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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:47898
Term: 4'-epidoxorubicin
Definition: An anthracycline that is the 4'-epi-isomer of doxorubicin.
Chemical ID: MESH:D015251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDEpirubicin results in decreased expression of BCL2 proteinPMID:26646421 PMID:29505745
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDEpirubicin analog results in increased expression of BCL2 mRNA; Epirubicin results in increased expression of BCL2 mRNAPMID:14503796 PMID:23867903 PMID:26335193
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDpaeonol inhibits the reaction [Epirubicin results in decreased expression of BCL2 protein]PMID:26646421 PMID:29505745
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Epirubicin analog co-treated with chrysophsin analog] results in increased expression of BCL2 mRNA; [Epirubicin co-treated with chrysophsin] results in increased expression of BCL2 mRNAPMID:26335193
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