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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:9944
Term: venlafaxine hydrochloride
Definition: A hydrochloride that has formula C17H27NO2.HCl.
Chemical ID: MESH:D000069470
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDVenlafaxine Hydrochloride results in decreased expression of BCL2 mRNAPMID:25423262
Bcl2multiple interactionsEXP 6480464CTDChloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]PMID:29852128 PMID:35104487
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