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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects expressionEXP 6480464CTDCyclosporine affects the expression of BCL2PMID:25299210
Bcl2decreases expressionEXP 6480464CTDCyclosporine results in decreased expression of BCL2 proteinPMID:32569592
Bcl2multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Cyclosporine results in decreased expression of BCL2 protein]PMID:32569592
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDCyclosporine results in decreased expression of BCL2 mRNA; Cyclosporine results in decreased expression of BCL2 proteinPMID:12086014 PMID:22343435 PMID:35033536
Bcl2increases expressionISOBcl2 (Mus musculus)6480464CTDCyclosporine results in increased expression of BCL2 proteinPMID:10205001
Bcl2increases methylationISOBCL2 (Homo sapiens)6480464CTDCyclosporine results in increased methylation of BCL2 promoterPMID:27989131
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDCyclosporine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2 protein]PMID:37308051
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Cyclosporine co-treated with NGF protein] results in decreased expression of BCL2 mRNA; cobaltous chloride inhibits the reaction [Cyclosporine results in decreased expression of BCL2 protein]; Cyclosporine promotes the reaction [Paclitaxel results in increased phosphorylation of and results in decreased activity of BCL2 protein]PMID:12086014 PMID:22343435 PMID:24244623
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