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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:52492
Term: mancozeb
Definition: A mixture composed from maneb and zineb, which is used as a broad-spectrum contact fungicide.
Chemical ID: MESH:C013099
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDmancozeb results in decreased expression of BCL2 proteinPMID:16005924
Bcl2multiple interactionsEXP 6480464CTDalpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]PMID:16005924
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDmancozeb results in decreased expression of BCL2 proteinPMID:35617905
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDmancozeb results in decreased expression of BCL2 mRNAPMID:27235710
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Sulfur co-treated with mancozeb co-treated with metrafenone] results in decreased expression of BCL2 mRNA; [Sulfur co-treated with mancozeb] results in decreased expression of BCL2 mRNA; lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA]PMID:27235710 PMID:35564597
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