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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDCadmium results in decreased expression of BCL2 mRNA; Cadmium results in decreased expression of BCL2 proteinPMID:20455018 PMID:23577223 PMID:23880342 PMID:25808797 PMID:25955216 PMID:32246071 PMID:37342552 PMID:37949422
Bcl2decreases response to substanceEXP 6480464CTDBCL2 results in decreased susceptibility to CadmiumPMID:12189181
Bcl2increases expressionEXP 6480464CTDCadmium results in increased expression of BCL2 proteinPMID:11781163 PMID:23741317
Bcl2multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of BCL2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of BCL2 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein; [cadmium nitrate results in increased abundance of Cadmium] which results in decreased expression of BCL2 mRNA; [Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in decreased expression of BCL2 mRNA; [Streptozocin co-treated with Cadmium] results in decreased expression of BCL2 mRNA; [Streptozocin co-treated with Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in decreased expression of BCL2 mRNA; bergenin inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; dendropanoxide inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; Lithium inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; MIR34A mRNA affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; pinostrobin inhibits the reaction [Cadmium results in decreased expression of BCL2 mRNA]; Silymarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]PMID:20455018 PMID:25955216 PMID:28413886 PMID:32246071 PMID:33031904 PMID:33652105 PMID:34558789 PMID:34767868 PMID:36718047 PMID:37342552 PMID:37949422
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDCadmium results in decreased expression of BCL2 proteinPMID:22356713
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDCadmium results in decreased expression of BCL2 mRNA; Cadmium results in decreased expression of BCL2 proteinPMID:27687512 PMID:32976933
Bcl2decreases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein results in decreased susceptibility to CadmiumPMID:11781163
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDCadmium results in increased expression of BCL2 mRNAPMID:21694771 PMID:33559965
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of BCL2 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]PMID:30796935 PMID:33359024
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased expression of BCL2 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein; [MIR16 mRNA affects the susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]] which affects the expression of BCL2 mRNA; MIR16 mRNA affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]PMID:28949029 PMID:33652105 PMID:37300854
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