases expression ISO pyrazole results in increased expression of BAG3 mRNA CTD PMID:17945193 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP [Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BAK1 mRNA CTD PMID:16610055 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO pyrazole results in increased expression of BAX mRNA CTD PMID:17945193 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl10 BCL10, immune signaling adaptor increases expression ISO pyrazole results in increased expression of BCL10 mRNA CTD PMID:17945193 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957 		JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO pyrazole results in increased expression of BCL2L11 mRNA CTD PMID:17945193 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression ISO pyrazole results in increased expression of BCL3 mRNA CTD PMID:17945193 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO pyrazole results in increased expression of BID mRNA CTD PMID:17945193 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Bik BCL2-interacting killer multiple interactions EXP [Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BIK mRNA CTD PMID:16610055 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447 		JBrowse link
G Blvra biliverdin reductase A multiple interactions ISO pyrazole results in increased expression of and results in increased activity of BLVRA protein CTD PMID:25478736 NCBI chr 3:119,552,550...119,577,796
Ensembl chr 3:119,561,290...119,577,806 		JBrowse link
G Bmf Bcl2 modifying factor decreases expression ISO pyrazole results in decreased expression of BMF mRNA CTD PMID:17945193 NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084 		JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO pyrazole results in decreased expression of BNIP3 mRNA CTD PMID:17945193 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO pyrazole results in decreased expression of BOK mRNA CTD PMID:17945193 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO pyrazole results in increased expression of BTG2 mRNA CTD PMID:17945193 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982 		JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression ISO pyrazole results in decreased expression of CAR3 mRNA CTD PMID:17945193 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Calr3 calreticulin 3 increases expression ISO pyrazole results in increased expression of CALR3 mRNA CTD PMID:17945193 NCBI chr16:19,097,391...19,124,062
Ensembl chr16:19,097,391...19,124,062 		JBrowse link
G Casp7 caspase 7 decreases expression ISO pyrazole results in decreased expression of CASP7 mRNA CTD PMID:17945193 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Cbr3 carbonyl reductase 3 increases expression ISO pyrazole results in increased expression of CBR3 mRNA CTD PMID:17945193 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO pyrazole results in increased expression of CCND1 mRNA CTD PMID:17945193 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 increases expression ISO pyrazole results in increased expression of CCT2 mRNA CTD PMID:17945193 NCBI chr 7:60,106,532...60,122,779
Ensembl chr 7:60,109,974...60,122,805 		JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 increases expression ISO pyrazole results in increased expression of CCT5 mRNA CTD PMID:17945193 NCBI chr 2:84,667,578...84,678,730
Ensembl chr 2:84,667,633...84,678,790 		JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 increases expression ISO pyrazole results in increased expression of CCT7 mRNA CTD PMID:17945193 NCBI chr 4:117,235,023...117,252,265
Ensembl chr 4:117,235,023...117,252,265 		JBrowse link
G Cdkl2 cyclin dependent kinase like 2 increases expression ISO pyrazole results in increased expression of CDKL2 mRNA CTD PMID:17945193 NCBI chr14:17,530,170...17,565,950
Ensembl chr14:17,531,398...17,565,950 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO pyrazole results in increased expression of CDKN1A mRNA CTD PMID:17945193 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression ISO pyrazole results in increased expression of CEBPG mRNA CTD PMID:17945193 NCBI chr 1:91,286,956...91,297,459
Ensembl chr 1:91,287,917...91,296,656 		JBrowse link
G Cideb cell death-inducing DFFA-like effector b decreases expression ISO pyrazole results in decreased expression of CIDEB mRNA CTD PMID:17945193 NCBI chr15:34,439,844...34,444,244
Ensembl chr15:34,439,876...34,444,244 		JBrowse link
G Cidec cell death-inducing DFFA-like effector c increases expression ISO pyrazole results in increased expression of CIDEC mRNA CTD PMID:17945193 NCBI chr 4:145,377,482...145,390,497
Ensembl chr 4:145,377,431...145,390,497 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO pyrazole results in increased expression of CRYAB mRNA CTD PMID:17945193 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO pyrazole results in decreased expression of CYP17A1 mRNA CTD PMID:17945193 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression
multiple interactions
increases activity		 EXP
ISO		 pyrazole results in increased expression of CYP2A3 mRNA
pyrazole results in increased expression of CYP2A5 mRNA; pyrazole results in increased expression of CYP2A5 protein
G6PDX affects the reaction [pyrazole results in increased expression of and results in increased activity of CYP2A5 protein]; G6PDX affects the reaction [pyrazole results in increased expression of CYP2A5 mRNA]; pyrazole promotes the reaction [HNRNPA1 protein binds to CYP2A5 mRNA]; pyrazole results in increased expression of and results in increased activity of CYP2A5 protein; Vitamin E inhibits the reaction [pyrazole results in increased expression of CYP2A5 mRNA]
pyrazole results in increased activity of CYP2A5 protein		 CTD PMID:7543189, PMID:9698299, PMID:11038160, PMID:11901218, PMID:12499123, PMID:12845369, PMID:14610226, PMID:17945193, PMID:18068688, PMID:25478736 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO pyrazole results in decreased expression of CYP2C38 mRNA CTD PMID:17945193 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases expression ISO pyrazole results in decreased expression of CYP2C29 mRNA CTD PMID:17945193 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases expression ISO pyrazole results in decreased expression of CYP2D22 mRNA CTD PMID:17945193 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
increases activity
affects expression		 ISO
EXP		 pyrazole results in increased expression of CYP2E1 protein
pyrazole results in increased activity of CYP2E1 protein
pyrazole affects the expression of CYP2E1 protein		 CTD PMID:3113478, PMID:3782137, PMID:8074729, PMID:8734847, PMID:9698299, PMID:19679878 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression ISO pyrazole results in decreased expression of CYP2F2 mRNA CTD PMID:17945193 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821 		JBrowse link
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 increases expression ISO pyrazole results in increased expression of CYP2R1 mRNA CTD PMID:17945193 NCBI chr 1:184,060,521...184,106,604
Ensembl chr 1:184,093,920...184,106,200 		JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 decreases expression ISO pyrazole results in decreased expression of CYP39A1 mRNA CTD PMID:17945193 NCBI chr 9:19,804,079...19,880,346
Ensembl chr 9:19,804,079...19,880,346 		JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression ISO pyrazole results in decreased expression of CYP4F14 mRNA CTD PMID:17945193 NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796 		JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 decreases expression ISO pyrazole results in decreased expression of CYP4V3 mRNA CTD PMID:17945193 NCBI chr16:50,111,803...50,136,741
Ensembl chr16:50,111,306...50,136,727 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression ISO pyrazole results in increased expression of CYP51 mRNA CTD PMID:17945193 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO pyrazole results in decreased expression of CYP7A1 mRNA CTD PMID:17945193 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO pyrazole results in decreased expression of CYP8B1 mRNA CTD PMID:17945193 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression ISO pyrazole results in decreased expression of DBP mRNA CTD PMID:17945193 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO pyrazole results in increased expression of DDIT3 mRNA CTD PMID:17945193 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO pyrazole results in increased expression of DDIT4L mRNA CTD PMID:17945193 NCBI chr 2:242,882,219...242,885,088
Ensembl chr 2:242,882,306...242,885,131 		JBrowse link
G Derl1 derlin 1 increases expression ISO pyrazole results in increased expression of DERL1 mRNA CTD PMID:17945193 NCBI chr 7:97,737,176...97,759,852
Ensembl chr 7:97,737,178...97,759,852 		JBrowse link
G Derl3 derlin 3 increases expression ISO pyrazole results in increased expression of DERL3 mRNA CTD PMID:17945193 NCBI chr20:13,692,102...13,707,645
Ensembl chr20:13,704,314...13,706,205 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 increases expression ISO pyrazole results in increased expression of DNAJA1 mRNA CTD PMID:17945193 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378 		JBrowse link
G Dnaja4 DnaJ heat shock protein family (Hsp40) member A4 increases expression ISO pyrazole results in increased expression of DNAJA4 mRNA CTD PMID:17945193 NCBI chr 8:59,278,262...59,294,003
Ensembl chr 8:59,278,262...59,294,003 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO pyrazole results in increased expression of DNAJB1 mRNA CTD PMID:17945193 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 increases expression ISO pyrazole results in increased expression of DNAJB11 mRNA CTD PMID:17945193 NCBI chr11:81,741,342...81,757,806
Ensembl chr11:81,741,297...81,757,813 		JBrowse link
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 increases expression ISO pyrazole results in increased expression of DNAJB2 mRNA CTD PMID:17945193 NCBI chr 9:82,436,453...82,444,669
Ensembl chr 9:82,436,458...82,444,668 		JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 increases expression ISO pyrazole results in increased expression of DNAJB6 mRNA CTD PMID:17945193 NCBI chr 4:2,711,329...2,774,969
Ensembl chr 4:2,711,385...2,774,890 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO pyrazole results in increased expression of DNAJB9 mRNA CTD PMID:17945193 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151 		JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 increases expression ISO pyrazole results in increased expression of DNAJC10 mRNA CTD PMID:17945193 NCBI chr 3:67,538,289...67,578,308
Ensembl chr 3:67,538,289...67,578,306 		JBrowse link
G Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 increases expression ISO pyrazole results in increased expression of DNAJC12 mRNA CTD PMID:17945193 NCBI chr20:26,893,139...26,913,041
Ensembl chr20:26,893,016...26,913,016 		JBrowse link
G Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 increases expression ISO pyrazole results in increased expression of DNAJC18 mRNA CTD PMID:17945193 NCBI chr18:28,466,892...28,501,013
Ensembl chr18:28,466,311...28,495,937 		JBrowse link
G Dnajc2 DnaJ heat shock protein family (Hsp40) member C2 increases expression ISO pyrazole results in increased expression of DNAJC2 mRNA CTD PMID:17945193 NCBI chr 4:9,881,505...9,908,693
Ensembl chr 4:9,882,904...9,908,689 		JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO pyrazole results in increased expression of DUSP10 mRNA CTD PMID:17945193 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO pyrazole results in increased expression of EDEM1 mRNA CTD PMID:17945193 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO pyrazole results in increased expression of EPHX1 mRNA CTD PMID:17945193 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression ISO pyrazole results in increased expression of ERCC1 mRNA CTD PMID:17945193 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO pyrazole results in increased expression of ERN1 mRNA CTD PMID:17945193 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO pyrazole results in increased expression of ERO1A mRNA CTD PMID:17945193 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381 		JBrowse link
G Erp44 endoplasmic reticulum protein 44 increases expression ISO pyrazole results in increased expression of ERP44 mRNA CTD PMID:17945193 NCBI chr 5:63,937,866...64,030,827
Ensembl chr 5:63,937,784...64,030,901 		JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO pyrazole analog binds to ESR1 protein CTD PMID:17909483 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 affects binding ISO pyrazole analog binds to ESR2 protein CTD PMID:17909483 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Fkbp11 FKBP prolyl isomerase 11 increases expression ISO pyrazole results in increased expression of FKBP11 mRNA CTD PMID:17945193 NCBI chr 7:140,398,253...140,402,664
Ensembl chr 7:140,398,199...140,437,467 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A increases expression ISO pyrazole results in increased expression of FKBP1A mRNA CTD PMID:17945193 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724 		JBrowse link
G Foxo3 forkhead box O3 decreases expression ISO pyrazole results in decreased expression of FOXO3 mRNA CTD PMID:17945193 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO pyrazole results in decreased expression of G6PC mRNA CTD PMID:17945193 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO G6PDX affects the reaction [pyrazole results in increased expression of and results in increased activity of CYP2A5 protein]; G6PDX affects the reaction [pyrazole results in increased expression of CYP2A5 mRNA]; G6PDX affects the reaction [pyrazole results in increased expression of HSPA5 protein] CTD PMID:18068688 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO pyrazole results in increased expression of GADD45A mRNA CTD PMID:17945193 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gbe1 1,4-alpha-glucan branching enzyme 1 increases expression ISO pyrazole results in increased expression of GBE1 mRNA CTD PMID:17945193 NCBI chr11:7,210,169...7,485,895
Ensembl chr11:7,210,209...7,485,890 		JBrowse link
G Gck glucokinase decreases expression ISO pyrazole results in decreased expression of GCK mRNA CTD PMID:17945193 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO pyrazole results in increased expression of GCLC mRNA CTD PMID:17945193 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO pyrazole results in increased expression of GPX2 mRNA CTD PMID:17945193 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO pyrazole results in increased expression of GSR mRNA CTD PMID:17945193 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gss glutathione synthetase increases expression ISO pyrazole results in increased expression of GSS mRNA CTD PMID:17945193 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO pyrazole results in increased expression of GSTA1 mRNA CTD PMID:17945193 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression ISO pyrazole results in decreased expression of GSTA3 mRNA CTD PMID:17945193 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023 		JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO pyrazole results in increased expression of GSTA1 mRNA CTD PMID:17945193 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176 		JBrowse link
G Gstcd glutathione S-transferase, C-terminal domain containing increases expression ISO pyrazole results in increased expression of GSTCD mRNA CTD PMID:17945193 NCBI chr 2:238,109,758...238,253,326
Ensembl chr 2:238,109,490...238,253,287 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO pyrazole results in decreased expression of GSTK1 mRNA CTD PMID:17945193 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO pyrazole results in increased expression of GSTM1 mRNA; pyrazole results in increased expression of GSTM1 protein CTD PMID:14610226, PMID:17945193 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 increases expression ISO pyrazole results in increased expression of GSTM4 mRNA CTD PMID:17945193 NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 decreases expression ISO pyrazole results in decreased expression of GSTT1 mRNA CTD PMID:17945193 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526 		JBrowse link
G Gyg1 glycogenin 1 increases expression ISO pyrazole results in increased expression of GYG mRNA CTD PMID:17945193 NCBI chr 2:104,916,734...104,958,219
Ensembl chr 2:104,916,738...104,958,034 		JBrowse link
G Gys2 glycogen synthase 2 decreases expression ISO pyrazole results in decreased expression of GYS2 mRNA CTD PMID:17945193 NCBI chr 4:176,638,632...176,679,805
Ensembl chr 4:176,638,629...176,679,815 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO pyrazole results in increased expression of H2AX mRNA CTD PMID:17945193 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO pyrazole results in increased expression of HMOX1 mRNA
pyrazole results in increased expression of and results in increased activity of HMOX1 protein		 CTD PMID:17945193, PMID:25478736 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 multiple interactions
increases expression		 ISO pyrazole promotes the reaction [HNRNPA1 protein binds to CYP2A5 mRNA]
pyrazole results in increased expression of HNRNPA1 protein		 CTD PMID:11901218 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO pyrazole results in decreased expression of HSD3B2 mRNA CTD PMID:17945193
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 decreases expression ISO pyrazole results in decreased expression of HSD3B3 mRNA CTD PMID:17945193 NCBI chr 2:200,756,557...200,762,492
Ensembl chr 2:200,585,748...200,762,492 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression ISO pyrazole results in increased expression of HSP90AA1 mRNA CTD PMID:17945193 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression ISO pyrazole results in increased expression of HSP90AB1 mRNA CTD PMID:17945193 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression ISO pyrazole results in increased expression of HSP90B1 mRNA CTD PMID:17945193 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533 		JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 increases expression ISO pyrazole results in increased expression of STCH mRNA CTD PMID:17945193 NCBI chr11:14,146,515...14,160,697
Ensembl chr11:14,144,130...14,160,892 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO pyrazole results in increased expression of HSPA1A mRNA CTD PMID:17945193 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO pyrazole results in increased expression of HSPA1B mRNA CTD PMID:17945193 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO pyrazole results in increased expression of HSPA4 mRNA CTD PMID:17945193 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397 		JBrowse link
G Hspa4l heat shock protein family A (Hsp70) member 4 like increases expression ISO pyrazole results in increased expression of HSPA4L mRNA CTD PMID:17945193 NCBI chr 2:127,625,737...127,682,864
Ensembl chr 2:127,625,683...127,677,503 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 ISO G6PDX affects the reaction [pyrazole results in increased expression of HSPA5 protein]; Vitamin E inhibits the reaction [pyrazole results in increased expression of HSPA5 protein]
pyrazole results in increased expression of HSPA5 mRNA; pyrazole results in increased expression of HSPA5 protein		 CTD PMID:12499123, PMID:14610226, PMID:17945193, PMID:18068688 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO pyrazole results in increased expression of HSPA8 mRNA CTD PMID:17945193 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression ISO pyrazole results in increased expression of HSPA9 mRNA CTD PMID:17945193 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO pyrazole results in increased expression of HSPB1 mRNA CTD PMID:17945193 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049 		JBrowse link
G Hspb8 heat shock protein family B (small) member 8 increases expression ISO pyrazole results in increased expression of HSPB8 mRNA CTD PMID:17945193 NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression ISO pyrazole results in increased expression of HSPE1 mRNA CTD PMID:17945193 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599 		JBrowse link
G Lig3 DNA ligase 3 increases expression ISO pyrazole results in increased expression of LIG3 mRNA CTD PMID:17945193 NCBI chr10:70,134,734...70,158,051
Ensembl chr10:70,134,729...70,158,055 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO pyrazole results in increased expression of MCL1 mRNA CTD PMID:17945193 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO pyrazole affects the localization of NFE2L2 protein CTD PMID:25478736 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nol3 nucleolar protein 3 increases expression ISO pyrazole results in increased expression of NOL3 mRNA CTD PMID:17945193 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649 		JBrowse link
G Npm3 nucleophosmin/nucleoplasmin, 3 increases expression ISO pyrazole results in increased expression of NPM3 mRNA CTD PMID:17945193 NCBI chr 1:265,504,105...265,506,080
Ensembl chr 1:265,504,575...265,506,046 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO pyrazole results in increased expression of NQO1 mRNA CTD PMID:17945193 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO pyrazole results in increased expression of NUPR1 mRNA CTD PMID:17945193 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression ISO pyrazole results in increased expression of OGG1 mRNA CTD PMID:17945193 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326 		JBrowse link
G Pawr pro-apoptotic WT1 regulator increases expression ISO pyrazole results in increased expression of PAWR mRNA CTD PMID:17945193 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068 		JBrowse link
G Pc pyruvate carboxylase decreases expression ISO pyrazole results in decreased expression of PCX mRNA CTD PMID:17945193 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression ISO pyrazole results in decreased expression of PCK1 mRNA CTD PMID:17945193 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression ISO pyrazole results in increased expression of PDIA3 mRNA CTD PMID:17945193 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 increases expression ISO pyrazole results in increased expression of PDIA4 mRNA CTD PMID:17945193 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 increases expression ISO pyrazole results in increased expression of PDIA6 mRNA CTD PMID:17945193 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652 		JBrowse link
G Pfdn4 prefoldin subunit 4 increases expression ISO pyrazole results in increased expression of PFDN4 mRNA CTD PMID:17945193 NCBI chr 3:168,124,634...168,132,739
Ensembl chr 3:168,124,673...168,132,786 		JBrowse link
G Pfkl phosphofructokinase, liver type decreases expression ISO pyrazole results in decreased expression of PFKL mRNA CTD PMID:17945193 NCBI chr20:11,393,860...11,415,889
Ensembl chr20:11,393,877...11,415,882 		JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase increases expression ISO pyrazole results in increased expression of PGAM5 mRNA CTD PMID:17945193 NCBI chr12:52,467,417...52,474,533
Ensembl chr12:52,467,450...52,474,511 		JBrowse link
G Pgk2 phosphoglycerate kinase 2 increases expression ISO pyrazole results in increased expression of PGK2 mRNA CTD PMID:17945193 NCBI chr 9:24,095,774...24,097,340
Ensembl chr 9:24,095,751...24,097,337 		JBrowse link
G Pgm1 phosphoglucomutase 1 increases expression ISO pyrazole results in increased expression of PGM1 mRNA CTD PMID:17945193 NCBI chr 5:118,743,632...118,803,055
Ensembl chr 5:118,743,632...118,803,055 		JBrowse link
G Pgm3 phosphoglucomutase 3 increases expression ISO pyrazole results in increased expression of PGM3 mRNA CTD PMID:17945193 NCBI chr 8:94,225,513...94,243,230
Ensembl chr 8:94,225,515...94,243,215 		JBrowse link
G Pmm1 phosphomannomutase 1 increases expression ISO pyrazole results in increased expression of PMM1 mRNA CTD PMID:17945193 NCBI chr 7:123,183,504...123,193,874
Ensembl chr 7:123,183,506...123,193,761 		JBrowse link
G Pomp proteasome maturation protein increases expression ISO pyrazole results in increased expression of POMP mRNA CTD PMID:17945193 NCBI chr12:8,746,948...8,759,433
Ensembl chr12:8,746,855...8,759,599 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO pyrazole results in increased expression of PPARG mRNA CTD PMID:17945193 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression ISO pyrazole results in decreased expression of PPARGC1A mRNA CTD PMID:17945193 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ppia peptidylprolyl isomerase A increases expression ISO pyrazole results in increased expression of PPIA mRNA CTD PMID:17945193 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443 		JBrowse link
G Ppid peptidylprolyl isomerase D increases expression ISO pyrazole results in increased expression of PPID mRNA CTD PMID:17945193 NCBI chr 2:178,354,830...178,366,843
Ensembl chr 2:178,354,890...178,366,685 		JBrowse link
G Prdx2 peroxiredoxin 2 decreases expression ISO pyrazole results in decreased expression of PRDX2 mRNA CTD PMID:17945193 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094 		JBrowse link
G Prpf19 pre-mRNA processing factor 19 increases expression ISO pyrazole results in increased expression of PRPF19 mRNA CTD PMID:17945193 NCBI chr 1:226,947,065...226,958,147
Ensembl chr 1:226,947,105...226,958,144 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO pyrazole results in increased expression of PSAT1 mRNA CTD PMID:17945193 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941 		JBrowse link
G Psma1 proteasome 20S subunit alpha 1 increases expression ISO pyrazole results in increased expression of PSMA1 mRNA CTD PMID:17945193 NCBI chr 1:183,733,567...183,744,586
Ensembl chr 1:183,733,567...183,744,586 		JBrowse link
G Psma2 proteasome 20S subunit alpha 2 increases expression ISO pyrazole results in increased expression of PSMA2 mRNA CTD PMID:17945193 NCBI chr17:53,091,937...53,102,324
Ensembl chr17:53,091,933...53,102,342 		JBrowse link
G Psma4 proteasome 20S subunit alpha 4 increases expression ISO pyrazole results in increased expression of PSMA4 mRNA CTD PMID:17945193 NCBI chr 8:59,532,456...59,539,916
Ensembl chr 8:59,532,389...59,539,920 		JBrowse link
G Psma5 proteasome 20S subunit alpha 5 increases expression ISO pyrazole results in increased expression of PSMA5 mRNA CTD PMID:17945193 NCBI chr 2:211,050,344...211,073,706
Ensembl chr 2:211,050,360...211,073,714 		JBrowse link
G Psma7 proteasome 20S subunit alpha 7 increases expression ISO pyrazole results in increased expression of PSMA7 mRNA CTD PMID:17945193 NCBI chr 3:175,420,042...175,426,384
Ensembl chr 3:175,420,039...175,426,395 		JBrowse link
G Psmb2 proteasome 20S subunit beta 2 increases expression ISO pyrazole results in increased expression of PSMB2 mRNA CTD PMID:17945193 NCBI chr 5:144,702,004...144,734,220
Ensembl chr 5:144,701,949...144,734,257 		JBrowse link
G Psmb3 proteasome 20S subunit beta 3 increases expression ISO pyrazole results in increased expression of PSMB3 mRNA CTD PMID:17945193 NCBI chr10:85,646,646...85,653,729
Ensembl chr10:85,646,633...85,653,729 		JBrowse link
G Psmb4 proteasome 20S subunit beta 4 increases expression ISO pyrazole results in increased expression of PSMB4 mRNA CTD PMID:17945193 NCBI chr 2:196,043,546...196,046,320
Ensembl chr 2:196,043,618...196,046,311 		JBrowse link
G Psmb5 proteasome 20S subunit beta 5 increases expression ISO pyrazole results in increased expression of PSMB5 mRNA CTD PMID:17945193 NCBI chr15:33,259,039...33,263,634
Ensembl chr15:33,259,043...33,263,659 		JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 increases expression ISO pyrazole results in increased expression of PSMC2 mRNA CTD PMID:17945193 NCBI chr 4:9,867,132...9,881,383
Ensembl chr 4:9,867,101...9,881,484 		JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 increases expression ISO pyrazole results in increased expression of PSMC3 mRNA CTD PMID:17945193 NCBI chr 3:79,876,938...79,882,319
Ensembl chr 3:79,876,938...79,882,319 		JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 increases expression ISO pyrazole results in increased expression of PSMC4 mRNA CTD PMID:17945193 NCBI chr 1:84,978,220...84,986,536
Ensembl chr 1:84,978,206...84,986,581 		JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 increases expression ISO pyrazole results in increased expression of PSMC6 mRNA CTD PMID:17945193 NCBI chr15:19,667,453...19,688,916
Ensembl chr15:19,667,453...19,688,914 		JBrowse link
G Psmd11 proteasome 26S subunit, non-ATPase 11 increases expression ISO pyrazole results in increased expression of PSMD11 mRNA CTD PMID:17945193 NCBI chr10:67,810,655...67,857,562
Ensembl chr10:67,810,655...67,857,223 		JBrowse link
G Psmd12 proteasome 26S subunit, non-ATPase 12 increases expression ISO pyrazole results in increased expression of PSMD12 mRNA CTD PMID:17945193 NCBI chr10:95,706,808...95,725,452
Ensembl chr10:95,706,685...95,725,812 		JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 increases expression ISO pyrazole results in increased expression of PSMD14 mRNA CTD PMID:17945193 NCBI chr 3:47,578,449...47,673,330
Ensembl chr 3:47,578,384...47,673,338 		JBrowse link
G Psmd2 proteasome 26S subunit, non-ATPase 2 increases expression ISO pyrazole results in increased expression of PSMD2 mRNA CTD PMID:17945193 NCBI chr11:83,934,098...83,944,725
Ensembl chr11:83,934,087...83,944,763 		JBrowse link
G Psmd3 proteasome 26S subunit, non-ATPase 3 increases expression ISO pyrazole results in increased expression of PSMD3 mRNA CTD PMID:17945193 NCBI chr10:86,599,007...86,611,180
Ensembl chr10:86,599,220...86,611,188 		JBrowse link
G Psmd4 proteasome 26S subunit, non-ATPase 4 increases expression ISO pyrazole results in increased expression of PSMD4 mRNA CTD PMID:17945193 NCBI chr 2:196,198,303...196,207,569
Ensembl chr 2:196,198,038...196,207,560 		JBrowse link
G Psmd5 proteasome 26S subunit, non-ATPase 5 increases expression ISO pyrazole results in increased expression of PSMD5 mRNA CTD PMID:17945193 NCBI chr 3:13,916,199...13,937,031
Ensembl chr 3:13,916,203...13,933,658 		JBrowse link
G Psmd6 proteasome 26S subunit, non-ATPase 6 increases expression ISO pyrazole results in increased expression of PSMD6 mRNA CTD PMID:17945193 NCBI chr15:12,407,557...12,416,153
Ensembl chr15:12,407,524...12,416,105 		JBrowse link
G Psmd7 proteasome 26S subunit, non-ATPase 7 increases expression ISO pyrazole results in increased expression of PSMD7 mRNA CTD PMID:17945193 NCBI chr19:39,639,432...39,646,718
Ensembl chr19:39,639,431...39,646,693 		JBrowse link
G Psmd8 proteasome 26S subunit, non-ATPase 8 increases expression ISO pyrazole results in increased expression of PSMD8 mRNA CTD PMID:17945193 NCBI chr 1:88,116,811...88,123,643
Ensembl chr 1:88,116,812...88,123,643 		JBrowse link
G Psme3 proteasome activator subunit 3 increases expression ISO pyrazole results in increased expression of PSME3 mRNA CTD PMID:17945193 NCBI chr10:89,236,256...89,244,041
Ensembl chr10:89,236,256...89,244,041 		JBrowse link
G Pten phosphatase and tensin homolog decreases expression ISO pyrazole results in decreased expression of PTEN mRNA CTD PMID:17945193 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Pygl glycogen phosphorylase L decreases expression ISO pyrazole results in decreased expression of PYGL mRNA CTD PMID:17945193 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847 		JBrowse link
G Qsox2 quiescin sulfhydryl oxidase 2 increases expression ISO pyrazole results in increased expression of QSOX2 mRNA CTD PMID:17945193 NCBI chr 3:3,662,324...3,691,972
Ensembl chr 3:3,662,324...3,691,972 		JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease increases expression ISO pyrazole results in increased expression of RAD1 mRNA CTD PMID:17945193 NCBI chr 2:60,461,513...60,469,646
Ensembl chr 2:60,461,551...60,469,685 		JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase increases expression ISO pyrazole results in increased expression of RAD18 mRNA CTD PMID:17945193 NCBI chr 4:144,537,329...144,620,606
Ensembl chr 4:144,536,729...144,620,731 		JBrowse link
G Rad51b RAD51 paralog B increases expression ISO pyrazole results in increased expression of RAD51B mRNA CTD PMID:17945193 NCBI chr 6:102,473,978...103,018,185
Ensembl chr 6:102,477,036...102,512,505 		JBrowse link
G Rad52 RAD52 homolog, DNA repair protein increases expression ISO pyrazole results in increased expression of RAD52 mRNA CTD PMID:17945193 NCBI chr 4:152,429,826...152,451,875
Ensembl chr 4:152,430,187...152,451,609 		JBrowse link
G Rtkn rhotekin increases expression ISO pyrazole results in increased expression of RTKN mRNA CTD PMID:17945193 NCBI chr 4:114,833,453...114,850,705
Ensembl chr 4:114,835,064...114,850,701 		JBrowse link
G Serpina7 serpin family A member 7 increases expression ISO pyrazole results in increased expression of SERPINA7 mRNA CTD PMID:17945193 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO pyrazole results in decreased expression of SOD2 mRNA CTD PMID:17945193 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sphk2 sphingosine kinase 2 decreases expression ISO pyrazole results in decreased expression of SPHK2 mRNA CTD PMID:17945193 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277 		JBrowse link
G Sprr1a small proline-rich protein 1A increases expression ISO pyrazole results in increased expression of SPRR1A mRNA CTD PMID:17945193 NCBI chr 2:192,669,143...192,671,059
Ensembl chr 2:192,669,143...192,671,059 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO pyrazole results in increased expression of SRXN1 mRNA CTD PMID:17945193 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression ISO pyrazole results in decreased expression of SULT1A1 mRNA CTD PMID:17945193 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 decreases expression ISO pyrazole results in decreased expression of SULT1B1 mRNA CTD PMID:17945193 NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231 		JBrowse link
G Tcp1 t-complex 1 increases expression ISO pyrazole results in increased expression of TCP1 mRNA CTD PMID:17945193 NCBI chr 1:48,025,664...48,033,343
Ensembl chr 1:48,025,663...48,033,396 		JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO pyrazole results in decreased expression of TK1 mRNA CTD PMID:17945193 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884 		JBrowse link
G Tnfaip1 TNF alpha induced protein 1 increases expression ISO pyrazole results in increased expression of TNFAIP1 mRNA CTD PMID:17945193 NCBI chr10:65,791,002...65,805,693
Ensembl chr10:65,791,003...65,805,693 		JBrowse link
G Tnfsf9 TNF superfamily member 9 multiple interactions EXP [Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of TNFSF9 mRNA CTD PMID:16610055 NCBI chr 9:9,909,942...9,912,276
Ensembl chr 9:9,909,948...9,912,276 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO pyrazole results in increased expression of TRP53 mRNA CTD PMID:17945193 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO pyrazole results in increased expression of TRP53BP1 mRNA CTD PMID:17945193 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO pyrazole results in increased expression of TRP53INP1 mRNA CTD PMID:17945193 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions EXP [Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in decreased expression of TRAF2 mRNA CTD PMID:16610055 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620 		JBrowse link
G Traip TRAF-interacting protein multiple interactions EXP [Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of TRAIP mRNA CTD PMID:16610055 NCBI chr 8:116,730,170...116,750,528
Ensembl chr 8:116,730,641...116,750,709 		JBrowse link
G Txnl1 thioredoxin-like 1 increases expression ISO pyrazole results in increased expression of TXNL1 mRNA CTD PMID:17945193 NCBI chr18:59,056,454...59,086,278
Ensembl chr18:59,059,375...59,086,256 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO pyrazole results in increased expression of TXNRD1 mRNA CTD PMID:17945193 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400 		JBrowse link
G Uba5 ubiquitin-like modifier activating enzyme 5 increases expression ISO pyrazole results in increased expression of UBA5 mRNA CTD PMID:17945193 NCBI chr 8:112,578,607...112,594,192
Ensembl chr 8:112,578,590...112,594,261 		JBrowse link
G Ubap1 ubiquitin-associated protein 1 increases expression ISO pyrazole results in increased expression of UBAP1 mRNA CTD PMID:17945193 NCBI chr 5:57,738,309...57,778,724
Ensembl chr 5:57,738,321...57,778,723 		JBrowse link
G Ube2f ubiquitin-conjugating enzyme E2F (putative) increases expression ISO pyrazole results in increased expression of UBE2F mRNA CTD PMID:17945193 NCBI chr 9:98,394,112...98,428,684
Ensembl chr 9:98,398,128...98,428,128 		JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I increases expression ISO pyrazole results in increased expression of UBE2I mRNA CTD PMID:17945193 NCBI chr10:14,618,615...14,639,274
Ensembl chr10:14,620,531...14,630,151 		JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression ISO pyrazole results in increased expression of UBE2L3 mRNA CTD PMID:17945193 NCBI chr11:88,047,186...88,088,477
Ensembl chr11:88,047,832...88,088,476 		JBrowse link
G Ube2u ubiquitin conjugating enzyme E2 U decreases expression ISO pyrazole results in decreased expression of UBE2U mRNA CTD PMID:17945193 NCBI chr 5:118,574,647...118,642,810
Ensembl chr 5:118,574,801...118,642,863 		JBrowse link
G Ube4b ubiquitination factor E4B increases expression ISO pyrazole results in increased expression of UBE4B mRNA CTD PMID:17945193 NCBI chr 5:166,156,033...166,259,069
Ensembl chr 5:166,156,033...166,259,069 		JBrowse link
G Ubl4a ubiquitin-like 4A increases expression ISO pyrazole results in increased expression of UBL4A mRNA CTD PMID:17945193 NCBI chr  X:156,340,919...156,343,771
Ensembl chr  X:156,340,925...156,343,777 		JBrowse link
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 decreases expression ISO pyrazole results in decreased expression of UBR2 mRNA CTD PMID:17945193 NCBI chr 9:16,003,058...16,080,152
Ensembl chr 9:16,003,058...16,080,152 		JBrowse link
G Uchl3 ubiquitin C-terminal hydrolase L3 increases expression ISO pyrazole results in increased expression of UCHL3 mRNA CTD PMID:17945193 NCBI chr15:86,153,624...86,198,127
Ensembl chr15:86,153,628...86,198,127 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 increases expression ISO pyrazole results in increased expression of UFD1 mRNA CTD PMID:17945193 NCBI chr11:86,304,836...86,328,478
Ensembl chr11:86,304,815...86,328,469 		JBrowse link
G Ufm1 ubiquitin-fold modifier 1 increases expression ISO pyrazole results in increased expression of UFM1 mRNA CTD PMID:17945193 NCBI chr 2:143,096,268...143,104,412
Ensembl chr 2:143,096,271...143,104,412 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases expression ISO pyrazole results in increased expression of UGT2B34 mRNA CTD PMID:17945193 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Ung uracil-DNA glycosylase increases expression ISO pyrazole results in increased expression of UNG mRNA CTD PMID:17945193 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822 		JBrowse link
G Upp2 uridine phosphorylase 2 decreases expression ISO pyrazole results in decreased expression of UPP2 mRNA CTD PMID:17945193 NCBI chr 3:44,806,106...44,846,464
Ensembl chr 3:44,806,106...44,846,464 		JBrowse link
G Usp14 ubiquitin specific peptidase 14 increases expression ISO pyrazole results in increased expression of USP14 mRNA CTD PMID:17945193 NCBI chr18:1,178,785...1,216,573
Ensembl chr18:1,178,787...1,216,409 		JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression ISO pyrazole results in decreased expression of USP2 mRNA CTD PMID:17945193 NCBI chr 8:48,403,985...48,432,525
Ensembl chr 8:48,406,260...48,430,885 		JBrowse link
G Usp22 ubiquitin specific peptidase 22 increases expression ISO pyrazole results in increased expression of USP22 mRNA CTD PMID:17945193 NCBI chr10:47,429,201...47,453,298
Ensembl chr10:47,429,002...47,453,442 		JBrowse link
G Vcp valosin-containing protein increases expression ISO pyrazole results in increased expression of VCP mRNA CTD PMID:17945193 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 increases expression ISO pyrazole results in increased expression of XRCC4 mRNA CTD PMID:17945193 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365 		JBrowse link
5-methyl-pyrazole-3-carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dao D-amino-acid oxidase decreases activity EXP 5-methylpyrazole-3-carboxylic acid results in decreased activity of DAO protein CTD PMID:20952482 NCBI chr12:48,353,691...48,373,647
Ensembl chr12:48,354,196...48,365,784 		JBrowse link
AM-251 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression		 ISO 4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased expression of ABCG2 protein]; 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased expression of ABCG2 protein] CTD PMID:27423937 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO AM 251 inhibits the reaction [Dronabinol results in decreased phosphorylation of and results in decreased activity of AKT1 protein] CTD PMID:17583570 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 decreases expression ISO AM 251 results in decreased expression of ARPC4 mRNA CTD PMID:16500647 NCBI chr 4:145,330,457...145,340,985
Ensembl chr 4:145,330,457...145,340,984 		JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 increases expression ISO AM 251 results in increased expression of ARPP21 mRNA CTD PMID:16500647 NCBI chr 8:120,323,895...120,492,790
Ensembl chr 8:120,323,897...120,446,507 		JBrowse link
G Ass1 argininosuccinate synthase 1 increases expression ISO AM 251 results in increased expression of ASS1 mRNA CTD PMID:16500647 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826 		JBrowse link
G Atf5 activating transcription factor 5 increases expression ISO AM 251 results in increased expression of ATF5 mRNA CTD PMID:16500647 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522 		JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions ISO AM 251 inhibits the reaction [anandamide results in decreased activity of BDKRB1 protein] CTD PMID:19022239 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574 		JBrowse link
G Cap2 cyclase associated actin cytoskeleton regulatory protein 2 decreases expression ISO AM 251 results in decreased expression of CAP2 mRNA CTD PMID:16500647 NCBI chr17:18,441,614...18,592,866
Ensembl chr17:18,442,127...18,592,750 		JBrowse link
G Cars cysteinyl-tRNA synthetase increases expression ISO AM 251 results in increased expression of CARS1 mRNA CTD PMID:16500647 NCBI chr 1:216,759,367...216,801,652
Ensembl chr 1:216,759,366...216,801,656 		JBrowse link
G Cavin2 caveolae associated protein 2 decreases expression ISO AM 251 results in decreased expression of CAVIN2 mRNA CTD PMID:16500647 NCBI chr 9:55,244,136...55,256,153
Ensembl chr 9:55,243,255...55,256,340 		JBrowse link
G Ccdc86 coiled-coil domain containing 86 decreases expression ISO AM 251 results in decreased expression of CCDC86 mRNA CTD PMID:16500647 NCBI chr 1:226,996,435...227,002,016
Ensembl chr 1:226,996,237...227,002,139 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO AM 251 results in increased expression of CD55 mRNA CTD PMID:16500647 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292 		JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression ISO AM 251 results in increased expression of CEBPG mRNA CTD PMID:16500647 NCBI chr 1:91,286,956...91,297,459
Ensembl chr 1:91,287,917...91,296,656 		JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit increases expression ISO AM 251 results in increased expression of CHRNB3 mRNA CTD PMID:16500647 NCBI chr16:68,876,442...68,913,628
Ensembl chr16:68,875,709...68,913,628 		JBrowse link
G Cklf chemokine-like factor increases expression ISO AM 251 results in increased expression of CKLF mRNA CTD PMID:16500647 NCBI chr19:903,609...914,880
Ensembl chr19:906,411...914,880 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
decreases activity		 ISO
EXP		 [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 1-(5-fluoropentyl)-3-(1-naphthoyl)indole; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 1-pentyl-3-(1-naphthoyl)indole; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to CP 47497; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to CP 47497 analog; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to HU 211
AM 251 results in decreased activity of CNR1 protein
[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased activity of nimesulide; AM 251 binds to and results in decreased activity of CNR1 protein		 CTD PMID:12509806, PMID:17596442, PMID:20590570, PMID:21907772, PMID:24211273, PMID:31622603 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056 		JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 multiple interactions
decreases expression		 ISO AM 251 inhibits the reaction [Ethanol results in increased cleavage of and results in increased activity of CREB3L3 protein]; AM 251 inhibits the reaction [Ethanol results in increased expression of CREB3L3 mRNA]
AM 251 results in decreased expression of CREB3L3 mRNA		 CTD PMID:23894352 NCBI chr 7:11,490,852...11,499,287
Ensembl chr 7:11,490,852...11,499,282 		JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO AM 251 results in increased expression of CTH mRNA CTD PMID:16500647 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; AM 251 promotes the reaction [iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; iodopravadoline promotes the reaction [AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]] CTD PMID:17484889 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions ISO AM 251 inhibits the reaction [Ethanol results in increased expression of CYP27A1 mRNA] CTD PMID:23894352 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO AM 251 inhibits the reaction [Ethanol results in increased expression of CYP7A1 mRNA] CTD PMID:23894352 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression
multiple interactions		 ISO AM 251 results in decreased expression of CYP7B1 mRNA
AM 251 inhibits the reaction [Ethanol results in increased expression of CYP7B1 mRNA]		 CTD PMID:23894352 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO AM 251 inhibits the reaction [Ethanol results in increased expression of CYP8B1 mRNA] CTD PMID:23894352 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO AM 251 results in increased expression of DDIT3 mRNA CTD PMID:16500647 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO AM 251 results in increased expression of DDIT4 mRNA CTD PMID:16500647 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382 		JBrowse link
G Dhx9 DExH-box helicase 9 decreases expression ISO AM 251 results in decreased expression of DHX9 mRNA CTD PMID:16500647 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245 		JBrowse link
G Eftud2 elongation factor Tu GTP binding domain containing 2 decreases expression ISO AM 251 results in decreased expression of EFTUD2 mRNA CTD PMID:16500647 NCBI chr10:90,932,071...90,983,971
Ensembl chr10:90,932,075...90,983,928 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases expression		 ISO 4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased expression of EGFR protein]; 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased expression of EGFR protein] CTD PMID:27423937 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Ervfrd-1 endogenous retrovirus group FRD member 1, envelope multiple interactions ISO AM 251 affects the reaction [Dronabinol results in decreased expression of ERVFRD-1 mRNA] CTD PMID:26070387 NCBI chr12:25,161,130...25,168,182
Ensembl chr12:25,161,130...25,168,182 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO [AM 251 co-treated with iodopravadoline] promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]; [AM 251 co-treated with iodopravadoline] promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]] CTD PMID:27556861 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 decreases expression ISO AM 251 results in decreased expression of FEN1 mRNA CTD PMID:16500647 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886 		JBrowse link
G Fra10ac1 FRA10A associated CGG repeat 1 increases expression ISO AM 251 results in increased expression of FRA10AC1 mRNA CTD PMID:16500647 NCBI chr 1:256,881,688...256,913,617
Ensembl chr 1:256,881,771...256,914,260 		JBrowse link
G Gpr55 G protein-coupled receptor 55 multiple interactions
increases activity		 ISO 4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased activity of GPR55 protein]; 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased activity of GPR55 protein] CTD PMID:27423937 NCBI chr 9:92,961,431...93,011,157
Ensembl chr 9:92,962,738...92,963,697 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO AM 251 results in increased expression of GPX1 mRNA CTD PMID:16500647 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gtf3c5 general transcription factor IIIC subunit 5 decreases expression ISO AM 251 results in decreased expression of GTF3C5 mRNA CTD PMID:16500647 NCBI chr 3:7,144,354...7,164,678
Ensembl chr 3:7,144,250...7,164,654 		JBrowse link
G Hax1 HCLS1 associated protein X-1 increases expression ISO AM 251 results in increased expression of HAX1 mRNA CTD PMID:16500647 NCBI chr 2:189,330,900...189,333,305
Ensembl chr 2:189,330,902...189,333,322 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO AM 251 results in increased expression of HMOX1 mRNA CTD PMID:16500647 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hnmt histamine N-methyltransferase increases expression ISO AM 251 results in increased expression of HNMT mRNA CTD PMID:16500647 NCBI chr 3:905,111...937,038
Ensembl chr 3:904,765...937,102 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression ISO AM 251 results in decreased expression of HSPA1B mRNA CTD PMID:16500647 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO AM 251 results in decreased expression of HSPA8 mRNA CTD PMID:16500647 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO AM 251 inhibits the reaction [Cannabidiol results in increased expression of ICAM1 mRNA] CTD PMID:22198381 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [AM 251 co-treated with iodopravadoline] promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]; [AM 251 co-treated with iodopravadoline] promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]] CTD PMID:27556861 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Immp2l inner mitochondrial membrane peptidase subunit 2 increases expression ISO AM 251 results in increased expression of IMMP2L mRNA CTD PMID:16500647 NCBI chr 6:60,958,351...61,859,457 JBrowse link
G Irf2bpl interferon regulatory factor 2 binding protein-like increases expression ISO AM 251 results in increased expression of IRF2BPL mRNA CTD PMID:16500647 NCBI chr 6:110,901,940...110,904,288
Ensembl chr 6:110,901,940...110,904,288 		JBrowse link
G Lmnb2 lamin B2 decreases expression ISO AM 251 results in decreased expression of LMNB2 mRNA CTD PMID:16500647 NCBI chr 7:11,657,870...11,676,936
Ensembl chr 7:11,660,934...11,675,472 		JBrowse link
G LOC103690190 histone H2A type 1-E increases expression ISO AM 251 results in increased expression of H2AC6 mRNA CTD PMID:16500647 NCBI chr17:44,747,686...44,748,229
Ensembl chr17:44,747,796...44,748,188
Ensembl chr17:44,747,796...44,748,188 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 decreases expression ISO AM 251 results in decreased expression of MAP2K3 mRNA CTD PMID:16500647 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; AM 251 inhibits the reaction [Dronabinol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; AM 251 inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [methanandamide results in increased phosphorylation of MAPK1 protein]
AM 251 results in increased phosphorylation of MAPK1 protein		 CTD PMID:17583570, PMID:17596442, PMID:18159069, PMID:19477951 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; AM 251 inhibits the reaction [Dronabinol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; AM 251 inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [methanandamide results in increased phosphorylation of MAPK3 protein]
AM 251 results in increased phosphorylation of MAPK3 protein		 CTD PMID:17583570, PMID:17596442, PMID:18159069, PMID:19477951 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO AM 251 results in decreased expression of MCM3 mRNA CTD PMID:16500647 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression ISO AM 251 results in decreased expression of MCM5 mRNA CTD PMID:16500647 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278 		JBrowse link
G Mfn2 mitofusin 2 decreases expression ISO AM 251 results in decreased expression of MFN2 mRNA CTD PMID:16500647 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145 		JBrowse link
G Ncapd3 non-SMC condensin II complex, subunit D3 decreases expression ISO AM 251 results in decreased expression of NCAPD3 mRNA CTD PMID:16500647 NCBI chr 8:28,075,629...28,145,024
Ensembl chr 8:28,075,551...28,144,741 		JBrowse link
G Ncoa7 nuclear receptor coactivator 7 increases expression ISO AM 251 results in increased expression of NCOA7 mRNA CTD PMID:16500647 NCBI chr 1:29,225,727...29,386,642
Ensembl chr 1:29,225,707...29,385,199 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions ISO AM 251 inhibits the reaction [Dronabinol results in decreased expression of OPRL1 mRNA]; AM 251 inhibits the reaction [Dronabinol results in decreased expression of OPRL1 protein] CTD PMID:21603976 NCBI chr 3:177,223,779...177,231,663
Ensembl chr 3:177,225,737...177,231,663 		JBrowse link
G Papola poly (A) polymerase alpha decreases expression ISO AM 251 results in decreased expression of PAPOLA mRNA CTD PMID:16500647 NCBI chr 6:129,609,068...129,662,002
Ensembl chr 6:129,609,074...129,661,531 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO AM 251 inhibits the reaction [HU 211 results in increased cleavage of PARP1 protein] CTD PMID:19509271 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 increases expression ISO AM 251 results in increased expression of PEA15 mRNA CTD PMID:16500647 NCBI chr13:90,579,844...90,589,466
Ensembl chr13:90,579,846...90,589,466 		JBrowse link
G Ppif peptidylprolyl isomerase F decreases expression ISO AM 251 results in decreased expression of PPIF mRNA CTD PMID:16500647 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908 		JBrowse link
G Ptbp1 polypyrimidine tract binding protein 1 decreases expression ISO AM 251 results in decreased expression of PTBP1 mRNA CTD PMID:16500647 NCBI chr 7:12,663,965...12,673,723
Ensembl chr 7:12,663,965...12,673,718 		JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO AM 251 results in decreased expression of RACGAP1 mRNA CTD PMID:16500647 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233 		JBrowse link
G Rad54l RAD54 like decreases expression ISO AM 251 results in decreased expression of RAD54L mRNA CTD PMID:16500647 NCBI chr 5:134,948,511...134,978,125
Ensembl chr 5:134,948,512...134,978,125 		JBrowse link
G Rcc1 regulator of chromosome condensation 1 decreases expression ISO AM 251 results in decreased expression of RCC1 mRNA CTD PMID:16500647 NCBI chr 5:150,508,840...150,531,062
Ensembl chr 5:150,509,040...150,525,254 		JBrowse link
G Rcc1l RCC1 like decreases expression ISO AM 251 results in decreased expression of RCC1L mRNA CTD PMID:16500647 NCBI chr12:25,561,871...25,592,337
Ensembl chr12:25,561,777...25,592,342 		JBrowse link
G Rfc5 replication factor C subunit 5 decreases expression ISO AM 251 results in decreased expression of RFC5 mRNA CTD PMID:16500647 NCBI chr12:44,931,494...44,941,051
Ensembl chr12:44,931,494...44,941,324 		JBrowse link
G Rnaseh1 ribonuclease H1 increases expression ISO AM 251 results in increased expression of RNASEH1 mRNA CTD PMID:16500647 NCBI chr 6:47,916,188...47,925,582
Ensembl chr 6:47,916,188...47,925,571 		JBrowse link
G Rpa1 replication protein A1 decreases expression ISO AM 251 results in decreased expression of RPA1 mRNA CTD PMID:16500647 NCBI chr10:62,140,419...62,191,518
Ensembl chr10:62,140,419...62,191,512 		JBrowse link
G Rwdd1 RWD domain containing 1 increases expression ISO AM 251 results in increased expression of RWDD1 mRNA CTD PMID:16500647 NCBI chr20:27,534,361...27,552,225
Ensembl chr20:27,535,324...27,552,349 		JBrowse link
G Sars1 seryl-tRNA synthetase 1 increases expression ISO AM 251 results in increased expression of SARS1 mRNA CTD PMID:16500647 NCBI chr 2:211,219,743...211,235,475
Ensembl chr 2:211,219,750...211,235,467 		JBrowse link
G Sesn2 sestrin 2 increases expression ISO AM 251 results in increased expression of SESN2 mRNA CTD PMID:16500647 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117 		JBrowse link
G Slc18b1 solute carrier family 18 member B1 decreases expression ISO AM 251 results in decreased expression of SLC18B1 mRNA CTD PMID:16500647 NCBI chr 1:22,705,980...22,748,571
Ensembl chr 1:22,705,916...22,748,422 		JBrowse link
G Slc1a4 solute carrier family 1 member 4 increases expression ISO AM 251 results in increased expression of SLC1A4 mRNA CTD PMID:16500647 NCBI chr14:104,582,884...104,612,417
Ensembl chr14:104,581,190...104,612,597 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 increases expression ISO AM 251 results in increased expression of SLC30A1 mRNA CTD PMID:16500647 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 increases expression ISO AM 251 results in increased expression of SLC46A1 mRNA CTD PMID:19145103 NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO AM 251 results in increased expression of SLC7A5 mRNA CTD PMID:16500647 NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563 		JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 decreases expression ISO AM 251 results in decreased expression of SPTBN1 mRNA CTD PMID:16500647 NCBI chr14:114,517,839...114,700,199
Ensembl chr14:114,518,816...114,692,764 		JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 decreases expression ISO AM 251 results in decreased expression of SRSF1 mRNA CTD PMID:16500647 NCBI chr10:75,334,200...75,341,197
Ensembl chr10:75,335,146...75,341,197 		JBrowse link
G Stam signal transducing adaptor molecule decreases expression ISO AM 251 results in decreased expression of STAM mRNA CTD PMID:16500647 NCBI chr17:81,209,795...81,256,111
Ensembl chr17:81,209,867...81,255,808 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression ISO AM 251 results in decreased expression of STAT3 mRNA CTD PMID:16500647 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Sugp2 SURP and G patch domain containing 2 decreases expression ISO AM 251 results in decreased expression of SUGP2 mRNA CTD PMID:16500647 NCBI chr16:20,908,162...20,939,574
Ensembl chr16:20,910,177...20,939,545 		JBrowse link
G Sun1 Sad1 and UNC84 domain containing 1 decreases expression ISO AM 251 results in decreased expression of SUN1 mRNA CTD PMID:16500647 NCBI chr12:17,488,482...17,533,334
Ensembl chr12:17,488,487...17,522,534 		JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 decreases expression ISO AM 251 results in decreased expression of TACC3 mRNA CTD PMID:16500647 NCBI chr14:82,336,283...82,350,069
Ensembl chr14:82,336,324...82,347,679 		JBrowse link
G Tbl1x transducin (beta)-like 1 X-linked increases expression ISO AM 251 results in increased expression of TBL1X mRNA CTD PMID:16500647 NCBI chr  X:44,959,883...44,988,551
Ensembl chr  X:44,830,849...44,988,551 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [iodopravadoline co-treated with AM 251] inhibits the reaction [Dronabinol results in increased expression of TIMP1 protein]; [iodopravadoline co-treated with AM 251] inhibits the reaction [methanandamide results in increased expression of TIMP1 protein]; AM 251 inhibits the reaction [Dronabinol results in increased expression of TIMP1 protein]; AM 251 inhibits the reaction [methanandamide results in increased expression of TIMP1 protein] CTD PMID:18159069 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Tmem126a transmembrane protein 126A increases expression ISO AM 251 results in increased expression of TMEM126A mRNA CTD PMID:16500647 NCBI chr 1:156,283,105...156,291,057
Ensembl chr 1:156,283,128...156,291,052 		JBrowse link
G Tnf tumor necrosis factor decreases response to substance ISO AM 251 results in decreased susceptibility to TNF protein CTD PMID:20626112 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO AM 251 results in increased expression of TRIB3 mRNA CTD PMID:16500647 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571 		JBrowse link
G Tspan10 tetraspanin 10 increases expression ISO AM 251 results in increased expression of TSPAN10 mRNA CTD PMID:16500647 NCBI chr10:109,614,664...109,619,581
Ensembl chr10:109,614,965...109,618,807 		JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO AM 251 results in increased expression of TXNIP mRNA CTD PMID:16500647 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974 		JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase decreases expression ISO AM 251 results in decreased expression of UGCG mRNA CTD PMID:16500647 NCBI chr 5:76,376,722...76,419,564
Ensembl chr 5:76,386,836...76,419,560 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO AM 251 results in decreased expression of UHRF1 mRNA CTD PMID:16500647 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954 		JBrowse link
G Vldlr very low density lipoprotein receptor increases expression ISO AM 251 results in increased expression of VLDLR mRNA CTD PMID:16500647 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO AM 251 results in increased expression of WARS1 mRNA CTD PMID:16500647 NCBI chr 6:132,771,026...132,802,262
Ensembl chr 6:132,771,021...132,802,210 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO AM 251 results in increased expression of XBP1 mRNA CTD PMID:16500647 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145 		JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 increases expression ISO AM 251 results in increased expression of YARS1 mRNA CTD PMID:16500647 NCBI chr 5:147,375,350...147,403,578
Ensembl chr 5:147,375,350...147,403,571 		JBrowse link
G Zfp142 zinc finger protein 142 decreases expression ISO AM 251 results in decreased expression of ZNF142 mRNA CTD PMID:16500647 NCBI chr 9:81,844,138...81,868,086
Ensembl chr 9:81,844,138...81,868,086 		JBrowse link
G Zmym6 zinc finger MYM-type containing 6 increases expression ISO AM 251 results in increased expression of ZMYM6 mRNA CTD PMID:16500647 NCBI chr 5:145,138,667...145,186,285
Ensembl chr 5:145,138,697...145,186,357 		JBrowse link
aminophenazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions
decreases methylation		 ISO Amoxicillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine]; Piperacillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine] CTD PMID:26763401 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Il1b interleukin 1 beta increases expression ISO Aminopyrine results in increased expression of IL1B mRNA CTD PMID:24747151 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Aminopyrine analog results in decreased activity of PTGS1 protein; Aminopyrine results in decreased activity of PTGS1 protein CTD PMID:16141368 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344 		JBrowse link
antipyrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgds prostaglandin D2 synthase decreases activity ISO Antipyrine results in decreased activity of PTGDS protein CTD PMID:15718289 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Antipyrine analog results in decreased activity of PTGS1 protein; Antipyrine results in decreased activity of PTGS1 protein CTD PMID:16141368 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein affects the reaction [Endotoxins results in increased abundance of Antipyrine] CTD PMID:15659313 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
AZD4547 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO AZD4547 results in decreased phosphorylation of AKT1 protein CTD PMID:26853465 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Akt1s1 AKT1 substrate 1 decreases phosphorylation ISO AZD4547 results in decreased phosphorylation of AKT1S1 protein CTD PMID:26853465 NCBI chr 1:100,845,443...100,851,961
Ensembl chr 1:100,845,563...100,851,960 		JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 increases phosphorylation ISO AZD4547 results in increased phosphorylation of FRS2 protein CTD PMID:26853465 NCBI chr 7:60,128,506...60,210,482
Ensembl chr 7:60,128,508...60,210,518 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta affects expression
multiple interactions		 ISO AZD4547 affects the expression of MAP1LC3B protein modified form
bafilomycin A1 affects the reaction [AZD4547 affects the expression of MAP1LC3B protein modified form]		 CTD PMID:26853465 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO AZD4547 results in decreased phosphorylation of RPS6 protein CTD PMID:26853465 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO AZD4547 results in decreased expression of SREBF1 protein CTD PMID:26853465 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
BMS-754807 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO BMS 754807 results in decreased phosphorylation of AKT1 protein
BMS 754807 inhibits the reaction [palbociclib results in increased phosphorylation of AKT1 protein]		 CTD PMID:24986516 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases response to substance		 ISO [BMS 754807 co-treated with palbociclib] results in increased expression of CCND1 protein; [CCND1 mutant form results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein CTD PMID:24986516 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO [[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases response to substance ISO CDKN2A gene mutant form results in decreased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
decreases phosphorylation		 ISO [BMS 754807 co-treated with palbociclib] results in decreased phosphorylation of IGF1R protein
BMS 754807 results in decreased phosphorylation of IGF1R protein		 CTD PMID:24986516 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases response to substance
decreases phosphorylation		 ISO BMS 754807 promotes the reaction [palbociclib results in decreased phosphorylation of RB1 protein]
RB1 mutant form results in decreased susceptibility to BMS 754807
BMS 754807 results in decreased phosphorylation of RB1 protein		 CTD PMID:24986516 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions		 ISO BMS 754807 results in decreased phosphorylation of RPS6KB1 protein
[[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CCND1 mutant form results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; palbociclib promotes the reaction [BMS 754807 results in decreased phosphorylation of RPS6KB1 protein]		 CTD PMID:24986516 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
C646 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir224 microRNA 224 decreases expression ISO C646 decreased expression of miR244 in a human hepatocellular carcinoma cell line RGD PMID:22459148 RGD:18182922 NCBI chr  X:152,223,754...152,223,835
Ensembl chr  X:152,223,754...152,223,835 		JBrowse link
cefoselis sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO cefoselis inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:16098483 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake
multiple interactions		 ISO SLC22A8 protein results in increased uptake of cefoselis
cefoselis inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]		 CTD PMID:16098483 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
celecoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 ISO Celecoxib results in decreased activity of ABCB11 protein
Celecoxib inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:22646477, PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
increases methylation
decreases activity
increases expression
multiple interactions		 ISO Celecoxib results in decreased expression of ABCB1 protein
Celecoxib results in increased methylation of ABCB1 promoter
Celecoxib results in decreased activity of ABCB1A protein
Celecoxib results in increased expression of ABCB1 mRNA
[Celecoxib results in decreased expression of ABCB1] which results in increased susceptibility to Etoposide; [Celecoxib results in decreased expression of ABCB1] which results in increased susceptibility to Tamoxifen		 CTD PMID:15458769, PMID:19562670, PMID:21745461 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases expression
increases expression		 ISO Celecoxib results in decreased expression of ABCC1 mRNA
Celecoxib results in increased expression of ABCC1 mRNA		 CTD PMID:18202791, PMID:21745461 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO Celecoxib results in decreased activity of ABCC2 protein CTD PMID:22646477 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO Celecoxib results in increased expression of ABCC4 mRNA; Celecoxib results in increased expression of ABCC4 protein CTD PMID:18690847 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases expression ISO Celecoxib results in increased expression of ABCC5 mRNA; Celecoxib results in increased expression of ABCC5 protein CTD PMID:18690847 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211 		JBrowse link
G Abcf1 ATP binding cassette subfamily F member 1 affects expression ISO Celecoxib affects the expression of ABCF1 mRNA CTD PMID:20562220 NCBI chr20:3,309,914...3,322,828
Ensembl chr20:3,309,899...3,322,825 		JBrowse link
G Abcf2 ATP binding cassette subfamily F member 2 affects expression ISO Celecoxib affects the expression of ABCF2 mRNA CTD PMID:20562220 NCBI chr 4:7,122,850...7,135,607
Ensembl chr 4:7,122,890...7,135,669 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression ISO Celecoxib results in decreased expression of ABCG2 mRNA CTD PMID:18202791 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Acan aggrecan affects expression EXP Celecoxib affects the expression of ACAN mRNA CTD PMID:16273290 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441 		JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity		 ISO donepezil inhibits the reaction [Celecoxib results in increased activity of ACHE protein]; Indinavir inhibits the reaction [Celecoxib results in increased activity of ACHE protein] CTD PMID:18208924, PMID:18343489 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression		 EXP Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
Celecoxib results in decreased expression of ACTA2 mRNA; Celecoxib results in decreased expression of ACTA2 protein		 CTD PMID:16420518, PMID:19201774 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Akap1 A-kinase anchoring protein 1 affects expression ISO Celecoxib affects the expression of AKAP1 mRNA CTD PMID:20562220 NCBI chr10:76,151,013...76,183,987
Ensembl chr10:76,151,038...76,166,276 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases response to substance
multiple interactions
decreases expression
affects phosphorylation
decreases phosphorylation
decreases activity
increases phosphorylation		 ISO
EXP		 AKT1 protein results in decreased susceptibility to Celecoxib
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein modified form; Celecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein]
Celecoxib results in decreased expression of AKT1 protein
Celecoxib affects the phosphorylation of AKT1 protein
Celecoxib analog results in decreased phosphorylation of AKT1 protein; Celecoxib results in decreased phosphorylation of AKT1 protein
Celecoxib results in decreased activity of AKT1 protein
Celecoxib analog results in increased phosphorylation of AKT1 protein; Celecoxib results in increased phosphorylation of AKT1 protein
[Atorvastatin co-treated with Celecoxib] results in decreased phosphorylation of AKT1 protein; [Celecoxib co-treated with Docetaxel] results in decreased phosphorylation of AKT1 protein; [Celecoxib co-treated with tetracycline CMT-3] results in decreased phosphorylation of AKT1 protein; Celecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein]; Celecoxib results in decreased phosphorylation of and results in decreased activity of AKT1 protein		 CTD PMID:10753955, PMID:12000750, PMID:12464646, PMID:14654083, PMID:15499625, PMID:15570007, PMID:15688368, PMID:17257745, PMID:17270149, PMID:17285134, PMID:17908994, PMID:18172863, PMID:19201774 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alb albumin multiple interactions EXP Celecoxib inhibits the reaction [Gentamicins results in decreased expression of ALB protein] CTD PMID:31628940 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member affects localization EXP celecoxib increases the release of aldh2 protein from the mitochondrial matrix RGD PMID:29491208 RGD:15036803 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C affects expression ISO Celecoxib affects the expression of ALDOC mRNA CTD PMID:20562220 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO Celecoxib inhibits the reaction [Butylated Hydroxytoluene affects the localization of ALOX5 protein] CTD PMID:12376474 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303 		JBrowse link
G App amyloid beta precursor protein affects cleavage ISO Celecoxib affects the cleavage of APP protein CTD PMID:14690522 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression		 EXP
ISO		 [Celecoxib co-treated with sulindac sulfone] results in decreased expression of AR protein
Celecoxib results in decreased expression of AR protein		 CTD PMID:15570007, PMID:17908994 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 affects expression ISO Celecoxib affects the expression of ATP6AP2 mRNA CTD PMID:20562220 NCBI chr  X:11,137,889...11,164,854
Ensembl chr  X:11,136,939...11,164,915 		JBrowse link
G Atp9a ATPase phospholipid transporting 9A (putative) affects expression ISO Celecoxib affects the expression of ATP9A mRNA CTD PMID:20562220 NCBI chr 3:165,405,588...165,511,104
Ensembl chr 3:165,412,803...165,477,771 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
decreases response to substance		 ISO
EXP		 Celecoxib analog results in increased expression of BAK1 protein; Celecoxib results in increased expression of BAK1 mRNA; Celecoxib results in increased expression of BAK1 protein
BAK1 results in decreased susceptibility to Celecoxib		 CTD PMID:18349538, PMID:19428934, PMID:19682443 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions
increases activity		 ISO Celecoxib results in decreased expression of BAX mRNA
Celecoxib results in increased expression of BAX protein
[docetaxel co-treated with Celecoxib] results in increased expression of BAX protein; [tetracycline CMT-3 co-treated with Celecoxib] results in increased expression of BAX protein; BBC3 mutant form inhibits the reaction [Celecoxib results in increased activity of and results in increased localization of BAX protein]; Celecoxib results in increased activity of and results in increased localization of BAX protein
Celecoxib results in increased activity of BAX protein		 CTD PMID:15688368, PMID:17342322, PMID:17368424, PMID:17952603 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases response to substance
increases expression
multiple interactions		 ISO BBC3 results in increased susceptibility to Celecoxib
Celecoxib results in increased expression of BBC3; Celecoxib results in increased expression of BBC3 protein
BBC3 mutant form inhibits the reaction [Celecoxib results in increased activity of and results in increased localization of BAX protein]; TP53 protein promotes the reaction [Celecoxib results in increased expression of BBC3 protein]		 CTD PMID:17368424, PMID:18760266 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions ISO Celecoxib results in increased cleavage of and results in increased localization of BCAR1 protein CTD PMID:16353145 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression		 ISO BCL2 protein inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib results in increased cleavage of CASP3 protein]; Celecoxib promotes the reaction [docetaxel results in increased expression of BCL2 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased expression of BCL2 protein]; tetraarsenic tetrasulfide promotes the reaction [Celecoxib results in decreased expression of BCL2 protein]
Celecoxib promotes the reaction [Dihematoporphyrin Ether results in increased cleavage of BCL2 protein]
Celecoxib results in increased expression of BCL2 mRNA		 CTD PMID:15688368, PMID:15911099, PMID:16230411, PMID:16391871, PMID:17342322, PMID:17612393, PMID:20104024, PMID:26586936 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
decreases expression		 ISO [Celecoxib co-treated with docetaxel] results in decreased expression of BCL2L1 protein; [Celecoxib co-treated with tetracycline CMT-3] results in decreased expression of BCL2L1 protein; BCL2L1 mutant form promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]
Celecoxib results in increased expression of BCL2L1 mRNA
Celecoxib results in decreased expression of BCL2L1 protein		 CTD PMID:15688368, PMID:17342322, PMID:20104024 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage
multiple interactions		 ISO Celecoxib results in increased cleavage of BID protein
[ABT-737 co-treated with Celecoxib] results in increased cleavage of BID protein; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of BID protein]		 CTD PMID:15197583, PMID:15572759, PMID:20104024 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
decreases expression
affects binding		 ISO [Celecoxib binds to BIRC5 promoter] which results in decreased expression of BIRC5 mRNA; BIRC5 protein inhibits the reaction [Celecoxib results in increased activity of CASP3 protein]
[Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of BIRC5 protein
Celecoxib results in increased expression of BIRC5 mRNA
Celecoxib results in decreased expression of BIRC5 mRNA; Celecoxib results in decreased expression of BIRC5 protein		 CTD PMID:16004971, PMID:16123214, PMID:16707021, PMID:17270149, PMID:17342322, PMID:17466271, PMID:18634847, PMID:21268125 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO Celecoxib binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity		 ISO Celecoxib binds to and results in decreased activity of CA2 protein
Celecoxib results in decreased activity of CA2 protein		 CTD PMID:16858005, PMID:17826101 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
increases activity
increases cleavage
increases expression		 ISO
EXP		 Celecoxib analog results in decreased expression of CASP3 protein; Celecoxib results in decreased expression of CASP3 protein
Celecoxib inhibits the reaction [Freund's Adjuvant results in increased activity of CASP3 protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of CASP3 protein]
Celecoxib results in increased activity of CASP3 protein
Celecoxib results in increased cleavage of CASP3 protein
Celecoxib results in increased expression of CASP3 protein
3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; [ABT-737 co-treated with Celecoxib] results in increased activity of CASP3 protein; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of and results in increased activity of CASP3 protein; ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib results in increased cleavage of CASP3 protein]; BCL2L1 mutant form promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; BIRC5 protein inhibits the reaction [Celecoxib results in increased activity of CASP3 protein]; Celecoxib analog results in increased cleavage of and results in increased activity of CASP3 protein; Celecoxib inhibits the reaction [Fluorouracil results in increased expression of CASP3 protein]; Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]; Celecoxib promotes the reaction [Docetaxel results in increased activity of and results in increased expression of CASP3 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased activity of and results in increased expression of CASP3 protein]; Celecoxib results in increased activity of and results in increased expression of CASP3 protein; Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein; Docetaxel promotes the reaction [Celecoxib results in increased activity of and results in increased expression of CASP3 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; tetracycline CMT-3 promotes the reaction [Celecoxib results in increased activity of and results in increased expression of CASP3 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]
Celecoxib results in increased activity of CASP3; Celecoxib results in increased activity of CASP3 protein		 CTD PMID:10753955, PMID:12824303, PMID:15197583, PMID:15499625, PMID:15572759, PMID:15688368, PMID:16123214, PMID:17201140, PMID:17461495, PMID:17466271, PMID:17761345, PMID:18172863, PMID:18202791, PMID:19635192, PMID:19665451, PMID:19682443, PMID:20104024, PMID:24932515, PMID:31628940 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp6 caspase 6 multiple interactions ISO Celecoxib results in increased cleavage of and results in increased activity of CASP6 protein; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP6 protein] CTD PMID:15572759 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
affects activity		 ISO Celecoxib results in increased activity of CASP7; Celecoxib results in increased activity of CASP7 protein
Celecoxib results in increased cleavage of and results in increased activity of CASP7 protein; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP7 protein]
Celecoxib analog affects the activity of CASP7 protein		 CTD PMID:15572759, PMID:18202791, PMID:18485224 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
increases activity		 ISO 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]; [ABT-737 co-treated with Celecoxib] results in increased activity of CASP8 protein; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of CASP8 protein; ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]; ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]; Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]; Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]; TNFRSF10B mutant form inhibits the reaction [Celecoxib results in increased cleavage of CASP8 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]
Celecoxib analog results in increased activity of CASP8 protein; Celecoxib results in increased activity of CASP8 protein		 CTD PMID:12824303, PMID:15197583, PMID:15499625, PMID:15572759, PMID:18172863, PMID:20104024 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases cleavage		 ISO 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; [ABT-737 co-treated with Celecoxib] results in increased activity of CASP9 protein; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of CASP9 protein; ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]; Celecoxib analog results in increased cleavage of and results in increased activity of CASP9 protein; Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]; Celecoxib promotes the reaction [Docetaxel results in increased cleavage of and results in increased activity of CASP9 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased cleavage of and results in increased activity of CASP9 protein]; Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein; Docetaxel promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein]; tetracycline CMT-3 promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]
Celecoxib results in increased activity of CASP9 protein		 CTD PMID:12824303, PMID:15197583, PMID:15499625, PMID:15572759, PMID:15688368, PMID:17201140, PMID:17612393, PMID:17761345, PMID:18172863, PMID:19665451, PMID:20104024 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase decreases expression
multiple interactions		 ISO Celecoxib results in decreased expression of CAT protein
Celecoxib inhibits the reaction [Smoke results in increased activity of CAT protein]		 CTD PMID:18848576, PMID:21280565 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cav1 caveolin 1 increases expression ISO Celecoxib results in increased expression of CAV1 protein CTD PMID:18848576 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO
EXP		 Celecoxib inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]
Celecoxib inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of CCL2 protein]
Celecoxib results in decreased expression of CCL2 mRNA		 CTD PMID:12902868, PMID:20039930, PMID:24530660 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Celecoxib results in decreased expression of CCL5 mRNA CTD PMID:12902868 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ccnb1 cyclin B1 affects expression ISO Celecoxib affects the expression of CCNB1 CTD PMID:19846907 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccnd1 cyclin D1 affects expression
multiple interactions
decreases expression		 ISO
EXP		 Celecoxib affects the expression of CCND1
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of CCND1 protein]
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of CCND1 protein
Celecoxib inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Celecoxib promotes the reaction [gemcitabine results in decreased expression of CCND1 protein]
Celecoxib results in decreased expression of CCND1 mRNA; Celecoxib results in decreased expression of CCND1 protein		 CTD PMID:15489888, PMID:16060994, PMID:17270149, PMID:17908994, PMID:19846907, PMID:32416088 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Celecoxib results in decreased expression of CCND2 mRNA; Celecoxib results in decreased expression of CCND2 protein CTD PMID:19428934 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression ISO Celecoxib results in decreased expression of CCR2 mRNA CTD PMID:12902868
G Ccr5 C-C motif chemokine receptor 5 decreases expression ISO Celecoxib results in decreased expression of CCR5 mRNA CTD PMID:12902868 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614 		JBrowse link
G Cd2ap CD2-associated protein multiple interactions EXP Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CD2AP mRNA] CTD PMID:19194550 NCBI chr 9:20,794,680...20,858,438
Ensembl chr 9:20,765,296...20,858,504 		JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
affects expression		 ISO Celecoxib analog results in increased expression of CDH1 protein; Celecoxib results in increased expression of CDH1 mRNA; Celecoxib results in increased expression of CDH1 protein
Celecoxib inhibits the reaction [SNAI1 protein binds to CDH1 promoter]
Celecoxib affects the expression of CDH1 protein		 CTD PMID:17224647, PMID:19682443, PMID:29932878 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Celecoxib results in decreased expression of CDK2 protein; Celecoxib results in decreased expression of CDK2 protein modified form CTD PMID:16136956, PMID:19428934 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Celecoxib results in decreased expression of CDK4 protein CTD PMID:16136956 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases localization
increases expression		 ISO [Atorvastatin co-treated with Celecoxib] results in increased expression of CDKN1A protein; Celecoxib promotes the reaction [Valproic Acid results in increased expression of CDKN1A protein]; TP53 affects the reaction [Celecoxib results in increased expression of CDKN1A mRNA]; Valproic Acid promotes the reaction [Celecoxib results in increased expression of CDKN1A protein]
Celecoxib results in increased localization of CDKN1A protein
Celecoxib results in increased expression of CDKN1A mRNA; Celecoxib results in increased expression of CDKN1A protein		 CTD PMID:16136956, PMID:18172863, PMID:19141979, PMID:19706164, PMID:21737646 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression		 ISO [Atorvastatin co-treated with Celecoxib] results in increased expression of CDKN1B protein; Celecoxib promotes the reaction [Valproic Acid results in increased expression of CDKN1B protein]; Valproic Acid promotes the reaction [Celecoxib results in increased expression of CDKN1B protein]
Celecoxib results in increased expression of CDKN1B mRNA; Celecoxib results in increased expression of CDKN1B protein		 CTD PMID:18172863, PMID:19428934, PMID:21737646 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP Celecoxib inhibits the reaction [Dietary Fats results in decreased expression of CEBPA mRNA] CTD PMID:19247274 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO Celecoxib results in decreased expression of CFLAR CTD PMID:17145853 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Celecoxib inhibits the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:15489888 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169 		JBrowse link
G Col10a1 collagen type X alpha 1 chain multiple interactions ISO [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of COL10A1 mRNA; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of COL10A1 protein CTD PMID:27050768 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression		 EXP Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]
Celecoxib results in decreased expression of COL1A1 mRNA		 CTD PMID:16420518, PMID:19201774 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein] CTD PMID:32416088 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crp C-reactive protein decreases expression ISO Celecoxib results in decreased expression of CRP CTD PMID:12551863 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Cryab crystallin, alpha B multiple interactions EXP Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of CRYAB mRNA] CTD PMID:16420518 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545 		JBrowse link
G Ctnnb1 catenin beta 1 affects localization ISO Celecoxib affects the localization of CTNNB1 protein; Celecoxib analog affects the localization of CTNNB1 protein CTD PMID:19682443 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 decreases expression ISO Celecoxib results in decreased expression of CXCR1 mRNA CTD PMID:12902868 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO Celecoxib results in decreased expression of CXCR2 mRNA CTD PMID:12902868 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
decreases expression		 ISO Celecoxib results in decreased activity of CYP19A1 protein
Celecoxib results in decreased expression of CYP19A1 mRNA		 CTD PMID:15964185 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Celecoxib results in decreased activity of CYP1A2 protein CTD PMID:18816299 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Dap3 death associated protein 3 affects expression ISO Celecoxib affects the expression of DAP3 mRNA CTD PMID:20562220 NCBI chr 2:188,225,607...188,255,324
Ensembl chr 2:188,225,613...188,252,725 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
affects expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 protein]; [epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 mRNA; [epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 protein; U 0126 inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 mRNA]; U 0126 inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 protein]
Celecoxib results in increased expression of DDIT3; Celecoxib results in increased expression of DDIT3 protein
Celecoxib analog affects the expression of DDIT3 protein		 CTD PMID:16463383, PMID:18485224, PMID:20104024, PMID:21567098 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Des desmin multiple interactions
increases expression		 ISO PTGS2 protein affects the reaction [Celecoxib results in increased expression of DES mRNA] CTD PMID:18089846 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha multiple interactions ISO TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of DFFA protein] CTD PMID:15572759 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects expression ISO Celecoxib affects the expression of DHCR24 mRNA CTD PMID:20562220 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206 		JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP Celecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRA protein] CTD PMID:25656942 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Celecoxib inhibits the reaction [BQ 788 results in decreased expression of EDNRB protein]; Celecoxib inhibits the reaction [Cyclosporine results in decreased expression of EDNRB protein]; Celecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRB protein]; Celecoxib results in decreased susceptibility to [BQ 788 binds to and results in decreased activity of EDNRB protein] CTD PMID:24462674, PMID:25656942 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP [Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein modified form; Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein] CTD PMID:15309881, PMID:17908994 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Emc3 ER membrane protein complex subunit 3 affects expression ISO Celecoxib affects the expression of EMC3 mRNA CTD PMID:20562220 NCBI chr 4:145,471,466...145,487,375
Ensembl chr 4:145,471,454...145,487,426 		JBrowse link
G Fadd Fas associated via death domain multiple interactions
affects response to substance		 ISO Celecoxib promotes the reaction [FAS protein binds to FADD protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of PARP1 protein]
FADD affects the susceptibility to Celecoxib		 CTD PMID:15197583, PMID:15572759 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO Celecoxib promotes the reaction [FAS protein binds to FADD protein]
Celecoxib results in increased expression of FAS mRNA; Celecoxib results in increased expression of FAS protein		 CTD PMID:15197583, PMID:19141979 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand multiple interactions EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of FASLG mRNA] CTD PMID:24932515 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fasn fatty acid synthase decreases activity
multiple interactions		 ISO Celecoxib results in decreased activity of FASN protein
Dinoprostone promotes the reaction [Celecoxib results in decreased activity of FASN protein]		 CTD PMID:19159447 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression
multiple interactions
decreases expression		 EXP
ISO		 Celecoxib affects the expression of FOS protein
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of FOS protein]
Celecoxib results in decreased expression of FOS protein		 CTD PMID:18988310, PMID:19463908, PMID:32416088 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of FSHB protein] CTD PMID:24932515 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions		 ISO Celecoxib results in increased expression of GDF15; Celecoxib results in increased expression of GDF15 mRNA
[Celecoxib co-treated with Octreotide] results in increased expression of GDF15 mRNA; GSK3B mutant form inhibits the reaction [Celecoxib results in increased expression of GDF15]; PTGS2 protein affects the reaction [Celecoxib results in increased expression of GDF15 mRNA]; SB 216763 inhibits the reaction [Celecoxib results in increased expression of GDF15]		 CTD PMID:17257745, PMID:17959037, PMID:18089846, PMID:20067113 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978 		JBrowse link
G Gorasp2 golgi reassembly stacking protein 2 affects expression ISO Celecoxib affects the expression of GORASP2 mRNA CTD PMID:20562220 NCBI chr 3:56,966,654...56,995,369
Ensembl chr 3:56,966,654...56,995,369 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Celecoxib promotes the reaction [Acetaminophen results in increased expression of GPT protein]; PTGES2 protein affects the reaction [Celecoxib promotes the reaction [Acetaminophen results in increased expression of GPT protein]] CTD PMID:31444509 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Celecoxib results in increased expression of GPX1 protein CTD PMID:20883674 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA] CTD PMID:21589914 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA2 mRNA] CTD PMID:21589914 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA3 mRNA] CTD PMID:21589914 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753 		JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA4 mRNA] CTD PMID:21589914 NCBI chr 8:1,548,145...2,045,874
Ensembl chr 8:1,548,146...2,045,817 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA] CTD PMID:21589914 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 multiple interactions ISO [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK2 mRNA CTD PMID:21589914 NCBI chr20:53,791,428...54,517,691
Ensembl chr20:53,789,760...54,517,709 		JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 multiple interactions ISO [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK3 mRNA CTD PMID:21589914 NCBI chr 5:143,500,441...143,715,546
Ensembl chr 5:143,500,441...143,715,546 		JBrowse link
G Grik4 glutamate ionotropic receptor kainate type subunit 4 multiple interactions ISO [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK4 mRNA CTD PMID:21589914 NCBI chr 8:46,804,134...47,237,546
Ensembl chr 8:46,806,147...47,094,352 		JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA] CTD PMID:21589914 NCBI chr 1:81,885,516...81,946,731
Ensembl chr 1:81,885,521...81,946,714 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN1 mRNA] CTD PMID:21589914 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2A mRNA] CTD PMID:21589914 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2B mRNA] CTD PMID:21589914 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA] CTD PMID:21589914 NCBI chr10:103,798,290...103,816,923
Ensembl chr10:103,798,291...103,816,287 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA] CTD PMID:21589914 NCBI chr 1:101,819,068...101,859,146
Ensembl chr 1:101,820,461...101,856,881 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA] CTD PMID:21589914 NCBI chr 5:64,928,620...65,073,012
Ensembl chr 5:64,928,620...65,073,012 		JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3B mRNA] CTD PMID:21589914 NCBI chr 7:12,764,993...12,771,310
Ensembl chr 7:12,764,993...12,771,310 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions		 ISO Celecoxib results in decreased phosphorylation of GSK3B protein
GSK3B mutant form inhibits the reaction [Celecoxib results in increased expression of GDF15]		 CTD PMID:17257745 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Gss glutathione synthetase affects expression ISO Celecoxib affects the expression of GSS mRNA CTD PMID:20562220 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions		 ISO Celecoxib results in increased expression of GSTP1 mRNA
PTGS2 protein affects the reaction [Celecoxib results in increased expression of GSTP1 mRNA]		 CTD PMID:18089846 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Celecoxib inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein] CTD PMID:21745461 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO Celecoxib inhibits the reaction [Nickel results in increased expression of HK2 mRNA] CTD PMID:27452194 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO
EXP		 Celecoxib results in increased expression of HMOX1 protein CTD PMID:19356721, PMID:23942037 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO [Celecoxib co-treated with NAD] binds to HPGD protein CTD PMID:25526675 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Celecoxib results in increased expression of HSPA5 CTD PMID:21567098 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression		 ISO Celecoxib inhibits the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Celecoxib inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]
Celecoxib results in increased expression of ICAM1 mRNA; Celecoxib results in increased expression of ICAM1 protein		 CTD PMID:14762100, PMID:26513172 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of IFNG protein] CTD PMID:32416088 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP		 Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in decreased expression of IL10 protein]
Celecoxib inhibits the reaction [Freund's Adjuvant results in decreased expression of IL10 protein]		 CTD PMID:16230411, PMID:24932515 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of IL17A protein] CTD PMID:32416088 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Celecoxib inhibits the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Celecoxib inhibits the reaction [IL1B protein results in increased expression of and results in increased secretion of NRG1 protein]; Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]; Celecoxib inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Celecoxib inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of SELE protein]]; Celecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Celecoxib promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]]
[Celecoxib co-treated with Hydrochloric Acid] results in increased expression of IL1B protein; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]]; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
Celecoxib inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of IL1B protein]		 CTD PMID:14762100, PMID:15309881, PMID:16230411, PMID:16357062, PMID:20844471, PMID:21893697 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP Celecoxib inhibits the reaction [BQ 788 results in increased expression of IL2 protein]; Celecoxib inhibits the reaction [Cyclosporine results in increased expression of IL2 protein] CTD PMID:24462674 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Polyphenols co-treated with Antioxidants co-treated with Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with Medroxyprogesterone Acetate co-treated with Celecoxib] results in decreased expression of IL6; Celecoxib inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of IL6 protein]; Celecoxib inhibits the reaction [IL6 protein results in increased secretion of and results in increased abundance of Dinoprostone]; Celecoxib inhibits the reaction [lead acetate results in increased secretion of IL6 protein]		 CTD PMID:16702388, PMID:24285838, PMID:24530660, PMID:31048000, PMID:32416088 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Atorvastatin co-treated with Celecoxib] results in increased expression of JUN protein; Celecoxib promotes the reaction [Atorvastatin results in increased phosphorylation of and results in increased activity of JUN protein]
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of JUN protein]		 CTD PMID:18172863, PMID:32416088 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Lct lactase increases activity EXP Celecoxib results in increased activity of LCT protein CTD PMID:18604318 NCBI chr13:44,998,414...45,040,593
Ensembl chr13:44,998,414...45,040,593 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Celecoxib inhibits the reaction [Nickel results in increased expression of LDHA mRNA] CTD PMID:27452194 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of LHB protein] CTD PMID:24932515 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein] CTD PMID:20104024 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases phosphorylation ISO Celecoxib results in decreased phosphorylation of MAP2K1 protein CTD PMID:16123214 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases phosphorylation ISO Celecoxib results in decreased phosphorylation of MAP2K2 protein CTD PMID:16123214 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP2K4 protein] CTD PMID:32416088 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
decreases phosphorylation		 ISO
EXP		 Celecoxib analog results in increased phosphorylation of MAPK1 protein
Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK1 protein]
Celecoxib inhibits the reaction [Acetic Acid results in increased activity of MAPK1]; Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]
Celecoxib analog results in decreased phosphorylation of MAPK1 protein; Celecoxib results in decreased phosphorylation of MAPK1 protein
[epigallocatechin gallate co-treated with Celecoxib] results in increased activity of MAPK1 protein		 CTD PMID:11891194, PMID:12464646, PMID:15499625, PMID:16463383, PMID:18988310, PMID:19682443, PMID:32416088 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [epigallocatechin gallate co-treated with Celecoxib] results in increased activity of MAPK14 protein CTD PMID:16463383 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
decreases phosphorylation		 ISO
EXP		 Celecoxib analog results in increased phosphorylation of MAPK3 protein
Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK3 protein]
Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]
[epigallocatechin gallate co-treated with Celecoxib] results in increased activity of MAPK3 protein
Celecoxib analog results in decreased phosphorylation of MAPK3 protein; Celecoxib results in decreased phosphorylation of MAPK3 protein		 CTD PMID:15499625, PMID:16463383, PMID:18988310, PMID:19682443, PMID:32416088 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Celecoxib inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of MAPK8 protein]
Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK8 protein]		 CTD PMID:16442704, PMID:32416088 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Celecoxib results in decreased expression of MCL1 protein CTD PMID:14654083, PMID:17952603, PMID:19665451, PMID:20836993 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions EXP Celecoxib inhibits the reaction [Acetic Acid results in increased expression of MET mRNA]; Celecoxib inhibits the reaction [Acetic Acid results in increased expression of MET protein] CTD PMID:11891194 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression
multiple interactions		 ISO Celecoxib results in decreased expression of MKI67
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of MKI67 protein]
[FEC protocol co-treated with Celecoxib] results in decreased expression of MKI67 protein		 CTD PMID:16507397, PMID:20697803, PMID:32416088 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
affects expression		 ISO
EXP		 Celecoxib promotes the reaction [arsenic trioxide results in decreased expression of MMP2 mRNA]; Celecoxib promotes the reaction [arsenic trioxide results in decreased expression of MMP2 protein]
Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of MMP2 mRNA]
Celecoxib affects the expression of MMP2 mRNA		 CTD PMID:16420518, PMID:18438340, PMID:21540248 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP		 Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of MMP9 protein]
Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of MMP9 mRNA]		 CTD PMID:16230411, PMID:16420518 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity		 EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in increased activity of MPO protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of MPO protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
Celecoxib results in increased activity of MPO protein		 CTD PMID:15309881, PMID:21893697, PMID:24932515, PMID:31628940 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Mrps26 mitochondrial ribosomal protein S26 affects expression ISO Celecoxib affects the expression of MRPS26 mRNA CTD PMID:20562220 NCBI chr 3:123,093,264...123,094,927
Ensembl chr 3:123,093,264...123,094,927 		JBrowse link
G Mtus1 microtubule associated scaffold protein 1 affects expression ISO Celecoxib affects the expression of MTUS1 mRNA CTD PMID:20562220 NCBI chr16:54,240,892...54,386,131
Ensembl chr16:54,291,251...54,386,129 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase decreases expression ISO Celecoxib results in decreased expression of MVD CTD PMID:17224647 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Celecoxib analog results in decreased expression of MYC protein; Celecoxib results in decreased expression of MYC protein CTD PMID:19682443 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Celecoxib inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Celecoxib inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15489888 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Celecoxib inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] CTD PMID:15489888 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Celecoxib results in increased expression of NGFR mRNA; Celecoxib results in increased expression of NGFR protein CTD PMID:17447067 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]]; Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of NOS2 protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of NOS2 protein]		 CTD PMID:21893697, PMID:24932515, PMID:32416088 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP Celecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA]; Celecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA] CTD PMID:23415682, PMID:25596430 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA] CTD PMID:19194550 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP Celecoxib affects the localization of and results in increased activity of NR3C1 protein CTD PMID:15700047 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO Celecoxib inhibits the reaction [IL1B protein results in increased expression of and results in increased secretion of NRG1 protein]; Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]; Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]] CTD PMID:16357062 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434 		JBrowse link
G Oxa1l OXA1L, mitochondrial inner membrane protein affects expression ISO Celecoxib affects the expression of OXA1L mRNA CTD PMID:20562220 NCBI chr15:33,004,957...33,012,584
Ensembl chr15:33,004,133...33,012,575 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
increases activity
affects cleavage		 ISO [Atorvastatin co-treated with Celecoxib] results in increased cleavage of PARP1 protein; Celecoxib inhibits the reaction [Fluorouracil results in increased cleavage of PARP1 protein]; Celecoxib promotes the reaction [Docetaxel results in increased cleavage of and results in increased expression of PARP1 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased cleavage of and results in increased expression of PARP1 protein]; Celecoxib results in increased cleavage of and results in increased expression of PARP1 protein; Docetaxel promotes the reaction [Celecoxib results in increased cleavage of and results in increased expression of PARP1 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of PARP1 protein]; tetracycline CMT-3 promotes the reaction [Celecoxib results in increased cleavage of and results in increased expression of PARP1 protein]; TNFRSF10B mutant form inhibits the reaction [Celecoxib results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of PARP1 protein]
Celecoxib promotes the reaction [Dihematoporphyrin Ether results in increased cleavage of PARP1 protein]
Celecoxib results in increased activity of PARP1 protein
Celecoxib analog affects the cleavage of PARP1 protein		 CTD PMID:12824303, PMID:15572759, PMID:15688368, PMID:15911099, PMID:16123214, PMID:16230411, PMID:17461495, PMID:17612393, PMID:18172863, PMID:18202791, PMID:18485224, PMID:19665451 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Celecoxib results in decreased expression of PCNA protein CTD PMID:15570007 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions ISO
EXP		 Celecoxib inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]; Celecoxib inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]; Celecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:19201774 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases activity
multiple interactions		 ISO Celecoxib analog results in decreased activity of PDPK1 protein; Celecoxib results in decreased activity of PDPK1 protein
[Atorvastatin co-treated with Celecoxib] results in decreased phosphorylation of and results in decreased expression of PDPK1 protein		 CTD PMID:12000750, PMID:15499625, PMID:18172863 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448 		JBrowse link
G Pdpn podoplanin decreases expression ISO Celecoxib results in decreased expression of PDPN mRNA CTD PMID:17285134 NCBI chr 5:161,947,137...161,981,441
Ensembl chr 5:161,947,137...161,981,441 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein] CTD PMID:20104024 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895 		JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO [Celecoxib co-treated with docetaxel] results in decreased expression of PLA2G4A protein; Celecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863, PMID:16052515 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693 		JBrowse link
G Plin2 perilipin 2 increases expression ISO Celecoxib results in increased expression of PLIN2 mRNA CTD PMID:19415698 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases response to substance ISO PMAIP1 results in increased susceptibility to Celecoxib CTD PMID:19665451 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102 		JBrowse link
G Poglut2 protein O-glucosyltransferase 2 affects expression ISO Celecoxib affects the expression of POGLUT2 mRNA CTD PMID:20562220 NCBI chr 9:50,872,492...50,884,596
Ensembl chr 9:50,872,492...50,884,596 		JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Celecoxib inhibits the reaction [docetaxel results in increased expression of POMC mRNA] CTD PMID:22902858 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Celecoxib results in increased expression of PPARA mRNA; Celecoxib results in increased expression of PPARA protein CTD PMID:19415698 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases expression ISO Celecoxib analog results in decreased expression of PPARD protein; Celecoxib results in decreased expression of PPARD protein CTD PMID:19682443 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
affects localization		 ISO
EXP		 2-chloro-5-nitrobenzanilide inhibits the reaction [Celecoxib affects the localization of PPARG protein]; [Celecoxib results in decreased activity of and results in decreased expression of PTGS2 protein] which results in increased expression of PPARG; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Celecoxib affects the localization of PPARG protein]
[Celecoxib co-treated with docetaxel] results in increased expression of PPARG protein
Celecoxib inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA]
Celecoxib results in increased expression of PPARG mRNA; Celecoxib results in increased expression of PPARG protein		 CTD PMID:16052515, PMID:19247274, PMID:19522023, PMID:23943857 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO Celecoxib promotes the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein] CTD PMID:19293639 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol affects the localization of PRKCA protein] CTD PMID:32416088 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol affects the localization of PRKCE protein] CTD PMID:32416088 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396 		JBrowse link
G Prkcg protein kinase C, gamma multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol affects the localization of PRKCG protein] CTD PMID:32416088 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636 		JBrowse link
G Ptgds prostaglandin D2 synthase increases expression ISO Celecoxib results in increased expression of PTGDS protein CTD PMID:23943857 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084 		JBrowse link
G Ptger1 prostaglandin E receptor 1 multiple interactions ISO Celecoxib inhibits the reaction [PTGER1 results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene] CTD PMID:21739481 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373 		JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions EXP Celecoxib inhibits the reaction [Heymann Nephritis Antigenic Complex results in increased expression of PTGER3 mRNA] CTD PMID:14636300 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698 		JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions EXP [Celecoxib co-treated with Heymann Nephritis Antigenic Complex] affects the expression of PTGER4 mRNA CTD PMID:14636300 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448 		JBrowse link
G Ptges prostaglandin E synthase multiple interactions
decreases expression		 ISO
EXP		 [Celecoxib co-treated with docetaxel] results in decreased expression of PTGES protein
Celecoxib results in decreased expression of PTGES mRNA		 CTD PMID:16052515, PMID:16273290 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752 		JBrowse link
G Ptges2 prostaglandin E synthase 2 multiple interactions ISO PTGES2 protein affects the reaction [Celecoxib promotes the reaction [Acetaminophen results in increased expression of GPT protein]] CTD PMID:31444509 NCBI chr 3:11,424,195...11,431,379
Ensembl chr 3:11,424,099...11,431,402 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity
decreases expression		 ISO
EXP		 Celecoxib analog results in decreased activity of PTGS1 protein; Celecoxib results in decreased activity of PTGS1 protein
Celecoxib results in decreased expression of PTGS1 mRNA alternative form		 CTD PMID:11375891, PMID:16141368 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
decreases activity
multiple interactions
increases response to substance
increases expression		 ISO
EXP		 Celecoxib analog results in decreased expression of PTGS2 protein; Celecoxib results in decreased expression of PTGS2; Celecoxib results in decreased expression of PTGS2 mRNA; Celecoxib results in decreased expression of PTGS2 protein
Celecoxib results in decreased activity of PTGS2 protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of PTGS2 protein; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]]; Celecoxib inhibits the reaction [BQ 788 results in decreased expression of PTGS2 protein]; Celecoxib inhibits the reaction [Cyclosporine results in decreased expression of PTGS2 protein]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of PTGS2 mRNA]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of PTGS2]; Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [PTGS2 protein affects the abundance of lipoxin A4]; Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in increased expression of PTGS2 mRNA]; Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of PTGS2 protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]
Celecoxib results in decreased activity of PTGS2 protein; Celecoxib results in decreased activity of PTGS2 protein alternative form
[Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Thromboxane A2; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of BIRC5 protein; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of COL10A1 mRNA; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of COL10A1 protein; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of RUNX2 mRNA; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of RUNX2 protein; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased phosphorylation of STAT3 protein; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Mustard Gas; [Celecoxib results in decreased activity of PTGS2 protein] which results in increased susceptibility to Acetaminophen; Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Celecoxib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [potassium superoxide results in increased expression of PTGS2 mRNA]; Celecoxib results in decreased susceptibility to [Lipopolysaccharides results in increased expression of PTGS2 protein]
PTGS2 results in increased susceptibility to Celecoxib
Celecoxib results in increased expression of PTGS2 mRNA; Celecoxib results in increased expression of PTGS2 protein
Celecoxib analog results in decreased activity of PTGS2 protein; Celecoxib results in decreased activity of PTGS2 protein; Celecoxib results in decreased activity of PTGS2 protein mutant form
[Celecoxib analog results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Celecoxib results in decreased activity of and results in decreased expression of PTGS2 protein] which results in increased expression of PPARG; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [FEC protocol co-treated with Celecoxib] results in decreased expression of PTGS2 protein; [tetraarsenic tetrasulfide co-treated with Celecoxib] results in decreased expression of PTGS2 protein; Celecoxib binds to and results in decreased activity of PTGS2 protein; Celecoxib inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 mRNA]; Celecoxib inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Celecoxib inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Celecoxib promotes the reaction [Arsenic Trioxide results in decreased expression of PTGS2 mRNA]; Celecoxib promotes the reaction [Arsenic Trioxide results in decreased expression of PTGS2 protein]; Celecoxib promotes the reaction [Quercetin results in decreased expression of PTGS2 protein]; Celecoxib results in decreased activity of and results in decreased expression of PTGS2 protein; Celecoxib results in increased expression of and results in increased activity of PTGS2 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Celecoxib results in increased activity of PTGS2 protein]; PTGS2 protein affects the reaction [Celecoxib results in increased expression of DES mRNA]; PTGS2 protein affects the reaction [Celecoxib results in increased expression of GDF15 mRNA]; PTGS2 protein affects the reaction [Celecoxib results in increased expression of GSTP1 mRNA]		 CTD PMID:11743745, PMID:12417326, PMID:12727271, PMID:12888902, PMID:12967936, PMID:15126378, PMID:15197583, PMID:15326064, PMID:15451306, PMID:15465334, PMID:15489888, PMID:15570007, PMID:15870389, PMID:16004971, PMID:16144915, PMID:16507397, PMID:17164136, PMID:17201140, PMID:17224647, PMID:17285134, PMID:17612393, PMID:17908994, PMID:18089846, PMID:18202791, PMID:18485224, PMID:18848576, PMID:18988310, PMID:19024521, PMID:19194550, PMID:19198759, PMID:19201774, PMID:19247274, PMID:19293639, PMID:19356723, PMID:19522023, PMID:19635192, PMID:19682443, PMID:20039930, PMID:20844471, PMID:20883674, PMID:20933508, PMID:21177414, PMID:21268125, PMID:21513785, PMID:21540248, PMID:21893697, PMID:22245433, PMID:23943857, PMID:24462674, PMID:24932515, PMID:25714890, PMID:26586936, PMID:27050768, PMID:28624453, PMID:31628940, PMID:32416088 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Pxk PX domain containing serine/threonine kinase affects expression ISO Celecoxib affects the expression of PXK mRNA CTD PMID:20562220 NCBI chr15:18,548,209...18,616,617
Ensembl chr15:18,548,212...18,616,589 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases expression		 ISO [Atorvastatin co-treated with Celecoxib] results in decreased expression of RB1 protein modified form; [Atorvastatin co-treated with Celecoxib] results in increased expression of RB1 protein
Celecoxib results in increased expression of RB1		 CTD PMID:18172863, PMID:19846907 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 ISO
EXP		 [irinotecan co-treated with Thalidomide co-treated with Celecoxib] results in increased expression of RELA protein; Celecoxib inhibits the reaction [Doxorubicin affects the localization of RELA protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Celecoxib inhibits the reaction [TNF protein results in increased activity of RELA protein]
Celecoxib inhibits the reaction [Gentamicins results in increased expression of RELA protein]
Celecoxib results in decreased expression of RELA protein		 CTD PMID:15489888, PMID:15570007, PMID:16685529, PMID:17097285, PMID:19635192, PMID:31628940 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Ren renin decreases expression EXP Celecoxib results in decreased expression of REN protein CTD PMID:10742298 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO Celecoxib promotes the reaction [Atorvastatin results in decreased localization of RHOA protein]; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOA protein] CTD PMID:18172863 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167 		JBrowse link
G Rhob ras homolog family member B multiple interactions ISO [Atorvastatin co-treated with Celecoxib] results in increased localization of RHOB protein; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOB protein] CTD PMID:18172863 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301 		JBrowse link
G Rhoc ras homolog family member C multiple interactions ISO Celecoxib promotes the reaction [Atorvastatin results in decreased localization of RHOC protein]; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOC protein] CTD PMID:18172863 NCBI chr 2:207,271,692...207,278,010
Ensembl chr 2:207,271,853...207,279,314 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Celecoxib affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of RUNX2 mRNA; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of RUNX2 protein CTD PMID:27050768 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092 		JBrowse link
G Saraf store-operated calcium entry-associated regulatory factor affects expression ISO Celecoxib affects the expression of SARAF mRNA CTD PMID:20562220 NCBI chr16:61,735,189...61,753,438
Ensembl chr16:61,735,181...61,753,476 		JBrowse link
G Sec23a Sec23 homolog A, COPII coat complex component affects expression ISO Celecoxib affects the expression of SEC23A mRNA CTD PMID:20562220 NCBI chr 6:80,059,742...80,107,340
Ensembl chr 6:80,060,916...80,107,236 		JBrowse link
G Sele selectin E multiple interactions ISO Celecoxib inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of SELE protein]] CTD PMID:14762100 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341 		JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions EXP Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of SERPINH1 mRNA] CTD PMID:16420518 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317 		JBrowse link
G Si sucrase-isomaltase increases activity EXP Celecoxib results in increased activity of SI protein CTD PMID:18604318 NCBI chr 2:170,220,794...170,301,348
Ensembl chr 2:170,221,245...170,301,348 		JBrowse link
G Slc16a3 solute carrier family 16 member 3 multiple interactions ISO Celecoxib inhibits the reaction [Nickel results in increased expression of SLC16A3 mRNA] CTD PMID:27452194 NCBI chr10:110,138,519...110,148,360
Ensembl chr10:110,138,586...110,148,358 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
increases expression		 ISO Celecoxib inhibits the reaction [Nickel results in increased expression of SLC2A1 mRNA]
Celecoxib results in increased expression of SLC2A1 mRNA		 CTD PMID:19327236, PMID:27452194 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions
decreases expression
affects expression		 ISO [Celecoxib results in decreased expression of SLC31A1 protein] which results in decreased import of and results in decreased susceptibility to Cisplatin
Celecoxib affects the expression of SLC31A1 mRNA		 CTD PMID:20562220, PMID:21177414 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358 		JBrowse link
G Snai1 snail family transcriptional repressor 1 affects localization
multiple interactions		 ISO Celecoxib affects the localization of SNAI1 protein
Celecoxib inhibits the reaction [SNAI1 protein binds to CDH1 promoter]		 CTD PMID:29932878 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Celecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO Celecoxib results in decreased expression of SOD2 protein CTD PMID:18848576 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sox2 SRY-box transcription factor 2 multiple interactions ISO Celecoxib inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]] CTD PMID:29396848 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Celecoxib inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] CTD PMID:19356721 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [Celecoxib co-treated with ABT-737] results in decreased expression of SQSTM1 protein CTD PMID:20104024 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Sstr2 somatostatin receptor 2 increases expression ISO Celecoxib results in increased expression of SSTR2 protein CTD PMID:17959037 NCBI chr10:102,136,283...102,143,449
Ensembl chr10:102,136,283...102,143,434 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in decreased expression of STAR mRNA] CTD PMID:24932515 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased phosphorylation of STAT3 protein CTD PMID:21268125 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Sts steroid sulfatase multiple interactions ISO Celecoxib inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions
affects activity		 ISO Celecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]
Celecoxib affects the activity of SULT2A1 protein		 CTD PMID:15483193, PMID:17239972 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions EXP Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein] CTD PMID:15309881 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 EXP Celecoxib inhibits the reaction [Cyclosporine results in increased expression of TGFB1 protein]; Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA]
Celecoxib results in decreased expression of TGFB1 mRNA		 CTD PMID:19194550, PMID:19201774, PMID:24462674 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP [Carbon Tetrachloride co-treated with Celecoxib] results in increased expression of TIMP2 mRNA CTD PMID:16420518 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072 		JBrowse link
G Tm9sf4 transmembrane 9 superfamily member 4 affects expression ISO Celecoxib affects the expression of TM9SF4 mRNA CTD PMID:20562220 NCBI chr 3:148,635,822...148,689,961
Ensembl chr 3:148,635,775...148,688,553 		JBrowse link
G Tmem131 transmembrane protein 131 affects expression ISO Celecoxib affects the expression of TMEM131 mRNA CTD PMID:20562220 NCBI chr 9:43,357,866...43,515,317
Ensembl chr 9:43,358,588...43,454,078 		JBrowse link
G Tmx2 thioredoxin-related transmembrane protein 2 affects expression ISO Celecoxib affects the expression of TMX2 mRNA CTD PMID:20562220 NCBI chr 3:72,073,429...72,081,079
Ensembl chr 3:72,073,431...72,081,079 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 [Polyphenols co-treated with Antioxidants co-treated with Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with Medroxyprogesterone Acetate co-treated with Celecoxib] results in decreased expression of TNF; Celecoxib inhibits the reaction [Mustard Gas results in increased secretion of TNF protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Celecoxib inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of RELA protein]; Celecoxib inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Celecoxib inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Celecoxib inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Celecoxib results in decreased expression of TNF protein
Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]]; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of TNF protein]; Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of TNF protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
Celecoxib inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of TNF protein]; Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of TNF protein]; Celecoxib inhibits the reaction [lead acetate results in increased secretion of TNF protein]		 CTD PMID:15489888, PMID:16230411, PMID:16702388, PMID:17908994, PMID:19247274, PMID:20039930, PMID:20844471, PMID:21893697, PMID:24530660, PMID:24932515, PMID:31048000, PMID:31628940, PMID:32416088 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Celecoxib results in increased expression of TNFRSF10A mRNA; Celecoxib results in increased expression of TNFRSF10A protein CTD PMID:15572759 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases secretion
increases expression		 ISO Celecoxib results in decreased secretion of TNFRSF11B protein
Celecoxib results in increased expression of TNFRSF11B mRNA		 CTD PMID:19327236 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP6 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP7 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of BID protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of DFFA protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of PARP1 protein] CTD PMID:15572759 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
increases response to substance		 ISO
EXP		 Celecoxib results in increased expression of TP53 mRNA; Celecoxib results in increased expression of TP53 protein
Celecoxib inhibits the reaction [Gentamicins results in increased expression of TP53 protein]
[Celecoxib co-treated with docetaxel] results in increased expression of TRP53 protein; Celecoxib promotes the reaction [Doxorubicin results in increased expression of TRP53 protein]
TP53 results in increased susceptibility to Celecoxib
[FEC protocol co-treated with Celecoxib] results in decreased expression of TP53 protein; Celecoxib results in increased activity of and results in increased localization of TP53 protein; Celecoxib results in increased expression of and results in increased phosphorylation of TP53 protein; pifithrin inhibits the reaction [Celecoxib results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 results in increased susceptibility to Celecoxib]; TP53 affects the reaction [Celecoxib results in increased expression of CDKN1A mRNA]; TP53 protein promotes the reaction [Celecoxib results in increased expression of BBC3 protein]		 CTD PMID:15458769, PMID:16052515, PMID:16507397, PMID:18202791, PMID:18760266, PMID:19706164, PMID:31628940 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vapb VAMP associated protein B and C affects expression ISO Celecoxib affects the expression of VAPB mRNA CTD PMID:20562220 NCBI chr 3:171,832,558...171,871,042
Ensembl chr 3:171,832,500...171,868,647 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
affects expression
increases expression		 ISO
EXP		 Celecoxib results in decreased expression of VEGFA; Celecoxib results in decreased expression of VEGFA protein
Celecoxib results in decreased expression of VEGFA mRNA; Celecoxib results in decreased expression of VEGFA protein
Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VEGFA mRNA]]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VEGFA mRNA]
[Celecoxib co-treated with docetaxel] results in decreased expression of VEGFA protein; Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of VEGFA protein]
Celecoxib affects the expression of VEGFA mRNA
Celecoxib results in increased expression of VEGFA mRNA; Celecoxib results in increased expression of VEGFA protein		 CTD PMID:15126378, PMID:16052515, PMID:16230411, PMID:17201140, PMID:17224647, PMID:18438340, PMID:19024521, PMID:21567098, PMID:21893697 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
crizotinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity		 ISO crizotinib inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; crizotinib inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; crizotinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]
crizotinib results in decreased activity of ABCB1 protein		 CTD PMID:22233293, PMID:28369651 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO crizotinib results in decreased activity of ABCG2 protein CTD PMID:28369651 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase decreases activity ISO crizotinib results in decreased activity of ABL1 protein CTD PMID:21812414 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO crizotinib results in increased phosphorylation of ACACA protein CTD PMID:23707608 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO crizotinib results in decreased phosphorylation of AKT1 protein
EGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; HBEGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; MET gene mutant form promotes the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; TGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]		 CTD PMID:22553343, PMID:22729845 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alk ALK receptor tyrosine kinase decreases response to substance
affects response to substance
decreases activity
increases mutagenesis
decreases stability
decreases phosphorylation
multiple interactions		 ISO ALK gene mutant form results in decreased susceptibility to crizotinib; ALK gene SNP results in decreased susceptibility to crizotinib; ALK protein mutant form results in decreased susceptibility to crizotinib
ALK protein affects the susceptibility to crizotinib
crizotinib results in decreased activity of ALK protein mutant form
crizotinib results in increased mutagenesis of ALK gene mutant form; crizotinib results in increased mutagenesis of ALK protein mutant form
crizotinib results in decreased stability of ALK protein mutant form
crizotinib results in decreased phosphorylation of ALK protein; crizotinib results in decreased phosphorylation of ALK protein mutant form
crizotinib results in decreased activity of ALK protein; crizotinib results in decreased activity of ALK protein mutant form
[ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]] which results in decreased susceptibility to crizotinib; [crizotinib results in increased mutagenesis of ALK gene mutant form] which results in decreased susceptibility to crizotinib; [crizotinib results in increased mutagenesis of ALK protein mutant form] which results in decreased susceptibility to crizotinib; [crizotinib results in increased mutagenesis of ALK protein mutant form] which results in increased activity of ALK protein; [Ethylnitrosourea results in increased mutagenesis of ALK protein] inhibits the reaction [crizotinib results in decreased phosphorylation of ALK protein]; [Ethylnitrosourea results in increased mutagenesis of ALK protein] which results in decreased susceptibility to crizotinib; ALK gene SNP inhibits the reaction [crizotinib results in decreased phosphorylation of ALK protein mutant form]; ALK protein mutant form inhibits the reaction [crizotinib binds to and results in decreased activity of ALK protein]; ALK protein mutant form inhibits the reaction [crizotinib results in decreased activity of ALK protein]; ALK protein mutant form inhibits the reaction [crizotinib results in decreased phosphorylation of ALK protein]; crizotinib inhibits the reaction [ALK protein mutant form results in increased phosphorylation of MAPK1 protein]; crizotinib inhibits the reaction [ALK protein mutant form results in increased phosphorylation of MAPK3 protein]; crizotinib inhibits the reaction [ALK protein results in increased expression of MYCN mRNA]; crizotinib inhibits the reaction [ALK protein results in increased expression of MYCN protein]; crizotinib results in decreased phosphorylation of and results in decreased activity of ALK protein mutant form		 CTD PMID:20979473, PMID:21030459, PMID:21502504, PMID:21767331, PMID:21791641, PMID:21812414, PMID:21838707, PMID:21948233, PMID:22034911, PMID:22072639, PMID:22129595, PMID:22235099, PMID:22277784, PMID:22286764, PMID:22553343, PMID:22659414, PMID:22789543, PMID:22912387, PMID:23104988, PMID:29458018 NCBI chr 6:22,696,415...23,203,791
Ensembl chr 6:22,696,397...23,203,775 		JBrowse link
G Bcl2l11 BCL2 like 11 increases expression
multiple interactions
affects response to substance		 ISO crizotinib results in increased expression of BCL2L11 protein
BCL2L11 protein affects the reaction [crizotinib results in increased cleavage of CASP3 protein]; MET gene mutant form promotes the reaction [crizotinib results in increased expression of BCL2L11 protein]
BCL2L11 protein affects the susceptibility to crizotinib		 CTD PMID:22729845 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions		 ISO crizotinib results in decreased expression of BIRC2 protein
MET gene mutant form promotes the reaction [crizotinib results in increased expression of BIRC2 protein]		 CTD PMID:22729845 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions		 ISO crizotinib results in decreased expression of BIRC5 protein
MET gene mutant form promotes the reaction [crizotinib results in increased expression of BIRC5 protein]		 CTD PMID:22729845 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C decreases activity ISO crizotinib results in decreased activity of CACNA1C protein CTD PMID:23707608 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity		 ISO BCL2L11 protein affects the reaction [crizotinib results in increased cleavage of CASP3 protein]; MET gene mutant form promotes the reaction [crizotinib results in increased cleavage of CASP3 protein]
[crizotinib co-treated with 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one] results in increased cleavage of CASP3 protein
crizotinib results in increased activity of CASP3 protein		 CTD PMID:22729845, PMID:22789543, PMID:23707608 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases activity ISO crizotinib results in increased activity of CASP7 protein CTD PMID:23707608 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO Crizotinib results in increased cleavage of CASP8 protein CTD PMID:31706006 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO crizotinib results in decreased expression of CD44 mRNA; crizotinib results in decreased expression of CD44 protein CTD PMID:22973962 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658 		JBrowse link
G Cda cytidine deaminase decreases expression
multiple interactions		 ISO crizotinib results in decreased expression of CDA protein
[crizotinib results in decreased expression of CDA protein] which results in increased susceptibility to gemcitabine		 CTD PMID:22973962 NCBI chr 5:156,703,579...156,734,541
Ensembl chr 5:156,703,579...156,734,541 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein multiple interactions ISO [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of CRKL protein CTD PMID:22683780 NCBI chr11:87,338,606...87,356,644
Ensembl chr11:87,778,312...87,815,043 		JBrowse link
G Egf epidermal growth factor multiple interactions
decreases response to substance		 ISO EGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; EGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein]; EGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK3 protein]; EGFR protein promotes the reaction [EGF protein results in decreased susceptibility to crizotinib]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in decreased susceptibility to crizotinib] CTD PMID:22553343 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor decreases response to substance
multiple interactions		 ISO EGFR protein mutant form results in decreased susceptibility to crizotinib; EGFR protein results in decreased susceptibility to crizotinib
[EGFR protein results in increased phosphorylation of EGFR protein] which results in decreased susceptibility to crizotinib; EGFR protein promotes the reaction [EGF protein results in decreased susceptibility to crizotinib]; EGFR protein promotes the reaction [HBEGF protein results in decreased susceptibility to crizotinib]; EGFR protein promotes the reaction [TGFA protein results in decreased susceptibility to crizotinib]		 CTD PMID:21791641, PMID:22235099, PMID:22277784, PMID:22553343 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Eml4 EMAP like 4 decreases stability
multiple interactions
increases mutagenesis		 ISO crizotinib results in decreased stability of EML4 protein mutant form
[crizotinib results in increased mutagenesis of EML4 gene mutant form] which results in decreased susceptibility to crizotinib		 CTD PMID:21502504, PMID:22912387 NCBI chr 6:6,618,370...6,674,550
Ensembl chr 6:6,619,076...6,674,554 		JBrowse link
G Epcam epithelial cell adhesion molecule decreases expression ISO crizotinib results in decreased expression of EPCAM mRNA; crizotinib results in decreased expression of EPCAM protein CTD PMID:22973962 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO crizotinib results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Fads2 fatty acid desaturase 2 increases expression ISO crizotinib results in increased expression of FADS2 mRNA CTD PMID:23707608 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524 		JBrowse link
G Fasn fatty acid synthase increases expression ISO crizotinib results in increased expression of FASN mRNA CTD PMID:23707608 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 multiple interactions ISO [PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] CTD PMID:22683780 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases secretion ISO crizotinib results in decreased secretion of FSHB protein CTD PMID:22488744 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO Crizotinib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions
decreases response to substance		 ISO EGFR protein promotes the reaction [HBEGF protein results in decreased susceptibility to crizotinib]; Erlotinib Hydrochloride inhibits the reaction [HBEGF protein results in decreased susceptibility to crizotinib]; HBEGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; HBEGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein]; HBEGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:22553343 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of CRKL protein; [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK1 protein; [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK3 protein; [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of STAT3 protein; [crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein; [PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] CTD PMID:22683780 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO crizotinib results in increased expression of HMGCR mRNA CTD PMID:23707608 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO crizotinib results in increased expression of HMGCS1 mRNA CTD PMID:23707608 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055 		JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO crizotinib results in increased expression of INSIG1 mRNA CTD PMID:23707608 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO crizotinib results in decreased activity of KCNH2 protein CTD PMID:23707608 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases response to substance ISO KIT gene mutant form results in decreased susceptibility to crizotinib CTD PMID:22277784 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610 		JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases response to substance ISO KRAS protein mutant form results in decreased susceptibility to crizotinib CTD PMID:22235099 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO crizotinib results in decreased activity of LCK protein CTD PMID:21812414 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases secretion ISO crizotinib results in decreased secretion of LHB protein CTD PMID:22488744 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK1 protein; [crizotinib results in decreased susceptibility to 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one] inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased phosphorylation of MAPK1 protein]; crizotinib inhibits the reaction [ALK protein mutant form results in increased phosphorylation of MAPK1 protein]; EGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein]; HBEGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein]; MET gene mutant form promotes the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein]; TGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein] CTD PMID:21266357, PMID:21502504, PMID:22034911, PMID:22553343, PMID:22683780, PMID:22729845, PMID:23104988 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK3 protein; [Crizotinib results in decreased susceptibility to 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one] inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased phosphorylation of MAPK3 protein]; Crizotinib inhibits the reaction [ALK protein mutant form results in increased phosphorylation of MAPK3 protein]; EGF protein inhibits the reaction [Crizotinib results in decreased phosphorylation of MAPK3 protein]; HBEGF protein inhibits the reaction [Crizotinib results in decreased phosphorylation of MAPK3 protein]; MET gene mutant form promotes the reaction [Crizotinib results in decreased phosphorylation of MAPK3 protein]; TGFA protein inhibits the reaction [Crizotinib results in decreased phosphorylation of MAPK3 protein]
crizotinib results in decreased phosphorylation of MAPK3 protein		 CTD PMID:21266357, PMID:21502504, PMID:22034911, PMID:22553343, PMID:22683780, PMID:22729845, PMID:23104988 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases activity
affects response to substance
increases response to substance
increases mutagenesis
multiple interactions
decreases phosphorylation		 ISO crizotinib results in decreased activity of MET protein
MET protein affects the susceptibility to Crizotinib
MET gene mutant form results in increased susceptibility to crizotinib
crizotinib results in increased mutagenesis of MET protein
[5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in increased mutagenesis of MET protein] which results in decreased susceptibility to Crizotinib; [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of CRKL protein; [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK1 protein; [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK3 protein; [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of STAT3 protein; [Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein; [Crizotinib results in decreased susceptibility to 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one] inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased phosphorylation of MET protein]; [Crizotinib results in increased mutagenesis of MET protein] inhibits the reaction [Crizotinib binds to and results in decreased activity of MET protein]; [PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein]; Crizotinib binds to and results in decreased activity of MET protein; Crizotinib inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one binds to and results in decreased activity of MET protein]; MET gene mutant form promotes the reaction [Crizotinib results in decreased phosphorylation of AKT1 protein]; MET gene mutant form promotes the reaction [Crizotinib results in decreased phosphorylation of MAPK1 protein]; MET gene mutant form promotes the reaction [Crizotinib results in decreased phosphorylation of MAPK3 protein]; MET gene mutant form promotes the reaction [Crizotinib results in decreased phosphorylation of MET protein]; MET gene mutant form promotes the reaction [Crizotinib results in decreased phosphorylation of STAT3 protein]; MET gene mutant form promotes the reaction [Crizotinib results in increased cleavage of CASP3 protein]; MET gene mutant form promotes the reaction [Crizotinib results in increased expression of BCL2L11 protein]; MET gene mutant form promotes the reaction [Crizotinib results in increased expression of BIRC2 protein]; MET gene mutant form promotes the reaction [Crizotinib results in increased expression of BIRC5 protein]; MET gene mutant form promotes the reaction [Crizotinib results in increased expression of XIAP protein]		 CTD PMID:21266357, PMID:21405128, PMID:21812414, PMID:22233293, PMID:22683780, PMID:22729845, PMID:22948846, PMID:31639374, PMID:31706006 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665 		JBrowse link
G Mst1r macrophage stimulating 1 receptor decreases activity ISO crizotinib results in decreased activity of MST1R protein CTD PMID:21812414 NCBI chr 8:116,686,601...116,700,132
Ensembl chr 8:116,686,601...116,700,132 		JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor multiple interactions ISO Crizotinib inhibits the reaction [ALK protein results in increased expression of MYCN mRNA]; Crizotinib inhibits the reaction [ALK protein results in increased expression of MYCN protein] CTD PMID:22286764 NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO Crizotinib results in increased cleavage of PARP1 protein
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Crizotinib results in increased cleavage of PARP1 protein]		 CTD PMID:31639374, PMID:31706006 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Prom1 prominin 1 decreases expression ISO crizotinib results in decreased expression of PROM1 mRNA; crizotinib results in decreased expression of PROM1 protein CTD PMID:22973962 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417 		JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase decreases phosphorylation ISO crizotinib results in decreased phosphorylation of ROS protein mutant form CTD PMID:22617245 NCBI chr20:33,100,190...33,323,544
Ensembl chr20:33,100,191...33,323,367 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO crizotinib results in decreased phosphorylation of RPS6 protein CTD PMID:22034911 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO crizotinib results in decreased activity of SCN5A protein CTD PMID:23707608 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression ISO crizotinib results in increased expression of SREBF2 mRNA CTD PMID:23707608 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions		 ISO crizotinib results in decreased phosphorylation of STAT3 protein
[[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of STAT3 protein; MET gene mutant form promotes the reaction [crizotinib results in decreased phosphorylation of STAT3 protein]		 CTD PMID:22034911, PMID:22553343, PMID:22683780, PMID:22729845 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tek TEK receptor tyrosine kinase decreases activity ISO crizotinib results in decreased activity of TEK protein CTD PMID:21812414 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions
decreases response to substance		 ISO EGFR protein promotes the reaction [TGFA protein results in decreased susceptibility to crizotinib]; Erlotinib Hydrochloride inhibits the reaction [TGFA protein results in decreased susceptibility to crizotinib]; TGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; TGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein]; TGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:22553343 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 decreases response to substance ISO TWIST1 protein results in decreased susceptibility to crizotinib CTD PMID:22155737 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214 		JBrowse link
G Vim vimentin decreases expression ISO crizotinib results in decreased expression of VIM protein CTD PMID:22973962 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression
multiple interactions		 ISO crizotinib results in decreased expression of XIAP protein
MET gene mutant form promotes the reaction [crizotinib results in increased expression of XIAP protein]		 CTD PMID:22729845 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000 		JBrowse link
doramapimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO BIRB 796 results in increased expression of ABCC2 mRNA CTD PMID:21328587 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Actg2 actin gamma 2, smooth muscle increases expression EXP BIRB 796 results in increased expression of ACTG2 mRNA CTD PMID:24303162 NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide increases expression EXP BIRB 796 results in increased expression of ADH7 mRNA CTD PMID:24303162 NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532 		JBrowse link
G Ahsg alpha-2-HS-glycoprotein decreases expression ISO BIRB 796 results in decreased expression of AHSG mRNA CTD PMID:21328587 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Ak5 adenylate kinase 5 increases expression EXP BIRB 796 results in increased expression of AK5 mRNA CTD PMID:24303162 NCBI chr 2:257,671,772...257,864,385
Ensembl chr 2:257,671,772...257,864,385 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases expression ISO BIRB 796 results in increased expression of AKR1B7 mRNA CTD PMID:21328587 NCBI chr 4:61,850,256...61,879,733
Ensembl chr 4:61,850,348...61,862,526 		JBrowse link
G Apoa4 apolipoprotein A4 decreases expression ISO BIRB 796 results in decreased expression of APOA4 mRNA CTD PMID:21328587 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376 		JBrowse link
G C1qa complement C1q A chain decreases expression ISO BIRB 796 results in decreased expression of C1QA mRNA CTD PMID:21328587 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143 		JBrowse link
G C1qb complement C1q B chain decreases expression ISO BIRB 796 results in decreased expression of C1QB mRNA CTD PMID:21328587 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003 		JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression ISO BIRB 796 results in decreased expression of CAR3 mRNA CTD PMID:21328587 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Cd5l Cd5 molecule-like decreases expression ISO BIRB 796 results in decreased expression of CD5L mRNA CTD PMID:21328587 NCBI chr 2:186,685,104...186,696,117
Ensembl chr 2:186,685,104...186,696,117 		JBrowse link
G Cd74 CD74 molecule decreases expression ISO BIRB 796 results in decreased expression of CD74 mRNA CTD PMID:21328587 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 decreases expression EXP BIRB 796 results in decreased expression of CEACAM1 mRNA CTD PMID:24303162 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345 		JBrowse link
G Ces3a</