GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | increases expression | EXP | | 6480464 | CTD | Fluorouracil results in increased expression of BCL2 mRNA; Fluorouracil results in increased expression of BCL2 protein | PMID:16888818 PMID:38078205 | Bcl2 | multiple interactions | EXP | | 6480464 | CTD | Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein] | PMID:31129132 | Bcl2 | affects expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Fluorouracil affects the expression of BCL2 protein | PMID:23941782 | Bcl2 | affects response to substance | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | BCL2 protein affects the susceptibility to Fluorouracil | PMID:15177426 PMID:16332177 PMID:16412276 PMID:16603448 PMID:18949393 | Bcl2 | decreases expression | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | Fluorouracil results in decreased expression of BCL2 protein | PMID:18567086 PMID:20844880 PMID:30542770 | Bcl2 | decreases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Fluorouracil results in decreased expression of BCL2; Fluorouracil results in decreased expression of BCL2 mRNA; Fluorouracil results in decreased expression of BCL2 protein | PMID:15754201 PMID:15996812 PMID:16557594 PMID:16929163 PMID:17287894 PMID:17589894 PMID:18161298 PMID:18205257 PMID:20570612 PMID:28599477 PMID:29054700 PMID:31587439 PMID:9388485 | Bcl2 | decreases response to substance | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | BCL2 protein results in decreased susceptibility to Fluorouracil | PMID:17439414 | Bcl2 | increases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Fluorouracil results in increased expression of BCL2 mRNA | PMID:14503796 | Bcl2 | increases phosphorylation | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Fluorouracil results in increased phosphorylation of BCL2 protein | PMID:7654318 | Bcl2 | multiple interactions | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | [Fluorouracil co-treated with casticin] results in decreased expression of BCL2 protein; [Fluorouracil co-treated with Chitosan co-treated with polyaspartate] results in decreased expression of BCL2 protein; IL1RN protein inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein] | PMID:18567086 PMID:20844880 PMID:32270916 | Bcl2 | multiple interactions | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of BCL2 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of BCL2 protein; [Docosahexaenoic Acids co-treated with Fluorouracil] results in decreased expression of BCL2 mRNA; [Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of BCL2 mRNA; [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in decreased expression of BCL2 protein; [Fluorouracil co-treated with Irinotecan] results in decreased expression of BCL2 mRNA; [Fluorouracil co-treated with Irinotecan] results in decreased expression of BCL2 protein; [Fluorouracil co-treated with RNF34 protein] results in increased expression of BCL2 mRNA; [Fluorouracil co-treated with RNF34 protein] results in increased expression of BCL2 protein; [SM-1 compound co-treated with Fluorouracil] results in decreased expression of BCL2 mRNA; [SM-1 compound co-treated with Fluorouracil] results in decreased expression of BCL2 protein; [wogonin co-treated with Fluorouracil] results in decreased expression of BCL2 protein; BAY 11-7085 inhibits the reaction [[Fluorouracil co-treated with RNF34 protein] results in increased expression of BCL2 mRNA]; Cadmium Chloride affects the reaction [Fluorouracil affects the expression of BCL2 protein]; Fluorouracil affects the reaction [Cadmium Chloride affects the expression of BCL2 mRNA]; Fluorouracil affects the reaction [rebamipide results in increased expression of BCL2 protein]; Fluorouracil promotes the reaction [gambogic acid results in decreased expression of BCL2 mRNA]; Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 mRNA]; Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]; rebamipide inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]; SM-1 compound promotes the reaction [Fluorouracil results in decreased expression of BCL2 mRNA] | PMID:15754201 PMID:16391804 PMID:16407826 PMID:16596200 PMID:16929163 PMID:19015929 PMID:19084572 PMID:20570612 PMID:23941782 PMID:28599477 PMID:29054700 PMID:31587439 PMID:32800223 | | ||||||||||||||||||||||
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