GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | decreases expression | EXP | | 6480464 | CTD | Arsenic results in decreased expression of BCL2 mRNA | PMID:32246071 | Bcl2 | increases expression | EXP | | 6480464 | CTD | Arsenic results in increased expression of BCL2 protein | PMID:11756236 | Bcl2 | multiple interactions | EXP | | 6480464 | CTD | [Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in decreased expression of BCL2 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 protein; [Streptozocin co-treated with Arsenic] results in decreased expression of BCL2 mRNA; [Streptozocin co-treated with Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in decreased expression of BCL2 mRNA; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA]; Succimer inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA]; sulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 protein] | PMID:30835071 PMID:32246071 PMID:32402895 PMID:36822304 | Bcl2 | affects expression | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | Arsenic affects the expression of BCL2 protein | PMID:27289040 | Bcl2 | affects methylation | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Arsenic affects the methylation of BCL2 gene | PMID:25304211 | Bcl2 | increases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Arsenic results in increased expression of BCL2 mRNA; Arsenic results in increased expression of BCL2 protein | PMID:12899209 PMID:27838757 PMID:30081983 PMID:33736254 | Bcl2 | multiple interactions | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] promotes the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in decreased expression of BCL2 mRNA]; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA; [Sodium Fluoride results in increased abundance of Fluorides] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA] | PMID:35714946 | Bcl2 | multiple interactions | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | [Palmitic Acid co-treated with Arsenic] results in increased expression of BCL2 mRNA | PMID:33736254 | |
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