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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:3908
Term: coumestrol
Definition: A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.
Chemical ID: MESH:D003375
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects bindingISOBCL2 (Homo sapiens)6480464CTDCoumestrol binds to BCL2 proteinPMID:28986287
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDCoumestrol results in decreased expression of BCL2 proteinPMID:20623010 PMID:28986287
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of BCL2 mRNAPMID:19167446
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