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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:81763
Term: fludioxonil
Definition: A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria.
Chemical ID: MESH:C108339
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDfludioxonil results in decreased expression of BCL2 proteinPMID:23052036
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDfludioxonil results in increased expression of BCL2 mRNAPMID:23052036
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDMIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of BCL2 protein]PMID:23052036
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