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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:33191
Term: potassium cyanide
Definition: A cyanide salt containing equal numbers of potassium cations and cyanide anions.
Chemical ID: MESH:D011190
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases response to substanceEXP 6480464CTDBCL2 protein results in decreased susceptibility to Potassium CyanidePMID:19361538
Bcl2multiple interactionsEXP 6480464CTD[[pirinixic acid results in increased expression of UCP2 protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Potassium Cyanide; Potassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]PMID:19361538
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