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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:73458
Term: NS-398
Definition: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Chemical ID: MESH:C080955
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of BCL2 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of BCL2 proteinPMID:19056168
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Dihematoporphyrin Ether results in increased cleavage of BCL2 protein]PMID:16230411
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with rosiglitazone] results in decreased expression of BCL2 mRNA; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with rosiglitazone] results in decreased expression of BCL2 proteinPMID:19056168
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