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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDCelecoxib results in decreased expression of BCL2 proteinPMID:15911099 PMID:16391871 PMID:17612393 PMID:26586936
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDCelecoxib results in increased expression of BCL2 mRNAPMID:17342322
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDCelecoxib promotes the reaction [Dihematoporphyrin Ether results in increased cleavage of BCL2 protein]PMID:16230411
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDBCL2 protein inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib results in increased cleavage of CASP3 protein]; Celecoxib promotes the reaction [docetaxel results in increased expression of BCL2 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased expression of BCL2 protein]; tetraarsenic tetrasulfide promotes the reaction [Celecoxib results in decreased expression of BCL2 protein]PMID:15688368 PMID:20104024 PMID:26586936
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