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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:4775
Term: ellagic acid
Definition: An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates.
Chemical ID: MESH:D004610
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTDEllagic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of BCL2 protein]; Ellagic Acid inhibits the reaction [sodium arsenate results in decreased expression of BCL2 mRNA]PMID:29854611 PMID:35236242
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDEllagic Acid results in decreased expression of BCL2 mRNAPMID:35179410
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDEllagic Acid results in increased expression of BCL2 proteinPMID:22386815
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BCL2 mRNA]PMID:20103723
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