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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:28216
Term: methylmercury chloride
Definition: A chlorine molecular entity that has formula CH3ClHg.
Chemical ID: MESH:C004925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDmethylmercuric chloride results in decreased expression of BCL2 mRNA; methylmercuric chloride results in decreased expression of BCL2 proteinPMID:28821999 PMID:32061141 PMID:35678294
Bcl2multiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 protein]PMID:32061141 PMID:35678294
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDmethylmercuric chloride results in decreased expression of BCL2 mRNA; methylmercuric chloride results in decreased expression of BCL2 proteinPMID:23202902 PMID:33338554
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDmethylmercuric chloride results in increased expression of BCL2 mRNAPMID:28001369
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDLEP protein affects the reaction [methylmercuric chloride results in decreased expression of BCL2 protein]PMID:33338554
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