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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDIndomethacin results in decreased expression of BCL2 mRNAPMID:19220725
Bcl2increases expressionEXP 6480464CTDIndomethacin results in increased expression of BCL2 mRNAPMID:29027214
Bcl2multiple interactionsEXP 6480464CTDIndomethacin inhibits the reaction [COL2A1 results in increased expression of BCL2 protein]; Indomethacin inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 mRNA]; Indomethacin inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of BCL2 mRNA]PMID:17570061 PMID:19220725 PMID:35446470
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDIndomethacin results in decreased expression of BCL2 mRNA; Indomethacin results in decreased expression of BCL2 proteinPMID:10785260 PMID:11721434 PMID:18678619 PMID:31916655
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDIndomethacin results in increased expression of BCL2 mRNAPMID:29027214
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Indomethacin co-treated with juglone] results in decreased expression of BCL2 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of BCL2 mRNAPMID:28628672 PMID:31916655
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