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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:42588
Term: 4-hydroxyphenyl retinamide
Definition: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Chemical ID: MESH:D017313
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein affects the susceptibility to FenretinidePMID:7811993
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDFenretinide results in decreased expression of BCL2 mRNAPMID:28973697
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDFenretinide results in decreased expression of BCL2 mRNA; Fenretinide results in decreased expression of BCL2 proteinPMID:16187019 PMID:16230421 PMID:17159502 PMID:7811993
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Fenretinide co-treated with Carmustine] results in decreased expression of BCL2 protein; Fenretinide inhibits the reaction [TNF protein results in increased expression of BCL2 protein]PMID:16187019 PMID:16230421
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