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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDArsenic results in decreased expression of BCL2 mRNAPMID:32246071
Bcl2increases expressionEXP 6480464CTDArsenic results in increased expression of BCL2 proteinPMID:11756236
Bcl2multiple interactionsEXP 6480464CTD[Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in decreased expression of BCL2 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 protein; [Streptozocin co-treated with Arsenic] results in decreased expression of BCL2 mRNA; [Streptozocin co-treated with Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in decreased expression of BCL2 mRNA; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA]; Succimer inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA]; sulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 protein]PMID:30835071 PMID:32246071 PMID:32402895 PMID:36822304
Bcl2affects expressionISOBcl2 (Mus musculus)6480464CTDArsenic affects the expression of BCL2 proteinPMID:27289040
Bcl2affects methylationISOBCL2 (Homo sapiens)6480464CTDArsenic affects the methylation of BCL2 genePMID:25304211
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDArsenic results in increased expression of BCL2 mRNA; Arsenic results in increased expression of BCL2 proteinPMID:12899209 PMID:27838757 PMID:30081983 PMID:33736254
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in decreased expression of BCL2 mRNA]; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA; [Sodium Fluoride results in increased abundance of Fluorides] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA]PMID:35714946
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Palmitic Acid co-treated with Arsenic] results in increased expression of BCL2 mRNAPMID:33736254
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