Bcl2 (BCL2, apoptosis regulator) - Rat Genome Database

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Gene: Bcl2 (BCL2, apoptosis regulator) Rattus norvegicus
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Symbol: Bcl2
Name: BCL2, apoptosis regulator
RGD ID: 2199
Description: Enables BH domain binding activity. Involved in several processes, including response to peptide; response to purine-containing compound; and response to vitamin. Located in mitochondrial crista and perinuclear region of cytoplasm. Used to study several diseases, including brain ischemia (multiple); end stage renal disease; gastric ulcer; intestinal disease (multiple); and status epilepticus. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); carcinoma (multiple); intrinsic cardiomyopathy (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; prostate cancer; and urinary bladder cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator); PARTICIPATES IN intrinsic apoptotic pathway; ceramide signaling pathway; erythropoietin signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-sesamin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apoptosis regulator Bcl-2; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl-2; Bcl-2alpha; Bcl2-like protein; ENSRNOG00000067693
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Iddm12
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81323,204,464 - 23,366,900 (-)NCBIGRCr8
mRatBN7.21322,689,783 - 22,853,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1322,684,989 - 22,853,743 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1322,684,989 - 22,853,743 (-)NCBImRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1323,013,354 - 23,175,038 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01324,297,817 - 24,459,509 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01322,983,528 - 23,145,223 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01326,605,426 - 26,769,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1326,605,426 - 26,769,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01331,758,213 - 31,920,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41312,730,736 - 12,905,108 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11312,730,735 - 12,905,108 (-)NCBI
Celera1322,550,362 - 22,711,143 (-)NCBICelera
Cytogenetic Map13p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (IEP)
acute kidney failure  (IEP)
Acute Lung Injury  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoma  (ISO)
Adrenal Insufficiency  (IEP)
AIDS-Related Kaposi Sarcoma  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (IEP)
Alzheimer's disease  (IDA,IEP,ISO)
amyotrophic lateral sclerosis  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
asthma  (ISO)
atherosclerosis  (IEP)
autistic disorder  (ISO)
azoospermia  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bilirubin metabolic disorder  (IEP)
brain glioma  (IDA,IEP)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (IEP,IMP)
brain ischemia  (IDA)
Breast Neoplasms  (ISO)
Burns  (IEP)
carcinoma  (ISO)
Cerebral Hemorrhage  (ISO)
cervix uteri carcinoma in situ  (ISO)
chromosome 18q deletion syndrome  (ISO)
Chronic Intermittent Hypoxia  (IDA)
clear cell adenocarcinoma  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (IDA)
Colonic Neoplasms  (IEP,ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (IEP)
contact dermatitis  (ISO)
dementia  (IEP)
Diabetic Cardiomyopathies  (IDA,ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (IEP)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
end stage renal disease  (IDA)
Endometrial Neoplasms  (ISO)
endometriosis  (IDA,ISO)
Endotoxemia  (IEP)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Allergic Asthma  (IEP)
Experimental Arthritis  (IEP)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IDA,IEP)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IDA)
Familial Prostate Cancer  (ISO)
Fetal Growth Retardation  (IEP)
follicular lymphoma  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (IDA)
genetic disease  (ISO)
glaucoma  (IEP)
Head and Neck Neoplasms  (ISO)
Hemorrhagic Shock  (IEP)
hepatocellular carcinoma  (IEP,ISO)
Huntington's disease  (IEP)
hypertension  (IEP,ISO)
hypertrophic cardiomyopathy  (IEP,ISO)
Hypothermia  (IEP)
impotence  (IDA,IEP,ISO)
intestinal disease  (IDA)
Intestinal Neoplasms  (ISO)
intracranial aneurysm  (ISO)
Kashin-Beck Disease  (ISO)
Kidney Reperfusion Injury  (IEP)
Knee Osteoarthritis  (IEP)
learning disability  (ISO)
leiomyoma  (IEP,ISO)
Liver Reperfusion Injury  (IDA,IEP,ISO)
Lung Reperfusion Injury  (IEP)
lung small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
male infertility  (ISO)
malignant mesothelioma  (ISO)
melanoma  (ISO)
Memory Disorders  (ISO)
mesenchymal chondrosarcoma  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (IEP)
morphine dependence  (IEP)
Multi-Infarct Dementia  (IEP)
multiple congenital anomalies-hypotonia-seizures syndrome 1  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (IEP)
Myocardial Reperfusion Injury  (IDA,IEP)
nasopharynx carcinoma  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
Nerve Degeneration  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (IEP)
oligomeganephronia  (ISS)
Optic Nerve Injuries  (IEP)
oral mucosa leukoplakia  (IEP)
osteoarthritis  (ISO)
osteochondrodysplasia  (ISO)
osteoporosis  (IEP)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (ISO)
plasmacytoma  (ISO)
polycystic ovary syndrome  (IEP,ISO)
post-traumatic stress disorder  (IEP)
Premature Aging  (ISO)
priapism  (IEP)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IEP)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (IDA)
retinal degeneration  (IEP,ISO)
Sarcopenia  (IEP)
Soft Tissue Neoplasms  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (IEP)
status epilepticus  (IDA,IEP)
stomach cancer  (ISO)
Subarachnoid Hemorrhage  (IEP)
synovial sarcoma  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
Testis Reperfusion Injury  (IEP)
Tongue Neoplasms  (IEP)
tongue squamous cell carcinoma  (ISO)
transient cerebral ischemia  (IDA,IEP)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
urinary bladder cancer  (ISO)
Ventricular Remodeling  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP)
(+)-sesamin  (EXP,ISO)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (EXP)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-gambogic acid  (ISO)
(-)-noscapine  (ISO)
(-)-selegiline  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one  (ISO)
(E)-roxithromycin  (ISO)
(E)-thiamethoxam  (ISO)
(E,E)-germacrone  (ISO)
(R)-adrenaline  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R)-salsolinol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(R,S)-Scoulerine  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dichloropropan-2-ol  (ISO)
1,3-dinitrobenzene  (EXP,ISO)
1,3-thiazolidine-2,4-dione  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
10-Hydroxycamptothecin  (ISO)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-pyrazole  (ISO)
2''-galloylhyperin  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-acetamidofluorene  (EXP)
2-acetamidophenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-aminoethoxydiphenylborane  (EXP)
2-chloroethanol  (EXP)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (EXP,ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP,ISO)
2-tert-butylhydroquinone  (EXP,ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
20-hydroxyecdysone  (ISO)
20-hydroxypregn-4-en-3-one  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-Dichlorobenzidine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3-methylthiopropanal  (ISO)
3-nitropropanoic acid  (EXP,ISO)
3-phenylprop-2-enal  (EXP,ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-1,8-naphthalimide  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-nitroaniline  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-Hydroxycapric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
6-anilino-5,8-quinolinedione  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-oxocampestanol  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (ISO)
7-ketocholesterol  (EXP)
8-Br-cAMP  (ISO)
8-OH-DPAT  (ISO)
9,10-anthraquinone  (ISO)
9,10-phenanthroquinone  (ISO)
9,11,13-octadecatrienoic acid  (ISO)
9-cis-retinoic acid  (ISO)
9-Methoxycamptothecin  (ISO)
[6]-Shogaol  (ISO)
abamectin  (EXP)
ABT-737  (ISO)
acadesine  (EXP,ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetamiprid  (ISO)
acetic acid  (EXP)
acetylsalicylic acid  (EXP,ISO)
acifluorfen  (ISO)
aconitine  (EXP)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
actinomycin D  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
agomelatine  (EXP)
AH23848  (ISO)
alachlor  (ISO)
alantolactone  (ISO)
alborixin  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alginic acid  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allethrin  (EXP,ISO)
allicin  (ISO)
allopurinol  (EXP)
alloxan  (EXP)
Allyl chloride  (EXP)
Aloe emodin  (ISO)
Aloperine  (EXP)
alpha-amanitin  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-mangostin  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (ISO)
alpinumisoflavone  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
AM-251  (ISO)
amentoflavone  (ISO)
amidotrizoic acid  (ISO)
amifostine  (ISO)
amino acid  (ISO)
aminoguanidine  (ISO)
aminophylline  (ISO)
amiodarone  (EXP,ISO)
amitriptyline  (EXP)
amitrole  (EXP)
amlexanox  (ISO)
amlodipine  (EXP,ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amodiaquine  (ISO)
amphetamine  (EXP,ISO)
amsacrine  (ISO)
andrographolide  (ISO)
Anemoside B4  (ISO)
anethole  (EXP)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony(0)  (EXP,ISO)
antimycin A  (ISO)
Antrocin  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
aprepitant  (ISO)
arachidonic acid  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
arecoline  (EXP,ISO)
aristolochic acid A  (EXP,ISO)
arjunolic acid  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP,ISO)
asarone  (ISO)
asbestos  (ISO)
asiatic acid  (EXP,ISO)
aspartame  (EXP,ISO)
Aspidin  (ISO)
astemizole  (EXP)
astilbin  (ISO)
astragaloside IV  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
Atranorin  (ISO)
atrasentan  (EXP)
atrazine  (EXP,ISO)
auranofin  (ISO)
aurantio-obtusin  (ISO)
Auriculasin  (ISO)
avermectin  (ISO)
azadirachtin A  (ISO)
azide  (ISO)
aziridines  (ISO)
bafilomycin A1  (EXP,ISO)
baicalein  (ISO)
baicalin  (EXP,ISO)
bathocuproine disulfonic acid  (ISO)
Bavachinin  (ISO)
Bay-K-8644  (ISO)
beauvericin  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benomyl  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (ISO)
benzoic acid  (ISO)
benzophenanthridine  (ISO)
benzothiazoles  (ISO)
berberine  (EXP,ISO)
Berberrubine  (ISO)
Bergenin  (EXP)
Besigomsin  (ISO)
beta-aminopropionitrile  (ISO)
beta-carotene  (ISO)
beta-Elemonic acid  (ISO)
beta-ionone  (ISO)
beta-naphthoflavone  (EXP)
Beta-Solamarine  (ISO)
Betanin  (EXP)
betulin  (ISO)
betulinic acid  (ISO)
bezafibrate  (EXP)
bicalutamide  (ISO)
bifenthrin  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP,ISO)
boric acid  (EXP,ISO)
boron atom  (EXP)
borrelidin  (ISO)
bortezomib  (ISO)
BQ 123  (EXP,ISO)
BQ 485  (EXP)
brassinin  (ISO)
brassinolide  (ISO)
brazilin  (ISO)
bromuconazole  (EXP)
brucine  (ISO)
Brusatol  (ISO)
bucladesine  (ISO)
budesonide  (ISO)
bufalin  (ISO)
bupivacaine  (ISO)
buprofezin  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
butein  (ISO)
Butralin  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium nitrate  (EXP)
cadmium sulfide  (ISO)
cafestol  (ISO)
caffeine  (EXP)
cajanol  (ISO)
calcidiol  (ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
calcium oxalate  (ISO)
calycosin-7-O-beta-D-glucoside  (ISO)
camalexin  (ISO)
camptothecin  (ISO)
Candesartan cilexetil  (EXP)
cannabidiol  (EXP,ISO)
cantharidin  (EXP,ISO)
capillarisin  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
captan  (ISO)
carbachol  (EXP,ISO)
carbamate ester  (ISO)
carbamazepine  (EXP)
carbendazim  (EXP)
CARBENOXOLONE  (EXP,ISO)
carbidopa  (ISO)
carbofuran  (EXP)
carbon disulfide  (ISO)
carbon nanotube  (EXP,ISO)
carboplatin  (ISO)
carboxy-PTIO  (ISO)
Cardamonin  (EXP)
Cardanol  (ISO)
carmustine  (ISO)
carnosic acid  (EXP,ISO)
carnosine  (EXP,ISO)
Carnosol  (ISO)
carvacrol  (EXP)
carvedilol  (EXP)
casticin  (ISO)
catalpol  (ISO)
CEDRELONE  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
ceric oxide  (ISO)
ceritinib  (ISO)
ceruletide  (ISO)
cetrorelix  (EXP,ISO)
chalcones  (ISO)
chelerythrine  (EXP,ISO)
chelidonine  (ISO)
Chikusetsusaponin-IV  (ISO)
Chikusetsusaponin-V  (ISO)
CHIR 99021  (ISO)
chitosan  (EXP,ISO)
chlorambucil  (ISO)
chlordecone  (ISO)
chloroacetic acid  (ISO)
chlorogenic acid  (EXP,ISO)
chloroprene  (ISO)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
Cholestane-3,5,6-triol  (EXP)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (EXP,ISO)
chrysazin  (ISO)
chrysin  (EXP,ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cilnidipine  (EXP,ISO)
cilostazol  (EXP,ISO)
cimetidine  (ISO)
Cinobufagin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
Citreoviridin  (EXP,ISO)
citric acid  (ISO)
citronellal  (EXP)
cladribine  (ISO)
clofibrate  (ISO)
clonazepam  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clorgyline  (ISO)
clozapine  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
codeinone  (ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
colistin  (EXP,ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
coptisine  (ISO)
cordycepin  (EXP,ISO)
corilagin  (EXP)
corosolic acid  (EXP,ISO)
corticosterone  (EXP)
Corynoxine B  (ISO)
coumarin  (ISO)
coumarins  (ISO)
coumermycin A1  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (EXP,ISO)
crotonaldehyde  (EXP)
crystal violet  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin B  (ISO)
cucurbitacin E  (EXP,ISO)
cudraflavone B  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyanamide  (EXP)
Cyanoginosin  (EXP)
cycloheximide  (ISO)
Cyclopamine  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (EXP,ISO)
cypermethrin  (EXP,ISO)
cytarabine  (ISO)
cytochalasin B  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (EXP)
D-penicillamine  (ISO)
daidzein  (ISO)
dantrolene  (EXP)
dapagliflozin  (EXP)
dapoxetine  (EXP)
DAPT  (EXP)
daunorubicin  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deferiprone  (ISO)
deguelin  (ISO)
dehydroascorbic acid  (ISO)
dehydrocostus lactone  (ISO)
dehydroepiandrosterone  (EXP)
dehydroepiandrosterone sulfate  (EXP)
delphinidin  (ISO)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
Dendrobine  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (EXP,ISO)
desipramine  (EXP)
desloratadine  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
dextromethorphan  (EXP)
Di-n-hexyl phthalate  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
diazoxide  (EXP,ISO)
dibenziodolium  (ISO)
dibenzoylmethane  (ISO)
dibromoacetic acid  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
Didymin  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
diepoxybutane  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (EXP,ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydroactinidiolide  (ISO)
diiodine  (ISO)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
dimethomorph  (ISO)
Dimethyl phthalate  (EXP)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioscin  (ISO)
diosgenin  (EXP,ISO)
diosmin  (EXP,ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
diprotium oxide  (ISO)
diquat  (EXP,ISO)
disodium cromoglycate  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dithionite(2-)  (EXP,ISO)
dizocilpine maleate  (EXP,ISO)
dobutamine  (ISO)
Dodecyl gallate  (ISO)
domoic acid  (ISO)
donepezil hydrochloride  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
drimenol  (ISO)
dronedarone  (EXP)
ebselen  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
Echinocystic acid  (EXP)
edaravone  (EXP)
edelfosine  (ISO)
elemental boron  (EXP)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
ellipticine  (ISO)
embelin  (ISO)
emodin  (EXP,ISO)
enalapril  (EXP)
enalaprilat dihydrate  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epichlorohydrin  (ISO)
epoxomicin  (ISO)
erdosteine  (EXP)
eriocitrin  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin estolate  (EXP)
esculetin  (ISO)
estramustine  (ISO)
ethanol  (EXP,ISO)
ethidium  (ISO)
ethylbenzene  (EXP)
ethylene glycol  (EXP)
Ethylenethiourea  (ISO)
etodolac  (ISO)
etoposide  (ISO)
eugenol  (ISO)
EUK-134  (ISO)
Evodiamine  (ISO)
excitatory amino acid agonist  (ISO)
farrerol  (ISO)
fasudil  (EXP)
febuxostat  (EXP)
fenbendazole  (ISO)
fenhexamid  (ISO)
fenitrothion  (EXP,ISO)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP,ISO)
ferric oxide  (EXP,ISO)
ferrosoferric oxide  (ISO)
ferrostatin-1  (EXP)
ferulic acid  (EXP)
finasteride  (EXP)
fingolimod hydrochloride  (ISO)
fipronil  (EXP,ISO)
fisetin  (EXP,ISO)
flavanones  (ISO)
flavones  (EXP,ISO)
flavonoids  (ISO)
flavonols  (ISO)
fluazinam  (ISO)
flubendazole  (ISO)
flucytosine  (ISO)
fludioxonil  (ISO)
flumethrin  (ISO)
fluoxetine  (EXP,ISO)
flutamide  (EXP)
fluvastatin  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (EXP,ISO)
formoterol fumarate  (ISO)
Forsythiaside  (ISO)
fraxetin  (ISO)
fructose  (EXP,ISO)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
fumagillin  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (EXP)
Fusarenone X  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (ISO)
galactose  (EXP,ISO)
galangin  (ISO)
galanthamine  (EXP)
Galbanic acid  (ISO)
gallein  (EXP)
gallic acid  (EXP,ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-tocopherol  (ISO)
ganciclovir  (ISO)
Ganoderic acid A  (ISO)
Garcinol  (ISO)
gardenin B  (ISO)
Gastrodin  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
Geniposide  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
Gentiopicrin  (ISO)
Geraniin  (ISO)
geraniol  (EXP,ISO)
geranyl acetate  (ISO)
gingerol  (ISO)
ginkgetin  (ISO)
Ginkgoic acid  (ISO)
Ginkgolide C  (EXP)
ginsenoside Rd  (EXP)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP,ISO)
ginsenoside Rg2  (EXP)
glabridin  (ISO)
gliclazide  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (EXP)
glycerol  (EXP)
glycidol  (EXP)
glycine betaine  (EXP,ISO)
glycyrrhetinate  (EXP,ISO)
glycyrrhetinic acid  (EXP,ISO)
glycyrrhizinic acid  (ISO)
glyoxylic acid  (ISO)
glyphosate  (EXP,ISO)
gold atom  (EXP,ISO)
gold(0)  (EXP,ISO)
Goserelin  (ISO)
gossypol  (ISO)
graphene oxide  (ISO)
graphite  (ISO)
Grifolin  (ISO)
GSK690693  (ISO)
guanidines  (ISO)
guggulsterone  (ISO)
Gyrophoric acid  (ISO)
haloperidol  (EXP)
hemin  (EXP,ISO)
heparin  (ISO)
heptachlor  (EXP)
hesperetin  (EXP,ISO)
hesperidin  (EXP,ISO)
hexachlorophene  (EXP)
hexadecanoic acid  (EXP,ISO)
hexaflumuron  (EXP)
hexane  (EXP)
hinokiflavone  (ISO)
histamine  (EXP)
homocysteine  (EXP,ISO)
homoeriodictyol  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
hydroxychloroquine  (ISO)
hydroxytyrosol  (EXP,ISO)
hymexazol  (EXP)
hyperforin  (EXP,ISO)
hypoxanthine  (ISO)
icariin  (EXP,ISO)
icariside II  (ISO)
ICI 118551  (ISO)
icosanoid  (EXP)
idelalisib  (ISO)
Idoxifene  (EXP)
ifosfamide  (EXP,ISO)
Ilimaquinone  (ISO)
imidacloprid  (EXP)
Imipenem-cilastatin  (EXP)
imiquimod  (ISO)
indirubin  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
inositol  (ISO)
iodoacetic acid  (ISO)
iohexol  (EXP,ISO)
Ioversol  (EXP)
iprodione  (EXP)
irbesartan  (EXP,ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dextran  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (EXP,ISO)
isocarbophos  (ISO)
isoflavones  (EXP,ISO)
isoflurane  (EXP)
Isoliensinine  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isoorientin  (EXP)
isoprenaline  (EXP,ISO)
isoquinoline-1,5-diol  (ISO)
isorhamnetin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
JBIR-99  (ISO)
juglone  (ISO)
kaempferol  (EXP,ISO)
kahweol  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP,ISO)
ketoconazole  (ISO)
KN-93  (ISO)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (ISO)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-dehydroascorbic acid  (ISO)
L-gamma-glutamyl-L-cysteine  (EXP)
L-glutamic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
L-mimosine  (ISO)
lactacystin  (EXP,ISO)
lamivudine  (ISO)
lamotrigine  (EXP)
lansoprazole  (EXP)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
leptomycin B  (ISO)
letrozole  (EXP)
leuprolide  (EXP)
levamisole  (ISO)
levetiracetam  (EXP)
levonorgestrel  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lignan  (ISO)
limonene  (ISO)
limonin  (ISO)
linalool  (ISO)
linoleic acid  (EXP)
linsidomine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
liraglutide  (EXP,ISO)
lisinopril dihydrate  (ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP,ISO)
loganin  (ISO)
lonafarnib  (ISO)
Longikaurin A  (ISO)
lonidamine  (ISO)
loperamide  (ISO)
losartan  (EXP)
lovastatin  (EXP,ISO)
Lupalbigenin  (ISO)
lupeol  (EXP,ISO)
Lupiwighteone  (ISO)
lutein  (ISO)
luteolin  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
maculosin  (ISO)
madecassoside  (ISO)
magnesium atom  (EXP)
magnesium oxide  (ISO)
Magnolol  (ISO)
malaoxon  (ISO)
malathion  (EXP,ISO)
malonic acid  (EXP)
malvidin  (ISO)
mancozeb  (EXP,ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
mebendazole  (ISO)
Mecamylamine  (ISO)
mechlorethamine  (ISO)
meglumine amidotrizoate  (EXP,ISO)
MeIQx  (ISO)
melamine  (ISO)
Melarsoprol  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
melphalan  (ISO)
memantine  (EXP,ISO)
menadione  (EXP,ISO)
menaquinone  (EXP)
mercaptopurine  (ISO)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
mesalamine  (EXP)
metaproterenol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methomyl  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methoxychlor  (EXP,ISO)
methyl caffeate  (ISO)
methyl methanesulfonate  (ISO)
methylene blue  (EXP)
methylglyoxal  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
methylseleninic acid  (EXP)
metipranolol  (EXP)
metiram  (ISO)
metrafenone  (ISO)
mevalonic acid  (EXP,ISO)
mevinphos  (EXP)
microcystin  (EXP)
microcystin RR  (ISO)
microcystin-LR  (EXP,ISO)
midazolam  (EXP)
mifepristone  (ISO)
miglustat  (ISO)
minocycline  (EXP,ISO)
mitomycin C  (ISO)
Mitotane  (EXP,ISO)
mitoxantrone  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotophos  (EXP)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (EXP,ISO)
montelukast  (ISO)
morin  (EXP,ISO)
morphine  (EXP,ISO)
Morroniside  (EXP,ISO)
morusin  (ISO)
mycophenolic acid  (ISO)
myricetin  (ISO)
myricitrin  (ISO)
myristicin  (ISO)
Myrtucommulone A  (ISO)
N'-Nitrosonornicotine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylsphingosine  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-phosphocreatine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nabumetone  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
naloxone  (EXP,ISO)
naphthalene  (ISO)
naphthalenes  (ISO)
naringin  (EXP,ISO)
Neferine  (EXP)
neoastilbin  (ISO)
neomycin  (ISO)
nerolidol  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel ferrite  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicorandil  (EXP)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nilotinib  (ISO)
nimesulide  (EXP,ISO)
nimodipine  (EXP,ISO)
Nitidine  (ISO)
nitrendipine  (EXP)
nitric oxide  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
nitroprusside  (EXP,ISO)
nitroxoline  (ISO)
nobiletin  (ISO)
nocodazole  (ISO)
Nodularin  (ISO)
Nonylphenol  (ISO)
Norbinaltorphimine  (ISO)
NORCANTHARIDIN  (ISO)
Norethindrone enanthate  (EXP)
norfloxacin  (ISO)
norwogonin  (EXP,ISO)
notoginsenoside R1  (EXP,ISO)
NS 1619  (ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
o-anisidine  (ISO)
o-cresol  (EXP)
Obacunone  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
octyl gallate  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleuropein  (EXP,ISO)
oligomycin A  (ISO)
oligopeptide  (ISO)
Olmesartan medoxomil  (EXP)
omacetaxine mepesuccinate  (ISO)
omeprazole  (ISO)
Ophiopogonin D  (ISO)
orciprenaline  (ISO)
organoselenium compound  (EXP)
oridonin  (EXP,ISO)
orlistat  (EXP)
oroxylin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
oxalic acid  (ISO)
oxaliplatin  (EXP,ISO)
oxidopamine  (EXP,ISO)
oxomalononitrile  (ISO)
oxytocin  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
Pachymic acid  (ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (EXP,ISO)
palmatine  (ISO)
Palmitic acid(d3)  (ISO)
pamidronate  (ISO)
Panaxynol  (EXP)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paricalcitol  (ISO)
parthenolide  (ISO)
pefloxacin  (ISO)
pemetrexed  (ISO)
pendimethalin  (EXP)
Pendulone  (ISO)
pentanal  (ISO)
pentobarbital  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (EXP)
perillyl alcohol  (ISO)
permethrin  (EXP,ISO)
peroxynitrous acid  (EXP)
pevonedistat  (ISO)
phenazine-1-carboxylic acid  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP,ISO)
phenytoin  (ISO)
PhIP  (ISO)
phloretin  (EXP)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidylcholine  (ISO)
phosphoramide mustard  (EXP)
phylloquinone  (EXP,ISO)
phytol  (ISO)
phytosphingosine  (ISO)
piclamilast  (EXP)
picoxystrobin  (ISO)
pimozide  (ISO)
pinostrobin  (EXP,ISO)
pioglitazone  (EXP)
piperazine  (ISO)
piperidine  (ISO)
piperine  (ISO)
Pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
PK-11195  (EXP,ISO)
platinum  (ISO)
platinum(0)  (ISO)
platycodin D  (ISO)
plumbagin  (EXP)
poly(I:C)  (ISO)
Polygodial  (ISO)
polysulfur  (ISO)
ponatinib  (ISO)
Ponicidin  (ISO)
porphyrins  (ISO)
potassium bromate  (EXP)
potassium cyanide  (EXP)
potassium dichromate  (EXP,ISO)
potassium iodide  (EXP)
Pramanicin  (ISO)
Pranoprofen  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP,ISO)
probenecid  (ISO)
probucol  (EXP)
procyanidin B2  (ISO)
prodigiosin  (EXP)
progesterone  (EXP,ISO)
promethazine  (ISO)
propionic acid  (EXP)
propofol  (EXP,ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
Protolichesterinic acid  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
Punicalagin  (EXP,ISO)
purine-6-thiol  (ISO)
puromycin  (ISO)
putrescine  (EXP)
pyrethrins  (EXP,ISO)
pyridaben  (ISO)
Pyridostigmine bromide  (ISO)
pyridoxal 5'-phosphate  (EXP)
pyrovalerone  (ISO)
pyrroles  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrroloquinoline quinone  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
quinazolines  (ISO)
quinolinic acid  (EXP)
quinoxyfen  (ISO)
quizartinib  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ramipril  (EXP)
ranitidine  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
remdesivir  (ISO)
reserpine  (EXP)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (ISO)
Riluzole  (EXP)
rimonabant  (ISO)
ritonavir  (ISO)
rivastigmine  (EXP)
Ro 31-8220  (EXP)
rocaglamide  (ISO)
roflumilast  (EXP,ISO)
rolipram  (EXP)
ropinirole  (ISO)
rosmarinic acid  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
royal jelly  (EXP,ISO)
RU 58668  (ISO)
rubitecan  (ISO)
ruthenium atom  (EXP)
rutin  (EXP,ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-allylcysteine  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
S-nitrosoglutathione  (ISO)
safrole  (ISO)
Salidroside  (EXP,ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (EXP)
salvianolic acid B  (EXP)
Sanggenon C  (EXP,ISO)
sanguinarine  (EXP,ISO)
sappanchalcone  (ISO)
sarin  (EXP)
sarpogrelate  (ISO)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SB-239063  (EXP)
SCH 23390  (EXP,ISO)
SCH772984  (ISO)
scoparone  (ISO)
scopolamine  (ISO)
Se-methyl-L-selenocysteine  (EXP,ISO)
Se-methylselenocysteine  (EXP,ISO)
selenium atom  (EXP,ISO)
selenocystine  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
Sesamol  (ISO)
sevoflurane  (EXP,ISO)
Shikonin  (EXP,ISO)
sibutramine  (ISO)
sildenafil citrate  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (EXP)
sodium chloride  (EXP)
sodium cholate  (ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sodium disulfite  (ISO)
sodium fluoride  (EXP,ISO)
sodium nitrite  (EXP)
sodium silicate  (EXP)
Sophoricoside  (ISO)
sorafenib  (ISO)
soybean oil  (EXP)
spermine  (EXP,ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (EXP)
Spiroquinazoline  (ISO)
squalene  (EXP)
stattic  (ISO)
staurosporine  (ISO)
stavudine  (ISO)
sterigmatocystin  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
styrene oxide  (EXP,ISO)
succimer  (EXP)
sulfadimethoxine  (EXP)
sulfaphenazole  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP,ISO)
sulfur atom  (ISO)
sulfur dioxide  (ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulpiride  (ISO)
sunitinib  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
Swertiamarin  (EXP)
syringic acid  (ISO)
syringin  (ISO)
T-2 toxin  (EXP,ISO)
tacrine  (ISO)
tacrolimus hydrate  (EXP,ISO)
tadalafil  (EXP,ISO)
taiwanin C  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
Tariquidar  (ISO)
taurine  (EXP)
taurocholic acid  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tazarotene  (ISO)
tebuconazole  (EXP,ISO)
telmisartan  (EXP)
temozolomide  (ISO)
TEMPO  (ISO)
Temsirolimus  (ISO)
terazosin  (ISO)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloroethene  (ISO)
tetrachlorohydroquinone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (EXP)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
theaflavin  (ISO)
theophylline  (ISO)
thiamethoxam  (ISO)
thiamine(1+) chloride  (EXP,ISO)
thioacetamide  (EXP,ISO)
thiostrepton  (ISO)
Thiotepa  (ISO)
thymol  (EXP,ISO)
thymol sulfate(1-)  (EXP,ISO)
thymoquinone  (EXP,ISO)
thyroxine  (EXP)
tigecycline  (EXP)
tin(II) chloride (anhydrous)  (EXP)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
Tomentosin  (ISO)
toosendanin  (ISO)
topotecan  (ISO)
trametinib  (ISO)
tranexamic acid  (ISO)
trans-anethole  (EXP)
trans-cinnamic acid  (EXP)
trans-piceid  (ISO)
tranylcypromine  (EXP)
triacetin  (ISO)
triazoles  (ISO)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (EXP)
tributyrin  (ISO)
tricetin  (ISO)
trichlorfon  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
trifluoperazine  (ISO)
trilobatin  (EXP)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
Tubeimoside I  (ISO)
tubocurarine  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
umbelliferone  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP)
vemurafenib  (ISO)
venetoclax  (ISO)
venlafaxine hydrochloride  (EXP)
venom  (ISO)
verapamil  (ISO)
Vernodalin  (ISO)
verteporfin  (EXP)
Vicanicin  (ISO)
vildagliptin  (EXP)
vinclozolin  (ISO)
vincristine  (EXP,ISO)
vindesine  (ISO)
vismodegib  (ISO)
vitamin D  (ISO)
vitamin E  (EXP,ISO)
vitexin  (ISO)
vorinostat  (EXP,ISO)
warfarin  (EXP)
water  (ISO)
WIN 55212-2  (ISO)
withaferin A  (EXP,ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (EXP,ISO)
Xanthorrhizol  (ISO)
xenon atom  (EXP)
xenon(0)  (EXP)
Y-27632  (ISO)
ytterbium  (ISO)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zerumbone  (EXP,ISO)
zidovudine  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP,ISO)
ziram  (EXP)
zoledronic acid  (ISO)
zolmitriptan  (EXP)
zoxamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IEA,ISO)
animal organ morphogenesis  (ISO)
apoptotic mitochondrial changes  (ISO)
apoptotic process  (ISO)
axon regeneration  (IEA,ISO)
axonogenesis  (IEA,ISO)
B cell apoptotic process  (IEA,ISO)
B cell differentiation  (ISO)
B cell homeostasis  (IEA,ISO)
B cell lineage commitment  (IEA,ISO)
B cell proliferation  (IEA,ISO)
B cell receptor signaling pathway  (IEA,ISO)
behavioral fear response  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
calcium ion transport into cytosol  (IEA,ISO)
CD8-positive, alpha-beta T cell lineage commitment  (IEA,ISO)
cell migration  (ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cell-cell adhesion  (IEA,ISO)
cellular response to fluoride  (IEP)
cellular response to glucose starvation  (IEA,ISO)
cellular response to glucose stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to hypoxia  (IEA,IEP,ISO)
cellular response to organic cyclic compound  (IEP)
cellular response to organic substance  (IEA,ISO)
cerebral cortex development  (IEP)
cochlear nucleus development  (IEA,ISO)
defense response to virus  (IEA,ISO)
dendritic cell apoptotic process  (IEA,ISO)
developmental growth  (ISO)
developmental pigmentation  (ISO)
digestive tract morphogenesis  (IEA,ISO)
DNA damage response  (ISO)
ear development  (IEA,ISO)
endoplasmic reticulum calcium ion homeostasis  (IEA,ISO)
epithelial cell apoptotic process  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
focal adhesion assembly  (IEA,ISO)
G1/S transition of mitotic cell cycle  (IEA,ISO)
gland morphogenesis  (IEA,ISO)
glial cell apoptotic process  (IEP)
glomerulus development  (IEA,ISO)
hair follicle morphogenesis  (IEA,ISO)
hematopoietic stem cell differentiation  (IEA,ISO)
hemopoiesis  (ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
immune system development  (ISO)
intracellular calcium ion homeostasis  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA,ISO)
kidney development  (ISO)
leukocyte homeostasis  (ISO)
liver regeneration  (IEP)
lymphocyte apoptotic process  (ISO)
lymphocyte homeostasis  (ISO)
lymphoid progenitor cell differentiation  (IEA,ISO)
male gonad development  (IEA,ISO)
melanin metabolic process  (IEA,ISO)
melanocyte differentiation  (IEA,ISO)
mesenchymal cell development  (IEA,ISO)
metanephros development  (IEA,ISO)
mitotic cell cycle  (ISO)
motor neuron apoptotic process  (IEA,ISO)
myeloid cell apoptotic process  (IEA,ISO)
negative regulation of anoikis  (IEA,ISO)
negative regulation of apoptotic process  (IDA,IMP,ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of autophagy  (IEA,ISO,ISS)
negative regulation of B cell apoptotic process  (IEA,ISO)
negative regulation of calcium ion transport into cytosol  (IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cell growth  (IEA,ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cellular pH reduction  (IEA,ISO)
negative regulation of dendritic cell apoptotic process  (IEA,ISO)
negative regulation of epithelial cell apoptotic process  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
negative regulation of intrinsic apoptotic signaling pathway  (IBA,IEA,ISO)
negative regulation of lymphocyte apoptotic process  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of motor neuron apoptotic process  (IEA,ISO)
negative regulation of myeloid cell apoptotic process  (IEA,ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of ossification  (IEA,ISO)
negative regulation of osteoblast proliferation  (IEA,ISO)
negative regulation of reactive oxygen species metabolic process  (IEA,ISO)
negative regulation of retinal cell programmed cell death  (IEA,ISO)
negative regulation of T cell apoptotic process  (IEA,ISO)
neuron apoptotic process  (ISO)
neuron maturation  (IEA,ISO)
oligodendrocyte differentiation  (IEP)
oocyte development  (IEA,ISO)
organ growth  (IEA,ISO)
ossification  (IEA,ISO)
osteoblast proliferation  (IEA,ISO)
ovarian follicle development  (IEA,IEP,ISO)
pigment granule organization  (IEA,ISO)
pigmentation  (ISO)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of cell growth  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of developmental pigmentation  (ISO)
positive regulation of melanocyte differentiation  (IEA,ISO)
positive regulation of multicellular organism growth  (IEA,ISO)
positive regulation of neuron maturation  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of skeletal muscle fiber development  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IEA,ISO)
post-embryonic development  (IEA,ISO)
protein polyubiquitination  (IEA,ISO)
reactive oxygen species metabolic process  (IEA,ISO)
regulation of apoptotic process  (ISO)
regulation of autophagy  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cell cycle  (ISO)
regulation of cell-matrix adhesion  (IEA,ISO)
regulation of developmental pigmentation  (ISO)
regulation of gene expression  (IEA,ISO)
regulation of glycoprotein biosynthetic process  (IEA,ISO)
regulation of growth  (ISO)
regulation of mitochondrial membrane permeability  (IEA,ISO,ISS)
regulation of mitochondrial membrane potential  (IEA,ISO,ISS)
regulation of nitrogen utilization  (IEA,ISO)
regulation of programmed cell death  (ISO)
regulation of protein localization  (IEA,ISO)
regulation of protein stability  (IEA,ISO)
regulation of viral genome replication  (IEA,ISO)
release of cytochrome c from mitochondria  (IEA,ISO,ISS)
renal system process  (IEA,ISO)
response to aluminum ion  (IEP)
response to amyloid-beta  (IEP)
response to caffeine  (IEP)
response to cAMP  (IEP)
response to copper ion  (IEP)
response to corticosterone  (IEP)
response to cytokine  (IEA,IEP,ISO)
response to electrical stimulus  (IEP)
response to erythropoietin  (IEP)
response to estrogen  (IEP)
response to ethanol  (IDA,IEP)
response to folic acid  (IEP)
response to gamma radiation  (IEA,ISO)
response to glucocorticoid  (IEA,ISO)
response to hydrogen peroxide  (IEA,ISO)
response to hypoxia  (IEP)
response to inorganic substance  (IEP)
response to insulin  (IEP)
response to iron ion  (IEA,ISO)
response to ischemia  (IEA,IEP,ISO)
response to L-ascorbic acid  (IEP)
response to monosaccharide  (IEP)
response to nicotine  (IEA,IEP,ISO)
response to nutrient  (IEP)
response to organic cyclic compound  (IEP)
response to organic substance  (IEP)
response to oxidative stress  (ISO)
response to peptide hormone  (IEP)
response to phenylpropanoid  (IEP)
response to steroid hormone  (ISO)
response to toxic substance  (IEA,ISO)
response to UV-B  (IEA,ISO)
response to vitamin E  (IEP)
response to xenobiotic stimulus  (IEA,IEP,ISO)
retinal cell programmed cell death  (IEA,ISO)
skeletal muscle fiber development  (IEA,ISO)
smooth muscle cell migration  (IEA,ISO)
spleen development  (IEA,ISO)
stem cell development  (IEA,ISO)
T cell apoptotic process  (IEA,ISO)
T cell differentiation  (ISO)
T cell differentiation in thymus  (IEA,ISO)
T cell homeostasis  (IEA,ISO)
T cell lineage commitment  (ISO)
thymus development  (IEA,ISO)
ureteric bud development  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The Bcl-2 apoptotic switch in cancer development and therapy. Adams JM and Cory S, Oncogene. 2007 Feb 26;26(9):1324-37.
2. Neuroprotective Effect of Nanodiamond in Alzheimer's Disease Rat Model: a Pivotal Role for Modulating NF-kappaB and STAT3 Signaling. Alawdi SH, etal., Mol Neurobiol. 2016 Feb 20.
3. Combination of PTEN gene therapy and radiation inhibits the growth of human prostate cancer xenografts. Anai S, etal., Hum Gene Ther. 2006 Oct;17(10):975-84.
4. BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer. Annunziata CM, etal., Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6585-92.
5. The AA genotype of the regulatory BCL2 promoter polymorphism ( 938C>A) is associated with a favorable outcome in lymph node negative invasive breast cancer patients. Bachmann HS, etal., Clin Cancer Res. 2007 Oct 1;13(19):5790-7.
6. Effects of sulfur dioxide on apoptosis-related gene expressions in lungs from rats. Bai J and Meng Z, Regul Toxicol Pharmacol. 2005 Dec;43(3):272-9. Epub 2005 Oct 26.
7. Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats. Baker DJ and Hepple RT, Exp Gerontol. 2006 Nov;41(11):1149-56. Epub 2006 Oct 6.
8. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
9. Altered expression of Bcl-2 and Bax in follicles within dehydroepiandrosterone-induced polycystic ovaries in rats. Bas D, etal., Cell Biol Int. 2011 May;35(5):423-9. doi: 10.1042/CBI20100542.
10. Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Bhattacharjee M, etal., Int Immunol. 2008 Dec;20(12):1489-505. Epub 2008 Oct 17.
11. T11TS Treatment Augments Apoptosis of Glioma Associated Brain Endothelial Cells, Hint Toward Anti-Angiogenic Action in Glioma. Bhattacharya D, etal., J Cell Physiol. 2017 Mar;232(3):526-539. doi: 10.1002/jcp.25447. Epub 2016 Jun 21.
12. Cell death is associated with reduced base excision repair during chronic alcohol administration in adult rat brain. Bhupanapadu Sunkesula SR, etal., Neurochem Res. 2008 Jun;33(6):1117-28. Epub 2008 Feb 8.
13. Double inhibition of XIAP and Bcl-2 axis is beneficial for retrieving sensitivity of renal cell cancer to apoptosis. Bilim V, etal., Br J Cancer. 2008 Mar 11;98(5):941-9. Epub 2008 Feb 19.
14. Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. Bishayee A, etal., Int J Cancer. 2013 Sep 1;133(5):1054-63. doi: 10.1002/ijc.28108. Epub 2013 Mar 29.
15. Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/cub rat strain bearing T-cell lymphoma. Bobkov K, etal., Anticancer Res 2001 Jul-Aug;21(4A):2725-31.
16. Optimizing chemotherapy for transitional cell carcinoma by application of bcl-2 and bcl-xL antisense oligodeoxynucleotides. Bolenz C, etal., Urol Oncol. 2007 Nov-Dec;25(6):476-82.
17. The antibiotic erythromycin induces tolerance against transient global cerebral ischemia in rats (pharmacologic preconditioning). Brambrink AM, etal., Anesthesiology. 2006 Jun;104(6):1208-15.
18. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cai D, etal., Cell Death Dis. 2016 Mar 31;7:e2161. doi: 10.1038/cddis.2016.67.
19. Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells. Carbott DE, etal., Apoptosis 2002 Feb;7(1):69-76.
20. Mutant animal models of stroke and gene expression: the stroke-prone spontaneously hypertensive rat. Carswell HV, etal., Methods Mol Med 2005;104:49-74.
21. Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury. Cayli S, etal., J Mol Histol. 2016 Feb;47(1):91-100. doi: 10.1007/s10735-016-9652-9. Epub 2016 Jan 11.
22. A purine antimetabolite attenuates toll-like receptor-2, -4, and subarachnoid hemorrhage-induced brain apoptosis. Chang CZ, etal., J Surg Res. 2015 Dec;199(2):676-87. doi: 10.1016/j.jss.2015.06.011. Epub 2015 Jun 12.
23. Cilostazol therapy attenuates monocrotaline-induced pulmonary arterial hypertension in rat model. Chang LT, etal., Circ J. 2008 May;72(5):825-31.
24. Induction of Bcl-2 and Bax was related to hyperphosphorylation of tau and neuronal death induced by okadaic acid in rat brain. Chen LQ, etal., Anat Rec A Discov Mol Cell Evol Biol. 2005 Dec;287(2):1236-45.
25. Interfering effect and mechanism of neuregulin on experimental dementia model in rats. Chen Y, etal., Behav Brain Res. 2011 Sep 23;222(2):321-5. doi: 10.1016/j.bbr.2011.03.063. Epub 2011 Apr 5.
26. Tournefolic acid B attenuates amyloid beta protein-mediated toxicity by abrogating the calcium overload in mitochondria and retarding the caspase 8-truncated Bid-cytochrome c pathway in rat cortical neurons. Chi CW, etal., Eur J Pharmacol. 2008 May 31;586(1-3):35-43. Epub 2008 Feb 29.
27. Influence of BCL2-938C>A and BAX-248G>A promoter polymorphisms in the development of AML: case-control study from South India. Cingeetham A, etal., Tumour Biol. 2015 Sep;36(10):7967-76. doi: 10.1007/s13277-015-3457-4. Epub 2015 May 10.
28. Molecular markers and mortality in prostate cancer. Concato J, etal., BJU Int. 2007 Dec;100(6):1259-63. Epub 2007 Sep 10.
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165. Suppression of NFkappaB and its Regulated Gene Products by Oral Administration of Green Tea Polyphenols in an Autochthonous Mouse Prostate Cancer Model. Siddiqui IA, etal., Pharm Res. 2008 Mar 4;.
166. BCL2 accelerates inflammation-induced BALB/c plasmacytomas and promotes novel tumors with coexisting T(12;15) and T(6;15) translocations. Silva S, etal., Cancer Res. 2003 Dec 15;63(24):8656-63.
167. Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. Soane L, etal., J Neurosci Res. 2008 May 1;86(6):1267-76.
168. MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1. Song L, etal., J Cell Mol Med. 2014 Nov;18(11):2266-74. doi: 10.1111/jcmm.12380. Epub 2014 Sep 11.
169. Ethanol extract from Epimedium brevicornum attenuates left ventricular dysfunction and cardiac remodeling through down-regulating matrix metalloproteinase-2 and -9 activity and myocardial apoptosis in rats with congestive heart failure. Song YH, etal., Int J Mol Med. 2008 Jan;21(1):117-24.
170. A novel angiogenesis inhibitor bevacizumab induces apoptosis in the rat endometriosis model. Soysal D, etal., Balkan J Med Genet. 2015 Apr 10;17(2):73-80. doi: 10.2478/bjmg-2014-0077. eCollection 2014 Dec.
171. Overexpression of BCL2 and BAX following BFM induction therapy predicts ch-ALL patients' poor response to treatment and short-term relapse. Stamati L, etal., J Cancer Res Clin Oncol. 2015 Nov;141(11):2023-36. doi: 10.1007/s00432-015-1982-6. Epub 2015 May 16.
172. Apoptosis and its pathway in early post-implantation embryos of diabetic rats. Sun F, etal., Diabetes Res Clin Pract. 2005 Feb;67(2):110-8.
173. The effects of simvastatin on hippocampal caspase-3 and Bcl-2 expression following kainate-induced seizures in rats. Sun J, etal., Int J Mol Med. 2012 Oct;30(4):739-46. doi: 10.3892/ijmm.2012.1076. Epub 2012 Jul 25.
174. Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. Sun Q, etal., Biochem Biophys Res Commun. 2018 Mar 25;498(1):164-170. doi: 10.1016/j.bbrc.2018.02.009. Epub 2018 Mar 5.
175. Protective effects of nicotine against glutamate-induced neurotoxicity in PC12 cells. Sun X, etal., Cell Mol Biol Lett. 2004;9(3):409-22.
176. [Expression of Bcl-2 mRNA and Bcl-2 protein in nasal mucusa of rat in allergic rhinitis model]. Suo L, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 Feb;18(2):105-7.
177. Primary breast cancer phenotypes associated with propensity for central nervous system metastases. Tham YL, etal., Cancer. 2006 Aug 15;107(4):696-704.
178. Argon inhalation attenuates retinal apoptosis after ischemia/reperfusion injury in a time- and dose-dependent manner in rats. Ulbrich F, etal., PLoS One. 2014 Dec 23;9(12):e115984. doi: 10.1371/journal.pone.0115984. eCollection 2014.
179. Segmental heterogeneity in Bcl-2, Bcl-xL and Bax expression in rat tubular epithelium after ischemia-reperfusion. Valdes F, etal., Nephrology (Carlton). 2008 Jan 23;.
180. The mitochondrial toxin 3-nitropropionic acid induces differential expression patterns of apoptosis-related markers in rat striatum. Vis JC, etal., Neuropathol Appl Neurobiol. 2001 Feb;27(1):68-76.
181. Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. Vukosavic S, etal., J Neurochem. 1999 Dec;73(6):2460-8.
182. Protective effects of Carthamus tinctorius injection on isoprenaline-induced myocardial injury in rats. Wan LH, etal., Pharm Biol. 2011 Nov;49(11):1204-9. doi: 10.3109/13880209.2011.576348.
183. Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. Wang J, etal., J Biol Chem. 2004 May 7;279(19):19948-54. Epub 2004 Mar 5.
184. Chondrocyte apoptosis and expression of Bcl-2, Bax, Fas, and iNOS in articular cartilage in patients with Kashin-Beck disease. Wang SJ, etal., J Rheumatol. 2006 Mar;33(3):615-9.
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186. Acupuncture protected cerebral multi-infarction rats from memory impairment by regulating the expression of apoptosis related genes Bcl-2 and Bax in hippocampus. Wang T, etal., Physiol Behav. 2009 Jan 8;96(1):155-61. doi: 10.1016/j.physbeh.2008.09.024. Epub 2008 Oct 9.
187. LncRNA TUG1 Promotes Apoptosis, Invasion, and Angiogenesis of Retinal Endothelial Cells in Retinopathy of Prematurity via MiR-145-5p. Wang Y, etal., Front Med (Lausanne). 2022 Apr 4;9:803214. doi: 10.3389/fmed.2022.803214. eCollection 2022.
188. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
189. Activation of autophagy in ischemic postconditioning contributes to cardioprotective effects against ischemia/reperfusion injury in rat hearts. Wei C, etal., J Cardiovasc Pharmacol. 2013 May;61(5):416-22. doi: 10.1097/FJC.0b013e318287d501.
190. Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees. Weng LH, etal., Arthritis Rheum. 2010 May;62(5):1393-402.
191. Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint. Weng LH, etal., Osteoarthritis Cartilage. 2009 Jul;17(7):933-43. doi: 10.1016/j.joca.2008.12.008. Epub 2008 Dec 30.
192. Lentiviral-mediated delivery of Bcl-2 or GDNF protects against excitotoxicity in the rat hippocampus. Wong LF, etal., Mol Ther. 2005 Jan;11(1):89-95.
193. Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma. Wortham NC, etal., Fertil Steril. 2006 Oct;86(4):961-71. Epub 2006 Sep 7.
194. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. Wu H, etal., Int J Clin Exp Pathol. 2015 Jun 1;8(6):6870-80. eCollection 2015.
195. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
196. 17Beta-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced neuroprotection. Wu TW, etal., Neuroscience. 2005;135(1):59-72.
197. [Effect of letrozole on endometrosis and apoptosis of ectopic endometrial cells in rats]. Xia X, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Jan;38(1):54-9. doi: 10.3969/j.issn.1672-7347.2013.01.010.
198. Effect of sodium fluoride on the expression of bcl-2 family and osteopontin in rat renal tubular cells. Xu H, etal., Biol Trace Elem Res. 2006 Jan;109(1):55-60.
199. Bajijiasu Ameliorates ß-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model. Xu TT, etal., Cell Physiol Biochem. 2018;46(1):107-117. doi: 10.1159/000488414. Epub 2018 Mar 20.
200. Upregulation of CREM-1 relates to retinal ganglion cells apoptosis after light-induced damage in vivo. Xu Y, etal., J Mol Neurosci. 2014 Mar;52(3):331-8. doi: 10.1007/s12031-013-0153-y. Epub 2013 Oct 30.
201. Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat. Yamagata K, etal., Neuroscience. 2008 May 2;153(2):428-35. Epub 2008 Feb 29.
202. Loss of anti-apoptotic genes in aging rat crura. Yamanaka M, etal., J Urol. 2002 Nov;168(5):2296-300.
203. Shenfu Formula reduces cardiomyocyte apoptosis in heart failure rats by regulating microRNAs. Yan X, etal., J Ethnopharmacol. 2018 May 8;227:105-112. doi: 10.1016/j.jep.2018.05.006.
204. Wentong decoction cures allergic bronchial asthma by regulating the apoptosis imbalance of EOS. Yan Y, etal., Chin Med. 2018 Apr 18;13:21. doi: 10.1186/s13020-018-0180-2. eCollection 2018.
205. A shift in the Bax/Bcl-2 balance may activate caspase-3 and modulate apoptosis in experimental glomerulonephritis. Yang B, etal., Kidney Int. 2002 Oct;62(4):1301-13.
206. Association of the functional BCL-2 rs2279115 genetic variant and small cell lung cancer. Yang X, etal., Tumour Biol. 2016 Feb;37(2):1693-8. doi: 10.1007/s13277-015-3934-9. Epub 2015 Aug 27.
207. Rho-kinase-dependent pathway mediates the hepatoprotective effects of sorafenib against ischemia/reperfusion liver injury in rats with nonalcoholic steatohepatitis. Yang YY, etal., Liver Transpl. 2012 Nov;18(11):1371-83. doi: 10.1002/lt.23520.
208. Hydrogen peroxide predisposes neonatal rat ventricular myocytes to Fas-mediated apoptosis. Yaniv G, etal., Biochem Biophys Res Commun. 2005 Oct 28;336(3):740-6. doi: 10.1016/j.bbrc.2005.08.167.
209. Protective effect of curcumin on chemotherapy-induced intestinal dysfunction. Yao Q, etal., Int J Clin Exp Pathol. 2013 Oct 15;6(11):2342-9. eCollection 2013.
210. Neuroprotective effects of breviscapine against apoptosis induced by transient focal cerebral ischaemia in rats. Yiming L, etal., J Pharm Pharmacol. 2008 Mar;60(3):349-55.
211. Influence of age or circadian time on Bcl-2 and Bax mRNA expression in the rat hippocampus after corticosterone exposure. Yoshimura A, etal., Brain Res Bull. 2007 Jul 12;73(4-6):254-8. Epub 2007 Apr 10.
212. A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer. Yu J, etal., Clin Cancer Res. 2007 Dec 15;13(24):7296-304.
213. Changes of inflammation and apoptosis in adrenal gland after experimental injury in rats with acute necrotizing pancreatitis. Yu J, etal., Inflammation. 2012 Feb;35(1):11-22.
214. [Effects of TX0201 abstracted from heart-regulating formula on spatial learning and regulation of Bax mRNA, Bcl-2 mRNA level in brain of rat with Alzheimer's disease] Yu ZH, etal., Zhongguo Zhong Yao Za Zhi. 2007 May;32(9):839-42.
215. Inhibition of microRNA-1 attenuates hypoxia/re-oxygenation-induced apoptosis of cardiomyocytes by directly targeting Bcl-2 but not GADD45Beta. Zhai C, etal., Am J Transl Res. 2015 Oct 15;7(10):1952-62. eCollection 2015.
216. Gingerol ameliorates neuronal damage induced by hypoxia-reoxygenation via the miR-210/brain-derived neurotrophic factor axis. Zhai Y, etal., Kaohsiung J Med Sci. 2022 Apr;38(4):367-377. doi: 10.1002/kjm2.12486. Epub 2021 Dec 28.
217. Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia. Zhang G, etal., J Ethnopharmacol. 2008 Feb 12;115(3):441-8. Epub 2007 Oct 25.
218. [Lipid peroxidation affects serum T and Bcl-2 expression in the testis of aging male rats] Zhang ZB, etal., Zhonghua Nan Ke Xue. 2007 Jan;13(1):46-9.
219. Elevated retinol binding protein 4 levels are associated with atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway. Zhou W, etal., World J Diabetes. 2021 Apr 15;12(4):466-479. doi: 10.4239/wjd.v12.i4.466.
Additional References at PubMed
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Genomics

Comparative Map Data
Bcl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81323,204,464 - 23,366,900 (-)NCBIGRCr8
mRatBN7.21322,689,783 - 22,853,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1322,684,989 - 22,853,743 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1322,684,989 - 22,853,743 (-)NCBImRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1323,013,354 - 23,175,038 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01324,297,817 - 24,459,509 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01322,983,528 - 23,145,223 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01326,605,426 - 26,769,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1326,605,426 - 26,769,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01331,758,213 - 31,920,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41312,730,736 - 12,905,108 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11312,730,735 - 12,905,108 (-)NCBI
Celera1322,550,362 - 22,711,143 (-)NCBICelera
Cytogenetic Map13p11NCBI
BCL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381863,123,346 - 63,320,090 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1863,123,346 - 63,320,128 (-)EnsemblGRCh38hg38GRCh38
GRCh371860,790,579 - 60,987,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361858,941,559 - 59,137,593 (-)NCBINCBI36Build 36hg18NCBI36
Build 341858,941,558 - 59,136,910NCBI
Celera1857,509,356 - 57,706,116 (-)NCBICelera
Cytogenetic Map18q21.33NCBI
HuRef1857,487,199 - 57,684,751 (-)NCBIHuRef
CHM1_11860,786,149 - 60,982,536 (-)NCBICHM1_1
T2T-CHM13v2.01863,326,497 - 63,525,122 (-)NCBIT2T-CHM13v2.0
Bcl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391106,465,906 - 106,642,020 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1106,465,908 - 106,642,004 (-)EnsemblGRCm39 Ensembl
GRCm381106,538,176 - 106,714,290 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1106,538,178 - 106,714,274 (-)EnsemblGRCm38mm10GRCm38
MGSCv371108,434,756 - 108,610,867 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361108,365,740 - 108,541,849 (-)NCBIMGSCv36mm8
Celera1109,386,734 - 109,563,656 (-)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map149.76NCBI
Bcl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540246,916,266 - 47,084,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540246,911,125 - 47,084,214 (-)NCBIChiLan1.0ChiLan1.0
BCL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21780,632,173 - 80,830,186 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11866,324,787 - 66,522,695 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01856,481,212 - 56,679,012 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11859,797,184 - 59,993,298 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1859,802,443 - 59,992,100 (-)Ensemblpanpan1.1panPan2
BCL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1113,733,849 - 13,900,653 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl113,731,406 - 13,900,658 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha114,699,877 - 14,866,689 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0113,595,394 - 13,762,294 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,595,394 - 13,762,292 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,633,483 - 13,799,972 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,562,764 - 13,729,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0113,811,587 - 13,978,482 (+)NCBIUU_Cfam_GSD_1.0
Bcl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494426,970,171 - 27,134,608 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364972,210,334 - 2,210,921 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364972,209,136 - 2,373,580 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1158,337,522 - 158,518,879 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11158,337,403 - 158,518,214 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21175,824,218 - 175,994,403 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11816,440,560 - 16,643,187 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1816,441,733 - 16,637,895 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660609,049,043 - 9,247,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247928,859,522 - 9,031,344 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247928,854,345 - 9,032,727 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcl2
646 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir16rno-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19232449
Mir1rno-miR-1-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI19506341
Mir15brno-miR-15b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19232449

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:24
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000003768
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2303031Bp326Blood pressure QTL 326arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131176653523001904Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat

Markers in Region
D13Kyo4   No map positions available.
RH142296  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,852,015 - 22,852,172 (+)MAPPERmRatBN7.2
Rnor_6.01326,769,152 - 26,769,308NCBIRnor6.0
Rnor_5.01331,919,628 - 31,919,784UniSTSRnor5.0
RGSC_v3.41312,904,886 - 12,905,042UniSTSRGSC3.4
Celera1322,710,921 - 22,711,077UniSTS
Cytogenetic Map13p13UniSTS
PMC150726P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,851,683 - 22,851,977 (+)MAPPERmRatBN7.2
Rnor_6.01326,768,820 - 26,769,113NCBIRnor6.0
Rnor_5.01331,919,296 - 31,919,589UniSTSRnor5.0
RGSC_v3.41312,904,554 - 12,904,847UniSTSRGSC3.4
Celera1322,710,589 - 22,710,882UniSTS
Cytogenetic Map13p13UniSTS
PMC16825P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,851,425 - 22,852,128 (+)MAPPERmRatBN7.2
Rnor_6.01326,768,562 - 26,769,264NCBIRnor6.0
Rnor_5.01331,919,038 - 31,919,740UniSTSRnor5.0
RGSC_v3.41312,904,296 - 12,904,998UniSTSRGSC3.4
Celera1322,710,331 - 22,711,033UniSTS
Cytogenetic Map13p13UniSTS
RH131732  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,737,170 - 22,737,383 (+)MAPPERmRatBN7.2
Rnor_6.01326,653,324 - 26,653,536NCBIRnor6.0
Rnor_5.01331,805,570 - 31,805,782UniSTSRnor5.0
RGSC_v3.41312,778,905 - 12,779,117UniSTSRGSC3.4
Celera1322,597,379 - 22,597,591UniSTS
Cytogenetic Map13p13UniSTS
PMC104155P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,851,427 - 22,851,695 (+)MAPPERmRatBN7.2
Rnor_6.01326,768,564 - 26,768,831NCBIRnor6.0
Rnor_5.01331,919,040 - 31,919,307UniSTSRnor5.0
RGSC_v3.41312,904,298 - 12,904,565UniSTSRGSC3.4
Celera1322,710,333 - 22,710,600UniSTS
Cytogenetic Map13p13UniSTS
PMC125347P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,851,488 - 22,851,935 (+)MAPPERmRatBN7.2
Rnor_6.01326,768,625 - 26,769,071NCBIRnor6.0
Rnor_5.01331,919,101 - 31,919,547UniSTSRnor5.0
RGSC_v3.41312,904,359 - 12,904,805UniSTSRGSC3.4
Celera1322,710,394 - 22,710,840UniSTS
Cytogenetic Map13p13UniSTS
UniSTS:461954  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,851,514 - 22,851,862 (+)MAPPERmRatBN7.2
Rnor_6.01326,768,651 - 26,768,998NCBIRnor6.0
Rnor_5.01331,919,127 - 31,919,474UniSTSRnor5.0
RGSC_v3.41312,904,385 - 12,904,732UniSTSRGSC3.4
Celera1322,710,420 - 22,710,767UniSTS
Cytogenetic Map13p13UniSTS
PMC316415P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,851,944 - 22,852,544 (+)MAPPERmRatBN7.2
Rnor_6.01326,769,081 - 26,769,680NCBIRnor6.0
Rnor_5.01331,919,557 - 31,920,156UniSTSRnor5.0
RGSC_v3.41312,904,815 - 12,905,414UniSTSRGSC3.4
Celera1322,710,850 - 22,711,449UniSTS
Cytogenetic Map13p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 18 2 2 7 8
Low 3 41 26 18 1 18 8 10 72 33 32 3 8
Below cutoff 23 23 23 1 2

Sequence


RefSeq Acc Id: ENSRNOT00000003768   ⟹   ENSRNOP00000003768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1326,605,426 - 26,769,374 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092763   ⟹   ENSRNOP00000075954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1326,767,685 - 26,768,708 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099529   ⟹   ENSRNOP00000093136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1322,684,989 - 22,853,743 (-)Ensembl
RefSeq Acc Id: NM_016993   ⟹   NP_058689
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81323,204,464 - 23,366,900 (-)NCBI
mRatBN7.21322,689,783 - 22,852,238 (-)NCBI
Rnor_6.01326,605,426 - 26,769,374 (-)NCBI
Rnor_5.01331,758,213 - 31,920,775 (-)NCBI
RGSC_v3.41312,730,736 - 12,905,108 (-)RGD
Celera1322,550,362 - 22,711,143 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058689 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA53662 (Get FASTA)   NCBI Sequence Viewer  
  AAA77687 (Get FASTA)   NCBI Sequence Viewer  
  AAD48410 (Get FASTA)   NCBI Sequence Viewer  
  AAP47159 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093136.1
GenBank Protein P49950 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058689   ⟸   NM_016993
- UniProtKB: Q64032 (UniProtKB/Swiss-Prot),   Q62837 (UniProtKB/Swiss-Prot),   P49950 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075954   ⟸   ENSRNOT00000092763
RefSeq Acc Id: ENSRNOP00000003768   ⟸   ENSRNOT00000003768
RefSeq Acc Id: ENSRNOP00000093136   ⟸   ENSRNOT00000099529

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49950-F1-model_v2 AlphaFold P49950 1-236 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2199 AgrOrtholog
BioCyc Gene G2FUF-18606 BioCyc
Ensembl Genes ENSRNOG00000002791 Ensembl
  ENSRNOG00000067693 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000099529.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.437.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Apop_reg_Bcl2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl-2-like_sf UniProtKB/TrEMBL
  Bcl-2_BH1-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl-2_fam UniProtKB/TrEMBL
  Bcl2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2/BclX UniProtKB/Swiss-Prot
  Bcl2_BH1_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH2_motif_CS UniProtKB/Swiss-Prot
  Bcl2_BH3_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH4_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Blc2-like_sf UniProtKB/Swiss-Prot
  Blc2_fam UniProtKB/Swiss-Prot
KEGG Report rno:24224 UniProtKB/Swiss-Prot
NCBI Gene 24224 ENTREZGENE
PANTHER APOPTOSIS REGULATOR BCL-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Bcl-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB BCL2 RGD
PhenoGen Bcl2 PhenoGen
PRINTS APOPREGBCL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCL2FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH2 UniProtKB/Swiss-Prot
  BH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002791 RatGTEx
  ENSRNOG00000067693 RatGTEx
SMART BCL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AJ02_RAT UniProtKB/TrEMBL
  BCL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62837 ENTREZGENE
  Q64032 ENTREZGENE
UniProt Secondary Q62837 UniProtKB/Swiss-Prot
  Q64032 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Bcl2  BCL2, apoptosis regulator  Bcl2  B cell leukemia/lymphoma 2  Data merged from RGD:150341388 737654 PROVISIONAL
2022-01-06 Bcl2  B cell leukemia/lymphoma 2  ENSRNOG00000067693    Symbol and/or name change 19259462 PROVISIONAL
2021-08-31 ENSRNOG00000067693        Symbol and Name status set to provisional 45752 PROVISIONAL
2016-06-22 Bcl2  BCL2, apoptosis regulator  Bcl2  B-cell CLL/lymphoma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Bcl2  B-cell CLL/lymphoma 2  Bcl2  B-cell leukemia/lymphoma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Bcl2  B-cell leukemia/lymphoma 2      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Bcl2  B-cell leukemia/lymphoma 2      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease combined DTX and PMEDAP treatment inhibited or significantly reduced lymphomas 70255
gene_expression mitochondrial level decreased with age 70304
gene_expression protein expression was greatest in fast-twitch glycolytic muscles than in slow-twitch or oxidative muscles 1298696
gene_expression expression is decreased neuronally after hypoxia in SHRSP rat strain compared with WKY rat strain 1553895
gene_mutations_overexpression overexpression is sufficient for survival of retinal ganglion cells (RGCs) without glial or trophic support 70671
gene_process anti-apoptotic 70304
gene_regulation expression increased by progesterone (and 19-norprogesterone) alone or in combination with estrogen 625452