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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDAflatoxin B1 results in decreased expression of BCL2 mRNAPMID:27288928 PMID:28442411 PMID:32418920
Bcl2multiple interactionsEXP 6480464CTD[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]PMID:27288928
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDAflatoxin B1 results in decreased expression of BCL2 mRNA; Aflatoxin B1 results in decreased expression of BCL2 proteinPMID:19770486 PMID:25445755 PMID:26968497 PMID:30126036 PMID:35304092
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of BCL2 proteinPMID:22743290
Bcl2decreases methylationISOBCL2 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased methylation of BCL2 intronPMID:30157460
Bcl2decreases phosphorylationISOBcl2 (Mus musculus)6480464CTDAflatoxin B1 results in decreased phosphorylation of BCL2 proteinPMID:34396909
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDdeoxynivalenol promotes the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]; PRKN protein affects the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]PMID:25445755 PMID:35304092
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDMethoxsalen inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]PMID:22743290
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