GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of BCL2 protein | PMID:16951259 | Bcl2 | multiple interactions | EXP | | 6480464 | CTD | [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of BCL2 protein; [Fulvestrant co-treated with Estradiol] results in increased expression of BCL2 protein; [Methylnitrosourea co-treated with Estradiol] results in increased expression of BCL2 mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of BCL2 mRNA; [norethindrone enanthate co-treated with Estradiol] results in decreased expression of BCL2 mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of BCL2 mRNA; Estradiol inhibits the reaction [Corticosterone results in decreased expression of BCL2 protein]; Estradiol inhibits the reaction [Dimethylnitrosamine results in decreased expression of BCL2 protein]; Estradiol promotes the reaction [Testosterone inhibits the reaction [Corticosterone results in decreased expression of BCL2 protein]]; Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in decreased expression of BCL2 protein]] | PMID:14659978 PMID:16951259 PMID:18829022 PMID:20732338 PMID:22465879 PMID:29625166 | Bcl2 | affects expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Estradiol affects the expression of BCL2 mRNA | PMID:11896290 PMID:22082530 | Bcl2 | decreases expression | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | Estradiol results in decreased expression of BCL2 mRNA | PMID:25210133 | Bcl2 | decreases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Estradiol analog results in decreased expression of BCL2 mRNA; Estradiol analog results in decreased expression of BCL2 protein; Estradiol results in decreased expression of BCL2 mRNA; Estradiol results in decreased expression of BCL2 protein | PMID:20945400 PMID:36460128 | Bcl2 | increases expression | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | Estradiol results in increased expression of BCL2 mRNA | PMID:17578864 | Bcl2 | increases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of BCL2 mRNA; Estradiol results in increased expression of BCL2 protein | PMID:10455518 PMID:10545406 PMID:11356682 PMID:15870704 PMID:15897899 PMID:16051634 PMID:18174961 PMID:19167446 PMID:19264808 PMID:19698761 PMID:19796866 PMID:20305694 PMID:22609851 PMID:23052036 PMID:23373633 PMID:23804311 PMID:24481588 PMID:24758408 PMID:31016752 PMID:33484789 PMID:34724321 | Bcl2 | multiple interactions | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | [mono-(2-ethylhexyl)phthalate co-treated with Estradiol] results in decreased expression of BCL2 mRNA; Estradiol inhibits the reaction [manganese chloride results in decreased expression of BCL2 protein] | PMID:24412242 PMID:29183790 | Bcl2 | multiple interactions | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | [Estradiol results in increased activity of ESR1 protein] which results in increased expression of BCL2 mRNA; [Estradiol results in increased expression of BCL2 mRNA] which results in increased susceptibility to Cisplatin; [Estradiol results in increased expression of BCL2 mRNA] which results in increased susceptibility to Doxorubicin; [Fulvestrant co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] inhibits the reaction [Estradiol results in increased expression of BCL2 protein]; [Hexachlorocyclohexane co-treated with Estradiol] results in increased expression of BCL2 protein; allyl sulfide inhibits the reaction [Estradiol results in increased expression of BCL2 protein]; ARTN protein inhibits the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; ARTN protein inhibits the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; Benzo(a)pyrene inhibits the reaction [Estradiol results in increased expression of BCL2 protein]; Decitabine inhibits the reaction [Estradiol affects the expression of BCL2 mRNA]; dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA]; EGF protein inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of BCL2 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of BCL2 protein]; ESR1 protein alternative form promotes the reaction [allyl sulfide inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; ESR1 protein alternative form promotes the reaction [MK 2206 inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; ESR2 protein affects the reaction [Estradiol results in increased expression of BCL2 mRNA]; Estradiol inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of BCL2 protein]; Estradiol inhibits the reaction [APP protein results in decreased expression of BCL2 protein]; Ethidium inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA]; ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [Estradiol results in increased expression of BCL2 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]; MIR21 mRNA mutant form promotes the reaction [Estradiol results in increased expression of BCL2 protein]; MK 2206 inhibits the reaction [Estradiol results in increased expression of BCL2 protein]; RTKI cpd inhibits the reaction [Estradiol results in increased expression of BCL2 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]; TXNIP protein inhibits the reaction [Estradiol inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of BCL2 protein]]; TXNIP protein inhibits the reaction [Estradiol inhibits the reaction [APP protein results in decreased expression of BCL2 protein]]; YC137 inhibits the reaction [ARTN protein inhibits the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]]; YC137 inhibits the reaction [ARTN protein inhibits the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]] | PMID:10545406 PMID:15870704 PMID:15897899 PMID:16051634 PMID:18174961 PMID:19264808 PMID:19796866 PMID:20305694 PMID:22082530 PMID:22403704 PMID:23052036 PMID:24758408 PMID:28323900 PMID:33484789 PMID:34318539 PMID:34724321 | | ||||||||||||||||||||||
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