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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in decreased expression of BCL2 mRNA; perfluorooctane sulfonic acid results in decreased expression of BCL2 proteinPMID:24616003 PMID:26844784 PMID:35934180
Bcl2increases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of BCL2 proteinPMID:31588057
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in decreased expression of BCL2 mRNA; perfluorooctane sulfonic acid results in decreased expression of BCL2 proteinPMID:21115943 PMID:23562911 PMID:34303733 PMID:36988283
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in decreased expression of BCL2 mRNA; perfluorooctane sulfonic acid results in decreased expression of BCL2 proteinPMID:19468714 PMID:22976841 PMID:26844784 PMID:34006824 PMID:36988283
Bcl2increases expressionISOBcl2 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased expression of BCL2 mRNAPMID:23562911
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDCannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of BCL2 mRNA]; Cannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of BCL2 protein]PMID:36988283
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of BCL2 mRNA]; Cannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of BCL2 mRNA]; Cannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of BCL2 protein]; MIR155 mRNA promotes the reaction [perfluorooctane sulfonic acid results in decreased expression of BCL2 protein]PMID:22976841 PMID:26844784 PMID:36988283
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