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chelerythrine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chelerythrine
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Accession:CHEBI:78373 term browser browse the term
Definition:A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.
Synonyms:exact_synonym: 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium
 related_synonym: 1,2-Dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium;   Formula=C21H18NO4;   InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1;   InChIKey=LLEJIEBFSOEYIV-UHFFFAOYSA-N;   SMILES=COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
 alt_id: CHEBI:31388
 xref: CAS:34316-15-9;   KEGG:C12227;   KNApSAcK:C00024634;   KNApSAcK:C00024660;   LINCS:LSM-1187
 xref_mesh: MESH:C016299
 xref: MetaCyc:CPD-16782;   PDBeChem:CTI;   PMID:23390024;   PMID:23900672;   PMID:24295957;   PMID:24300194;   PMID:24824737;   PMID:24928629;   PMID:24948079;   PMID:25010289;   Reaxys:3915260;   Wikipedia:Chelerythrine

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chelerythrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO chelerythrine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
chelerythrine results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein] CTD PMID:10037446 PMID:15364539 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP [chelerythrine cotreatment with morphine] inhibits the reaction [morphine decreases expression of AQP4 protein in cultured astrocytes] RGD PMID:28341892 RGD:597978120 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP chelerythrine inhibits the reaction [sodium arsenite inhibits the reaction [Cisplatin results in increased expression of BAX protein]] CTD PMID:12690470 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO		 chelerythrine inhibits the reaction [sodium arsenite inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]]
chelerythrine inhibits the reaction [Resveratrol affects the expression of BCL2 protein]		 CTD PMID:12690470 PMID:31151226 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP chelerythrine inhibits the reaction [Capsaicin results in increased expression of CALCA protein] CTD PMID:18752301 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Casp2 caspase 2 increases cleavage ISO chelerythrine results in increased cleavage of CASP2 protein CTD PMID:26124276 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage		 EXP
ISO		 malonic acid inhibits the reaction [chelerythrine results in increased activity of CASP3 protein]; Rotenone inhibits the reaction [chelerythrine results in increased activity of CASP3 protein]
chelerythrine results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Dithiothreitol inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; S-methyl glutathione inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]		 CTD PMID:21664962 PMID:26124276 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 increases cleavage ISO chelerythrine results in increased cleavage of CASP6 protein CTD PMID:26124276 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO chelerythrine results in increased cleavage of CASP7 protein CTD PMID:26124276 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases cleavage		 EXP
ISO		 malonic acid inhibits the reaction [chelerythrine results in increased activity of CASP9 protein]; Rotenone inhibits the reaction [chelerythrine results in increased activity of CASP9 protein]
chelerythrine results in increased cleavage of CASP9 protein		 CTD PMID:21664962 PMID:26124276 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO chelerythrine inhibits the reaction [CASR protein results in increased uptake of Calcium] CTD PMID:21562303 NCBI chr11:77,738,398...77,813,639
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions ISO chelerythrine inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA] CTD PMID:15117851 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO chelerythrine results in decreased activity of CFTR protein CTD PMID:14744818 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:16901605 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO chelerythrine inhibits the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; chelerythrine promotes the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]] CTD PMID:10037446 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP chelerythrine inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:18436224 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO chelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]; chelerythrine inhibits the reaction [EGF protein results in decreased susceptibility to Acetaldehyde] CTD PMID:17991733 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO chelerythrine inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:12388107 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP chelerythrine results in decreased activity of G6PD protein CTD PMID:19429815 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP chelerythrine inhibits the reaction [Acrolein results in increased secretion of GPT protein]; chelerythrine inhibits the reaction [allyl alcohol results in increased secretion of GPT protein] CTD PMID:12755590 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP chelerythrine inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein] CTD PMID:12690470 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP chelerythrine inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein] CTD PMID:16178011 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Igf1 insulin-like growth factor 1 affects activity EXP chelerythrine affects the activity of IGF1 protein CTD PMID:11548882 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of IL1B mRNA]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of IL1B protein] CTD PMID:34006824 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO chelerythrine inhibits the reaction [Acids results in increased expression of IL6 mRNA]; chelerythrine inhibits the reaction [Acids results in increased secretion of IL6 protein]
chelerythrine inhibits the reaction [Ethanol results in increased expression of IL6 protein]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of IL6 mRNA]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of IL6 protein]		 CTD PMID:19074641 PMID:24300194 PMID:34006824 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP chelerythrine results in decreased phosphorylation of and results in decreased activity of JAK2 protein CTD PMID:15746188 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 multiple interactions ISO chelerythrine inhibits the reaction [Phenylephrine results in decreased activity of KCND3 protein alternative form] CTD PMID:11709419 NCBI chr 2:195,626,316...195,843,690
Ensembl chr 2:192,937,950...193,155,345 		JBrowse link
G Lmna lamin A/C increases cleavage ISO chelerythrine results in increased cleavage of LMNA protein CTD PMID:26124276 NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
chelerythrine inhibits the reaction [CXCL8 protein results in increased phosphorylation of MAPK1 protein]
chelerythrine inhibits the reaction [Estradiol results in increased activity of MAPK1 protein]		 CTD PMID:10037446 PMID:14511371 PMID:15831558 PMID:16713447 PMID:19854188 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 chelerythrine inhibits the reaction [CXCL8 protein results in increased phosphorylation of MAPK3 protein]
chelerythrine inhibits the reaction [[Lead co-treated with Lipopolysaccharides] results in increased phosphorylation of MAPK3 protein]; chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
chelerythrine inhibits the reaction [Estradiol results in increased activity of MAPK3 protein]		 CTD PMID:10037446 PMID:14511371 PMID:15831558 PMID:16581537 PMID:16713447 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [AG 1879 co-treated with chelerythrine] inhibits the reaction [CXCL8 protein results in increased secretion of MMP9 protein] CTD PMID:15831558 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO chelerythrine inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:24300194 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO chelerythrine inhibits the reaction [Resveratrol affects the expression of MYC protein] CTD PMID:31151226 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myl1 myosin, light chain 1 multiple interactions EXP chelerythrine inhibits the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein] CTD PMID:37963515 Ensembl chr 9:68,437,517...68,458,261 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP chelerythrine inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:18436224 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased degradation of NFKBIA protein] CTD PMID:34006824 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [chelerythrine co-treated with tyrphostin 47] inhibits the reaction [Quercetin results in increased expression of NOS3 protein] CTD PMID:22557973 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP chelerythrine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; chelerythrine promotes the reaction [2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:16787574 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nts neurotensin increases activity ISO chelerythrine results in increased activity of NTS protein CTD PMID:18313772 NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP [chelerythrine cotreatment with morphine] inhibits the reaction [morphine decreases expression of Oprm1 protein in cultured astrocytes] RGD PMID:28341892 RGD:597978120 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP chelerythrine inhibits the reaction [Testosterone results in increased expression of PCNA mRNA] CTD PMID:21374593 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions EXP chelerythrine inhibits the reaction [Norepinephrine results in increased phosphorylation of PPP1R14A protein] CTD PMID:37963515 NCBI chr 1:93,708,269...93,718,218
Ensembl chr 1:84,586,627...84,590,671 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP chelerythrine inhibits the reaction [Capsaicin results in increased expression of PRKCA protein] CTD PMID:18752301 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO
EXP		 chelerythrine inhibits the reaction [Calcium results in increased phosphorylation of PRKCE protein]
[chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrine		 CTD PMID:12700091 PMID:21562303 NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Ptges3 prostaglandin E synthase 3 increases cleavage ISO chelerythrine results in increased cleavage of PTGES3 protein CTD PMID:26124276 NCBI chr 7:1,075,230...1,092,363
Ensembl chr 7:490,656...508,084 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions EXP chelerythrine inhibits the reaction [Isoflurane results in increased phosphorylation of PTK2 protein]; chelerythrine inhibits the reaction [Thiopental results in increased phosphorylation of PTK2 protein] CTD PMID:15194624 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO chelerythrine inhibits the reaction [Acids results in increased activity of RELA protein]; chelerythrine inhibits the reaction [Glucose results in increased activity of RELA protein]
chelerythrine inhibits the reaction [Ethanol results in increased expression of RELA protein]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of RELA protein]		 CTD PMID:12388107 PMID:19074641 PMID:24300194 PMID:34006824 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases activity
multiple interactions		 EXP chelerythrine results in decreased activity of SLC1A1 protein
chelerythrine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; chelerythrine inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]		 CTD PMID:17382927 PMID:22511482 PMID:23262392 PMID:23602688 PMID:24355585 NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP [chelerythrine cotreatment with morphine] inhibits the reaction [morphine decreases expression of GLT-1 protein in cultured astrocytes] RGD PMID:28341892 RGD:597978120 NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO chelerythrine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:31,039,865...31,051,671
Ensembl chr 6:25,320,442...25,331,712 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO chelerythrine results in increased cleavage of SPTAN1 protein CTD PMID:26124276 NCBI chr 3:33,639,020...33,703,890
Ensembl chr 3:13,241,217...13,306,046 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions EXP chelerythrine results in decreased phosphorylation of and results in decreased activity of STAT5A protein CTD PMID:15746188 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP chelerythrine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]; chelerythrine inhibits the reaction [HU 211 results in decreased expression of TH mRNA] CTD PMID:18992715 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO chelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]] CTD PMID:17991733 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chelerythrine inhibits the reaction [Ethanol results in increased expression of TNF protein]; chelerythrine inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; chelerythrine inhibits the reaction [lead acetate results in increased expression of TNF protein]; chelerythrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of TNF mRNA]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of TNF protein]; chelerythrine inhibits the reaction [TNF protein results in increased transport of Chlorides]; chelerythrine inhibits the reaction [TNF protein results in increased transport of Potassium] CTD PMID:10783394 PMID:15302094 PMID:16581537 PMID:24300194 PMID:34006824 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions ISO chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TNNI3 protein] CTD PMID:12003851 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions ISO chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TNNT2 protein] CTD PMID:12003851 NCBI chr13:49,819,123...49,837,125
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP chelerythrine inhibits the reaction [Capsaicin results in increased expression of TRPV1 protein] CTD PMID:18752301 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        antimicrobial agent 18257
          antibacterial agent 16505
            chelerythrine 59
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            organic molecule 19713
                              organic cyclic compound 19505
                                organic heterocyclic compound 18875
                                  organonitrogen heterocyclic compound 18154
                                    benzophenanthridine 146
                                      benzophenanthridine alkaloid 125
                                        chelerythrine 59
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