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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of BCL2 mRNA; Acetaminophen results in decreased expression of BCL2 proteinPMID:22093918 PMID:26767949
Bcl2increases expressionEXP 6480464CTDAcetaminophen results in increased expression of BCL2 mRNA; Acetaminophen results in increased expression of BCL2 protein modified formPMID:20166895 PMID:33387578
Bcl2multiple interactionsEXP 6480464CTDAcetaminophen inhibits the reaction [Vitamin K 3 results in decreased expression of BCL2 mRNA]; Acetaminophen inhibits the reaction [Vitamin K 3 results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; morin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of BCL2 protein modified form]; Taurine inhibits the reaction [Acetaminophen results in increased expression of BCL2 protein modified form]PMID:19265712 PMID:20166895 PMID:22093918 PMID:26767949
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of BCL2 proteinPMID:18467506 PMID:22939915 PMID:31697998 PMID:31967706 PMID:32040233 PMID:33571619 PMID:35166444 PMID:35179299
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of BCL2 mRNAPMID:9444671
Bcl2increases expressionISOBcl2 (Mus musculus)6480464CTDAcetaminophen results in increased expression of BCL2 mRNA; Acetaminophen results in increased expression of BCL2 proteinPMID:12540782 PMID:25319358 PMID:37046119 PMID:37179516
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of BCL2 mRNAPMID:26690555 PMID:29067470
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDAcetaminophen promotes the reaction [saikosaponin D results in increased expression of BCL2 mRNA]; allicin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; amlexanox inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; dioscin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; Irbesartan inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; KITL protein inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of BCL2 mRNA]; P2RX1 protein affects the reaction [Acetaminophen results in increased expression of BCL2 protein]; schizandrol B promotes the reaction [Acetaminophen results in increased expression of BCL2 protein]PMID:12540782 PMID:18467506 PMID:22939915 PMID:25265579 PMID:25319358 PMID:31697998 PMID:31967706 PMID:32040233 PMID:35166444 PMID:35179299 PMID:37046119
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