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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:78741
Term: oxidopamine
Definition: A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Chemical ID: MESH:D016627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDOxidopamine results in decreased expression of BCL2 proteinPMID:16480889 PMID:21397656 PMID:25446857 PMID:28802652
Bcl2multiple interactionsEXP 6480464CTD5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; Tea inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]PMID:16480889 PMID:21397656 PMID:25446857
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDOxidopamine results in decreased expression of BCL2 proteinPMID:33571554
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDOxidopamine results in decreased expression of BCL2 mRNA; Oxidopamine results in decreased expression of BCL2 proteinPMID:25446857 PMID:30707903 PMID:31176653
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[2-chloro-5-hydroxyphenylglycine co-treated with Oxidopamine] results in decreased expression of BCL2 protein; [6-methyl-2-(phenylethynyl)pyridine co-treated with Oxidopamine] results in decreased expression of BCL2 proteinPMID:33571554
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDPINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; pyrazolanthrone inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; SB 203580 inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; tricetin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 mRNA]; tricetin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]PMID:25446857 PMID:30707903 PMID:31176653
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