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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzophenanthridine alkaloid
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Accession:CHEBI:38517 term browser browse the term
Definition:A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family.
Synonyms:related_synonym: benzophenanthridine alkaloids

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chelerythrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO chelerythrine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
chelerythrine results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein] CTD PMID:10037446 PMID:15364539 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP chelerythrine inhibits the reaction [sodium arsenite inhibits the reaction [Cisplatin results in increased expression of BAX protein]] CTD PMID:12690470 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO		 chelerythrine inhibits the reaction [sodium arsenite inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]]
chelerythrine inhibits the reaction [Resveratrol affects the expression of BCL2 protein]		 CTD PMID:12690470 PMID:31151226 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP chelerythrine inhibits the reaction [Capsaicin results in increased expression of CALCA protein] CTD PMID:18752301 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Casp2 caspase 2 increases cleavage ISO chelerythrine results in increased cleavage of CASP2 protein CTD PMID:26124276 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity		 EXP
ISO		 malonic acid inhibits the reaction [chelerythrine results in increased activity of CASP3 protein]; Rotenone inhibits the reaction [chelerythrine results in increased activity of CASP3 protein]
Acetylcysteine inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Dithiothreitol inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; S-methyl glutathione inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]		 CTD PMID:21664962 PMID:26124276 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp6 caspase 6 increases cleavage ISO chelerythrine results in increased cleavage of CASP6 protein CTD PMID:26124276 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO chelerythrine results in increased cleavage of CASP7 protein CTD PMID:26124276 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity		 EXP
ISO		 malonic acid inhibits the reaction [chelerythrine results in increased activity of CASP9 protein]; Rotenone inhibits the reaction [chelerythrine results in increased activity of CASP9 protein]
chelerythrine results in increased cleavage of CASP9 protein		 CTD PMID:21664962 PMID:26124276 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO chelerythrine inhibits the reaction [CASR protein results in increased uptake of Calcium] CTD PMID:21562303 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771 		JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions ISO chelerythrine inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA] CTD PMID:15117851 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312 		JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO chelerythrine results in decreased activity of CFTR protein CTD PMID:14744818 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:16901605 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO chelerythrine inhibits the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; chelerythrine promotes the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]] CTD PMID:10037446 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP chelerythrine inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:18436224 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO chelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]; chelerythrine inhibits the reaction [EGF protein results in decreased susceptibility to Acetaldehyde] CTD PMID:17991733 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO chelerythrine inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:12388107 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP chelerythrine results in decreased activity of G6PD protein CTD PMID:19429815 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP chelerythrine inhibits the reaction [Acrolein results in increased secretion of GPT protein]; chelerythrine inhibits the reaction [allyl alcohol results in increased secretion of GPT protein] CTD PMID:12755590 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP chelerythrine inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein] CTD PMID:12690470 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP chelerythrine inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein] CTD PMID:16178011 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Igf1 insulin-like growth factor 1 affects activity EXP chelerythrine affects the activity of IGF1 protein CTD PMID:11548882 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO chelerythrine inhibits the reaction [Acids results in increased expression of IL6 mRNA]; chelerythrine inhibits the reaction [Acids results in increased secretion of IL6 protein]
chelerythrine inhibits the reaction [Ethanol results in increased expression of IL6 protein]		 CTD PMID:19074641 PMID:24300194 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP chelerythrine results in decreased phosphorylation of and results in decreased activity of JAK2 protein CTD PMID:15746188 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509 		JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 multiple interactions ISO chelerythrine inhibits the reaction [Phenylephrine results in decreased activity of KCND3 protein alternative form] CTD PMID:11709419 NCBI chr 2:207,923,775...208,140,727
Ensembl chr 2:207,923,775...208,140,727 		JBrowse link
G Lmna lamin A/C increases cleavage ISO chelerythrine results in increased cleavage of LMNA protein CTD PMID:26124276 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
chelerythrine inhibits the reaction [Estradiol results in increased activity of MAPK1 protein]
chelerythrine inhibits the reaction [CXCL8 protein results in increased phosphorylation of MAPK1 protein]		 CTD PMID:10037446 PMID:14511371 PMID:15831558 PMID:16713447 PMID:19854188 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 chelerythrine inhibits the reaction [CXCL8 protein results in increased phosphorylation of MAPK3 protein]
chelerythrine inhibits the reaction [Estradiol results in increased activity of MAPK3 protein]
chelerythrine inhibits the reaction [[Lead co-treated with Lipopolysaccharides] results in increased phosphorylation of MAPK3 protein]; chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]		 CTD PMID:10037446 PMID:14511371 PMID:15831558 PMID:16581537 PMID:16713447 PMID:19854188 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [AG 1879 co-treated with chelerythrine] inhibits the reaction [CXCL8 protein results in increased secretion of MMP9 protein] CTD PMID:15831558 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO chelerythrine inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:24300194 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO chelerythrine inhibits the reaction [Resveratrol affects the expression of MYC protein] CTD PMID:31151226 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP chelerythrine inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:18436224 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [chelerythrine co-treated with tyrphostin 47] inhibits the reaction [Quercetin results in increased expression of NOS3 protein] CTD PMID:22557973 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP chelerythrine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; chelerythrine promotes the reaction [2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:16787574 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705 		JBrowse link
G Nts neurotensin increases activity ISO chelerythrine results in increased activity of NTS protein CTD PMID:18313772 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP chelerythrine inhibits the reaction [Testosterone results in increased expression of PCNA mRNA] CTD PMID:21374593 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP chelerythrine inhibits the reaction [Capsaicin results in increased expression of PRKCA protein] CTD PMID:18752301 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO
EXP		 chelerythrine inhibits the reaction [Calcium results in increased phosphorylation of PRKCE protein]
[chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrine		 CTD PMID:12700091 PMID:21562303 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396 		JBrowse link
G Ptges3 prostaglandin E synthase 3 increases cleavage ISO chelerythrine results in increased cleavage of PTGES3 protein CTD PMID:26124276 NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO chelerythrine inhibits the reaction [Acids results in increased activity of RELA protein]; chelerythrine inhibits the reaction [Glucose results in increased activity of RELA protein]
chelerythrine inhibits the reaction [Ethanol results in increased expression of RELA protein]		 CTD PMID:12388107 PMID:19074641 PMID:24300194 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases activity
multiple interactions		 EXP chelerythrine results in decreased activity of SLC1A1 protein
chelerythrine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; chelerythrine inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]		 CTD PMID:17382927 PMID:22511482 PMID:23262392 PMID:23602688 PMID:24355585 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056 		JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO chelerythrine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO chelerythrine results in increased cleavage of SPTAN1 protein CTD PMID:26124276 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions EXP chelerythrine results in decreased phosphorylation of and results in decreased activity of STAT5A protein CTD PMID:15746188 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP chelerythrine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]; chelerythrine inhibits the reaction [HU 211 results in decreased expression of TH mRNA] CTD PMID:18992715 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO chelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]] CTD PMID:17991733 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chelerythrine inhibits the reaction [Ethanol results in increased expression of TNF protein]; chelerythrine inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; chelerythrine inhibits the reaction [lead acetate results in increased expression of TNF protein]; chelerythrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; chelerythrine inhibits the reaction [TNF protein results in increased transport of Chlorides]; chelerythrine inhibits the reaction [TNF protein results in increased transport of Potassium] CTD PMID:10783394 PMID:15302094 PMID:16581537 PMID:24300194 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions ISO chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TNNI3 protein] CTD PMID:12003851 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488 		JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions ISO chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TNNT2 protein] CTD PMID:12003851 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP chelerythrine inhibits the reaction [Capsaicin results in increased expression of TRPV1 protein] CTD PMID:18752301 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679 		JBrowse link
chelidonine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects expression ISO chelidonine affects the expression of BAX mRNA CTD PMID:25265580 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO chelidonine affects the expression of BCL2 mRNA CTD PMID:25265580 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing		 ISO [CYP1A2 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog CTD PMID:31102647 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing
multiple interactions		 ISO CYP2C19 protein results in increased metabolism of chelidonine
[CYP2C19 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog		 CTD PMID:31102647 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions		 ISO CYP2D6 protein results in increased metabolism of chelidonine
[CYP2D6 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog		 CTD PMID:31102647 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases metabolic processing
multiple interactions		 ISO CYP3A4 protein results in increased metabolism of chelidonine
[CYP3A4 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog		 CTD PMID:31102647 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Dapk1 death associated protein kinase 1 affects expression ISO chelidonine affects the expression of DAPK1 mRNA CTD PMID:25265580 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO chelidonine results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517 		JBrowse link
G Tert telomerase reverse transcriptase decreases activity
decreases expression		 ISO chelidonine results in decreased activity of TERT protein
chelidonine results in decreased expression of TERT mRNA		 CTD PMID:25265580 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476 		JBrowse link
dihydrosanguinarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO dihydrosanguinarine results in increased activity of CASP3 protein CTD PMID:19346183 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 increases activity ISO dihydrosanguinarine results in increased activity of CASP9 protein CTD PMID:19346183 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases chemical synthesis EXP NQO1 protein results in increased chemical synthesis of dihydrosanguinarine CTD PMID:24300172 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
sanguinarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO sanguinarine promotes the reaction [AHR protein binds to ARNT protein]; sanguinarine results in increased activity of and affects the localization of AHR protein; sanguinarine results in increased localization of and results in increased activity of AHR protein CTD PMID:15993743 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO sanguinarine promotes the reaction [AHR protein binds to ARNT protein] CTD PMID:15993743 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO
EXP		 sanguinarine results in increased expression of BAX protein
sanguinarine results in increased expression of BAX mRNA; sanguinarine results in increased expression of BAX protein
NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX protein]		 CTD PMID:22215411 PMID:24300172 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of BBC3 mRNA CTD PMID:24345465 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 sanguinarine results in decreased expression of BCL2 protein
sanguinarine results in decreased expression of BCL2 mRNA; sanguinarine results in decreased expression of BCL2 protein
NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 protein]
[sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of BCL2 protein		 CTD PMID:22215411 PMID:23660334 PMID:24300172 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l14 BCL2 like 14 multiple interactions
increases expression		 ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of BCL2L14 mRNA
sanguinarine results in increased expression of BCL2L14 mRNA		 CTD PMID:24345465 NCBI chr 4:168,139,964...168,183,726
Ensembl chr 4:168,142,271...168,183,096 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases cleavage		 ISO [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [sanguinarine results in increased cleavage of BID protein] CTD PMID:23660334 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Bik BCL2-interacting killer multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of BIK mRNA CTD PMID:24345465 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of BIRC2 protein CTD PMID:23660334 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of BNIP3L mRNA CTD PMID:24345465 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029 		JBrowse link
G Card6 caspase recruitment domain family, member 6 multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of CARD6 mRNA CTD PMID:24345465 NCBI chr 2:54,810,676...54,824,050
Ensembl chr 2:54,810,110...54,824,033 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression		 ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of CASP1 mRNA
sanguinarine results in increased expression of CASP1 mRNA		 CTD PMID:24345465 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
increases activity		 ISO sanguinarine results in decreased expression of CASP3 protein alternative form
[sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [sanguinarine co-treated with arsenic trioxide] results in increased activity of CASP3 protein; [sanguinarine co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in increased activity of CASP3 protein
sanguinarine results in increased activity of CASP3 protein		 CTD PMID:19135517 PMID:19346183 PMID:20150630 PMID:22215411 PMID:23660334 PMID:24345465 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp4 caspase 4 multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of CASP4 mRNA CTD PMID:24345465 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions		 ISO sanguinarine results in increased activity of CASP8 protein
[sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [sanguinarine co-treated with arsenic trioxide] results in increased activity of CASP8 protein; [sanguinarine co-treated with TNFSF10 protein] results in increased activity of CASP8 protein		 CTD PMID:19346183 PMID:23660334 PMID:24345465 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 decreases expression
multiple interactions
increases activity		 ISO sanguinarine results in decreased expression of CASP9 protein alternative form
[sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in increased activity of CASP9 protein
sanguinarine results in increased activity of CASP9 protein		 CTD PMID:19135517 PMID:19346183 PMID:22215411 PMID:23660334 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of CAT protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of CAT protein CTD PMID:20691676 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO sanguinarine results in increased expression of CDKN1A protein CTD PMID:15981203 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cldn2 claudin 2 decreases expression ISO sanguinarine results in decreased expression of CLDN2 protein CTD PMID:19063874 NCBI chr  X:111,122,552...111,133,188
Ensembl chr  X:111,122,552...111,137,769 		JBrowse link
G Cldn3 claudin 3 decreases expression ISO sanguinarine results in decreased expression of CLDN3 protein CTD PMID:19063874 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813 		JBrowse link
G Cldn4 claudin 4 decreases expression ISO sanguinarine results in decreased expression of CLDN4 protein CTD PMID:19063874 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005 		JBrowse link
G Cldn5 claudin 5 decreases expression ISO sanguinarine results in decreased expression of CLDN5 protein CTD PMID:19063874 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
increases activity		 ISO
EXP		 sanguinarine results in decreased activity of CYP1A1 protein
sanguinarine results in increased expression of CYP1A1 mRNA; sanguinarine results in increased expression of CYP1A1 protein
sanguinarine results in increased activity of CYP1A1 protein		 CTD PMID:15993743 PMID:24300172 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
increases activity		 ISO sanguinarine results in increased expression of CYP1B1 mRNA
sanguinarine results in increased activity of CYP1B1 protein		 CTD PMID:15993743 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Dedd2 death effector domain containing 2 multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of DEDD2 mRNA CTD PMID:24345465 NCBI chr 1:82,073,024...82,089,028
Ensembl chr 1:82,072,544...82,088,275 		JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
decreases expression		 ISO sanguinarine promotes the reaction [Reactive Oxygen Species results in increased activity of EGR1 protein]
sanguinarine results in increased expression of EGR1 protein
sanguinarine results in decreased expression of EGR1 protein		 CTD PMID:23660334 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of FAS mRNA CTD PMID:24345465 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of FASLG mRNA CTD PMID:24345465 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression ISO sanguinarine results in increased expression of GGT1 protein CTD PMID:15981203 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of GSR protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of GSR protein CTD PMID:20691676 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression		 ISO sanguinarine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]; sanguinarine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; sanguinarine inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]
sanguinarine results in increased expression of GSTP1 protein		 CTD PMID:15313406 PMID:15981203 PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Hal histidine ammonia lyase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of HAL protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of HAL protein CTD PMID:20691676 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413 		JBrowse link
G Hpgds hematopoietic prostaglandin D synthase decreases activity ISO sanguinarine results in decreased activity of HPGDS protein CTD PMID:25603235 NCBI chr 4:95,945,356...95,970,666
Ensembl chr 4:95,946,025...95,970,666 		JBrowse link
G Ltb lymphotoxin beta increases expression
multiple interactions		 ISO sanguinarine results in increased expression of LTB mRNA
[sanguinarine co-treated with arsenic trioxide] results in increased expression of LTB mRNA		 CTD PMID:24345465 NCBI chr20:5,184,631...5,186,476
Ensembl chr20:5,184,515...5,186,503
Ensembl chr20:5,184,515...5,186,503 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO sanguinarine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:19135517 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein] CTD PMID:19135517 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 ISO pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK8 protein] CTD PMID:19135517 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 ISO pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK9 protein] CTD PMID:19135517 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO sanguinarine results in decreased expression of MMP2 mRNA; sanguinarine results in decreased expression of MMP2 protein CTD PMID:19063874 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO sanguinarine results in decreased expression of MMP9 mRNA; sanguinarine results in decreased expression of MMP9 protein CTD PMID:19063874 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression ISO sanguinarine results in increased expression of NFKBIZ mRNA CTD PMID:24345465 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A multiple interactions
increases expression		 ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of NLRP1 mRNA
sanguinarine results in increased expression of NLRP1 mRNA		 CTD PMID:24345465 NCBI chr10:57,692,474...57,747,608
Ensembl chr10:57,692,474...57,822,498 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
increases reduction
multiple interactions		 ISO
EXP		 sanguinarine results in decreased expression of NQO1 mRNA; sanguinarine results in decreased expression of NQO1 protein
NQO1 protein results in increased reduction of sanguinarine
NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 protein]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX protein]		 CTD PMID:22021338 PMID:24300172 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of PMAIP1 mRNA CTD PMID:24345465 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of PYCARD mRNA CTD PMID:24345465 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO sanguinarine results in decreased expression of SNAI1 protein CTD PMID:19063874 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO sanguinarine inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of TNFRSF1B mRNA CTD PMID:24345465 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases expression		 ISO [sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [sanguinarine co-treated with arsenic trioxide] results in increased expression of TNFSF10 mRNA; [sanguinarine co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [sanguinarine co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; TNFSF10 protein results in increased susceptibility to [arsenic trioxide co-treated with sanguinarine]
sanguinarine results in increased expression of TNFSF10 mRNA		 CTD PMID:24345465 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899 		JBrowse link
G Tyr tyrosinase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of TYR protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of TYR protein CTD PMID:20691676 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of XIAP protein CTD PMID:23660334 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        biochemical role 19301
          metabolite 19282
            alkaloid 5624
              isoquinoline alkaloid 1135
                benzophenanthridine alkaloid 98
                  (+/-)-6-Acetonyldihydrochelerythrine 0
                  (+/-)-6-Acetonyldihydrosanguinarine 0
                  (+/-)-Bocconarborine A 0
                  (+/-)-Bocconarborine B 0
                  (+/-)-Homochelidonine 0
                  10-hydroxydihydrochelirubine 0
                  10-hydroxydihydrosanguinarine 0
                  12-hydroxydihydrochelirubine 0
                  6-(2-Hydroxyethyl)-5,6-dihydrosanguinarine 0
                  6-Oxochelerythrine 0
                  Angoline 0
                  Chelilutine 0
                  Decarine 0
                  Fagaridine 0
                  Hydroxysanguinarine 0
                  N-Methyl-2,3,7,8-tetramethoxy-5,6-dihydrobenzophenathridine-6-ethanoic acid 0
                  N-methyl-2,3,7,8-tetramethoxybenzophenanthridine-6(5H)-one 0
                  Norchelerythrine 0
                  Sanguilutine 0
                  Sanguirubine 0
                  chelerythrine 51
                  chelidonine + 9
                  chelirubine + 0
                  corynoline 0
                  dihydrochelerythrine 0
                  dihydrochelirubine 0
                  dihydromacarpine 0
                  dihydrosanguinarine + 3
                  fagaronine 0
                  macarpine 0
                  sanguinarine + 51
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                organic heterocyclic compound 18510
                                  organonitrogen heterocyclic compound 17521
                                    benzophenanthridine 121
                                      benzophenanthridine alkaloid 98
                                        (+/-)-6-Acetonyldihydrochelerythrine 0
                                        (+/-)-6-Acetonyldihydrosanguinarine 0
                                        (+/-)-Bocconarborine A 0
                                        (+/-)-Bocconarborine B 0
                                        (+/-)-Homochelidonine 0
                                        10-hydroxydihydrochelirubine 0
                                        10-hydroxydihydrosanguinarine 0
                                        12-hydroxydihydrochelirubine 0
                                        6-(2-Hydroxyethyl)-5,6-dihydrosanguinarine 0
                                        6-Oxochelerythrine 0
                                        Angoline 0
                                        Chelilutine 0
                                        Decarine 0
                                        Fagaridine 0
                                        Hydroxysanguinarine 0
                                        N-Methyl-2,3,7,8-tetramethoxy-5,6-dihydrobenzophenathridine-6-ethanoic acid 0
                                        N-methyl-2,3,7,8-tetramethoxybenzophenanthridine-6(5H)-one 0
                                        Norchelerythrine 0
                                        Sanguilutine 0
                                        Sanguirubine 0
                                        chelerythrine 51
                                        chelidonine + 9
                                        chelirubine + 0
                                        corynoline 0
                                        dihydrochelerythrine 0
                                        dihydrochelirubine 0
                                        dihydromacarpine 0
                                        dihydrosanguinarine + 3
                                        fagaronine 0
                                        macarpine 0
                                        sanguinarine + 51
paths to the root