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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDnickel chloride results in decreased expression of BCL2 proteinPMID:20391133
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDnickel chloride results in decreased expression of BCL2 mRNA; nickel chloride results in decreased expression of BCL2 proteinPMID:36421005
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDnickel chloride results in decreased expression of BCL2 mRNAPMID:17442357
Bcl2decreases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein results in decreased susceptibility to nickel chloridePMID:23828460
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDnickel chloride results in increased expression of BCL2 proteinPMID:21837363
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDMelatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in decreased expression of BCL2 mRNA]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in decreased expression of BCL2 protein]PMID:36421005
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