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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:33130
Term: aluminium hydroxide
Definition: A member of the aluminium hydroxides that has formula H3AlO3.
Chemical ID: MESH:D000536
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:7363066480464CTDIL4 protein affects the susceptibility to Aluminum Hydroxide

PMID:11160013
increases expressionISORGD:107966480464CTDAluminum Hydroxide results in increased expression of IL4 mRNA

PMID:9328138
increases expressionISORGD:7363066480464CTDAluminum Hydroxide results in increased expression of IL4 mRNA

PMID:11160013
multiple interactionsISORGD:7363066480464CTDAluminum Hydroxide inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD1A protein], Aluminum Hydroxide inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD80 protein], Aluminum Hydroxide promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CCR7 protein], Aluminum Hydroxide promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of TFRC protein]

PMID:18390722
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.