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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:76604
Term: MeIQx
Definition: An imidazoquinoxaline that is 3H-imidazo[4,5-f]quinoxaline substituted at positions 3 and 8 by methyl groups and at position 2 by an amino group. A mutagenic compound found in cooked beef.
Chemical ID: MESH:C036990
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTD2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of BCL2 mRNA; 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of BCL2 proteinPMID:23810796
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