RGD Reference Report - A novel angiogenesis inhibitor bevacizumab induces apoptosis in the rat endometriosis model. - Rat Genome Database

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A novel angiogenesis inhibitor bevacizumab induces apoptosis in the rat endometriosis model.

Authors: Soysal, D  Kizildag, S  Saatli, B  Posaci, C  Soysal, S  Koyuncuoglu, M  Dogan, O 
Citation: Soysal D, etal., Balkan J Med Genet. 2015 Apr 10;17(2):73-80. doi: 10.2478/bjmg-2014-0077. eCollection 2014 Dec.
RGD ID: 11353846
Pubmed: PMID:25937801   (View Abstract at PubMed)
PMCID: PMC4413445   (View Article at PubMed Central)
DOI: DOI:10.2478/bjmg-2014-0077   (Journal Full-text)

Our aim was to investigate the effects of anti-vascular endothelial growth factor (anti-VEGF) antibody Bevacizumab on endometrial explants and on apoptotic gene expression levels in the rat endometriosis model. Endometriotic implants were surgically formed, and rats treated with (i) 1 mg/kg single subcutaneous injection of depot leuprolide acetate; (ii) 2.5 mg/kg of single intaperitoneal injection of bevacizumab; (iii) intraperitoneal injection of saline. Histopathologic scores and adhesion scores of endometriotic foci and levels of Bcl-2-associated X protein (Bax), Cytochrome c (Cyt-c), B-cell lymphoma/leukemia 2 (Bcl-2) and B-cell lymphoma-extra large (Bcl-xl) mRNA gene expressions of endometriotic foci. Bevacizumab treatment decreased the endometriotic explant size compared with control. Bevacizumab-treated rats had lower total adhesion scores when compared with the control group. Semi-quantitative evaluation of the persistence of endometrial epithelial cells in the explants showed a lower score in gonadotropin-releasing hormone (GnRH) agonist-treated rats compared with control rats. In Bevacizumab increased expression of Bax 3.1-fold, Cyt-c 1.3-fold and decreased expression of Bcl-2 0.4-fold, Bcl-xl 0.8-fold compared with the control group. The GnRH agonist increased expression of Bax 3.0 fold, Cyt-c 1.3 fold and decreased expression of Bcl-2 0.4-fold, Bcl-xl 0.8-fold, compared with the control group. This study suggests that a novel angiogenesis inhibitor, anti-VEGF antibody bevacizumab is as effective as GnRH agonist in the regression of the endometriotic lesions in rat endometriosis model. One possible mechanism of this effect is the induction of apoptosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
endometriosis treatmentISOBcl2 (Rattus norvegicus)11353846; 11353846 RGD 
endometriosis treatmentISOBcl2l1 (Rattus norvegicus)11353846; 11353846 RGD 
endometriosis treatmentIDA 11353846; 11353846 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bcl2  (BCL2, apoptosis regulator)
Bcl2l1  (Bcl2-like 1)

Genes (Mus musculus)
Bcl2  (B cell leukemia/lymphoma 2)
Bcl2l1  (BCL2-like 1)

Genes (Homo sapiens)
BCL2  (BCL2 apoptosis regulator)
BCL2L1  (BCL2 like 1)


Additional Information