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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:65585
Term: carnosic acid
Definition: An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from rosemary (Rosmarinus officinalis) and common sage (Salvia officinalis) and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity.
Chemical ID: MESH:C018381
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTDsalvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]PMID:25446857
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDsalvin results in decreased expression of BCL2 proteinPMID:28918123
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDsalvin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]PMID:29854073
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [salvin results in decreased expression of BCL2 protein]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]PMID:25446857 PMID:26577515 PMID:26686574 PMID:28918123 PMID:30707903
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