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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:48843
Term: disodium selenite
Definition: An inorganic sodium salt composed of sodium and selenite ions in a 2:1 ratio.
Chemical ID: MESH:D018038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2increases expressionEXP 6480464CTDSodium Selenite results in increased expression of BCL2 proteinPMID:18209489
Bcl2multiple interactionsEXP 6480464CTDSodium Selenite inhibits the reaction [2-cresol results in increased expression of BCL2 mRNA]; Sodium Selenite inhibits the reaction [cholestane-3,5,6-triol results in increased expression of BCL2 mRNA]; Sodium Selenite inhibits the reaction [citreoviridin results in decreased expression of BCL2 protein]PMID:16039982 PMID:21705299 PMID:31419397
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDSodium Selenite results in decreased expression of BCL2 mRNAPMID:16542727 PMID:17989939 PMID:19363675
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDSodium Selenite results in decreased expression of BCL2 proteinPMID:34520753
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDSodium Selenite inhibits the reaction [citreoviridin results in decreased expression of BCL2 protein]; Sodium Selenite promotes the reaction [Buthionine Sulfoximine results in decreased expression of BCL2 mRNA]PMID:17989939 PMID:31419397
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of BCL2 proteinPMID:28757135
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