GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | affects expression | EXP | | 6480464 | CTD | lead acetate affects the expression of BCL2 mRNA | PMID:18618274 | Bcl2 | decreases expression | EXP | | 6480464 | CTD | lead acetate results in decreased expression of BCL2 mRNA; lead acetate results in decreased expression of BCL2 protein | PMID:23146751 PMID:24960054 PMID:29797346 PMID:32116774 PMID:34553816 PMID:37471654 | Bcl2 | increases expression | EXP | | 6480464 | CTD | lead acetate results in increased expression of BCL2 protein | PMID:17959157 PMID:19026729 PMID:23086308 | Bcl2 | multiple interactions | EXP | | 6480464 | CTD | [[lead acetate results in increased abundance of Lead] which co-treated with Carbenoxolone] results in decreased expression of BCL2 protein; [Cadmium Chloride co-treated with lead acetate] results in decreased expression of BCL2 protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of BCL2 protein; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of BCL2 protein; Ascorbic Acid promotes the reaction [lead acetate results in increased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]; Genistein inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]; Hemin inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]; lead acetate promotes the reaction [Zinc Oxide results in decreased expression of BCL2 mRNA]; Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BCL2 protein]; sinapinic acid inhibits the reaction [lead acetate results in decreased expression of BCL2 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BCL2 protein]; Zinc Oxide promotes the reaction [lead acetate results in decreased expression of BCL2 mRNA] | PMID:17959157 PMID:25031709 PMID:26396915 PMID:26797587 PMID:29797346 PMID:32116774 PMID:33242459 PMID:34553816 PMID:36925031 PMID:37471654 | Bcl2 | affects expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | lead acetate affects the expression of BCL2 protein | PMID:26542248 | Bcl2 | decreases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | lead acetate results in decreased expression of BCL2 protein | PMID:26498409 | Bcl2 | increases expression | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | lead acetate results in increased expression of BCL2 mRNA | PMID:22609695 | Bcl2 | multiple interactions | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | NFE2L2 protein inhibits the reaction [lead acetate results in decreased expression of BCL2 protein] | PMID:26498409 | | ||||||||||||||||||||||
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