|
G |
Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
multiple interactions |
ISO |
angoline inhibits the reaction [monobutyl phthalate results in increased expression of ACSL4 protein] |
CTD |
PMID:37121744 |
|
NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
|
|
G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions |
ISO |
angoline inhibits the reaction [monobutyl phthalate results in decreased expression of GPX4 protein] |
CTD |
PMID:37121744 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
angoline inhibits the reaction [monobutyl phthalate results in increased expression of IL6 mRNA] |
CTD |
PMID:37121744 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
angoline inhibits the reaction [monobutyl phthalate results in increased expression of STAT3 mRNA] |
CTD |
PMID:37121744 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
angoline inhibits the reaction [monobutyl phthalate results in increased expression of TNF mRNA] |
CTD |
PMID:37121744 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
chelerythrine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] chelerythrine results in decreased activity of ABCB11 protein |
CTD |
PMID:24014644 |
|
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein] |
CTD |
PMID:10037446 PMID:15364539 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [sodium arsenite inhibits the reaction [Cisplatin results in increased expression of BAX protein]] |
CTD |
PMID:12690470 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP ISO |
chelerythrine inhibits the reaction [sodium arsenite inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]] chelerythrine inhibits the reaction [Resveratrol affects the expression of BCL2 protein] |
CTD |
PMID:12690470 PMID:31151226 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [Capsaicin results in increased expression of CALCA protein] |
CTD |
PMID:18752301 |
|
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
|
|
G |
Casp2 |
caspase 2 |
increases cleavage |
ISO |
chelerythrine results in increased cleavage of CASP2 protein |
CTD |
PMID:26124276 |
|
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity increases cleavage |
EXP ISO |
malonic acid inhibits the reaction [chelerythrine results in increased activity of CASP3 protein]; Rotenone inhibits the reaction [chelerythrine results in increased activity of CASP3 protein] chelerythrine results in increased cleavage of CASP3 protein Acetylcysteine inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Dithiothreitol inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; S-methyl glutathione inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein] |
CTD |
PMID:21664962 PMID:26124276 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp6 |
caspase 6 |
increases cleavage |
ISO |
chelerythrine results in increased cleavage of CASP6 protein |
CTD |
PMID:26124276 |
|
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
|
|
G |
Casp7 |
caspase 7 |
increases cleavage |
ISO |
chelerythrine results in increased cleavage of CASP7 protein |
CTD |
PMID:26124276 |
|
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
|
|
G |
Casp9 |
caspase 9 |
multiple interactions increases activity increases cleavage |
EXP ISO |
malonic acid inhibits the reaction [chelerythrine results in increased activity of CASP9 protein]; Rotenone inhibits the reaction [chelerythrine results in increased activity of CASP9 protein] chelerythrine results in increased cleavage of CASP9 protein |
CTD |
PMID:21664962 PMID:26124276 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Casr |
calcium-sensing receptor |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [CASR protein results in increased uptake of Calcium] |
CTD |
PMID:21562303 |
|
NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
|
|
G |
Ccn1 |
cellular communication network factor 1 |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA] |
CTD |
PMID:15117851 |
|
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
|
|
G |
Cftr |
CF transmembrane conductance regulator |
decreases activity |
ISO |
chelerythrine results in decreased activity of CFTR protein |
CTD |
PMID:14744818 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] |
CTD |
PMID:16901605 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; chelerythrine promotes the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]] |
CTD |
PMID:10037446 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Edn1 |
endothelin 1 |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] |
CTD |
PMID:18436224 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
|
|
G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]; chelerythrine inhibits the reaction [EGF protein results in decreased susceptibility to Acetaldehyde] |
CTD |
PMID:17991733 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
|
|
G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [Glucose results in increased expression of FN1 protein] |
CTD |
PMID:12388107 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
decreases activity |
EXP |
chelerythrine results in decreased activity of G6PD protein |
CTD |
PMID:19429815 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [Acrolein results in increased secretion of GPT protein]; chelerythrine inhibits the reaction [allyl alcohol results in increased secretion of GPT protein] |
CTD |
PMID:12755590 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein] |
CTD |
PMID:12690470 |
|
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
|
|
G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein] |
CTD |
PMID:16178011 |
|
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
|
|
G |
Igf1 |
insulin-like growth factor 1 |
affects activity |
EXP |
chelerythrine affects the activity of IGF1 protein |
CTD |
PMID:11548882 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of IL1B mRNA]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of IL1B protein] |
CTD |
PMID:34006824 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [Acids results in increased expression of IL6 mRNA]; chelerythrine inhibits the reaction [Acids results in increased secretion of IL6 protein] chelerythrine inhibits the reaction [Ethanol results in increased expression of IL6 protein]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of IL6 mRNA]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of IL6 protein] |
CTD |
PMID:19074641 PMID:24300194 PMID:34006824 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
chelerythrine results in decreased phosphorylation of and results in decreased activity of JAK2 protein |
CTD |
PMID:15746188 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
|
|
G |
Kcnd3 |
potassium voltage-gated channel subfamily D member 3 |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [Phenylephrine results in decreased activity of KCND3 protein alternative form] |
CTD |
PMID:11709419 |
|
NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345
|
|
G |
Lmna |
lamin A/C |
increases cleavage |
ISO |
chelerythrine results in increased cleavage of LMNA protein |
CTD |
PMID:26124276 |
|
NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO EXP |
chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] chelerythrine inhibits the reaction [CXCL8 protein results in increased phosphorylation of MAPK1 protein] chelerythrine inhibits the reaction [Estradiol results in increased activity of MAPK1 protein] |
CTD |
PMID:10037446 PMID:14511371 PMID:15831558 PMID:16713447 PMID:19854188 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO EXP |
chelerythrine inhibits the reaction [CXCL8 protein results in increased phosphorylation of MAPK3 protein] chelerythrine inhibits the reaction [[Lead co-treated with Lipopolysaccharides] results in increased phosphorylation of MAPK3 protein]; chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] chelerythrine inhibits the reaction [Estradiol results in increased activity of MAPK3 protein] |
CTD |
PMID:10037446 PMID:14511371 PMID:15831558 PMID:16581537 PMID:16713447 PMID:19854188 More...
|
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
[AG 1879 co-treated with chelerythrine] inhibits the reaction [CXCL8 protein results in increased secretion of MMP9 protein] |
CTD |
PMID:15831558 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [Ethanol results in increased activity of MPO protein] |
CTD |
PMID:24300194 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [Resveratrol affects the expression of MYC protein] |
CTD |
PMID:31151226 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
|
|
G |
Myl1 |
myosin, light chain 1 |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein] |
CTD |
PMID:37963515 |
|
NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
|
|
G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] |
CTD |
PMID:18436224 |
|
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased degradation of NFKBIA protein] |
CTD |
PMID:34006824 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
EXP |
[chelerythrine co-treated with tyrphostin 47] inhibits the reaction [Quercetin results in increased expression of NOS3 protein] |
CTD |
PMID:22557973 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
G |
Nppa |
natriuretic peptide A |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; chelerythrine promotes the reaction [2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] |
CTD |
PMID:16787574 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
|
|
G |
Nts |
neurotensin |
increases activity |
ISO |
chelerythrine results in increased activity of NTS protein |
CTD |
PMID:18313772 |
|
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
|
|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [Testosterone results in increased expression of PCNA mRNA] |
CTD |
PMID:21374593 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
|
|
G |
Ppp1r14a |
protein phosphatase 1, regulatory (inhibitor) subunit 14A |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [Norepinephrine results in increased phosphorylation of PPP1R14A protein] |
CTD |
PMID:37963515 |
|
NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671
|
|
G |
Prkca |
protein kinase C, alpha |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [Capsaicin results in increased expression of PRKCA protein] |
CTD |
PMID:18752301 |
|
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
|
|
G |
Prkce |
protein kinase C, epsilon |
multiple interactions |
ISO EXP |
chelerythrine inhibits the reaction [Calcium results in increased phosphorylation of PRKCE protein] [chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrine |
CTD |
PMID:12700091 PMID:21562303 |
|
NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
|
|
G |
Ptges3 |
prostaglandin E synthase 3 |
increases cleavage |
ISO |
chelerythrine results in increased cleavage of PTGES3 protein |
CTD |
PMID:26124276 |
|
NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [Acids results in increased activity of RELA protein]; chelerythrine inhibits the reaction [Glucose results in increased activity of RELA protein] chelerythrine inhibits the reaction [Ethanol results in increased expression of RELA protein]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of RELA protein] |
CTD |
PMID:12388107 PMID:19074641 PMID:24300194 PMID:34006824 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Slc1a1 |
solute carrier family 1 member 1 |
decreases activity multiple interactions |
EXP |
chelerythrine results in decreased activity of SLC1A1 protein chelerythrine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; chelerythrine inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein] |
CTD |
PMID:17382927 PMID:22511482 PMID:23262392 PMID:23602688 PMID:24355585 |
|
NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
|
|
G |
Slc5a6 |
solute carrier family 5 member 6 |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
CTD |
PMID:15561972 |
|
NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712
|
|
G |
Sptan1 |
spectrin, alpha, non-erythrocytic 1 |
increases cleavage |
ISO |
chelerythrine results in increased cleavage of SPTAN1 protein |
CTD |
PMID:26124276 |
|
NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
|
|
G |
Stat5a |
signal transducer and activator of transcription 5A |
multiple interactions |
EXP |
chelerythrine results in decreased phosphorylation of and results in decreased activity of STAT5A protein |
CTD |
PMID:15746188 |
|
NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
|
|
G |
Th |
tyrosine hydroxylase |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]; chelerythrine inhibits the reaction [HU 211 results in decreased expression of TH mRNA] |
CTD |
PMID:18992715 |
|
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
|
|
G |
Tjp1 |
tight junction protein 1 |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]] |
CTD |
PMID:17991733 |
|
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [Ethanol results in increased expression of TNF protein]; chelerythrine inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; chelerythrine inhibits the reaction [lead acetate results in increased expression of TNF protein]; chelerythrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of TNF mRNA]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of TNF protein]; chelerythrine inhibits the reaction [TNF protein results in increased transport of Chlorides]; chelerythrine inhibits the reaction [TNF protein results in increased transport of Potassium] |
CTD |
PMID:10783394 PMID:15302094 PMID:16581537 PMID:24300194 PMID:34006824 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tnni3 |
troponin I3, cardiac type |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TNNI3 protein] |
CTD |
PMID:12003851 |
|
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
|
|
G |
Tnnt2 |
troponin T2, cardiac type |
multiple interactions |
ISO |
chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TNNT2 protein] |
CTD |
PMID:12003851 |
|
NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
|
|
G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions |
EXP |
chelerythrine inhibits the reaction [Capsaicin results in increased expression of TRPV1 protein] |
CTD |
PMID:18752301 |
|
NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
|
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
affects expression |
ISO |
chelidonine affects the expression of BAX mRNA |
CTD |
PMID:25265580 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
affects expression |
ISO |
chelidonine affects the expression of BCL2 mRNA |
CTD |
PMID:25265580 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases metabolic processing |
ISO |
[CYP1A2 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog |
CTD |
PMID:31102647 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
increases metabolic processing multiple interactions |
ISO |
CYP2C19 protein results in increased metabolism of chelidonine [CYP2C19 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog |
CTD |
PMID:31102647 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
|
|
G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
increases metabolic processing multiple interactions |
ISO |
CYP2D6 protein results in increased metabolism of chelidonine [CYP2D6 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog |
CTD |
PMID:31102647 |
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases metabolic processing multiple interactions |
ISO |
CYP3A4 protein results in increased metabolism of chelidonine [CYP3A4 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog |
CTD |
PMID:31102647 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
|
|
G |
Dapk1 |
death associated protein kinase 1 |
affects expression |
ISO |
chelidonine affects the expression of DAPK1 mRNA |
CTD |
PMID:25265580 |
|
NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
|
|
G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
chelidonine results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
|
|
G |
Mapt |
microtubule-associated protein tau |
decreases expression |
ISO |
chelidonine results in decreased expression of MAPT protein |
CTD |
PMID:16930453 |
|
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
|
|
G |
Tert |
telomerase reverse transcriptase |
decreases activity decreases expression |
ISO |
chelidonine results in decreased activity of TERT protein chelidonine results in decreased expression of TERT mRNA |
CTD |
PMID:25265580 |
|
NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
|
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased activity of GPT protein]]; corynoline inhibits the reaction [Zearalenone results in increased activity of GPT protein] |
CTD |
PMID:36161741 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation |
ISO |
corynoline results in increased phosphorylation of GSK3B protein |
CTD |
PMID:34477289 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline promotes the reaction [Zearalenone results in increased expression of HMOX1 protein]]; corynoline promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]; corynoline promotes the reaction [Zearalenone results in increased expression of HMOX1 protein] |
CTD |
PMID:34477289 PMID:36161741 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased expression of IL1B protein]]; corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; corynoline inhibits the reaction [Zearalenone results in increased expression of IL1B protein] |
CTD |
PMID:34477289 PMID:36161741 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased activity of MPO protein]]; corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of MPO protein]; corynoline inhibits the reaction [Zearalenone results in increased activity of MPO protein] |
CTD |
PMID:34477289 PMID:36161741 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline promotes the reaction [Zearalenone results in increased expression of NFE2L2 protein]]; corynoline promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NFE2L2 protein]; corynoline promotes the reaction [Zearalenone results in increased expression of NFE2L2 protein] |
CTD |
PMID:34477289 PMID:36161741 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of NFKBIA protein]]; corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]; corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:34477289 PMID:36161741 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of RELA protein]]; corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]; corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of RELA protein] |
CTD |
PMID:34477289 PMID:36161741 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Sirt1 |
sirtuin 1 |
multiple interactions |
ISO |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in decreased expression of SIRT1 protein]]; corynoline inhibits the reaction [Zearalenone results in decreased expression of SIRT1 protein] |
CTD |
PMID:36161741 |
|
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased expression of TNF protein]]; corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; corynoline inhibits the reaction [Zearalenone results in increased expression of TNF protein] |
CTD |
PMID:34477289 PMID:36161741 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Casp3 |
caspase 3 |
increases activity |
ISO |
dihydrosanguinarine results in increased activity of CASP3 protein |
CTD |
PMID:19346183 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
increases activity |
ISO |
dihydrosanguinarine results in increased activity of CASP9 protein |
CTD |
PMID:19346183 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases chemical synthesis |
EXP |
NQO1 protein results in increased chemical synthesis of dihydrosanguinarine |
CTD |
PMID:24300172 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
sanguinarine promotes the reaction [AHR protein binds to ARNT protein]; sanguinarine results in increased activity of and affects the localization of AHR protein; sanguinarine results in increased localization of and results in increased activity of AHR protein |
CTD |
PMID:15993743 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions |
ISO |
sanguinarine promotes the reaction [AHR protein binds to ARNT protein] |
CTD |
PMID:15993743 |
|
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO EXP |
sanguinarine results in increased expression of BAX protein sanguinarine results in increased expression of BAX mRNA; sanguinarine results in increased expression of BAX protein NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX protein] |
CTD |
PMID:22215411 PMID:24300172 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bbc3 |
Bcl-2 binding component 3 |
multiple interactions |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of BBC3 mRNA |
CTD |
PMID:24345465 |
|
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
sanguinarine results in decreased expression of BCL2 protein sanguinarine results in decreased expression of BCL2 mRNA; sanguinarine results in decreased expression of BCL2 protein NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 protein] [sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of BCL2 protein |
CTD |
PMID:22215411 PMID:23660334 PMID:24300172 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Bcl2l14 |
Bcl2-like 14 |
multiple interactions increases expression |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of BCL2L14 mRNA sanguinarine results in increased expression of BCL2L14 mRNA |
CTD |
PMID:24345465 |
|
NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086
|
|
G |
Bid |
BH3 interacting domain death agonist |
multiple interactions increases cleavage |
ISO |
[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [sanguinarine results in increased cleavage of BID protein] |
CTD |
PMID:23660334 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
|
|
G |
Bik |
BCL2-interacting killer |
multiple interactions |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of BIK mRNA |
CTD |
PMID:24345465 |
|
NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
|
|
G |
Birc2 |
baculoviral IAP repeat-containing 2 |
multiple interactions |
ISO |
[sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of BIRC2 protein |
CTD |
PMID:23660334 |
|
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
|
|
G |
Bnip3l |
BCL2 interacting protein 3 like |
multiple interactions |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of BNIP3L mRNA |
CTD |
PMID:24345465 |
|
NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
|
|
G |
Card6 |
caspase recruitment domain family, member 6 |
multiple interactions |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of CARD6 mRNA |
CTD |
PMID:24345465 |
|
NCBI chr 2:54,194,343...54,206,902
Ensembl chr 2:54,195,739...54,206,846
|
|
G |
Casp1 |
caspase 1 |
multiple interactions increases expression |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of CASP1 mRNA sanguinarine results in increased expression of CASP1 mRNA |
CTD |
PMID:24345465 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
|
|
G |
Casp3 |
caspase 3 |
decreases expression multiple interactions increases activity |
ISO |
sanguinarine results in decreased expression of CASP3 protein alternative form [sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [sanguinarine co-treated with arsenic trioxide] results in increased activity of CASP3 protein; [sanguinarine co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in increased activity of CASP3 protein sanguinarine results in increased activity of CASP3 protein |
CTD |
PMID:19135517 PMID:19346183 PMID:20150630 PMID:22215411 PMID:23660334 PMID:24345465 More...
|
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp4 |
caspase 4 |
multiple interactions |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of CASP4 mRNA |
CTD |
PMID:24345465 |
|
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
|
|
G |
Casp8 |
caspase 8 |
increases activity multiple interactions |
ISO |
sanguinarine results in increased activity of CASP8 protein [sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [sanguinarine co-treated with arsenic trioxide] results in increased activity of CASP8 protein; [sanguinarine co-treated with TNFSF10 protein] results in increased activity of CASP8 protein |
CTD |
PMID:19346183 PMID:23660334 PMID:24345465 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Casp9 |
caspase 9 |
decreases expression multiple interactions increases activity |
ISO |
sanguinarine results in decreased expression of CASP9 protein alternative form [sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in increased activity of CASP9 protein sanguinarine results in increased activity of CASP9 protein |
CTD |
PMID:19135517 PMID:19346183 PMID:22215411 PMID:23660334 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
multiple interactions |
ISO |
[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of CAT protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of CAT protein |
CTD |
PMID:20691676 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
sanguinarine results in increased expression of CDKN1A protein |
CTD |
PMID:15981203 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cldn2 |
claudin 2 |
decreases expression |
ISO |
sanguinarine results in decreased expression of CLDN2 protein |
CTD |
PMID:19063874 |
|
NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838
|
|
G |
Cldn3 |
claudin 3 |
decreases expression |
ISO |
sanguinarine results in decreased expression of CLDN3 protein |
CTD |
PMID:19063874 |
|
NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
|
|
G |
Cldn4 |
claudin 4 |
decreases expression |
ISO |
sanguinarine results in decreased expression of CLDN4 protein |
CTD |
PMID:19063874 |
|
NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
|
|
G |
Cldn5 |
claudin 5 |
decreases expression |
ISO |
sanguinarine results in decreased expression of CLDN5 protein |
CTD |
PMID:19063874 |
|
NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
|
|
G |
Cryz |
crystallin zeta |
multiple interactions decreases activity |
EXP |
sanguinarine inhibits the reaction [Methylcholanthrene results in increased activity of CRYZ protein] sanguinarine results in decreased activity of CRYZ protein |
CTD |
PMID:19788401 |
|
NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity multiple interactions increases expression increases activity |
ISO EXP |
sanguinarine results in decreased activity of CYP1A1 protein sanguinarine inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; sanguinarine results in decreased expression of and results in decreased activity of CYP1A1 protein sanguinarine results in increased expression of CYP1A1 mRNA; sanguinarine results in increased expression of CYP1A1 protein sanguinarine results in increased activity of CYP1A1 protein |
CTD |
PMID:15993743 PMID:19788401 PMID:24300172 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
sanguinarine inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A2 protein]; sanguinarine results in decreased expression of and results in decreased activity of CYP1A2 protein |
CTD |
PMID:19788401 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression increases activity |
ISO |
sanguinarine results in increased expression of CYP1B1 mRNA sanguinarine results in increased activity of CYP1B1 protein |
CTD |
PMID:15993743 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
decreases activity |
EXP |
sanguinarine results in decreased activity of CYP2B1 protein |
CTD |
PMID:19788401 |
|
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
sanguinarine results in decreased expression of and results in decreased activity of CYP2E1 protein |
CTD |
PMID:19788401 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions |
EXP |
sanguinarine results in decreased expression of and results in decreased activity of CYP3A23-3A1 protein |
CTD |
PMID:19788401 |
|
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
|
|
G |
Dedd2 |
death effector domain containing 2 |
multiple interactions |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of DEDD2 mRNA |
CTD |
PMID:24345465 |
|
NCBI chr 1:80,789,084...80,807,789
Ensembl chr 1:80,792,000...80,807,714
|
|
G |
Egr1 |
early growth response 1 |
multiple interactions increases expression decreases expression |
ISO |
sanguinarine promotes the reaction [Reactive Oxygen Species results in increased activity of EGR1 protein] sanguinarine results in increased expression of EGR1 protein sanguinarine results in decreased expression of EGR1 protein |
CTD |
PMID:23660334 |
|
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
|
|
G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of FAS mRNA |
CTD |
PMID:24345465 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
|
|
G |
Faslg |
Fas ligand |
multiple interactions |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of FASLG mRNA |
CTD |
PMID:24345465 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
|
|
G |
Ggt1 |
gamma-glutamyltransferase 1 |
increases expression |
ISO |
sanguinarine results in increased expression of GGT1 protein |
CTD |
PMID:15981203 |
|
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of GSR protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of GSR protein |
CTD |
PMID:20691676 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions increases expression |
ISO |
sanguinarine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]; sanguinarine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; sanguinarine inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] sanguinarine results in increased expression of GSTP1 protein |
CTD |
PMID:15313406 PMID:15981203 PMID:23769903 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
|
|
G |
Hal |
histidine ammonia lyase |
multiple interactions |
ISO |
[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of HAL protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of HAL protein |
CTD |
PMID:20691676 |
|
NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
|
|
G |
Hpgds |
hematopoietic prostaglandin D synthase |
decreases activity |
ISO |
sanguinarine results in decreased activity of HPGDS protein |
CTD |
PMID:25603235 |
|
NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883
|
|
G |
Ltb |
lymphotoxin beta |
increases expression multiple interactions |
ISO |
sanguinarine results in increased expression of LTB mRNA [sanguinarine co-treated with arsenic trioxide] results in increased expression of LTB mRNA |
CTD |
PMID:24345465 |
|
NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO |
sanguinarine results in increased phosphorylation of MAPK1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:19135517 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:19135517 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation |
ISO |
pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:19135517 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions increases phosphorylation |
ISO |
pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:19135517 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
ISO |
sanguinarine results in decreased expression of MMP2 mRNA; sanguinarine results in decreased expression of MMP2 protein |
CTD |
PMID:19063874 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression |
ISO |
sanguinarine results in decreased expression of MMP9 mRNA; sanguinarine results in decreased expression of MMP9 protein |
CTD |
PMID:19063874 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Nfkbiz |
NFKB inhibitor zeta |
increases expression |
ISO |
sanguinarine results in increased expression of NFKBIZ mRNA |
CTD |
PMID:24345465 |
|
NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723
|
|
G |
Nlrp1a |
NLR family, pyrin domain containing 1A |
multiple interactions increases expression |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of NLRP1 mRNA sanguinarine results in increased expression of NLRP1 mRNA |
CTD |
PMID:24345465 |
|
NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
decreases expression increases reduction multiple interactions |
ISO EXP |
sanguinarine results in decreased expression of NQO1 mRNA; sanguinarine results in decreased expression of NQO1 protein NQO1 protein results in increased reduction of sanguinarine NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 protein]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX protein] |
CTD |
PMID:22021338 PMID:24300172 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
multiple interactions |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of PMAIP1 mRNA |
CTD |
PMID:24345465 |
|
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
|
|
G |
Por |
cytochrome p450 oxidoreductase |
multiple interactions decreases activity |
EXP |
sanguinarine inhibits the reaction [Phenobarbital results in increased activity of POR protein]; sanguinarine promotes the reaction [Methylcholanthrene results in decreased activity of POR protein] sanguinarine results in decreased activity of POR protein |
CTD |
PMID:19788401 |
|
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
|
|
G |
Pycard |
PYD and CARD domain containing |
multiple interactions |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of PYCARD mRNA |
CTD |
PMID:24345465 |
|
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
|
|
G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
sanguinarine results in decreased expression of SNAI1 protein |
CTD |
PMID:19063874 |
|
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
sanguinarine inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] |
CTD |
PMID:15313406 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
multiple interactions |
ISO |
[sanguinarine co-treated with arsenic trioxide] results in increased expression of TNFRSF1B mRNA |
CTD |
PMID:24345465 |
|
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
|
|
G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions increases expression |
ISO |
[sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [sanguinarine co-treated with arsenic trioxide] results in increased expression of TNFSF10 mRNA; [sanguinarine co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [sanguinarine co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; TNFSF10 protein results in increased susceptibility to [arsenic trioxide co-treated with sanguinarine] sanguinarine results in increased expression of TNFSF10 mRNA |
CTD |
PMID:24345465 |
|
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
|
|
G |
Tyr |
tyrosinase |
multiple interactions |
ISO |
[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of TYR protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of TYR protein |
CTD |
PMID:20691676 |
|
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
|
|
G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions |
ISO |
[sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of XIAP protein |
CTD |
PMID:23660334 |
|
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
|
|