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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:16716
Term: benzene
Definition: A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.
Chemical ID: MESH:D001554
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDBenzene results in decreased expression of BCL2 mRNAPMID:21143203
Bcl2multiple interactionsEXP 6480464CTDdecitabine inhibits the reaction [Benzene results in decreased expression of BCL2 mRNA]; trichostatin A inhibits the reaction [Benzene results in decreased expression of BCL2 mRNA]PMID:21143203
Bcl2affects expressionISOBcl2 (Mus musculus)6480464CTDBenzene affects the expression of BCL2 mRNAPMID:11896287
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDBenzene results in decreased expression of BCL2 mRNAPMID:18724895 PMID:19162166
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDBenzene results in increased expression of BCL2 proteinPMID:20850422
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDTRP53 protein affects the reaction [Benzene results in increased expression of BCL2 mRNA]PMID:11896287
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