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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aluminium hydroxides
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Accession:CHEBI:33626 term browser browse the term
Synonyms:related_synonym: aluminum hydroxides;   hydroxides of aluminium;   hydroxides of aluminum


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aluminium hydroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP Aluminum Hydroxide results in decreased expression of ABCC2 protein CTD PMID:14976346 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of ACTA2 protein; dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of ACTA2 protein] CTD PMID:35481609 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases expression		 ISO [Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of AKT1 protein; dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of AKT1 protein]
Aluminum Hydroxide results in increased expression of AKT1 protein
[Tretinoin co-treated with BDNF protein co-treated with Aluminum Hydroxide] results in decreased expression of AKT1 protein; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein co-treated with Aluminum Hydroxide] results in decreased expression of AKT1 protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide results in increased expression of AKT1 protein]		 CTD PMID:35481609 PMID:37409350 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein increases expression
multiple interactions		 ISO Aluminum Hydroxide results in increased expression of APP protein
Aluminum Hydroxide promotes the reaction [[BDNF protein co-treated with Tretinoin] results in increased expression of APP protein]; Coconut Oil inhibits the reaction [Aluminum Hydroxide promotes the reaction [[BDNF protein co-treated with Tretinoin] results in increased expression of APP protein]]; Coconut Oil inhibits the reaction [Aluminum Hydroxide results in increased expression of APP protein]		 CTD PMID:37989595 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO [BDNF protein co-treated with Tretinoin co-treated with Aluminum Hydroxide] results in increased expression of MAPT protein; [BDNF protein co-treated with Tretinoin co-treated with Aluminum Hydroxide] results in increased expression of SNCA protein; [Tretinoin co-treated with Aluminum Hydroxide co-treated with BDNF protein] results in decreased expression of CTNNB1 protein; [Tretinoin co-treated with BDNF protein co-treated with Aluminum Hydroxide] results in decreased expression of AKT1 protein; Aluminum Hydroxide inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of MAPT protein]; Aluminum Hydroxide promotes the reaction [[BDNF protein co-treated with Tretinoin] results in decreased expression of SLC6A3 protein]; Aluminum Hydroxide promotes the reaction [[BDNF protein co-treated with Tretinoin] results in increased expression of APP protein]; Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of PPP1CA protein]; Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of WNT5A protein]; Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of GSK3B protein]; Coconut Oil inhibits the reaction [[BDNF protein co-treated with Tretinoin co-treated with Aluminum Hydroxide] results in increased expression of MAPT protein]; Coconut Oil inhibits the reaction [[BDNF protein co-treated with Tretinoin co-treated with Aluminum Hydroxide] results in increased expression of SNCA protein]; Coconut Oil inhibits the reaction [Aluminum Hydroxide promotes the reaction [[BDNF protein co-treated with Tretinoin] results in decreased expression of SLC6A3 protein]]; Coconut Oil inhibits the reaction [Aluminum Hydroxide promotes the reaction [[BDNF protein co-treated with Tretinoin] results in increased expression of APP protein]]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with Aluminum Hydroxide co-treated with BDNF protein] results in decreased expression of CTNNB1 protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein co-treated with Aluminum Hydroxide] results in decreased expression of AKT1 protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of PPP1CA protein]]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of WNT5A protein]]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of GSK3B protein]]; dihydrolipoic acid promotes the reaction [Aluminum Hydroxide inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of MAPT protein]] CTD PMID:37409350 PMID:37989595 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO [Aluminum Hydroxide co-treated with Magnesium Hydroxide] promotes the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine results in increased activity of CASP1 protein]; [Aluminum Hydroxide co-treated with Magnesium Hydroxide] promotes the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine results in increased expression of and results in increased secretion of CASP1 protein modified form]; CASP1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]
[Aluminum Hydroxide co-treated with Magnesium Hydroxide] promotes the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine results in increased expression of and results in increased secretion of CASP1 protein modified form]; [OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of and results in increased cleavage of CASP1 protein; [OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of CASP1 mRNA; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of and results in increased cleavage of CASP1 protein]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of CASP1 mRNA]		 CTD PMID:18604214 PMID:22075093 PMID:38176579 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Cat catalase decreases activity
multiple interactions
increases activity		 EXP
ISO		 Aluminum Hydroxide results in decreased activity of CAT protein
[Thimerosal co-treated with Aluminum Hydroxide] results in increased activity of CAT protein
Aluminum Hydroxide results in increased activity of CAT protein		 CTD PMID:14976346 PMID:36411272 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO Aluminum Hydroxide results in increased secretion of CCL2 protein CTD PMID:18390722 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion ISO Aluminum Hydroxide results in increased secretion of CCL3 protein CTD PMID:18390722 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases secretion ISO Aluminum Hydroxide results in increased secretion of CCL4 protein CTD PMID:18390722 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases secretion ISO Aluminum Hydroxide results in increased secretion of CCL5 protein CTD PMID:18390722 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO Aluminum Hydroxide promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CCR7 protein] CTD PMID:18390722 NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Cd14 CD14 molecule decreases expression ISO Aluminum Hydroxide results in decreased expression of CD14 protein CTD PMID:18390722 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd4 Cd4 molecule affects response to substance ISO CD4 protein affects the susceptibility to Aluminum Hydroxide CTD PMID:11160013 NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:157,668,878...157,695,191 		JBrowse link
G Cd40 CD40 molecule increases expression ISO Aluminum Hydroxide results in increased expression of CD40 protein CTD PMID:11160013 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Aluminum Hydroxide inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD80 protein] CTD PMID:18390722 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd83 CD83 molecule increases expression ISO Aluminum Hydroxide results in increased expression of CD83 protein CTD PMID:11160013 NCBI chr17:21,093,281...21,113,223
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Cd86 CD86 molecule increases expression
multiple interactions		 ISO Aluminum Hydroxide results in increased expression of CD86 protein
Aluminum Hydroxide promotes the reaction [CSF2 protein results in increased expression of CD86 protein]		 CTD PMID:11160013 PMID:18390722 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Aluminum Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:22750351 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Aluminum Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:22750351 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Crlf2 cytokine receptor-like factor 2 multiple interactions ISO [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of CRLF2 mRNA; [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of CRLF2 protein; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of CRLF2 mRNA]; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of CRLF2 protein] CTD PMID:36029577 NCBI chr14:118,932...123,632
Ensembl chr14:103,939...108,642 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Aluminum Hydroxide inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD1A protein]; Aluminum Hydroxide inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD80 protein]; Aluminum Hydroxide promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CCR7 protein]; Aluminum Hydroxide promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of TFRC protein]; Aluminum Hydroxide promotes the reaction [CSF2 protein results in increased expression of CD86 protein] CTD PMID:18390722 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO [Tretinoin co-treated with Aluminum Hydroxide co-treated with BDNF protein] results in decreased expression of CTNNB1 protein; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with Aluminum Hydroxide co-treated with BDNF protein] results in decreased expression of CTNNB1 protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide results in decreased expression of CTNNB1 protein] CTD PMID:37409350 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Aluminum Hydroxide co-treated with Magnesium Hydroxide] inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein] CTD PMID:17404311 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions ISO [Thimerosal co-treated with Aluminum Hydroxide] results in increased expression of DBH protein CTD PMID:36411272 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Aluminum Hydroxide co-treated with Ovalbumin] affects the expression of EGFR mRNA; cang er zi wan affects the reaction [[Aluminum Hydroxide co-treated with Ovalbumin] affects the expression of EGFR mRNA] CTD PMID:36855022 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Gata3 GATA binding protein 3 multiple interactions ISO [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of GATA3 mRNA; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of GATA3 mRNA] CTD PMID:36029577 NCBI chr17:73,544,234...73,575,670
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO [OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of and results in increased cleavage of GSDMD protein; [OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of GSDMD mRNA; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of and results in increased cleavage of GSDMD mRNA]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of and results in increased cleavage of GSDMD protein] CTD PMID:38176579 NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases expression		 ISO Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of GSK3B protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of GSK3B protein]]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide results in increased expression of GSK3B protein] CTD PMID:37409350 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Aluminum Hydroxide results in increased expression of ICAM1 protein CTD PMID:11160013 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il13 interleukin 13 increases expression
multiple interactions		 ISO Aluminum Hydroxide results in increased expression of IL13 mRNA
[Aluminum Hydroxide co-treated with Ovalbumin] affects the expression of IL13 protein; [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL13 protein; cang er zi wan affects the reaction [[Aluminum Hydroxide co-treated with Ovalbumin] affects the expression of IL13 protein]; Dexamethasone inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL13 protein]; dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL13 protein]		 CTD PMID:9328138 PMID:35481609 PMID:36029577 PMID:36855022 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO [OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of IL18 mRNA; [OVAL protein co-treated with Aluminum Hydroxide] results in increased secretion of IL18 protein; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of IL18 mRNA]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased secretion of IL18 protein] CTD PMID:38176579 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form; [Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein; CASP1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL1B protein]
[[Aluminum Hydroxide co-treated with Magnesium Hydroxide] co-treated with N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein; [OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of IL1B mRNA; [OVAL protein co-treated with Aluminum Hydroxide] results in increased secretion of IL1B protein; IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of IL1B mRNA]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]		 CTD PMID:17404311 PMID:18604214 PMID:22075093 PMID:38176579 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions ISO IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein] CTD PMID:18604214 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il1rn interleukin 1 receptor antagonist increases secretion ISO Aluminum Hydroxide results in increased secretion of IL1RN protein CTD PMID:18390722 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 increases expression
multiple interactions		 ISO Aluminum Hydroxide results in increased expression of IL2 mRNA
[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein; N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]; TLR4 protein affects the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]]		 CTD PMID:9328138 PMID:22075093 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions
affects response to substance		 ISO Aluminum Hydroxide results in increased expression of IL4 mRNA
Aluminum Hydroxide inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD1A protein]; Aluminum Hydroxide inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD80 protein]; Aluminum Hydroxide promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CCR7 protein]; Aluminum Hydroxide promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of TFRC protein]
IL4 protein affects the susceptibility to Aluminum Hydroxide
[Aluminum Hydroxide co-treated with Ovalbumin] affects the expression of IL4 protein; [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein; cang er zi wan affects the reaction [[Aluminum Hydroxide co-treated with Ovalbumin] affects the expression of IL4 protein]; Dexamethasone inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein]; dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein]; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein]		 CTD PMID:9328138 PMID:11160013 PMID:18390722 PMID:35481609 PMID:36029577 More... NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 increases expression
multiple interactions		 ISO Aluminum Hydroxide results in increased expression of IL5 mRNA
[Aluminum Hydroxide co-treated with Ovalbumin] affects the expression of IL5 protein; [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL5 protein; cang er zi wan affects the reaction [[Aluminum Hydroxide co-treated with Ovalbumin] affects the expression of IL5 protein]; Dexamethasone inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL5 protein]; dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL5 protein]; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL5 protein]		 CTD PMID:9328138 PMID:35481609 PMID:36029577 PMID:36855022 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Aluminum Hydroxide results in increased expression of IL6 mRNA
[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of IL6 mRNA; [OVAL protein co-treated with Aluminum Hydroxide] results in increased secretion of IL6 protein; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of IL6 mRNA]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased secretion of IL6 protein]		 CTD PMID:9328138 PMID:38176579 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il7r interleukin 7 receptor multiple interactions ISO [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL7R mRNA; [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL7R protein; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL7R mRNA]; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL7R protein] CTD PMID:36029577 NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO [Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of JAK1 protein; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of JAK1 protein] CTD PMID:36029577 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO [Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of JAK2 protein; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of JAK2 protein] CTD PMID:36029577 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Aluminum Hydroxide co-treated with Ovalbumin] affects the expression of MAPK3 mRNA; cang er zi wan affects the reaction [[Aluminum Hydroxide co-treated with Ovalbumin] affects the expression of MAPK3 mRNA] CTD PMID:36855022 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases expression		 ISO [BDNF protein co-treated with Tretinoin co-treated with Aluminum Hydroxide] results in increased expression of MAPT protein; Aluminum Hydroxide inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of MAPT protein]; Coconut Oil inhibits the reaction [[BDNF protein co-treated with Tretinoin co-treated with Aluminum Hydroxide] results in increased expression of MAPT protein]; Coconut Oil inhibits the reaction [Aluminum Hydroxide results in increased expression of MAPT protein]; dihydrolipoic acid promotes the reaction [Aluminum Hydroxide inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of MAPT protein]] CTD PMID:37409350 PMID:37989595 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of MUC5AC mRNA; dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of MUC5AC mRNA] CTD PMID:35481609 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO Aluminum Hydroxide promotes the reaction [Thimerosal results in increased expression of NFE2L2 protein]
Aluminum Hydroxide results in increased expression of NFE2L2 protein		 CTD PMID:36411272 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO [OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of NLRP3 protein; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of NLRP3 protein]; nonylphenol results in increased expression of [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of NLRP3 mRNA] CTD PMID:18604214 PMID:38176579 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha multiple interactions ISO Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of PPP1CA protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of PPP1CA protein]] CTD PMID:37409350 NCBI chr 1:210,914,576...210,918,193
Ensembl chr 1:201,485,085...201,497,327 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Aluminum Hydroxide co-treated with Ovalbumin] affects the expression of PTGS2 mRNA; cang er zi wan affects the reaction [[Aluminum Hydroxide co-treated with Ovalbumin] affects the expression of PTGS2 mRNA] CTD PMID:36855022 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO [OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of PYCARD mRNA; [OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of PYCARD protein; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of PYCARD mRNA]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein] CTD PMID:18604214 PMID:38176579 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [OVAL protein co-treated with Aluminum Hydroxide] results in increased phosphorylation of RELA protein; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased phosphorylation of RELA protein] CTD PMID:38176579 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 increases expression
multiple interactions
decreases expression		 ISO Aluminum Hydroxide results in increased expression of SLC6A3 protein
[Thimerosal co-treated with Aluminum Hydroxide] results in increased expression of SLC6A3 protein; Aluminum Hydroxide promotes the reaction [[BDNF protein co-treated with Tretinoin] results in decreased expression of SLC6A3 protein]; Coconut Oil inhibits the reaction [Aluminum Hydroxide promotes the reaction [[BDNF protein co-treated with Tretinoin] results in decreased expression of SLC6A3 protein]]; Coconut Oil inhibits the reaction [Aluminum Hydroxide results in decreased expression of SLC6A3 protein]		 CTD PMID:36411272 PMID:37989595 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Snca synuclein alpha multiple interactions
increases expression		 ISO [BDNF protein co-treated with Tretinoin co-treated with Aluminum Hydroxide] results in increased expression of SNCA protein; Coconut Oil inhibits the reaction [[BDNF protein co-treated with Tretinoin co-treated with Aluminum Hydroxide] results in increased expression of SNCA protein]
Aluminum Hydroxide results in increased expression of SNCA protein		 CTD PMID:37989595 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of STAT3 protein; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of STAT3 protein] CTD PMID:36029577 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Aluminum Hydroxide promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of TFRC protein] CTD PMID:18390722 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TGFB1 protein; dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TGFB1 protein] CTD PMID:35481609 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO TLR4 protein affects the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]]; TLR4 protein affects the susceptibility to [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] co-treated with N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine]; TLR4 protein affects the susceptibility to [Aluminum Hydroxide co-treated with Magnesium Hydroxide] CTD PMID:22075093 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of TNF mRNA; [OVAL protein co-treated with Aluminum Hydroxide] results in increased secretion of TNF protein; [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNF protein; Dexamethasone inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNF protein]; dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNF protein]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of TNF mRNA]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased secretion of TNF protein] CTD PMID:35481609 PMID:38176579 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 multiple interactions ISO [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNFRSF4 mRNA; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNFRSF4 mRNA] CTD PMID:36029577 NCBI chr 5:171,889,134...171,891,824
Ensembl chr 5:166,606,909...166,609,599 		JBrowse link
G Tnfsf4 TNF superfamily member 4 multiple interactions ISO [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNFSF4 mRNA; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNFSF4 mRNA] CTD PMID:36029577 NCBI chr13:76,256,654...76,280,133
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TSLP mRNA; [Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TSLP protein; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TSLP protein] CTD PMID:36029577 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
G Wnt5a Wnt family member 5A multiple interactions
decreases expression		 ISO Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of WNT5A protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of WNT5A protein]]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide results in decreased expression of WNT5A protein] CTD PMID:37409350 NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19904
    chemical entity 19902
      atom 19902
        metal atom 18051
          aluminium atom 287
            aluminium molecular entity 287
              aluminium hydroxides 62
                aluminium hydroxide + 62
                hydroxidooxidoaluminium + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19904
    subatomic particle 19902
      composite particle 19902
        hadron 19902
          baryon 19902
            nucleon 19902
              atomic nucleus 19902
                atom 19902
                  main group element atom 19841
                    p-block element atom 19841
                      boron group element atom 1141
                        boron group molecular entity 1122
                          aluminium molecular entity 287
                            aluminium hydroxides 62
                              aluminium hydroxide + 62
                              hydroxidooxidoaluminium + 0
paths to the root