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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDMorphine results in decreased expression of BCL2 mRNA; Morphine results in decreased expression of BCL2 proteinPMID:12196588 PMID:18976035
Bcl2multiple interactionsEXP 6480464CTDLithium inhibits the reaction [Morphine results in decreased expression of BCL2 mRNA]PMID:18976035
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDMorphine results in decreased expression of BCL2 proteinPMID:10534122 PMID:19292871 PMID:21483469
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]; Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]; Morphine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]; PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]PMID:10534122 PMID:12927789 PMID:17542780 PMID:20190558 PMID:21483469
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