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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTDValproic Acid inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]; Valproic Acid inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]PMID:19149911 PMID:22711276
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of BCL2 mRNAPMID:23179753
Bcl2decreases response to substanceISOBcl2 (Mus musculus)6480464CTDBCL2 protein results in decreased susceptibility to Valproic AcidPMID:19060243
Bcl2increases expressionISOBcl2 (Mus musculus)6480464CTDValproic Acid results in increased expression of BCL2 mRNAPMID:9098922
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDValproic Acid results in increased expression of BCL2 mRNAPMID:19101580 PMID:24935251 PMID:32623605
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]]; ABT-737 inhibits the reaction [BCL2 protein results in decreased susceptibility to Valproic Acid]; Valproic Acid inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]PMID:19060243 PMID:25453207
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Cisplatin co-treated with Pemetrexed co-treated with Valproic Acid] results in decreased expression of BCL2 protein; [Valproic Acid co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA; [Valproic Acid co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; CEBPA protein affects the reaction [Valproic Acid results in increased expression of BCL2 mRNA]PMID:19351772 PMID:25815518 PMID:32623605
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