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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDMelatonin results in decreased expression of BCL2 mRNAPMID:16499559
Bcl2multiple interactionsEXP 6480464CTD[Puromycin Aminonucleoside co-treated with Melatonin] results in increased expression of BCL2 protein; Melatonin inhibits the reaction [decamethrin results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Galactose results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Methionine results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of BCL2 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of BCL2 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]PMID:14993511 PMID:16213988 PMID:17645694 PMID:18715270 PMID:18724894 PMID:19220725 PMID:20041988 PMID:34673010 PMID:35093381
Bcl2affects localizationISOBCL2 (Homo sapiens)6480464CTDMelatonin affects the localization of BCL2 proteinPMID:18339127
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDMelatonin results in decreased expression of BCL2 proteinPMID:14690559
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDMelatonin results in decreased expression of BCL2 mRNA; Melatonin results in decreased expression of BCL2 proteinPMID:33507000
Bcl2increases expressionISOBcl2 (Mus musculus)6480464CTDMelatonin results in increased expression of BCL2 proteinPMID:12220328
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDMelatonin results in increased expression of BCL2 proteinPMID:18078454
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]]PMID:21138475 PMID:23963992 PMID:35643323 PMID:36421005 PMID:38008054
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Doxorubicin co-treated with Melatonin] results in decreased expression of BCL2 protein; [Melatonin co-treated with Tretinoin] results in decreased expression of BCL2 protein; [Tretinoin co-treated with Melatonin] results in decreased expression of BCL2 protein; Doxorubicin promotes the reaction [Melatonin results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Cisplatin affects the expression of BCL2 protein]; Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2 protein]PMID:10965999 PMID:20333787 PMID:21244482 PMID:24799992 PMID:33507000 PMID:33962019 PMID:9649124
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