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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:6736
Term: melittin
Definition: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active component of bee venom.
Chemical ID: MESH:D008555
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTDMelitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of BCL2 mRNA]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of BCL2 protein]PMID:21354845
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDMelitten results in decreased expression of BCL2 proteinPMID:37678661
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDMelitten analog results in decreased expression of BCL2 mRNA; Melitten analog results in decreased expression of BCL2 protein; Melitten results in decreased expression of BCL2 proteinPMID:21456063 PMID:22027265 PMID:29387245
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDMelitten affects the reaction [TGFB1 protein affects the localization of BCL2 protein]PMID:21871910
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