GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | decreases expression | EXP | | 6480464 | CTD | Cadmium results in decreased expression of BCL2 mRNA; Cadmium results in decreased expression of BCL2 protein | PMID:20455018 PMID:23577223 PMID:23880342 PMID:25808797 PMID:25955216 PMID:32246071 PMID:37342552 PMID:37949422 | Bcl2 | decreases response to substance | EXP | | 6480464 | CTD | BCL2 results in decreased susceptibility to Cadmium | PMID:12189181 | Bcl2 | increases expression | EXP | | 6480464 | CTD | Cadmium results in increased expression of BCL2 protein | PMID:11781163 PMID:23741317 | Bcl2 | multiple interactions | EXP | | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of BCL2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of BCL2 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein; [cadmium nitrate results in increased abundance of Cadmium] which results in decreased expression of BCL2 mRNA; [Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in decreased expression of BCL2 mRNA; [Streptozocin co-treated with Cadmium] results in decreased expression of BCL2 mRNA; [Streptozocin co-treated with Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in decreased expression of BCL2 mRNA; bergenin inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; dendropanoxide inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; Lithium inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; MIR34A mRNA affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; pinostrobin inhibits the reaction [Cadmium results in decreased expression of BCL2 mRNA]; Silymarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein] | PMID:20455018 PMID:25955216 PMID:28413886 PMID:32246071 PMID:33031904 PMID:33652105 PMID:34558789 PMID:34767868 PMID:36718047 PMID:37342552 PMID:37949422 | Bcl2 | decreases expression | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | Cadmium results in decreased expression of BCL2 protein | PMID:22356713 | Bcl2 | decreases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Cadmium results in decreased expression of BCL2 mRNA; Cadmium results in decreased expression of BCL2 protein | PMID:27687512 PMID:32976933 | Bcl2 | decreases response to substance | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | BCL2 protein results in decreased susceptibility to Cadmium | PMID:11781163 | Bcl2 | increases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Cadmium results in increased expression of BCL2 mRNA | PMID:21694771 PMID:33559965 | Bcl2 | multiple interactions | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of BCL2 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein] | PMID:30796935 PMID:33359024 | Bcl2 | multiple interactions | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased expression of BCL2 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein; [MIR16 mRNA affects the susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]] which affects the expression of BCL2 mRNA; MIR16 mRNA affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein] | PMID:28949029 PMID:33652105 PMID:37300854 | |
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