GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | decreases expression | EXP | | 6480464 | CTD | Morphine results in decreased expression of BCL2 mRNA; Morphine results in decreased expression of BCL2 protein | PMID:12196588 PMID:18976035 | Bcl2 | multiple interactions | EXP | | 6480464 | CTD | Lithium inhibits the reaction [Morphine results in decreased expression of BCL2 mRNA] | PMID:18976035 | Bcl2 | decreases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Morphine results in decreased expression of BCL2 protein | PMID:10534122 PMID:19292871 PMID:21483469 | Bcl2 | multiple interactions | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | [[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]; Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]; Morphine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]; PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein] | PMID:10534122 PMID:12927789 PMID:17542780 PMID:20190558 PMID:21483469 | |
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