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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:34696
Term: dieldrin
Definition: An organochlorine compound resulting from the epoxidation of the double bond of aldrin. It is the active metabolite of the proinsecticde aldrin.
Chemical ID: MESH:D004026
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein results in decreased susceptibility to DieldrinPMID:15183012
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDBCL2 protein inhibits the reaction [Dieldrin results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Dieldrin results in increased activity of PRKCD protein]PMID:15033812 PMID:15183012
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