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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:72544
Term: flavonoids
Definition: Any organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them.
Chemical ID: MESH:D005419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDFlavonoids results in decreased expression of BCL2 mRNA; Flavonoids results in decreased expression of BCL2 proteinPMID:23063593 PMID:24036141 PMID:28811126
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDFlavonoids inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 mRNA]PMID:23279844
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDFlavonoids inhibits the reaction [AGT protein results in decreased expression of BCL2 mRNA]; Flavonoids inhibits the reaction [AGT protein results in decreased expression of BCL2 protein]; Flavonoids inhibits the reaction [BCL2 mutant form promotes the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]]; Flavonoids inhibits the reaction [BCL2 mutant form promotes the reaction [AGT protein results in increased expression of AGTRAP protein]]; Flavonoids inhibits the reaction [BCL2 mutant form promotes the reaction [AGT protein results in increased expression of BAX mRNA]]; Flavonoids inhibits the reaction [BCL2 mutant form promotes the reaction [AGT protein results in increased expression of CYBA mRNA]]; Flavonoids inhibits the reaction [BCL2 mutant form promotes the reaction [AGT protein results in increased expression of CYBA protein]]PMID:23994555
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