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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:3374
Term: capsaicin
Definition: A capsaicinoid that has formula C18H27NO3.
Chemical ID: MESH:D002211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects expressionISOBCL2 (Homo sapiens)6480464CTDCapsaicin affects the expression of BCL2 proteinPMID:34939720
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDCapsaicin results in decreased expression of BCL2 proteinPMID:15595419 PMID:17295509 PMID:17306913
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDCapsaicin results in decreased expression of BCL2; Capsaicin results in decreased expression of BCL2 proteinPMID:11275362 PMID:17505005 PMID:18405923 PMID:18991268 PMID:19002586 PMID:19331147
Bcl2decreases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein results in decreased susceptibility to CapsaicinPMID:9580328
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDCapsaicin results in increased expression of BCL2 mRNAPMID:19502594 PMID:21310942 PMID:22230393
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