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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:6570
Term: lupeol
Definition: A pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in many edible fruits and vegetables.
Chemical ID: MESH:C010480
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTDlupeol inhibits the reaction [COL2A1 results in increased expression of BCL2 protein]PMID:35446470
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDlupeol results in decreased expression of BCL2 mRNA; lupeol results in decreased expression of BCL2 proteinPMID:30506710 PMID:31112703
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDlupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA]PMID:27235710
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