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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:28757
Term: fructose
Definition: A ketohexose that is an isomer of glucose.
Chemical ID: MESH:D005632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2increases expressionEXP 6480464CTDFructose results in increased expression of BCL2 proteinPMID:17883899
Bcl2multiple interactionsEXP 6480464CTD[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; [Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; Kangen-karyu inhibits the reaction [Fructose results in increased expression of BCL2 protein]PMID:17883899 PMID:32259528
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDFructose results in decreased expression of BCL2 proteinPMID:27531227
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDFructose results in increased expression of BCL2 mRNAPMID:31655124
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA; [Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]PMID:28916335
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